Nicotine Is Not a Proinflammatory Component of E-cigarette Vapor
By: Carr J. Smith and Thomas A. Perfetti
References
- Centers for Disease Control and Prevention (CDC): Website - National Health Interview Survey : 2022 NHIS Questionnaires, Datasets, and Documentation; CDC, Atlanta, GA, USA, last updated November 20, 2024. Available at:
https://www.cdc.gov/nchs/nhis/documentation/2022-nhis.html (accessed July 12, 2026). - Karban, A. and R. Eliakim: Effect of Smoking on Inflammatory Bowel Disease: Is It Disease or Organ Specific?; World J. Gastroenterol. 13 (2007) 2150–2152. DOI: 10.3748/wjg.v13.i15.2150
- Mínguez, A. and P. Nos: Association of Smoking and Crohn's Disease: An Update; J. Cell. Immunol. 6 (2024) 140–147. DOI: 10.33696/immunology.6.200
- Masuko, K.: Cigarette Smoking: A Modifiable Environmental Factor in the Pathogenesis of Rheumatoid Arthritis; JMA J. 8 (2025) 1077–1086. DOI: 10.31662/jmaj.2025-0029
- Rothbard, J.B., J.J. Rothbard, L. Soares, C.G. Fathman, and L. Steinman: Identification of a Common Immune Regulatory Pathway Induced by Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine; Proc. Natl. Acad. Sci. U.S.A. 115 (2018) 7081–7086. DOI: 10.1073/pnas.1804599115
- Zhang, W., H. Lin, M. Zou, Q. Yuan, Z. Huang, X. Pan, and W. Zhang: Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects; Front. Immunol. 13 (2022) 826889. DOI: 10.3389/fimmu.2022.826889
- Cao, Y., J. Sun, X. Wang, X. Zhang, H. Tian, L. Huang, Z. Huang, Y. Zhang, J. Zhang, L. Li, and S. Zhou: The Double-Edged Nature of Nicotine: Toxicities and Therapeutic Potentials; Front. Pharmacol. 15 (2024) 1427314. DOI: 10.3389/fphar.2024.1427314
- Liu, Y., G. Cheng, J. Cao, J. Zhang, C. Luo, and L. Huang: The “Double-Edged Sword Effect” of Nicotine; Fitoterapia 177 (2024) 106102. DOI: 10.1016/j.fitote.2024.106102
- Scherer, G., N. Pluym, and M. Scherer: Literature Review on Nicotine’s Role in Human Health; Contrib. Tob. Nicotine Res. 33 (2024) 1–111. DOI: 10.2478/cttr-2024-0001
- Lee, Y.H., M. Gawron, and M.L. Goniewicz: Changes in Puffing Behavior among Smokers Who Switched from Tobacco to Electronic Cigarettes; Addict. Behav. 48 (2015) 1–4. DOI: 10.1016/j.addbeh.2015.04.003
- Perfetti, T.A. and A. Rodgman: The Complexity of Tobacco and Tobacco Smoke; Beitr. Tabakforsch. Int. 24 (2011) 215–232. DOI: 10.2478/cttr-2013-0902
- Borgerding, M. and H. Klus: Analysis of Complex Mixtures – Cigarette Smoke; Exp. Toxicol. Pathol. 57 (2005) 43–73. DOI: 10.1016/j.etp.2005.05.010
- Rennard, S. and D. Daughton: Smoking Reduction and Biological Markers of Response; Monaldi Arch. Chest Dis. 48 (1993) 580–582.
- Perricone, R., C. de Carolis, G. de Sanctis, and L. Fontana: Complement Activation by Cigarette Smoke Condensate and Tobacco Infusion; Arch. Environ. Health 38 (1983) 176–179. DOI: 10.1080/00039896.1983.10544001
- Kew, R.R., B. Ghebrehiwet, and A. Janoff: The Fifth Component of Complement (C5) Is Necessary for Maximal Pulmonary Leukocytosis in Mice Chronically Exposed to Cigarette Smoke; Clin. Immunol. Immunopathol. 43 (1987) 73–81. DOI: 10.1016/0090-1229(87)90158-9
- Robbins, R.A., G.L. Gossman, K.J. Nelson, S. Koyama, A.B. Thompson, and S.I. Rennard: Inactivation of Chemotactic Factor Inactivator by Cigarette Smoke. A Potential Mechanism of Modulating Neutrophil Recruitment to the Lung; Am. Rev. Respir. Dis. 142 (1990) 763–768. DOI: 10.1164/ajrccm/142.4.763
- Hunninghake, G.W. and R.G. Crystal: Cigarette Smoking and Lung Destruction. Accumulation of Neutrophils in the Lungs of Cigarette Smokers; Am. Rev. Respir. Dis. 128 (1983) 833–838. DOI: 10.1164/arrd.1983.128.5.833
- Shoji, S., R.F. Ertl, S. Koyama, R. Robbins, G. Leikauf, S. Von Essen, and S.I. Rennard: Cigarette Smoke Stimulates Release of Neutrophil Chemotactic Activity from Cultured Bovine Bronchial Epithelial Cells; Clin. Sci. 88 (1995) 337–344. DOI: 10.1042/cs0880337
- Mio, T., D.J. Romberger, A.B. Thompson, R.A. Robbins, A. Heires, and S.I. Rennard: Cigarette Smoke Induces Interleukin-8 Release from Human Bronchial Epithelial Cells; Am. J. Respir. Crit. Care Med. 155 (1997) 1770–1776. DOI: 10.1164/ajrccm.155.5.9154890
- Fujita, J., N.L. Nelson, D.M. Daughton, C.A. Dobry, J.R. Spurzem, S. Irino, and S.I. Rennard: Evaluation of Elastase and Antielastase Balance in Patients with Chronic Bronchitis and Pulmonary Emphysema; Am. Rev. Respir. Dis. 142 (1990) 57–62. DOI: 10.1164/ajrccm/142.1.57
- Carp, H., F. Miller, J.R. Hoidal, and A. Janoff: Potential Mechanism of Emphysema: a1-Proteinase Inhibitor Recovered from Lungs of Cigarette Smokers Contains Oxidized Methionine and Has Decreased Elastase Inhibitory Capacity; Proc. Natl. Acad. Sci. U.S.A. 79 (1982) 2041–2045. DOI: 10.1073/pnas.79.6.2041
- Hubbard, R.C., F. Ogushi, G.A. Fells, A.M. Cantin, S. Jallat, M. Courtney, and R.G. Crystal: Oxidants Spontaneously Released by Alveolar Macrophages of Cigarette Smokers Can Inactivate the Active Site of Alpha 1-Antitrypsin, Rendering It Ineffective as an Inhibitor of Neutrophil Elastase; J. Clin. Invest. 80 (1987) 1289–1295. DOI: 10.1172/JCI113204
- Shapiro, S.D.: Elastolytic Metalloproteinases Produced by Human Mononuclear Phagocytes: Potential Roles in Destructive Lung Disease; Am. J. Respir. Crit. Care Med. 150 (1994) S160–S164. DOI: 10.1164/ajrccm/150.6_Pt_2.S160
- Hunninghake, G.W., J.M. Davidson, S. Rennard, S. Szapiel, J.E. Gadek, and R.G. Crystal: Elastin Fragments Attract Macrophage Precursors to Diseased Sites in Pulmonary Emphysema; Science 212 (1981) 925–927. DOI: 10.1126/science.7233186
- Senior, R.M., G.L. Griffin, and R.P. Mecham: Chemotactic Activity of Elastin-Derived Peptides; J. Clin. Invest. 66 (1980) 859–862. DOI: 10.1172/JCI109926
- Chang, J.C., M. Lesser, O.H. Yoo, and M. Orlowski: Increased Cathepsin B-Like Activity in Alveolar Macrophages and Bronchoalveolar Lavage Fluid from Smokers; Am. Rev. Respir. Dis. 134 (1986) 538–541. DOI: 10.1164/arrd.1986.134.3.538
- Gairola, C.G., N.I. Galicki, C. Cardozo, Y.L. Lai, and M. Lesser: Cigarette Smoke Stimulates Cathepsin B Activity in Alveolar Macrophages of Rats; J. Lab. Clin. Med. 114 (1989) 419–425.
- Lesser, M., M.L. Padilla, and C. Cardozo: Induction of Emphysema in Hamsters by Intratracheal Instillation of Cathepsin B; Am. Rev. Respir. Dis. 145 (1992) 661–668. DOI: 10.1164/ajrccm/145.3.661
- Chang, J.C., O.H. Yoo, and M. Lesser: Cathepsin D Activity Is Increased in Alveolar Macrophages and Bronchoalveolar Lavage Fluid of Smokers; Am. Rev. Respir. Dis. 140 (1989) 958–960. DOI: 10.1164/ajrccm/140.4.958
- Lesser, M., N. Galicki, C. Cardozo, and C.G. Gariola: Cathepsin L Activity in Alveolar Macrophages of Rats: Response to Cigarette Smoke; Am. J. Respir. Cell Mol. Biol. 1 (1989) 371–376. DOI: 10.1165/ajrcmb/1.5.371
- Levänen, B., P. Glader, B. Dahlén, B. Billing, I. Qvarfordt, L. Palmberg, K. Larsson, and A. Lindén: Impact of Tobacco Smoking on Cytokine Signaling via Interleukin-17a in the Peripheral Airways; Int. J. Chron. Obstruct. Pulmon. Dis. 11 (2016) 2109–2116. DOI: 10.2147/COPD.S99900
- Elisia, I., V. Lam, B. Cho, M. Hay, M.Y. Li, M. Yeung, L. Bu, W. Jia, N. Norton, S. Lam, and G. Krystal: The Effect of Smoking on Chronic Inflammation, Immune Function and Blood Cell Composition; Sci. Rep. 10 (2020) 19480. DOI: 10.1038/s41598-020-76556-7
- Che, Karlhans F., E. Tufvesson, S. Tengvall, E. Lappi-Blanco, R. Kaarteenaho, B. Levänen, M. Ekberg, A. Brauner, Åsa M. Wheelock, L. Bjermer, C.M. Sköld, and A. Lindén: The Neutrophil-Mobilizing Cytokine Interleukin-26 in the Airways of Long-Term Tobacco Smokers; Clin. Sci. 132 (2018) 959–983. DOI: 10.1042/cs20180057
- Niewoehner, D.E., J. Kleinerman, and D.B. Rice: Pathologic Changes in the Peripheral Airways of Young Cigarette Smokers; N. Engl. J. Med. 291 (1974) 755–758. DOI: 10.1056/NEJM197410102911503
- Kominami, E., T. Tsukahara, K. Hara, and N. Katunuma: Biosyntheses and Processing of Lysosomal Cysteine Proteinases in Rat Macrophages; FEBS Lett. 231 (1988) 225–228. DOI: 10.1016/0014-5793(88)80736-1
- Jones, P.W., F.H. Quirk, and C.M. Baveystock: The St George's Respiratory Questionnaire; Respir. Med. 85 Suppl B (1991) 25–31; discussion 33–27. DOI: 10.1016/s0954-6111(06)80166-6
- Jones, P.W., F.H. Quirk, C.M. Baveystock, and P. Littlejohns: A Self-Complete Measure of Health Status for Chronic Airflow Limitation: The St. George's Respiratory Questionnaire; Am. Rev. Respir. Dis. 145 (1992) 1321–1327. DOI: 10.1164/ajrccm/145.6.1321
- Barr, J.T., G.E. Schumacher, S. Freeman, M. LeMoine, A.W. Bakst, and P.W. Jones: American Translation, Modification, and Validation of the St. George's Respiratory Questionnaire; Clin. Ther. 22 (2000) 1121–1145. DOI: 10.1016/S0149-2918(00)80089-2
- McFadden, E.R. and D.A. Linden: A Reduction in Maximum Mid-Expiratory Flow Rate: A Spirographic Manifestation of Small Airway Disease; Am. J. Med. 52 (1972) 725–737. DOI: 10.1016/0002-9343(72)90078-2
- Kwon, D.S., Y.J. Choi, T.H. Kim, M.K. Byun, J.H. Cho, H.J. Kim, and H.J. Park: FEF25-75% Values in Patients with Normal Lung Function Can Predict the Development of Chronic Obstructive Pulmonary Disease; Int. J. Chron. Obstruct. Pulmon. Dis. 15 (2020) 2913–2921. DOI: 10.2147/COPD.S261732
- Pisi, R., M. Aiello, A. Frizzelli, L. Calzetta, L. Marchi, G. Bertorelli, G. Pisi, and A. Chetta: Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System; Int. J. Chron. Obstruct. Pulmon. Dis. 16 (2021) 2585–2590. DOI: 10.2147/COPD.S319972
- Coates, G. and H. O'Brodovich: Measurement of Pulmonary Epithelial Permeability with 99mTc-DTPA Aerosol; Semin. Nucl. Med. 16 (1986) 275–284. DOI: 10.1016/S0001-2998(86)80014-9
- Stewart, J.C., R.W. Hyde, J. Boscia, M.Y. Chow, R.E. O'Mara, I. Perillo, A. Pietropaoli, C.J. Smith, A. Torres, M.J. Utell, and M.W. Frampton: Changes in Markers of Epithelial Permeability and Inflammation in Chronic Smokers Switching to a Nonburning Tobacco Device (Eclipse); Nicotine Tob. Res. 8 (2006) 773–783. DOI: 10.1080/14622200601004091
- Rößler, G., J. Labode, J. Schipke, S.A. Tschanz, and C. Mühlfeld: Three-Dimensional Characteristics of the Alveolar Capillary Network in Infant and Adult Human Lungs; Pediatr. Res. 97 (2025) 2136–2144. DOI: 10.1038/s41390-024-03572-y
- Tigner, A., S.A. Ibrahim, and I.V. Murray: Website - Histology, White Blood Cell; StatPearls Publishing, Treasure Island, FL, USA, last updated February 14, 2026. Available at:
https://www.ncbi.nlm.nih.gov/books/NBK563148/ (accessed June 23, 2026). - Roberts, R.E. and M.B. Hallett: Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis; Int. J. Mol. Sci. 20 (2019) 1383. DOI: 10.3390/ijms20061383
- Gullberg, U., E. Andersson, D. Garwicz, A. Lindmark, and I. Olsson: Biosynthesis, Processing and Sorting of Neutrophil Proteins: Insight into Neutrophil Granule Development; Eur. J. Haaematol. 58 (1997) 137–153. DOI: 10.1111/j.1600-0609.1997.tb00940.x
- Vlahovic, G., M.L. Russell, R.R. Mercer, and J.D. Crapo: Cellular and Connective Tissue Changes in Alveolar Septal Walls in Emphysema; Am. J. Respir. Crit. Care Med. 160 (1999) 2086–2092. DOI: 10.1164/ajrccm.160.6.9706031
- Budde, R. and H.E. Schaefer: Smokers' Dysmyelopoiesis – Bone Marrow Alterations Associated with Cigarette Smoking; Pathol. Res. Pract. 185 (1989) 347–350. DOI: 10.1016/S0344-0338(89)80011-1
- Bain, B.J.: Bone Marrow Trephine Biopsy; J. Clin. Pathol. 54 (2001) 737–742.
- van Eeden, S. and J. Hogg: The Response of Human Bone Marrow to Chronic Cigarette Smoking; Eur. Respir. J. 15 (2000) 915–921. DOI: 10.1034/j.1399-3003.2000.15e18.x
- Linderkamp, O., P. Ruef, B. Brenner, E. Gulbins, and F. Lang: Passive Deformability of Mature, Immature, and Active Neutrophils in Healthy and Septicemic Neonates; Pediatr. Res. 44 (1998) 946–950. DOI: 10.1203/00006450-199812000-00021
- Demkow, U. and F.J. van Overveld: Role of Elastases in the Pathogenesis of Chronic Obstructive Pulmonary Disease: Implications for Treatment; Eur. J. Med. Res. 15 (2010) 27. DOI: 10.1186/2047-783X-15-S2-27
- Molet, S., C. Belleguic, H. Lena, N. Germain, C.P. Bertrand, S.D. Shapiro, J.M. Planquois, P. Delaval, and V. Lagente: Increase in Macrophage Elastase (MMP-12) in Lungs from Patients with Chronic Obstructive Pulmonary Disease; Inflamm. Res. 54 (2005) 31–36. DOI: 10.1007/s00011-004-1319-4
- Lee, J., V. Taneja, and R. Vassallo: Cigarette Smoking and Inflammation: Cellular and Molecular Mechanisms; J. Dent. Res. 91 (2012) 142–149. DOI: 10.1177/0022034511421200
- Marcilla, A., I. Martínez, D. Berenguer, A. Gómez-Siurana, and M.I. Beltrán: Comparative Study of the Main Characteristics and Composition of the Mainstream Smoke of Ten Cigarette Brands Sold in Spain; Food Chem. Toxicol. 50 (2012) 1317–1333. DOI: 10.1016/j.fct.2012.01.046
- Berkowitz, L., B.M. Schultz, G.A. Salazar, C. Pardo-Roa, V.P. Sebastian, M.M. Alvarez-Lobos, and S.M. Bueno: Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis; Front. Immunol. 9 (2018) 74. DOI: 10.3389/fimmu.2018.00074
- Smith, C.J., T.A. Perfetti, R. Garg, and C. Hansch: Utility of the Mouse Dermal Promotion Assay in Comparing the Tumorigenic Potential of Cigarette Mainstream Smoke; Food Chem. Toxicol. 44 (2006) 1699–1706. DOI: 10.1016/j.fct.2006.05.008
- Smith, C.J., T.A. Perfetti, and J.A. King: Perspectives on Pulmonary Inflammation and Lung Cancer Risk in Cigarette Smokers; Inhal. Toxicol. 18 (2006) 667–677. DOI: 10.1080/08958370600742821
- Madsen, C., P. Nafstad, L. Eikvar, P.E. Schwarze, K.S. Rønningen, and L.L. Haaheim: Association between Tobacco Smoke Exposure and Levels of C-Reactive Protein in the Oslo II Study; Eur. J. Epidemiol. 22 (2007) 311–317. DOI: 10.1007/s10654-007-9121-6
- Kianoush, S., M.S. Bittencourt, P.A. Lotufo, I.M. Bensenor, S.R. Jones, A.P. DeFilippis, P.P. Toth, J.D. Otvos, M. Tibuakuu, M.E. Hall, P.H.N. Harada, and M.J. Blaha: Association between Smoking and Serum GlycA and High-Sensitivity C-Reactive Protein Levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil); J. Am. Heart Assoc. 6 (2017) e006545. DOI: 10.1161/JAHA.117.006545
- Tuut, M. and H.-W. Hense: Smoking, Other Risk Factors and Fibrinogen Levels: Evidence of Effect Modification; Ann. Epidemiol. 11 (2001) 232–238. DOI: 10.1016/S1047-2797(00)00226-X
- Petitti, D.B. and H. Kipp: The Leukocyte Count: Associations with Intensity of Smoking and Persistence of Effect after Quitting; Am. J. Epidemiol. 123 (1986) 89–95. DOI: 10.1093/oxfordjournals.aje.a114227
- Yarnell, J.W., P.M. Sweetnam, S. Rogers, P.C. Elwood, D. Bainton, I.A. Baker, R. Eastham, J.R. O'Brien, and M.D. Etherington: Some Long Term Effects of Smoking on the Haemostatic System: a Report from the Caerphilly and Speedwell Collaborative Surveys; J. Clin. Pathol. 40 (1987) 909–913. DOI: 10.1136/jcp.40.8.909
- Schwartz, J. and S.T. Weiss: Host and Environmental Factors Influencing the Peripheral Blood Leukocyte Count; Am. J. Epidemiol. 134 (1991) 1402–1409. DOI: 10.1093/oxfordjournals.aje.a116045
- Schwartz, J. and S.T. Weiss: Cigarette Smoking and Peripheral Blood Leukocyte Differentials; Ann. Epidemiol. 4 (1994) 236–242. DOI: 10.1016/1047-2797(94)90102-3
- Freedman, D.S., W.D. Flanders, J.J. Barboriak, A.M. Malarcher, and L. Gates: Cigarette Smoking and Leukocyte Subpopulations in Men; Ann. Epidemiol. 6 (1996) 299–306. DOI: 10.1016/s1047-2797(96)00024-5
- Sunyer, J., A. Muñoz, Y. Peng, J. Margolick, J.S. Chmiel, J. Oishi, L. Kingsley, and J.M. Samet: Longitudinal Relation between Smoking and White Blood Cells; Am. J. Epidemiol. 144 (1996) 734–741. DOI: 10.1093/oxfordjournals.aje.a008997
- van Tiel, E.D., P.H.M. Peeters, H.A. Smit, N.J.D. Nagelkerke, A.J.M. Van Loon, D.E. Grobbee, and H.B. Bueno-De-Mesquita: Quitting Smoking May Restore Hematological Characteristics within Five Years; Ann. Epidemiol. 12 (2002) 378–388. DOI: 10.1016/S1047-2797(01)00282-4
- Fröhlich, M., M. Sund, H. Löwel, A. Imhof, A. Hoffmeister, and W. Koenig: Independent Association of Various Smoking Characteristics with Markers of Systemic Inflammation in Men: Results from a Representative Sample of the General Population (Monica Augsburg Survey 1994/95); Eur. Heart J. 24 (2003) 1365–1372. DOI: 10.1016/s0195-668x(03)00260-4
- Smith, M.R., A.-L. Kinmonth, R.N. Luben, S. Bingham, N.E. Day, N.J. Wareham, A. Welch, and K.-T. Khaw: Smoking Status and Differential White Cell Count in Men and Women in the Epic-Norfolk Population; Atherosclerosis 169 (2003) 331–337. DOI: 10.1016/S0021-9150(03)00200-4
- Lao, X.Q., C.Q. Jiang, W.S. Zhang, P. Adab, T.H. Lam, K.K. Cheng, and G.N. Thomas: Smoking, Smoking Cessation and Inflammatory Markers in Older Chinese Men: The Guangzhou Biobank Cohort Study; Atherosclerosis 203 (2009) 304–310. DOI: 10.1016/j.atherosclerosis.2008.06.028
- Higuchi, T., F. Omata, K. Tsuchihashi, K. Higashioka, R. Koyamada, and S. Okada: Current Cigarette Smoking Is a Reversible Cause of Elevated White Blood Cell Count: Cross-Sectional and Longitudinal Studies; Prev. Med. Rep. 4 (2016) 417–422. DOI: 10.1016/j.pmedr.2016.08.009
- Zhu, Y.P., L. Padgett, H.Q. Dinh, P. Marcovecchio, A. Blatchley, R. Wu, E. Ehinger, C. Kim, Z. Mikulski, G. Seumois, A. Madrigal, P. Vijayanand, and C.C. Hedrick: Identification of an Early Unipotent Neutrophil Progenitor with Pro-Tumoral Activity in Mouse and Human Bone Marrow; Cell Rep. 24 (2018) 2329–2341.e2328. DOI: 10.1016/j.celrep.2018.07.097
- Ghaedi, M., Catherine A. Steer, I. Martinez-Gonzalez, Timotheus Y.F. Halim, N. Abraham, and F. Takei: Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development; Cell Rep. 15 (2016) 471–480. DOI: 10.1016/j.celrep.2016.03.039
- Weiskopf, K., P.J. Schnorr, W.W. Pang, M.P. Chao, A. Chhabra, J. Seita, M. Feng, and I.L. Weissman: Myeloid Cell Origins, Differentiation, and Clinical Implications; in: Myeloid Cells in Health and Disease, 2016, pp. 857–875. DOI: 10.1128/9781555819194.ch50
- Mukhopadhyay, S., J.R. Hoidal, and T.K. Mukherjee: Role of TNFα in Pulmonary Pathophysiology; Respir. Res. 7 (2006) 125. DOI: 10.1186/1465-9921-7-125
- Tsantikos, E., M. Lau, C.M.N. Castelino, M.J. Maxwell, S.L. Passey, M.J. Hansen, N.E. McGregor, N.A. Sims, D.P. Steinfort, L.B. Irving, G.P. Anderson, and M.L. Hibbs: Granulocyte-CSF Links Destructive Inflammation and Comorbidities in Obstructive Lung Disease; J. Clin. Invest. 128 (2018) 2406–2418. DOI: 10.1172/JCI98224
- Pietras, E.M., C. Mirantes-Barbeito, S. Fong, D. Loeffler, L.V. Kovtonyuk, S. Zhang, R. Lakshminarasimhan, C.P. Chin, J.-M. Techner, B. Will, C. Nerlov, U. Steidl, M.G. Manz, T. Schroeder, and E. Passegué: Chronic Interleukin-1 Exposure Drives Haematopoietic Stem Cells Towards Precocious Myeloid Differentiation at the Expense of Self-Renewal; Nat. Cell Biol. 18 (2016) 607–618. DOI: 10.1038/ncb3346
- Florentin, J., J. Zhao, Y.-Y. Tai, S.B. Vasamsetti, S.P. O’Neil, R. Kumar, A. Arunkumar, A. Watson, J. Sembrat, G.C. Bullock, L. Sanders, B. Kassa, M. Rojas, B.B. Graham, S.Y. Chan, and P. Dutta: Interleukin-6 Mediates Neutrophil Mobilization from Bone Marrow in Pulmonary Hypertension; Cell. Mol. Immunol. 18 (2021) 374–384. DOI: 10.1038/s41423-020-00608-1
- van Eeden, S.E. and T. Terashima: Interleukin 8 (IL-8) and the Release of Leukocytes from the Bone Marrow; Leuk. Lymphoma 37 (2000) 259–271. DOI: 10.3109/10428190009089427
- McCormick, T.S., R.B. Hejal, L.O. Leal, and M.A. Ghannoum: GM-CSF: Orchestrating the Pulmonary Response to Infection; Front. Pharmacol. 12 (2022) 735443. DOI: 10.3389/fphar.2021.735443
- McGill, H.C.: Personal Communication during a Visit to the Texas Biomedical Research Institute, San Antonio, Texas; ca. 1988.
- Gidding, S.S., J.S. Rana, C. Prendergast, H. McGill, J.J. Carr, K. Liu, L.A. Colangelo, C.M. Loria, J. Lima, J.G. Terry, J.P. Reis, and C.A. McMahan: Pathobiological Determinants of Atherosclerosis in Youth (Pday) Risk Score in Young Adults Predicts Coronary Artery and Abdominal Aorta Calcium in Middle Age; Circulation 133 (2016) 139–146. DOI: 10.1161/CIRCULATIONAHA.115.018042
- Theofilis, P., M. Sagris, E. Oikonomou, A.S. Antonopoulos, G. Siasos, C. Tsioufis, and D. Tousoulis: Inflammatory Mechanisms Contributing to Endothelial Dysfunction; Biomedicines 9 (2021) 781. DOI: 10.3390/biomedicines9070781
- Benowitz, N.L., J. Hukkanen, and P. Jacob III: Nicotine Chemistry, Metabolism, Kinetics and Biomarkers; in: Nicotine Psychopharmacology, edited by J.E. Henningfield, E.D. London, and S. Pogun, Springer Heidelberg, Germany, 2009, pp. 29–60. DOI: 10.1007/978-3-540-69248-5_2
- Hukkanen, J., P. Jacob III, and N.L. Benowitz: Metabolism and Disposition Kinetics of Nicotine; Pharmacol. Rev. 57 (2005) 79–115. DOI: 10.1124/pr.57.1.3
- Yingst, J.M., C. Bordner, S. Hrabovsky, A.L. Hobkirk, N. Trushin, J.P. Richie, Jr., and J. Foulds: Nicotine Delivery of a Menthol-Flavored Heat-Not-Burn Tobacco Product during Directed Use; Nicotine Tob. Res. 26 (2024) 397–401. DOI: 10.1093/ntr/ntad119
- Philip Morris International (PMI): Website - Heated Tobacco Products; PMI, Lausanne, Switzerland, Available at:
https://www.pmi.com/our-business/smoke-free-products/heated-tobacco-products (accessed June 23, 2026). - Smith, M.R., B. Clark, F. Lüdicke, J.P. Schaller, P. Vanscheeuwijck, J. Hoeng, and M.C. Peitsch: Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program; Regul. Toxicol. Pharmacol. 81 Suppl 2 (2016) S17–S26. DOI: 10.1016/j.yrtph.2016.07.006
- Claus, E.D., B.C. Moeller, D. Harbour, P.J. Kuehl, M. McGuire, J.C. Vivar, and M.J. Schroeder: Use Behaviors, Dependence, and Nicotine Exposure Associated with Ad Libitum Cigar Smoking; Tob. Regul. Sci. 4 (2018) 548–561. DOI: 10.18001/TRS.4.1.2
- Lunell, E., K. Fagerström, J. Hughes, and R. Pendrill: Pharmacokinetic Comparison of a Novel Non-Tobacco-Based Nicotine Pouch (Zyn) with Conventional, Tobacco-Based Swedish Snus and American Moist Snuff; Nicotine Tob. Res. 22 (2020) 1757–1763. DOI: 10.1093/ntr/ntaa068
- Renard, K., D. Nishihara, J. Nilsson, S. Larroque, J. Martinez, and L. Giles: Characterization of the Nicotine Uptake and Safety of Nordic Spirit Tobacco-Free Oral Nicotine Pouches: A Randomized Crossover Study; Psychopharmacology 242 (2025) 855–865. DOI: 10.1007/s00213-024-06721-7
- Digard, H., C. Proctor, A. Kulasekaran, U. Malmqvist, and A. Richter: Determination of Nicotine Absorption from Multiple Tobacco Products and Nicotine Gum; Nicotine Tob. Res. 15 (2013) 255–261. DOI: 10.1093/ntr/nts123
- Mallock-Ohnesorg, N., A. Rabenstein, Y. Stoll, M. Gertzen, B. Rieder, S. Malke, N. Burgmann, P. Laux, E. Pieper, T. Schulz, K. Franzen, A. Luch, and T. Ruther: Small Pouches, but High Nicotine Doses-Nicotine Delivery and Acute Effects after Use of Tobacco-Free Nicotine Pouches; Front. Pharmacol. 15 (2024) 1392027. DOI: 10.3389/fphar.2024.1392027
- Azzopardi, D., E. Brown, F. Meichanetzidis, S. Fiebelkorn, L.E. Haswell, G. Hardie, and M. McEwan: A Randomized Crossover Clinical Study to Assess the Effect of Oral Nicotine Pouches Used for Different Durations on Plasma Nicotine Pharmacokinetics in Healthy Oral Pouch Consumers; J. Clin. Pharmacol. 66 (2026) e70090. DOI: 10.1002/jcph.70090
- Pickworth, W.B., Z.R. Rosenberry, W. Gold, and B. Koszowski: Nicotine Absorption from Smokeless Tobacco Modified to Adjust pH; J. Addict Res. Ther. 5 (2014) 1000184. DOI: 10.4172/2155-6105.1000184
- Voos, N., L. Kaiser, M.C. Mahoney, C.M. Bradizza, L.T. Kozlowski, N.L. Benowitz, R.J. O'Connor, and M.L. Goniewicz: Randomized within-Subject Trial to Evaluate Smokers' Initial Perceptions, Subjective Effects and Nicotine Delivery across Six Vaporized Nicotine Products; Addiction 114 (2019) 1236–1248. DOI: 10.1111/add.14602
- Hajek, P., D. Przulj, A. Phillips, R. Anderson, and H. McRobbie: Nicotine Delivery to Users from Cigarettes and from Different Types of E-Cigarettes; Psychopharmacology 234 (2017) 773–779. DOI: 10.1007/s00213-016-4512-6
- Yuki, D., C. Sakaguchi, A. Kikuchi, and Y. Futamura: Pharmacokinetics of Nicotine Following the Controlled Use of a Prototype Novel Tobacco Vapor Product; Regul. Toxicol. Pharmacol. 87 (2017) 30–35. DOI: 10.1016/j.yrtph.2017.05.005
- Goldenson, N.I., I.M. Fearon, A.R. Buchhalter, and J.E. Henningfield: An Open-Label, Randomized, Controlled, Crossover Study to Assess Nicotine Pharmacokinetics and Subjective Effects of the JUUL System with Three Nicotine Concentrations Relative to Combustible Cigarettes in Adult Smokers; Nicotine Tob. Res. 23 (2021) 947–955. DOI: 10.1093/ntr/ntab001
- An Open-Label, Randomized, Crossover Study to Assess Nicotine Uptake, Tobacco-Related Biomarkers of Exposure, Biomarkers of Potential Harm, and Puff Topography with Use of Myblutm Electronic Cigarettes in Adult Smokers; 2020, Available at:
https://clinicaltrials.gov/study/NCT04430634 (accessed June 23, 2026). - St. Helen, G., K.C. Ross, D.A. Dempsey, C.M. Havel, P. Jacob III, and N.L. Benowitz: Nicotine Delivery and Vaping Behavior during Ad Libitum E-Cigarette Access; Tob. Regul. Sci. 2 (2016) 363–376. DOI: 10.18001/TRS.2.4.8
- Farsalinos, K.E., A. Spyrou, K. Tsimopoulou, C. Stefopoulos, G. Romagna, and V. Voudris: Nicotine Absorption from Electronic Cigarette Use: Comparison between First and New-Generation Devices; Sci. Rep. 4 (2014) 4133. DOI: 10.1038/srep04133
- Centers for Disease Control and Prevention (CDC): Website - Smoking and Tobacco Use – About E-Cigarettes (Vapes); CDC, Atlanta, GA, USA, last updated October 24, 2024. Available at:
https://www.cdc.gov/tobacco/e-cigarettes/about.html (accessed June 23, 2026). - Margham, J., K. McAdam, A. Cunningham, A. Porter, S. Fiebelkorn, D. Mariner, H. Digard, and C. Proctor: The Chemical Complexity of E-Cigarette Aerosols Compared with the Smoke from a Tobacco Burning Cigarette; Front. Chem. 9 (2021) 743060. DOI: 10.3389/fchem.2021.743060
- Wilkinson, P.J., A. Clarke, I.M. Fearon, and R. Barry: Emissions from Conventional and Electronic Waterpipes Relative to Cigarettes and a Heated Tobacco Product; Sci. Rep. 15 (2025) 14176. DOI: 10.1038/s41598-025-90721-w
- White, J.L., B.T. Conner, T.A. Perfetti, B.R. Bombick, J.T. Avalos, K.W. Fowler, C.J. Smith, and D.J. Doolittle: Effect of Pyrolysis Temperature on the Mutagenicity of Tobacco Smoke Condensate; Food Chem. Toxicol. 39 (2001) 499–505. DOI: 10.1016/s0278-6915(00)00155-1
- Rowell, T.R. and R. Tarran: Will Chronic E-Cigarette Use Cause Lung Disease?; Am. J. Physiol. Lung Cell. Mol. Physiol. 309 (2015) L1398–L1409. DOI: 10.1152/ajplung.00272.2015
- Cui, H., L. Zhao, M. Fan, S. Liu, L. Chen, J. Cai, Y. Qin, X. Ding, and Z. Jiang: Study on Vaporisation Temperature of Electronic Cigarette; presented at the CORESTA Meeting, Smoke Science/Product Technology, Kitzbühel, Austria, 2017, Paper STPOST 12.
- Chen, W., P. Wang, K. Ito, J. Fowles, D. Shusterman, P.A. Jaques, and K. Kumagai: Measurement of Heating Coil Temperature for E-Cigarettes with a “Top-Coil” Clearomizer; PLOS ONE 13 (2018) e0195925. DOI: 10.1371/journal.pone.0195925
- Baker, R.R.: Temperature Distribution inside a Burning Cigarette; Nature 247 (1974) 405–406. DOI: 10.1038/247405a0
- Baker, R.R.: Development of Temperature Distribution inside the Reaction Zone of a Burning Cigarette; in: Thermal Analysis, Volume 1, edited by H.G. Wiedemann, Birkhäuser, Basel, Switzerland, 1980, pp. 439–444. DOI: 10.1007/978-3-0348-6719-1_69
- Baker, R.R.: Smoke Chemistry; in: Tobacco. Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford, UK, ISBN: 9780632047918, 1999, pp. 398–439.
- Baker, R.R.: Smoke Generation inside a Burning Cigarette: Modifying Combustion to Develop Cigarettes That May Be Less Hazardous to Health; Prog. Energy Combust. Sci. 32 (2006) 373–385. DOI: 10.1016/j.pecs.2006.01.001
- Rodgman, A. and T.A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke; 2nd ed., CRC Press, Boca Raton, FL, USA, 2013, 2332 pp. ISBN: 9780429096266. DOI: 10.1201/b13973
- Goniewicz, M.L., J. Knysak, M. Gawron, L. Kosmider, A. Sobczak, J. Kurek, A. Prokopowicz, M. Jablonska-Czapla, C. Rosik-Dulewska, C. Havel, P. Jacob III, and N. Benowitz: Levels of Selected Carcinogens and Toxicants in Vapour from Electronic Cigarettes; Tob. Control 23 (2014) 133–139. DOI: 10.1136/tobaccocontrol-2012-050859
- U.S. Department of Health and Human Services (DHHS): E-Cigarette Use among Youth and Young Adults. A Report of the Surgeon General; DHHS, Rockville, MD, USA, 2016, 275 pp. Available at:
https://e-cigarettes.surgeongeneral.gov/documents/2016_SGR_Full_Report_non-508.pdf - Tehrani, M.W., M.N. Newmeyer, A.M. Rule, and C. Prasse: Characterizing the Chemical Landscape in Commercial E-Cigarette Liquids and Aerosols by Liquid Chromatography-High-Resolution Mass Spectrometry; Chem. Res. Toxicol. 34 (2021) 2216–2226. DOI: 10.1021/acs.chemrestox.1c00253
- Mi, Y., Y. Tan, Y. Yu, D. An, R. Mo, S. Shi, and M. Li: Relationship between Smoking Status and Ulcerative Colitis: a Meta-Analysis Based on a Case–Control Study; Sci. Rep. 15 (2025) 13329. DOI: 10.1038/s41598-025-97617-9
- Pullan, R.D., J. Rhodes, S. Ganesh, V. Mani, J.S. Morris, G.T. Williams, R.G. Newcombe, M. Russell, C. Feyerabend, G. Thomas, and U. Sawe: Transdermal Nicotine for Active Ulcerative Colitis; N. Engl. J. Med. 330 (1994) 811–815. DOI: 10.1056/nejm199403243301202
- Sandborn, W.J., W.J. Tremaine, K.P. Offord, G.M. Lawson, B.T. Petersen, K.P. Batts, I.T. Croghan, L.C. Dale, D.R. Schroeder, and R.D. Hurt: Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis. A Randomized, Double-Blind, Placebo-Controlled Trial; Ann. Intern. Med. 126 (1997) 364–371. DOI: 10.7326/0003-4819-126-5-199703010-00004
- Sheehan, G.T., S.W. Twardus, A. Cagan, and A.N. Ananthakrishnan: E-Cigarette Use and Disease Outcomes in Inflammatory Bowel Diseases: A Case-Control Study; Dig. Dis. Sci. 68 (2023) 208–213. DOI: 10.1007/s10620-022-07539-z
- Parigi, T.L., O.M. Nardone, M. Lisa, L. Massimino, R. Gabbiadini, T. Innocenti, L. Bertani, A. Del Gaudio, P. Florez, L. Bertin, B. Barberio, M. Hupé, L. Lopetuso, M. Allocca, F. D'Amico, F. Furfaro, A. Zilli, G. Fiorino, F. Ungaro, F. Castiglione, et al.: The Impact of E-Cigarettes and Heat-Not-Burn Tobacco on Postoperative Recurrence of Crohn's Disease: A Multicenter International Study; Am. J. Gastroenterol. 121 (2025) 1954–1962. DOI: 10.14309/ajg.0000000000003810
- Ingram, J.R., J. Rhodes, B.K. Evans, and G.A. Thomas: Nicotine Enemas for Active Crohn's Colitis: An Open Pilot Study; Gastroenterol. Res. Pract. 2008 (2008) 237185. DOI: 10.1155/2008/237185
- Rosso, M. and T. Chitnis: Association between Cigarette Smoking and Multiple Sclerosis: A Review; JAMA Neurol. 77 (2020) 245–253. DOI: 10.1001/jamaneurol.2019.4271
- Hedström, A.K., J. Hillert, T. Olsson, and L. Alfredsson: Nicotine Might Have a Protective Effect in the Etiology of Multiple Sclerosis; Mult. Scler. 19 (2013) 1009–1013. DOI: 10.1177/1352458512471879
- Cleveland Clinic and Neurological Institute: Website - Smoking and MS: Unraveling the Links, Impact on Disease Progression, and Cessation Strategies; Cleveland Clinic, Cleveland, OH, USA, last updated 2026. Available at:
https://my.clevelandclinic.org/departments/neurological/depts/multiple-sclerosis/ms-approaches/ms-and-smoking (accessed June 23, 2026). - Hao, J., A.R. Simard, G.H. Turner, J. Wu, P. Whiteaker, R.J. Lukas, and F.D. Shi: Attenuation of CNS Inflammatory Responses by Nicotine Involves a7 and Non-a7 Nicotinic Receptors; Exp. Neurol. 227 (2011) 110–119. DOI: 10.1016/j.expneurol.2010.09.020
- Gao, Z., J.C. Nissen, K. Ji, and S.E. Tsirka: The Experimental Autoimmune Encephalomyelitis Disease Course Is Modulated by Nicotine and Other Cigarette Smoke Components; PLOS ONE 9 (2014) e107979. DOI: 10.1371/journal.pone.0107979
- Jiang, W., S. St-Pierre, P. Roy, B.J. Morley, J. Hao, and A.R. Simard: Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis; J. Immunol. 196 (2016) 2095–2108. DOI: 10.4049/jimmunol.1501613
- Dehara, M., N.V. Nguyen, and E.V. Arkema: Smoking and the Risk of Sarcoidosis: a Systematic Review and Meta-Analysis; Respir. Med. (2025) 108089. DOI: 10.1016/j.rmed.2025.108089
- Julian, M.W., G. Shao, L.S. Schlesinger, Q. Huang, D.G. Cosmar, N.Y. Bhatt, D.A. Culver, R.P. Baughman, K.L. Wood, and E.D. Crouser: Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis; Chest 143 (2013) 461–470. DOI: 10.1378/chest.12-0383
- Crouser, E.D., R.M. Smith, D.A. Culver, M.W. Julian, K. Martin, J. Baran, C. Diaz, B.S. Erdal, and E.M. Hade: A Pilot Randomized Trial of Transdermal Nicotine for Pulmonary Sarcoidosis; Chest 160 (2021) 1340–1349. DOI: 10.1016/j.chest.2021.05.031
- Tang, I.Y.K. and C.C. Mok: How the Cigarette Fire Burns the Rheumatoid Joints; JMA J. 8 (2025) 1087–1088. DOI: 10.31662/jmaj.2025-0361
- Ishikawa, Y. and C. Terao: The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review; Cells 9 (2020) 475. DOI: 10.3390/cells9020475
- Carlens, C., M.P. Hergens, J. Grunewald, A. Ekbom, A. Eklund, C.O. Hoglund, and J. Askling: Smoking, Use of Moist Snuff, and Risk of Chronic Inflammatory Diseases; Am. J. Respir. Crit. Care Med. 181 (2010) 1217–1222. DOI: 10.1164/rccm.200909-1338OC
- Bruchfeld, A., R.S. Goldstein, S. Chavan, N.B. Patel, M. Rosas-Ballina, N. Kohn, A.R. Qureshi, and K.J. Tracey: Whole Blood Cytokine Attenuation by Cholinergic Agonists Ex vivo and Relationship to Vagus Nerve Activity in Rheumatoid Arthritis; J. Intern. Med. 268 (2010) 94–101. DOI: 10.1111/j.1365-2796.2010.02226.x
- Esbensen, B.A., T. Thomsen, I.K. Roelsgaard, M. Østergaard, M.L. Hetland, L. Andersen, H. Tønnesen, A.G. Semb, and R. Christensen: Effect of an Intensive Smoking Cessation Intervention on Smoking Cessation and Disease Activity in Patients with RA: a Randomized Controlled Trial; Rheumatology 65 (2026). DOI: 10.1093/rheumatology/keaf448
- Cleveland Clinic: Website - Sepsis; Cleveland Clinic, Cleveland, OH, USA, last updated February 18, 2026. Available at:
https://my.clevelandclinic.org/health/diseases/12361-sepsis (accessed June 23, 2026). - Lee, E.H., K.H. Lee, K.-n. Lee, Y. Park, K. Do Han, and S.H. Han: The Relation between Cigarette Smoking and Development of Sepsis: A 10-Year Follow-up Study of Four Million Adults from the National Health Screening Program; J. Epidemiol. Glob. Health 14 (2024) 444–452. DOI: 10.1007/s44197-024-00197-6
- Özdemir-Kumral, Z.N., D. Özbeyli, A.F. Özdemir, B.M. Karaaslan, K. Kaytaz, M.F. Kara, O.E. Tok, F. Ercan, and B.C. Yeğen: Protective Effect of Nicotine on Sepsis-Induced Oxidative Multiorgan Damage: Role of Neutrophils; Nicotine Tob. Res. 19 (2017) 859–864. DOI: 10.1093/ntr/ntw198
- Wang, H., H. Liao, M. Ochani, M. Justiniani, X. Lin, L. Yang, Y. Al-Abed, H. Wang, C. Metz, E.J. Miller, K.J. Tracey, and L. Ulloa: Cholinergic Agonists Inhibit Hmgb1 Release and Improve Survival in Experimental Sepsis; Nat. Med. 10 (2004) 1216–1221. DOI: 10.1038/nm1124
- Keever, K.R., K. Cui, J.L. Casteel, S. Singh, D.B. Hoover, D.L. Williams, V.A. Pavlov, and V.P. Yakubenko: Cholinergic signaling via the α7 Nicotinic Acetylcholine Receptor regulates the Migration of Monocyte-Derived Macrophages during Acute Inflammation; J. Neuroinflamm. 21 (2024) 3. DOI: 10.1186/s12974-023-03001-7
- Thomas, G.A., J. Rhodes, V. Mani, G.T. Williams, R.G. Newcombe, M.A. Russell, and C. Feyerabend: Transdermal Nicotine as Maintenance Therapy for Ulcerative Colitis; N. Engl. J. Med. 332 (1995) 988–992. DOI: 10.1056/NEJM199504133321503
- Thomas, G.A., J. Rhodes, K. Ragunath, V. Mani, G.T. Williams, R.G. Newcombe, M.A. Russell, and C. Feyerabend: Transdermal Nicotine Compared with Oral Prednisolone Therapy for Active Ulcerative Colitis; Eur. J. Gastroenterol. Hepatol. 8 (1996) 769–776.
- McGrath, J., J.W. McDonald, and J.K. Macdonald: Transdermal Nicotine for Induction of Remission in Ulcerative Colitis; Cochrane Database Syst. Rev. (2004) CD004722. DOI: 10.1002/14651858.CD004722.pub2
- Mayo Clinic: Website - Ulcerative Colitis; Mayo Clinic, last updated June 6, 2026. Available at:
https://www.mayoclinic.org/diseases-conditions/ulcerative-colitis/diagnosis-treatment/drc-20353331#:~:text=Types%20of%20biologics%20used%20to,produced%20by%20the%20immune%20system (accessed June 23, 2026). - Briggs, F.B.: Nicotinic Acetylcholine Receptors α7 and α9 Modifies Tobacco Smoke Risk for Multiple Sclerosis; Mult. Scler. J. 27 (2021) 1166–1174. DOI: 10.1177/1352458520958361
- Khezri, S., S.M. Abtahi Froushani, and M. Shahmoradi: Nicotine Augments the Beneficial Effects of Mesenchymal Stem Cell-Based Therapy in Rat Model of Multiple Sclerosis; Immunol. Invest. 47 (2018) 113–124. DOI: 10.1080/08820139.2017.1391841
- Rothbard, J.B., M.P. Kurnellas, S.S. Ousman, S. Brownell, J.J. Rothbard, and L. Steinman: Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies; Cold Spring Harb. Perspect. Med. 9 (2019) a034223. DOI: 10.1101/cshperspect.a034223
- Xiao, X., T. Cui, S. Hu, S. Shen, Y. Huang, C. Cui, H. Tan, W. Qiu, and Y. Zhao: Mechanistic Insights into Nicotine-Derived Nitrosamine Ketone (NNK) in Multiple Sclerosis via Integrated Systems Analyses; Gene 997 (2026) 150158. DOI: 10.1016/j.gene.2026.150158
- Richmond, R.C. and G. Davey Smith: Mendelian Randomization: Concepts and Scope; Cold Spring Harb. Perspect. Med. 12 (2022) a040501. DOI: 10.1101/cshperspect.a040501
- Huang, J., X. Liu, Y. Wei, X. Li, S. Gao, L. Dong, X. Rao, and J. Zhong: Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease; Front. Immunol. 13 (2022) 830863. DOI: 10.3389/fimmu.2022.830863
- Belperio, J.A., M.C. Fishbein, F. Abtin, J. Channick, S.A. Balasubramanian, and J.P. Lynch III: Pulmonary Sarcoidosis: A Comprehensive Review: Past to Present; J. Autoimmun. 149 (2024) 103107. DOI: 10.1016/j.jaut.2023.103107
- Arkema, E.V. and Y.C. Cozier: Sarcoidosis Epidemiology: Recent Estimates of Incidence, Prevalence and Risk Factors; Curr. Opin. Pulm. Med. 26 (2020) 527–534. DOI: 10.1097/mcp.0000000000000715
- Rossides, M., P. Darlington, S. Kullberg, and E.V. Arkema: Sarcoidosis: Epidemiology and Clinical Insights; J. Intern. Med. 293 (2023) 668–680. DOI: 10.1111/joim.13629
- Isaji, H. and K. Yamada: A Survey on the Actual Use of and Reasons for Heated Tobacco Products in Patients with Rheumatoid Arthritis; Int. J. Environ. Res. Public Health 19 (2022) 12465. DOI: 10.3390/ijerph191912465
- Lee, J., A. Luria, C. Rhodes, H. Raghu, N. Lingampalli, O. Sharpe, B. Rada, D.H. Sohn, W.H. Robinson, and J. Sokolove: Nicotine Drives Neutrophil Extracellular Traps Formation and Accelerates Collagen-Induced Arthritis; Rheumatology 56 (2017) 644–653. DOI: 10.1093/rheumatology/kew449
- van Maanen, M.A., M.C. Lebre, T. van der Poll, G.J. LaRosa, D. Elbaum, M.J. Vervoordeldonk, and P.P. Tak: Stimulation of Nicotinic Acetylcholine Receptors Attenuates Collagen-Induced Arthritis in Mice; Arthritis Rheum. 60 (2009) 114–122. DOI: 10.1002/art.24177
- Yu, H., Y.-H. Yang, R. Rajaiah, and K.D. Moudgil: Nicotine-Induced Differential Modulation of Autoimmune Arthritis in the Lewis Rat Involves Changes in Interleukin-17 and Anti–Cyclic Citrullinated Peptide Antibodies; Arthritis Rheum. 63 (2011) 981–991. DOI: 10.1002/art.30219
- Wasén, C., M. Turkkila, A. Bossios, M. Erlandsson, K.M. Andersson, L. Ekerljung, C. Malmhäll, M. Brisslert, S. Töyrä Silfverswärd, B. Lundbäck, and M.I. Bokarewa: Smoking Activates Cytotoxic Cd8+ T Cells and Causes Survivin Release in Rheumatoid Arthritis; J. Autoimmun. 78 (2017) 101–110. DOI: 10.1016/j.jaut.2016.12.009
- Chiou, S.K., M.K. Jones, and A.S. Tarnawski: Survivin - an Anti-Apoptosis Protein: Its Biological Roles and Implications for Cancer and Beyond; Med. Sci. Monit. 9 (2003) PI43–PI47.
- Hashimoto, M., S.S. Ramalingam, and R. Ahmed: Harnessing Cd8 T Cell Responses Using PD-1–IL-2 Combination Therapy; Trends Cancer 10 (2024) 332–346. DOI: 10.1016/j.trecan.2023.11.008
- Lourido, L., V. Calamia, P. Fernández-Puente, J. Mateos, N. Oreiro, F.J. Blanco, and C. Ruiz-Romero: Secretome Analysis of Human Articular Chondrocytes Unravels Catabolic Effects of Nicotine on the Joint; Proteomics Clin. Appl. 10 (2016) 671–680. DOI: 10.1002/prca.201400186
- Wu, W. and J. Krijgsveld: Secretome Analysis: Reading Cellular Sign Language to Understand Intercellular Communication; Mol. Cell. Proteomics 23 (2024) 100692. DOI: 10.1016/j.mcpro.2023.100692
- Recklies, A.D., H. Ling, C. White, and S.M. Bernier: Inflammatory Cytokines Induce Production of Chi3l1 by Articular Chondrocytes; J. Biol. Chem. 280 (2005) 41213–41221. DOI: 10.1074/jbc.M510146200
- World Health Organization (WHO): Website - International Statistical Classification of Diseases and Related Health Problems (Icd) - ICD-10 Version:2016; WHO, Geneva, Switzerland, Available at:
https://icd.who.int/browse10/2016/en (accessed August 13, 2026). - Lawand, J., A. Ghali, J. Hauck, S. Trejo Corona, R. Gonzalez, and L. Deveza: The Smokeless Paradox: Nontobacco Nicotine Use and Complications in Anterior Cervical Discectomy and Fusion; J. Am. Acad. Orthop. Surg. 33 (2024) 1032–1039. DOI: 10.5435/JAAOS-D-24-00801
- Fuller, Z., A. Chopra, J. Thomas, D. Oliver, M. Fisher, and Z.E. Abdo: Increased Postoperative Complications in Non-Tobacco Nicotine Users Following Total Hip Arthroplasty; J. Arthroplasty 41 (2026) 2113–2118 e2111. DOI: 10.1016/j.arth.2025.10.032
- Good, L.M., C.W. Blackburn, J.M. Adelstein, A.N. Berk, S.A. Florentino, H.S. Jawanda, and W.B. Cohen-Levy: What Is the Association between Nontobacco Nicotine Dependence and Postoperative Complications in Total Hip Arthroplasty? A Large Propensity-Matched Cohort Study; Arthroplast. Today 34 (2025) 101743. DOI: 10.1016/j.artd.2025.101743
- Hirpara, A., A. Shah, A.J. Moyal, J.M. Adelstein, R.J. Burkhart, C. Stirpe, C.W. Cheng, Z.L. Gordon, C.G. Furey, and P.V. Rajan: Impact of Non-Tobacco Nicotine Dependence on Outcomes Following Anterior Lumbar Interbody Fusion; Spine (2025) DOI: 10.1097/brs.0000000000005555
- Lawand, J., A. Ghali, A.-H. Dajani, P. Boufadel, H. Bey, A. Khan, and J. Abboud: Nontobacco Nicotine Dependence and Rates of Periprosthetic Joint Infection and Other Postoperative Complications in Shoulder Arthroplasty: A Retrospective Analysis; J. Am. Acad. Orthop. Surg. 33 (2025) 92–99. DOI: 10.5435/jaaos-d-24-00706
- Spitzer, C., M. Romoff, M. Brunette, M.K. Peterson, A. Ton, R. Le, A. Sharma, J.P. Chan, H.-H. Wu, S. Hashmi, and M.S. Kim: Non-Tobacco Nicotine Dependence Increases Risk of Complications Following Lumbar Spine Decompression and Fusion; N. Am. Spine Soc. J. 24 (2025) 100790. DOI: 10.1016/j.xnsj.2025.100790
- Glenn, E.R., A.R. Zhu, E. Mao, A. Astavans, I.R. Beeram, and U. Srikumaran: Nontobacco Nicotine Dependence as a Risk Factor for Poor Long-Term Outcomes after Shoulder Arthroplasty and Rotator Cuff Repair; J. Am. Acad. Orthop. Surg. Glob. Res. Rev. 10 (2026) e25.00035. DOI: 10.5435/JAAOSGlobal-D-25-00035
- Lawand, J.J., A. Ghali, J.T. Morrow, D. Birhiray, Y.M. Khalafallah, and L. Deveza: Non-Tobacco Nicotine Dependence and Incidence of Pseudarthrosis and Other Postoperative Complications in Lumbar Fusion Surgery: a Retrospective Analysis; Eur. J. Orthop. Surg. Traumatol. 36 (2026) 137. DOI: 10.1007/s00590-026-04714-0
- McCahon, J.A.S., S. Fehr, G.M. Thomas, J.N. Daniel, D.I. Pedowitz, and S.G. Parekh: Non-Tobacco Nicotine Dependence and Postoperative Complications after Total Ankle Arthroplasty: A Propensity-Matched Cohort Study; Food Ankle Surg. (2026). DOI: 10.1016/j.fas.2026.04.006
- Wang, J., A. Patel, P. Nguyen, M. Panchbhavi, and V.K. Panchbhavi: Postoperative Complications after Hammertoe Correction: The Influence of Tobacco and Non-Tobacco Nicotine; J. Foot Ankle Surg. 65 (2026) 33.e31–33.e35. DOI: 10.1053/j.jfas.2025.09.007
- Corriden, R., A. Moshensky, C.M. Bojanowski, A. Meier, J. Chien, R.K. Nelson, and L.E. Crotty Alexander: E-Cigarette Use Increases Susceptibility to Bacterial Infection by Impairment of Human Neutrophil Chemotaxis, Phagocytosis, and Net Formation; Am. J. Physiol. Cell Physiol. 318 (2020) C205–C214. DOI: 10.1152/ajpcell.00045.2019
- Zuck, K.: Evidence Related to the Health Risk of IQOS Use; presented at the TPSAC Meeting, Evaluation of Product Chemistry, January 24–25, 2018.
- Fried, N.D. and J.D. Gardner: Heat-Not-Burn Tobacco Products: An Emerging Threat to Cardiovascular Health; Am. J. Physiol. Heart Circ. Physiol. 319 (2020) H1234–H1239. DOI: 10.1152/ajpheart.00708.2020
- R.J. Reynolds Tobacco Company: Chemical and Biological Studies on New Cigarette Prototypes That Heat Instead of Burn Tobacco; 1988, XXV, 744 S. pp. Available at:
https://www.industrydocuments.ucsf.edu/tobacco/documents/viewer/?iid=ltnb0140&id=ltnb0140&q=null%2Cbates%2Ccontains%2C570247258&db-set=documents&industry=tobacco&sort=relevance&pg=1&npp=20&rtool=metadata (accessed June 23, 2026). - Schaller, J.-P., D. Keller, L. Poget, P. Pratte, E. Kaelin, D. McHugh, G. Cudazzo, D. Smart, A.R. Tricker, L. Gautier, M. Yerly, R. Reis Pires, S. Le Bouhellec, D. Ghosh, I. Hofer, E. Garcia, P. Vanscheeuwijck, and S. Maeder: Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol; Regul. Toxicol. Pharmacol. 81 Suppl 2 (2016) S27–S47. DOI: 10.1016/j.yrtph.2016.10.001
- Cozzani, V., F. Barontini, T. McGrath, B. Mahler, M. Nordlund, M. Smith, J.P. Schaller, and G. Zuber: An Experimental Investigation into the Operation of an Electrically Heated Tobacco System; Thermochim. Acta 684 (2020) 178475. DOI: 10.1016/j.tca.2019.178475
- Rennard, S.I., T. Umino, T. Millatmal, D.M. Daughton, L.S. Manouilova, F.A. Ullrich, K.D. Patil, D.J. Romberger, A.A. Floreani, and J.R. Anderson: Evaluation of Subclinical Respiratory Tract Inflammation in Heavy Smokers Who Switch to a Cigarette-Like Nicotine Delivery Device That Primarily Heats Tobacco; Nicotine Tob. Res. 4 (2002) 467–476. DOI: 10.1080/1462220021000018407
- Caponnetto, P., D. Campagna, G. Papale, C. Russo, and R. Polosa: The Emerging Phenomenon of Electronic Cigarettes; Expert Rev. Respir. Med. 6 (2012) 63–74. DOI: 10.1586/ers.11.92
- Shen, X., M. Hindle, and P.R. Byron: Effect of Energy on Propylene Glycol Aerosols Using the Capillary Aerosol Generator; Int. J. Pharm. 275 (2004) 249–258. DOI: 10.1016/j.ijpharm.2004.02.005
- Weaver, M., A. Breland, T. Spindle, and T. Eissenberg: Electronic Cigarettes: a Review of Safety and Clinical Issues; J. Addict. Med. 8 (2014) 234–240. DOI: 10.1097/ADM.0000000000000043
- Jaegers, N.R., W. Hu, T.J. Weber, and J.Z. Hu: Low-Temperature (< 200 °C) Degradation of Electronic Nicotine Delivery System Liquids Generates Toxic Aldehydes; Sci. Rep. 11 (2021) 7800. DOI: 10.1038/s41598-021-87044-x
- Oh, A.Y. and A. Kacker: Do Electronic Cigarettes Impart a Lower Potential Disease Burden Than Conventional Tobacco Cigarettes?: Review on E-Cigarette Vapor Versus Tobacco Smoke; Laryngoscope 124 (2014) 2702–2706. DOI: 10.1002/lary.24750
- Saliba, N.A., A. El Hellani, E. Honein, R. Salman, S. Talih, J. Zeaiter, and A. Shihadeh: Surface Chemistry of Electronic Cigarette Electrical Heating Coils: Effects of Metal Type on Propylene Glycol Thermal Decomposition; J. Anal. Appl. Pyrolysis 134 (2018) 520–525. DOI: 10.1016/j.jaap.2018.07.019
- AlGemayel, C., E. Honein, A.E. Hellani, R. Salman, N.A. Saliba, A. Shihadeh, and J. Zeaiter: Kinetic Modeling of the Pyrolysis of Propylene Glycol; Eng. Sci. 20 (2022) 162–179. DOI: 10.30919/es8d757
- BenchChem Technical Support Team: The Thermal Decomposition of Propylene Glycol: A Comprehensive Technical Guide; BenchChem, Ontario, CA, USA, 2026, Available at:
https://www.benchchem.com/product/b7767615/docs#the-thermal-decomposition-ofpropylene-glycol-a-comprehensive-technical-guide (accessed June 23, 2026). - Pinto, M.I., J. Thissen, N. Hermes, A. Cunningham, H. Digard, and J. Murphy: Chemical Characterisation of the Vapour Emitted by an E-Cigarette Using a Ceramic Wick-Based Technology; Sci. Rep. 12 (2022) 16497. DOI: 10.1038/s41598-022-19761-w
- David, G., E.A. Parmentier, I. Taurino, and R. Signorell: Tracing the Composition of Single E-Cigarette Aerosol Droplets in situ by Laser-Trapping and Raman Scattering; Sci. Rep. 10 (2020) 7929. DOI: 10.1038/s41598-020-64886-5
- Orellana-Barrios, M.A., D. Payne, Z. Mulkey, and K. Nugent: Electronic Cigarettes—A Narrative Review for Clinicians; Am. J. Med. 128 (2015) 674–681. DOI: 10.1016/j.amjmed.2015.01.033
- Yayan, J., K.J. Franke, C. Biancosino, and K. Rasche: Comparative Systematic Review on the Safety of E-Cigarettes and Conventional Cigarettes; Food Chem. Toxicol. 185 (2024) 114507. DOI: 10.1016/j.fct.2024.114507
- Balfour, D.J.K., N.L. Benowitz, S.M. Colby, D.K. Hatsukami, H.A. Lando, S.J. Leischow, C. Lerman, R.J. Mermelstein, R. Niaura, K.A. Perkins, O.F. Pomerleau, N.A. Rigotti, G.E. Swan, K.E. Warner, and R. West: Balancing Consideration of the Risks and Benefits of E-Cigarettes; Am. J. Public Health 111 (2021) 1661–1672. DOI: 10.2105/ajph.2021.306416
- U.S. Food & Drug Administration (FDA): Website - FDA Makes Determinations On More Than 99% of the 26 Million Tobacco Products for Which Applications Were Submitted; FDA, Silver Spring, MD, USA, last updated March 15, 2023. Available at:
https://www.fda.gov/tobacco-products/ctp-newsroom/fda-makes-determinations-more-99-26-million-tobacco-products-which-applications-were-submitted#:~:text=To%20date%2C%20FDA%20has%20made%20determinations%20on,deemed%20products%20for%20which%20applications%20were%20submitted (accessed June 23, 2026). - U.S. Food & Drug Administration (FDA): Website - Advisory and Enforcement Actions against Industry for Unauthorized Tobacco Products; FDA, Silver Spring, MD, USA, last updated May 18, 2026. Available at:
https://www.fda.gov/tobacco-products/compliance-enforcement-training/advisory-and-enforcement-actions-against-industry-unauthorized-tobacco-products#:~:text=On%20December%2019%2C%202024%2C%20FDA,is%20subject%20to%20enforcement%20action (accessed June 23, 2026). - U.S. Department of Health and Human Services (DHHS), U.S. Food & Drug Administration (FDA), and Center for Tobacco Products (CTP): Website - FDA Deems Certain Tobacco Products Subject to FDA Authority, Sales and Distribution Restrictions, and Health Warning Requirements for Packages and Advertisements – Guidance for Industry, Small Entity Compliance Guide; FDA, Silver Spring, MD, USA, last updated March 17, 2023. Available at:
https://www.fda.gov/regulatory-information/search-fda-guidance-documents/fda-deems-certain-tobacco-products-subject-fda-authority-sales-and-distribution-restrictions-and (accessed June 23, 2026). - U.S. Food & Drug Administration (FDA): Website - Want to Quit Smoking? FDA-Approved and FDA-Cleared Cessation Products Can Help; FDA, Silver Spring, MD, USA, last updated July 21, 2022. Available at:
https://www.fda.gov/consumers/consumer-updates/want-quit-smoking-fda-approved-and-fda-cleared-cessation-products-can-help (accessed June 23, 2026). - Rigotti, N.A.: Electronic Cigarettes for Smoking Cessation — Have We Reached a Tipping Point?; N. Engl. J. Med. 390 (2024) 664–665. DOI: 10.1056/NEJMe2314977
- Nichols, M. and E. Rivera: Website - Faa Issues Final Mosaic Rule: Key Updates and Changes – Major Modernizations for Light-Sport Aircraft Certification, Operation, and Privileges; DLA Piper US, last updated July 25, 2025. Available at:
https://www.dlapiper.com/en-us/insights/publications/2025/07/faa-issues-final-mosaic-rule (accessed June 23, 2026). - U.S. Department of Health and Human Services (DHHS) and Centers for Disease Control and Prevention (CDC): E-Cigarette, or Vaping, Products Visual Dictionary; CDC, 2019, 25 pp. Available at:
https://stacks.cdc.gov/view/cdc/103783/cdc_103783_DS1.pdf (accessed June 23, 2026). - Meebaco: Website - MBC0018 DTL Device | Replaceable Pods, 15w/25w Modes & Dynamic Screen; Available at:
https://www.meebaco.com/products/mbc0018.html (accessed July 12, 2026). - Jackson, R.: Website - What Wattage Should I Vape At?; OK Vape, Exeter, UK, last updated May 6, 2026. Available at:
https://okvape.co.uk/blog/vaping-beginners/what-wattage-should-i-vape-at/?srsltid=AfmBOopTBC2CqiHrBLWztBqgb8aedKdPZxYs35wpXEsQ_oPtS80Z_Oki (accessed June 23, 2026). - Li, Y., A.E. Burns, L.N. Tran, K.A. Abellar, M. Poindexter, X. Li, A.K. Madl, K.E. Pinkerton, and T.B. Nguyen: Impact of E-Liquid Composition, Coil Temperature, and Puff Topography on the Aerosol Chemistry of Electronic Cigarettes; Chem. Res. Toxicol. 34 (2021) 1640–1654. DOI: 10.1021/acs.chemrestox.1c00070
- Tran, L.N., E.Y. Chiu, H.C. Hunsaker, K.-C. Wu, B.A. Poulin, A.K. Madl, K.E. Pinkerton, and T.B. Nguyen: Carbonyls and Aerosol Mass Generation from Vaping Nicotine Salt Solutions Using Fourth- and Third-Generation E-Cigarette Devices: Effects of Coil Resistance, Coil Age, and Coil Metal Material; Chem. Res. Toxicol. 36 (2023) 1599–1610. DOI: 10.1021/acs.chemrestox.3c00172
- Zhao, J., G. Pyrgiotakis, and P. Demokritou: Development and Characterization of Electronic-Cigarette Exposure Generation System (Ecig-EGS) for the Physico-Chemical and Toxicological Assessment of Electronic Cigarette Emissions; Inhal. Toxicol. 28 (2016) 658–669. DOI: 10.1080/08958378.2016.1246628
- Lalo, H., L. Leclerc, J. Sorin, and J. Pourchez: Aerosol Droplet-Size Distribution and Airborne Nicotine Portioning in Particle and Gas Phases Emitted by Electronic Cigarettes; Sci. Rep. 10 (2020) 21707. DOI: 10.1038/s41598-020-78749-6
- Salazar, M.R., L. Saini, T.B. Nguyen, K.E. Pinkerton, A.K. Madl, A.M. Cole, and B.A. Poulin: Elevated Toxic Element Emissions from Popular Disposable E-Cigarettes: Sources, Life Cycle, and Health Risks; ACS Cent. Sci. 11 (2025) 1345–1354. DOI: 10.1021/acscentsci.5c00641
- Aherrera, A., J.J. Lin, R. Chen, M. Tehrani, A. Schultze, A. Borole, S. Tanda, W. Goessler, and A.M. Rule: Metal Concentrations in E-Cigarette Aerosol Samples: A Comparison by Device Type and Flavor; Environ. Health Perspect. 131 (2023) 127004. DOI: 10.1289/ehp11921
- AlGemayel, C., R. Salman, N.A. Saliba, A. Shihadeh, and J. Zeaiter: An Experimental Investigation of PG/VG Pyrolysis Combined with Molecular Dynamics; J. Anal. Appl. Pyrolysis 179 (2024) 106483. DOI: 10.1016/j.jaap.2024.106483
- Hikisz, P. and D. Jacenik: The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity; Cells 12 (2023) 879. DOI: 10.3390/cells12060879
- Bhat, A.A., M. Afzal, A. Goyal, G. Gupta, R. Thapa, W.H. almalki, I. Kazmi, S.I. Alzarea, M. Shahwan, K.R. Paudel, H. Ali, D. Sahu, P. Prasher, S.K. Singh, and K. Dua: The Impact of Formaldehyde Exposure on Lung Inflammatory Disorders: Insights into Asthma, Bronchitis, and Pulmonary Fibrosis; Chem. Biol. Interact. 394 (2024) 111002. DOI: 10.1016/j.cbi.2024.111002
- Matsuse, H., C. Fukushima, T. Shimoda, S. Asai, and S. Kohno: Effects of Acetaldehyde on Human Airway Constriction and Inflammation; in: Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide, 2006, pp. 97–109. DOI: 10.1002/9780470511848.ch7
- Kawano, T., H. Matsuse, S. Fukahori, T. Tsuchida, T. Nishino, C. Fukushima, and S. Kohno: Acetaldehyde at a Low Concentration Syner-gistically Exacerbates Allergic Airway Inflammation as an Endocrine-Disrupting Chemical and as a Volatile Organic Compound; Respiration 84 (2012) 135–141. DOI: 10.1159/000337112
- National Research Council: Acetaldehyde; in: Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants: Volume 3, The National Academies Press, Washington, DC, USA, ISBN: 0309143799, 2009, pp. 20–45. DOI: 10.17226/12741
- Simovic, T., C. Matheson, A. Rodgers, F. Baig, A. Breland, C. Cobb O, P. Nana-Sinkam, and P. Rodriguez-Miguelez: Immune Cell Profile in Young Adults Who Regularly Use E-Cigarettes and the Role of Nicotine; Physiology 39 (2024) 1591. DOI: 10.1152/physiol.2024.39.S1.1591
- Chatterjee, S., J.Q. Tao, A. Johncola, W. Guo, A. Caporale, M.C. Langham, and F.W. Wehrli: Acute Exposure to E-Cigarettes Causes Inflammation and Pulmonary Endothelial Oxidative Stress in Nonsmoking, Healthy Young Subjects; Am. J. Physiol. Lung Cell. Mol. Physiol. 317 (2019) L155–L166. DOI: 10.1152/ajplung.00110.2019
- Chatterjee, S., A. Caporale, J.Q. Tao, W. Guo, A. Johncola, A.A. Strasser, F.T. Leone, M.C. Langham, and F.W. Wehrli: Acute E-Cig Inhalation Impacts Vascular Health: a Study in Smoking Naïve Subjects; Am. J. Physiol. Heart Circ. Physiol. 320 (2021) H144–H158. DOI: 10.1152/ajpheart.00628.2020
- Andreozzi, P., G. Gussoni, G. Sesti, N. Montano, A. Pietrangelo, S. Basili, C. Bracco, A. Cittadini, G. Desideri, G. Mancuso, M. Persico, S. Petrolani, M. Pirisi, L.A. Sechi, P. Suppressa, A. Vacca, V. Zaccone, and G. the Italian Society of Internal Medicine Council Member: Impact of Electronic Cigarettes (E-Cigs) and Heat-Not-Burn/Heated Tobacco Products (HnB/HTP) on Asthma and Chronic Obstructive Pulmonary Disease: A Viewpoint of the Italian Society of Internal Medicine; Intern. Emerg. Med. 19 (2024) 1829–1837. DOI: 10.1007/s11739-024-03648-x
- Coppeta, L., A. Magrini, A. Pietroiusti, S. Perrone, and M. Grana: Effects of Smoking Electronic Cigarettes on Pulmonary Function and Environmental Parameters; Open Public Health J. 11 (2018) 360–368. DOI: 10.2174/1874944501811010360
- Ghosh, A., R.C. Coakley, T. Mascenik, T.R. Rowell, E.S. Davis, K. Rogers, M.J. Webster, H. Dang, L.E. Herring, M.F. Sassano, A. Livraghi-Butrico, S.K. Van Buren, L.M. Graves, M.A. Herman, S.H. Randell, N.E. Alexis, and R. Tarran: Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome; Am. J. Respir. Crit. Care Med. 198 (2018) 67–76. DOI: 10.1164/rccm.201710-2033OC
- Ghosh, A., R.D. Coakley, A.J. Ghio, M.S. Muhlebach, C.R. Esther, N.E. Alexis, and R. Tarran: Chronic E-Cigarette Use Increases Neutrophil Elastase and Matrix Metalloprotease Levels in the Lung; Am. J. Respir. Crit. Care Med. 200 (2019) 1392–1401. DOI: 10.1164/rccm.201903-0615OC
- Hernandez, M.L., A.J. Burbank, N.E. Alexis, M.E. Rebuli, E.D. Hickman, I. Jaspers, and G. Guidos: Electronic Cigarettes and Their Impact on Allergic Respiratory Diseases: A Work Group Report of the AAAAI Environmental Exposures and Respiratory Health Committee; J. Allergy Clin. Immunol. Pract. 9 (2021) 1142–1151. DOI: 10.1016/j.jaip.2020.12.065
- Kim, T. and J. Kang: Association between Dual Use of E-Cigarette and Cigarette and Chronic Obstructive Pulmonary Disease: An Analysis of a Nationwide Representative Sample from 2013 to 2018; BMC Pulm. Med. 21 (2021) 231. DOI: 10.1186/s12890-021-01590-8
- Kotoulas, S.C., A. Pataka, K. Domvri, D. Spyratos, P. Katsaounou, K. Porpodis, E. Fouka, A. Markopoulou, K. Passa-Fekete, I. Grigoriou, T. Kontakiotis, P. Argyropoulou, and D. Papakosta: Acute Effects of E-Cigarette Vaping on Pulmonary Function and Airway Inflammation in Healthy Individuals and in Patients with Asthma; Respirology 25 (2020) 1037–1045. DOI: 10.1111/resp.13806
- Lappas, A.S., A.S. Tzortzi, E.M. Konstantinidi, S.I. Teloniatis, C.K. Tzavara, S.A. Gennimata, N.G. Koulouris, and P.K. Behrakis: Short-Term Respiratory Effects of E-Cigarettes in Healthy Individuals and Smokers with Asthma; Respirology 23 (2018) 291–297. DOI: 10.1111/resp.13180
- McConnell, R., J.L. Barrington-Trimis, K. Wang, R. Urman, H. Hong, J. Unger, J. Samet, A. Leventhal, and K. Berhane: Electronic Cigarette Use and Respiratory Symptoms in Adolescents; Am. J. Respir. Crit. Care Med. 195 (2017) 1043–1049. DOI: 10.1164/rccm.201604-0804OC
- Meo, S.A., M.A. Ansary, F.R. Barayan, A.S. Almusallam, A.M. Almehaid, N.S. Alarifi, T.A. Alsohaibani, and I. Zia: Electronic Cigarettes: Impact on Lung Function and Fractional Exhaled Nitric Oxide among Healthy Adults; Am. J. Mens. Health 13 (2019) 1557988318806073. DOI: 10.1177/1557988318806073
- Reidel, B., G. Radicioni, P.W. Clapp, A.A. Ford, S. Abdelwahab, M.E. Rebuli, P. Haridass, N.E. Alexis, I. Jaspers, and M. Kesimer: E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion; Am. J. Respir. Crit. Care Med. 197 (2018) 492–501. DOI: 10.1164/rccm.201708-1590OC
- Shields, P.G., M.-A. Song, J.L. Freudenheim, T.M. Brasky, J.P. McElroy, S.A. Reisinger, D.Y. Weng, R. Ren, T. Eissenberg, M.D. Wewers, and K. Shilo: Lipid Laden Macrophages and Electronic Cigarettes in Healthy Adults; EBioMedicine 60 (2020) 102982. DOI: 10.1016/j.ebiom.2020.102982
- Singh, K.P., G. Lawyer, T. Muthumalage, K.P. Maremanda, N.A. Khan, S.R. McDonough, D. Ye, S. McIntosh, and I. Rahman: Systemic Biomarkers in Electronic Cigarette Users: Implications for Noninvasive Assessment of Vaping-Associated Pulmonary Injuries; ERJ Open Res. 5 (2019) 00182–02019. DOI: 10.1183/23120541.00182-2019
- Song, M.A., J.L. Freudenheim, T.M. Brasky, E.A. Mathe, J.P. McElroy, Q.A. Nickerson, S.A. Reisinger, D.J. Smiraglia, D.Y. Weng, K.L. Ying, M.D. Wewers, and P.G. Shields: Biomarkers of Exposure and Effect in the Lungs of Smokers, Nonsmokers, and Electronic Cigarette Users; Cancer Epidemiol. Biomarkers Prev. 29 (2020) 443–451. DOI: 10.1158/1055-9965.Epi-19-1245
- Song, M.A., S.A. Reisinger, J.L. Freudenheim, T.M. Brasky, E.A. Mathé, J.P. McElroy, Q.A. Nickerson, D.Y. Weng, M.D. Wewers, and P.G. Shields: Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial; Cancer Prev. Res. 13 (2020) 145–152. DOI: 10.1158/1940-6207.Capr-19-0400
- Kim, T., Y. Kim, and J. Kang: Association of Electronic Cigarette Exposure with Serum Uric Acid Level and Hyperuricemia: 2016–2017 Korea National Health and Nutritional Examination Survey; PLOS ONE 16 (2021) e0247868. DOI: 10.1371/journal.pone.0247868
- Xie, Z., D.J. Ossip, I. Rahman, and D. Li: Use of Electronic Cigarettes and Self-Reported Chronic Obstructive Pulmonary Disease Diagnosis in Adults; Nicotine Tob. Res. 22 (2020) 1155–1161. DOI: 10.1093/ntr/ntz234
- Amraotkar, A.R., U.S. Owolabi, M.V. Malovichko, S. Majid, R.M. Weisbrod, E.J. Benjamin, J.L. Fetterman, G.A. Hirsch, S. Srivastava, R. Poudel, R.M. Robertson, A. Bhatnagar, N.M. Hamburg, and R.J. Keith: Association of Electronic Cigarette Use with Circulating Angiogenic Cell Levels in Healthy Young Adults: Evidence for Chronic Systemic Injury; Vasc. Med. 28 (2023) 18–27. DOI: 10.1177/1358863x221126205
- Benowitz, N.L., G. St.Helen, N. Nardone, N. Addo, J. Zhang, A.M. Harvanko, C.S. Calfee, and P. Jacob III: Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared with Cigarette Smoking in Dual Users; J. Am. Heart Assoc. 9 (2020) e017317. DOI: 10.1161/JAHA.120.017317
- Boakye, E., S.M.I. Uddin, N. Osuji, J. Meinert, O.H. Obisesan, M. Mirbolouk, E. Tasdighi, O. El-Shahawy, J. Erhabor, A.D. Osei, T. Rajan, M. Patatanian, J.T. Holbrook, A. Bhatnagar, S.S. Biswal, and M.J. Blaha: Examining the Association of Habitual E-Cigarette Use with Inflammation and Endothelial Dysfunction in Young Adults: The Vapors-Endothelial Function Study; Tob. Induc. Dis. 21 (2023) 75. DOI: 10.18332/tid/162327
- Chaumont, M., B. de Becker, W. Zaher, A. Culié, G. Deprez, C. Mélot, F. Reyé, P. Van Antwerpen, C. Delporte, N. Debbas, K.Z. Boudjeltia, and P. van de Borne: Differential Effects of E-Cigarette on Microvascular Endothelial Function, Arterial Stiffness and Oxidative Stress: A Randomized Crossover Trial; Sci. Rep. 8 (2018) 10378. DOI: 10.1038/s41598-018-28723-0
- Haptonstall, K.P., Y. Choroomi, R. Moheimani, K. Nguyen, E. Tran, K. Lakhani, I. Ruedisueli, J. Gornbein, and H.R. Middlekauff: Differential Effects of Tobacco Cigarettes and Electronic Cigarettes on Endothelial Function in Healthy Young People; Am. J. Physiol. Heart Circ. Physiol. 319 (2020) H547–H556. DOI: 10.1152/ajpheart.00307.2020
- Kim, C.Y., Y.J. Paek, H.G. Seo, Y.S. Cheong, C.M. Lee, S.M. Park, D.W. Park, and K. Lee: Dual Use of Electronic and Conventional Cigarettes Is Associated with Higher Cardiovascular Risk Factors in Korean Men; Sci. Rep. 10 (2020) 5612. DOI: 10.1038/s41598-020-62545-3
- Moheimani, R.S., M. Bhetraratana, K.M. Peters, B.K. Yang, F. Yin, J. Gornbein, J.A. Araujo, and H.R. Middlekauff: Sympathomimetic Effects of Acute E-Cigarette Use: Role of Nicotine and Non-Nicotine Constituents; J. Am. Heart Assoc. 6 (2017) e006579. DOI: 10.1161/jaha.117.006579
- Moheimani, R.S., M. Bhetraratana, F. Yin, K.M. Peters, J. Gornbein, J.A. Araujo, and H.R. Middlekauff: Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk; JAMA Cardiol. 2 (2017) 278–284. DOI: 10.1001/jamacardio.2016.5303
- Oliveri, D., Q.W. Liang, and M. Sarkar: Real-World Evidence of Differences in Biomarkers of Exposure to Select Harmful and Potentially Harmful Constituents and Biomarkers of Potential Harm between Adult E-Vapor Users and Adult Cigarette Smokers; Nicotine Tob. Res. 22 (2020) 1114–1122. DOI: 10.1093/ntr/ntz185
- Stokes, A.C., W. Xie, A.E. Wilson, H. Yang, O.A. Orimoloye, A.F. Harlow, J.L. Fetterman, A.P. DeFilippis, E.J. Benjamin, R.M. Robertson, A. Bhatnagar, N.M. Hamburg, and M.J. Blaha: Association of Cigarette and Electronic Cigarette Use Patterns with Levels of Inflammatory and Oxidative Stress Biomarkers among US Adults: Population Assessment of Tobacco and Health Study; Circulation 143 (2021) 869–871. DOI: 10.1161/circulationaha.120.051551
- Hecht, S.S., S.G. Carmella, D. Kotandeniya, M.E. Pillsbury, M. Chen, B.W.S. Ransom, R.I. Vogel, E. Thompson, S.E. Murphy, and D.K. Hatsukami: Evaluation of Toxicant and Carcinogen Metabolites in the Urine of E-Cigarette Users Versus Cigarette Smokers; Nicotine Tob. Res. 17 (2015) 704–709. DOI: 10.1093/ntr/ntu218
- Kim, H.-J. and H.-S. Shin: Determination of Tobacco-Specific Nitrosamines in Replacement Liquids of Electronic Cigarettes by Liquid Chromatography-Tandem Mass Spectrometry; J. Chromatogr. A 1291 (2013) 48–55. DOI: 10.1016/j.chroma.2013.03.035
- Lizhnyak, P.N., B. Noggle, L. Wei, J. Edmiston, E. Becker, R.A. Black, and M. Sarkar: Understanding Heterogeneity among Individuals Who Smoke Cigarettes and Vape: Assessment of Biomarkers of Exposure and Potential Harm among Subpopulations from the PATH Wave 1 Data; Harm Reduct. J. 19 (2022) 90. DOI: 10.1186/s12954-022-00673-x
- Pulvers, K., N.L. Nollen, M. Rice, C.H. Schmid, K. Qu, N.L. Benowitz, and J.S. Ahluwalia: Effect of Pod E-Cigarettes vs Cigarettes on Carcinogen Exposure among African American and Latinx Smokers A Randomized Clinical Trial; JAMA Netw. Open 3 (2020) 13. DOI: 10.1001/jamanetworkopen.2020.26324
- Shahab, L., M.L. Goniewicz, B.C. Blount, J. Brown, A. McNeill, K.U. Alwis, J. Feng, L. Wang, and R. West: Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users: A Cross-Sectional Study; Ann. Intern. Med. 166 (2017) 390–400. DOI: 10.7326/M16-1107
- Chitteti, R., J.P. Zuniga-Hertz, J.A. Masso-Silva, J. Shin, I. Niesman, C.M. Bojanowski, A.J. Kumar, M. Hepokoski, L.E. Crotty Alexander, H.H. Patel, and D.M. Roth: E-Cigarette-Induced Changes in Cell Stress and Mitochondrial Function; Free Radical Biology and Medicine 228 (2025) 329–338. DOI: 10.1016/j.freeradbiomed.2025.01.004
- Kanithi, M., S. Junapudi, S.I. Shah, A. Matta Reddy, G. Ullah, and B. Chidipi: Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping; Cells 11 (2022) 1688. DOI: 10.3390/cells11101688
- Tommasi, S., N. Pabustan, M. Li, Y. Chen, K.D. Siegmund, and A. Besaratinia: A Novel Role for Vaping in Mitochondrial Gene Dysregulation and Inflammation Fundamental to Disease Development; Sci. Rep. 11 (2021) 22773. DOI: 10.1038/s41598-021-01965-1
- Kim, M.D., N. Baumlin, A. Guerrero-Cignarella, A. Schmid, C. Aguiar, M. Mohiuddin, J.S. Dennis, J.S. Ahluwalia, E.L. Leavens, N. Nollen, M. Campos, and M. Salathe: Persistence of Airway Inflammation in Smokers Who Switch to Electronic Cigarettes; ERJ Open Res. 8 (2022) 00117–02022. DOI: 10.1183/23120541.00117-2022
- Mainous III, A.G., S. Yadav, Y.-R. Hong, and J. Huo: E-Cigarette and Conventional Tobacco Cigarette Use, Dual Use, and C-Reactive Protein; J. Am. Coll. Cardiol. 75 (2020) 2271–2273. DOI: 10.1016/j.jacc.2020.02.061
- Moon, J., H. Lee, M. Kong, H. Kim, and Y. Oh: Association between Electronic Cigarette Use and Levels of High-Sensitivity C-Reactive Protein and Uric Acid; Asia Pac. J. Public Health 32 (2020) 35–41. DOI: 10.1177/1010539519899777
- Perez, M.F., E.L. Mead, N.C. Atuegwu, E.M. Mortensen, M. Goniewicz, and C. Oncken: Biomarkers of Toxicant Exposure and Inflammation among Women of Reproductive Age Who Use Electronic or Conventional Cigarettes; J. Womens Health 30 (2021) 539–550. DOI: 10.1089/jwh.2019.8075
- Yao, Z., E. Tasdighi, Z.A. Dardari, J. Erhabor, K.K. Jha, N. Osuji, T. Rajan, E. Boakye, C.J. Rodriguez, J.A.C. Lima, S. Judd, T. Feldman, J.A. Fialkow, V.S. Ramachandran, O. El Shahawy, E.J. Benjamin, A. Bhatnagar, A.P. DeFilippis, K. Nasir, and M.J. Blaha: Use of E-Cigarette, Traditional Cigarettes, and C-Reactive Protein: The Cross Cohort Collaboration; Am. Heart J. 280 (2025) 1–6. DOI: 10.1016/j.ahj.2024.10.012
- Williams, M., A. Villarreal, K. Bozhilov, S. Lin, and P. Talbot: Metal and Silicate Particles Including Nanoparticles Are Present in Electronic Cigarette Cartomizer Fluid and Aerosol; PLOS ONE 8 (2013) e57987. DOI: 10.1371/journal.pone.0057987
- Sakamaki-Ching, S., M. Williams, M. Hua, J. Li, S.M. Bates, A.N. Robinson, T.W. Lyons, M.L. Goniewicz, and P. Talbot: Correlation between Biomarkers of Exposure, Effect and Potential Harm in the Urine of Electronic Cigarette Users; BMJ Open Respir. Res. 7 (2020) e000452. DOI: 10.1136/bmjresp-2019-000452
- Tommasi, S., H. Blumenfeld, and A. Besaratinia: Vaping Dose, Device Type, and E-Liquid Flavor Are Determinants of DNA Damage in Electronic Cigarette Users; Nicotine Tob. Res. 25 (2023) 1145–1154. DOI: 10.1093/ntr/ntad003
- Navas-Acien, A., I. Martinez-Morata, M. Hilpert, A. Rule, D. Shimbo, and N.J. LoIacono: Early Cardiovascular Risk in E-Cigarette Users: The Potential Role of Metals; Curr. Environ. Health Rep. 7 (2020) 353–361. DOI: 10.1007/s40572-020-00297-y, Correction in Curr. Environ. Health Rep. 7 (2020) 362. DOI: 10.1007/s40572-020-00302-4
- Lamas, G.A., A. Bhatnagar, M.R. Jones, K.K. Mann, K. Nasir, M. Tellez-Plaza, F. Ujueta, A. Navas-Acien, E.a.P. American Heart Association Council on, Council on Cardiovascular and Stroke Nursing, Council on Lifestyle and Cardiometabolic Health, Council on Peripheral Vascular Disease, and Council on the Kidney in Cardiovascular Disease: Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement from the American Heart Association; J. Am. Heart Assoc. 12 (2023) e029852. DOI: 10.1161/JAHA.123.029852
- Besaratinia, A.: Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers; Chem. Res. Toxicol. 38 (2025) 542–556. DOI: 10.1021/acs.chemrestox.4c00520
- Antonini, J.M., M.D. Taylor, A.T. Zimmer, and J.R. Roberts: Pulmonary Responses to Welding Fumes: Role of Metal Constituents; J. Toxicol. Environ. Health A 67 (2004) 233–249. DOI: 10.1080/15287390490266909
- Wu, L., F. Cui, J. Ma, Z. Huang, S. Zhang, Z. Xiao, J. Li, X. Ding, and P. Niu: Associations of Multiple Metals with Lung Function in Welders by Four Statistical Models; Chemosphere 298 (2022) 134202. DOI: 10.1016/j.chemosphere.2022.134202
- Zhang, J., Y. Hu, X. Wang, X. Ding, X. Cen, B. Wang, S. Yang, Z. Ye, W. Qiu, W. Chen, and M. Zhou: Associations of Personal PM2.5-Bound Heavy Metals and Heavy Metal Mixture with Lung Function: Results from a Panel Study in Chinese Urban Residents; Chemosphere 364 (2024) 143084. DOI: 10.1016/j.chemosphere.2024.143084
- Jin, Z., W. Sun, J. Huang, and G. Wang: Heavy Metals and Their Relationships with Lung Function and Airway Inflammation: Insights from a Population-Based Study; J. Transl. Med. 23 (2025) 642. DOI: 10.1186/s12967-025-06538-8
- Zhu, Y. and M. Costa: Metals and Molecular Carcinogenesis; Carcinogenesis 41 (2020) 1161–1172. DOI: 10.1093/carcin/bgaa076
- International Agency for Research on Cancer (IARC): Cobalt, Antimony Compounds, and Weapons-Grade Tungsten Alloy; IARC Monographs on the Identification of Carcinogenic Hazards to Humans, Vol. 131, IARC, Lyon, France, 2023, 594 pp. ISBN: 978-92-832-0171-7. Available at:
https://www.ncbi.nlm.nih.gov/books/NBK598318 (accessed June 23, 2026). - Morabito, J.A., M.R. Holman, Y.S. Ding, X. Yan, M. Chan, D. Chafin, J. Perez, M.I. Mendez, R.B. Cardenas, and C. Watson: The Use of Charcoal in Modified Cigarette Filters for Mainstream Smoke Carbonyl Reduction; Regul. Toxicol. Pharmacol. 86 (2017) 117–127. DOI: 10.1016/j.yrtph.2017.02.019
- Kang, Y.-J., H.-K. Jo, M.-H. Jang, X. Ma, Y. Jeon, K. Oh, and J.-I. Park: A Brief Review of Formaldehyde Removal through Activated Carbon Adsorption; Appl. Sci. 12 (2022) 5025. DOI: 10.3390/app12105025
- Branton, P.J., K.G. McAdam, D.B. Winter, C. Liu, M.G. Duke, and C.J. Proctor: Reduction of Aldehydes and Hydrogen Cyanide Yields in Mainstream Cigarette Smoke Using an Amine Functionalised Ion Exchange Resin; Chem. Cent. J. 5 (2011) 15. DOI: 10.1186/1752-153X-5-15
- de Falco, B., A. Petridis, P. Paramasivan, A.D. Troise, A. Scaloni, Y. Deeni, W.E. Stephens, and A. Fiore: Reducing Toxic Reactive Carbonyl Species in E-Cigarette Emissions: Testing a Harm-Reduction Strategy Based on Dicarbonyl Trapping; RSC Adv. 10 (2020) 21535–21544. DOI: 10.1039/d0ra02138e
- Kosmider, L., A. Sobczak, M. Fik, J. Knysak, M. Zaciera, J. Kurek, and M.L. Goniewicz: Carbonyl Compounds in Electronic Cigarette Vapors: Effects of Nicotine Solvent and Battery Output Voltage; Nicotine Tob. Res. 16 (2014) 1319–1326. DOI: 10.1093/ntr/ntu078
- Jensen, R.P., W. Luo, J.F. Pankow, R.M. Strongin, and D.H. Peyton: Hidden Formaldehyde in E-Cigarette Aerosols; N. Engl. J. Med. 372 (2015) 392–394. DOI: 10.1056/NEJMc1413069
- Brown, C.J. and J.M. Cheng: Electronic Cigarettes: Product Characterisation and Design Considerations; Tob. Control 23 Suppl 2 (2014) ii4–10. DOI: 10.1136/tobaccocontrol-2013-051476
- Dibaji, S.A.R., B. Oktem, L. Williamson, J. DuMond, T. Cecil, J.P. Kim, S. Wickramasekara, M. Myers, and S. Guha: Characterization of Aerosols Generated by High-Power Electronic Nicotine Delivery Systems (ENDS): Influence of Atomizer, Temperature and PG:VG Ratios; PLOS ONE 17 (2022) e0279309. DOI: 10.1371/journal.pone.0279309
- Korzun, T., M. Lazurko, I. Munhenzva, K.C. Barsanti, Y. Huang, R.P. Jensen, J.O. Escobedo, W. Luo, D.H. Peyton, and R.M. Strongin: E-Cigarette Airflow Rate Modulates Toxicant Profiles and Can Lead to Concerning Levels of Solvent Consumption; ACS Omega 3 (2018) 30–36. DOI: 10.1021/acsomega.7b01521
- Staal, Y.C., S. van de Nobelen, A. Havermans, and R. Talhout: New Tobacco and Tobacco-Related Products: Early Detection of Product Development, Marketing Strategies, and Consumer Interest; JMR Public Health Surveill. 4 (2018) e55. DOI: 10.2196/publichealth.7359
- Smith, C.J. and P. Martin: Conducting Clinical Evaluations in Human Smokers Switching to Reduced-Toxicity Cigarettes; in: Toxicological Evaluation of Tobacco Products, Vol. 28, Proc. 56th Tobacco Science Research Conference (TSRC), 2002, Lexington, KY, USA, TSRC, 2002, pp. 166–190.
- Lin, X., Y. Fan, X. Wang, M. Chi, X. Li, X. Zhang, and D. Sun: Correlation between Tumor Necrosis Factor-A and Interleukin-1β in Exhaled Breath Condensate and Pulmonary Function; Am. J. Med. Sci. 354 (2017) 388–394. DOI: 10.1016/j.amjms.2017.06.004
- Maskey-Warzęchowska, M., P. Nejman-Gryz, K. Osinka, P. Lis, K. Malesa, K. Górska, and R. Krenke: Acute Response to Cigarette Smoking Assessed in Exhaled Breath Condensate in Patients with Chronic Obstructive Pulmonary Disease and Healthy Smokers; in: Respiratory Treatment and Prevention, edited by M. Pokorski, Springer International Publishing, Cham, ISBN: 978-3-319-44488-8, 2017, pp. 73–80. DOI: 10.1007/5584_2016_43
- Garey, K.W., M.M. Neuhauser, R.A. Robbins, L.H. Danziger, and I. Rubinstein: Markers of Inflammation in Exhaled Breath Condensate of Young Healthy Smokers; Chest 125 (2004) 22–26. DOI: 10.1378/chest.125.1.22
- Menzel, A., H. Samouda, F. Dohet, S. Loap, M.S. Ellulu, and T. Bohn: Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?; Antioxidants 10 (2021) 414. DOI: 10.3390/antiox10030414
- Li, H., X. Xie, L. Tang, C. Chen, and J. Li: Multi-Omics Signatures of Chronic Inflammation across Immune-Related Disease States; Front. Immunol. 17 (2026) 1753156. DOI: 10.3389/fimmu.2026.1753156
- Russell, M.A.H.: Low-Tar Medium-Nicotine Cigarettes: A New Approach to Safer Smoking; Br. Med. J. 1 (1976) 1430–1433. DOI: 10.1136/bmj.1.6023.1430
DOI: https://doi.org/10.2478/cttr-2026-0009 | Journal eISSN: 2719-9509 (formerly 1612-9237)
Language: English, French, German
Page range: 116 - 147
Submitted on: Mar 9, 2026
Accepted on: Jun 18, 2026
Published on: Aug 31, 2026
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