Impact of caffeine intake on squat performance and biomechanics: A randomized crossover trial
References
- Bernárdez-Vázquez, R., Raya-González, J., Castillo, D., & Beato, M. (2022). Resistance training variables for optimization of muscle hypertrophy: An umbrella review. Frontiers in Sports and Active Living, 4, 949021. https://doi.org/10.3389/fspor.2022.949021
- Bühler, E., Lachenmeier, D. W., Schlegel, K., & Winkler, G. (2014). Development of a tool to assess the caffeine intake among teenagers and young adults. Ernahrungs Umschau, 61(4), 58–63. https://doi.org/10.4455/eu.2014.011
- Dwan, K., Li, T., Altman, D. G., & Elbourne, D. (2019). CONSORT 2010 statement: Extension to randomised crossover trials. British Medical Journal, 366, l4378. https://doi.org/10.1136/bmj.l4378
- El-Kotob, R., Ponzano, M., Chaput, J.-P., Janssen, I., Kho, M. E., Poitras, V. J., Ross, R., Ross-White, A., Saunders, T. J., & Giangregorio, L. M. (2020). Resistance training and health in adults: An overview of systematic reviews. Applied Physiology, Nutrition, and Metabolism, 45(10, Suppl. 2), S165–S179. https://doi.org/10.1139/apnm-2020-0245
- Elkin, L. A., Kay, M., Higgins, J. J., & Wobbrock, J. O. (2021). An aligned rank transform procedure for multifactor contrast tests. Proceedings of the 34th annual ACM symposium on user interface software and technology, USA (pp. 754–768). https://doi.org/10.1145/3472749.3474784
- Filip-Stachnik, A., Krzysztofik, M., Del Coso, J., & Wilk, M. (2022). Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: A randomized, crossover, double-blind study involving control and placebo conditions. European Journal of Nutrition, 61(2), 947–955. https://doi.org/10.1007/s00394-021-02708-8
- Filip, A., Wilk, M., Krzysztofik, M., & Del Coso, J. (2020). Inconsistency in the ergogenic effect of caffeine in athletes who regularly consume caffeine: Is it due to the disparity in the criteria that defines habitual caffeine intake? Nutrients, 12(4), 1087. https://doi.org/10.3390/nu12041087
- Gathercole, R. J., Sporer, B. C., Stellingwerff, T., & Sleivert, G. G. (2015). Comparison of the capacity of different jump and sprint field tests to detect neuromuscular fatigue. Journal of Strength and Conditioning Research, 29(9), 2522–2531. https://doi.org/10.1519/JSC.0000000000000912
- Glassbrook, D. J., Brown, S. R., Helms, E. R., Duncan, S., & Storey, A. G. (2019). The high-bar and low-bar back-squats: A biomechanical analysis. Journal of Strength and Conditioning Research, 33(Suppl. 1), S1–S18. https://doi.org/10.1519/JSC.0000000000001836
- Grgic, J. (2018). Are there non-responders to the ergogenic effects of caffeine ingestion on exercise performance? Nutrients, 10(11), 1736. https://doi.org/10.3390/nu10111736
- Grgic, J. (2022). A comprehensive assessment of caffeine’s effects on components of countermovement jump performance. Biology of Sport, 39(3), 515–520. https://doi.org/10.5114/biolsport.2022.107017
- Grgic, J., & Mikulic, P. (2022). Effects of caffeine on rate of force development: A meta-analysis. Scandinavian Journal of Medicine & Science in Sports, 32(4), 644–653. https://doi.org/10.1111/sms.14109
- Grgic, J., Sabol, F., Venier, S., Tallis, J., Schoenfeld, B. J., Del Coso, J., & Mikulic, P. (2019). Caffeine supplementation for powerlifting competitions: An evidence-based approach. Journal of Human Kinetics, 68, 37–48. https://doi.org/10.2478/hukin-2019-0054
- Grgic, J., Scapec, B., Pedisic, Z., & Mikulic, P. (2020). Test-retest reliability of velocity and power in the deadlift and squat exercises assessed by the gymaware powertool system. Frontiers in Physiology, 11, 561682. https://doi.org/10.3389/fphys.2020.561682
- Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: Caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
- Haahr, M. (1998). Random.org: True random number service. Retrieved March 17, 2022 from https://www.random.org
- Hooper, D. R., Szivak, T. K., Comstock, B. A., Dunn-Lewis, C., Apicella, J. M., Kelly, N. A., Creighton, B. C., Flanagan, S. D., Looney, D. P., Volek, J. S., Maresh, C. M., & Kraemer, W. J. (2014). Effects of fatigue from resistance training on barbell back squat biomechanics. Journal of Strength and Conditioning Research, 28(4), 1127–1134. https://doi.org/10.1097/JSC.0000000000000237
- Hopewell, S., Chan, A.-W., Collins, G. S., Hróbjartsson, A., Moher, D., Schulz, K. F., Tunn, R., Aggarwal, R., Berkwits, M., Berlin, J. A., Bhandari, N., Butcher, N. J., Campbell, M. K., Chidebe, R. C. W., Elbourne, D., Farmer, A., Fergusson, D. A., Golub, R. M., Goodman, S. N., … Boutron, I. (2025). CONSORT 2025 explanation and elaboration: Updated guideline for reporting randomised trials. British Medical Journal, 389, e081124. https://doi.org/10.1136/bmj-2024-081124
- Kassiano, W., Costa, B., Nunes, J. P., Ribeiro, A. S., Schoenfeld, B. J., & Cyrino, E. S. (2023). Which ROMs lead to Rome? A systematic review of the effects of range of motion on muscle hypertrophy. Journal of Strength and Conditioning Research, 37(5), 1135–1144. https://doi.org/10.1519/JSC.0000000000004415
- Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., Greenwood, M., Lowery, L. M., Wildman, R., Antonio, J., & Kreider, R. B. (2018). ISSN exercise & sports nutrition review update: Research & recommendations. Journal of the International Society of Sports Nutrition, 15(1), 38. https://doi.org/10.1186/s12970-018-0242-y
- Lesinski, M., Prieske, O., Demps, M., & Granacher, U. (2016). Effects of fatigue and surface instability on neuromuscular performance during jumping. Scandinavian Journal of Medicine and Science in Sports, 26(10), 1140–1150. https://doi.org/10.1111/sms.12548
- Magkos, F., & Kavouras, S. A. (2005). Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Critical Reviews in Food Science and Nutrition, 45(7–8), 535–562. https://doi.org/10.1080/1040-830491379245
- Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., Meeusen, R., Van Loon, L. J. C., Shirreffs, S. M., Spriet, L. L., Stuart, M., Vernec, A., Currell, K., Ali, V. M., Budgett, R. G., … Engebretsen, L. (2018). IOC consensus statement: Dietary supplements and the high-performance athlete. British Journal of Sports Medicine, 52(7), 439–455. https://doi.org/10.1136/bjsports-2018-099027
- Montalvo-Alonso, J. J., Del Val-Manzano, M., Cerezo-Telléz, E., Ferragut, C., Valadés, D., Rodríguez-Falces, J., & Pérez-López, A. (2025a). Acute caffeine intake improves muscular strength, power, and endurance performance, reversing the time-of-day effect regardless of muscle activation level in resistance-trained males: A randomized controlled trial. European Journal of Applied Physiology, 125, 3259–3272. https://doi.org/10.1007/s00421-025-05820-3
- Montalvo-Alonso, J. J., Del Val-Manzano, M., Ferragut, C., Valadés, D., López-Samanes, Á., Domínguez, R., & Pérez-López, A. (2025b). Single and combined effect of beetroot juice and caffeine intake on muscular strength, power and endurance performance in resistance-trained males. Scientific Reports, 15(1), 16781. https://doi.org/10.1038/s41598-025-02021-y
- Montalvo-Alonso, J. J., Ferragut, C., Del Val-Manzano, M., Valadés, D., Roberts, J., & Pérez-López, A. (2024a). Sex differences in the ergogenic response of acute caffeine intake on muscular strength, power and endurance performance in resistance-trained individuals: A randomized controlled trial. Nutrients, 16(11), 1760. https://doi.org/10.3390/nu16111760
- Montalvo-Alonso, J. J., Munilla, C., Garriga-Alonso, L., Ferragut, C., Valadés, D., Gonzalo-Encabo, P., & Pérez-López, A. (2024b). Acute co-ingestion of caffeine and sodium bicarbonate on muscular endurance performance. Nutrients, 16(24), 4382. https://doi.org/10.3390/nu16244382
- Moreno-Villanueva, A., Pino-Ortega, J., & Rico-González, M. (2024). Validity and reliability of linear position transducers and linear velocity transducers: A systematic review. Sports Biomechanics, 23(10), 1340–1369. https://doi.org/10.1080/14763141.2021.1988136
- Muñoz, A., López-Samanes, Á., Aguilar-Navarro, M., Varillas-Delgado, D., Rivilla-García, J., Moreno-Pérez, V., & Del Coso, J. (2020). Effects of CYP1A2 and ADORA2A genotypes on the ergogenic response to caffeine in professional handball players. Genes, 11(8), 933. https://doi.org/10.3390/genes11080933
- Myer, G. D., Kushner, A. M., Brent, J. L., Schoenfeld, B. J., Hugentobler, J., Lloyd, R. S., Vermeil, A., Chu, D. A., Harbin, J., & McGill, S. M. (2014). The back squat: A proposed assessment of functional deficits and technical factors that limit performance. Strength and Conditioning Journal, 36(6), 4–27. https://doi.org/10.1519/SSC.0000000000000103
- National Cancer Institute. (2022). Automated self-administered 24-hour (ASA24®) dietary assessment tool. Retrieved January 19, 2023 from https://epi.grants.cancer.gov/asa24
- Ortiz-Sánchez, D., Bravo-Sánchez, A., Ramírez-delaCruz, M., Abián, P., & Abián-Vicén, J. (2024). Placebo effect of caffeine on physiological parameters and physical performance. Nutrients, 16(10), 1405. https://doi.org/10.3390/nu16101405
- Pickering, C., & Kiely, J. (2018). Are the current guidelines on caffeine use in sport optimal for everyone? Inter-individual variation in caffeine ergogenicity, and a move towards personalised sports nutrition. Sports Medicine, 48(1), 7–16. https://doi.org/10.1007/s40279-017-0776-1
- Puig-Diví, A., Escalona-Marfil, C., Padullés-Riu, J. M., Busquets, A., Padullés-Chando, X., & Marcos-Ruiz, D. (2019). Validity and reliability of the Kinovea program in obtaining angles and distances using coordinates in 4 perspectives. PLoS One, 14(6), e0216448. https://doi.org/10.1371/journal.pone.0216448
- Raya-González, J., Rendo-Urteaga, T., Domínguez, R., Castillo, D., Rodríguez-Fernández, A., & Grgic, J. (2020). Acute effects of caffeine supplementation on movement velocity in resistance exercise: A systematic review and meta-analysis. Sports Medicine, 50(4), 717–729. https://doi.org/10.1007/s40279-019-01211-9
- Ruiz-Fernández, I., Valadés, D., Dominguez, R., Ferragut, C., & Pérez-López, A. (2023). Load and muscle group size influence the ergogenic effect of acute caffeine intake in muscular strength, power and endurance. European Journal of Nutrition, 62(4), 1783–1794. https://doi.org/10.1007/s00394-023-03109-9
- Sánchez-Medina, L., Pallarés, J. G., Pérez, C. E., Morán-Navarro, R., & González-Badillo, J. J. (2017). Estimation of relative load from bar velocity in the full back squat exercise. Sports Medicine International Open, 1(2), E80–E88. https://doi.org/10.1055/s-0043-102933
- Santos Junior, E. R. T., de Salles, B. F., Dias, I., Ribeiro, A. S., Simão, R., & Willardson, J. M. (2021). Classification and determination model of resistance training status. Strength and Conditioning Journal, 43(5), 77–86. https://doi.org/10.1519/ssc.0000000000000627
- Saunders, B., de Oliveira, L. F., da Silva, R. P., de Salles Painelli, V., Gonçalves, L. S., Yamaguchi, G., Mutti, T., Maciel, E., Roschel, H., Artioli, G. G., & Gualano, B. (2017). Placebo in sports nutrition: A proof-of-principle study involving caffeine supplementation. Scandinavian Journal of Medicine and Science in Sports, 27(11), 1240–1247. https://doi.org/10.1111/sms.12793
- Schoenfeld, B. J. (2010). Squatting kinematics and kinetics and their application to exercise performance. Journal of Strength and Conditioning Research, 24(12), 3497–3506. https://doi.org/10.1519/JSC.0b013e3181bac2d7
- Serafim, T. T., de Oliveira, E. S., Maffulli, N., Migliorini, F., & Okubo, R. (2023). Which resistance training is safest to practice? A systematic review. Journal of Orthopaedic Surgery and Research, 18(1), 296. https://doi.org/10.1186/s13018-023-03781-x
- Urbaniak, G. C., & Plous, S. (1999). Research randomizer (Version 4.0). Retrieved March 17, 2022 from http://www.randomizer.org
- Wobbrock, J. O., Findlater, L., Gergle, D., & Higgins, J. J. (2011). The aligned rank transform for nonparametric factorial analyses using only ANOVA procedures. Proceedings of the SIGCHI conference on human factors in computing systems, USA (pp. 143–146). https://doi.org/10.1145/1978942.1978963
Language: English
Page range: 217 - 231
Submitted on: Mar 12, 2026
Accepted on: Apr 16, 2026
Published on: Aug 4, 2026
Published by: University of Physical Education in Warsaw
In partnership with: Paradigm Publishing Services
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© 2026 Arnau Baena-Riera, Xantal Borràs-Boix, Javier Peña, published by University of Physical Education in Warsaw
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