Moderate aerobic exercise increases adiponectin but not pancreatic β-cell function in men with type 2 diabetes: A randomized controlled trial

Sony Wibisono Mudjanarko; Anugrahini Irawati; Jessica Leoni; Damayanti Tinduh

doi:10.2478/bhk-2026-0012

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Moderate aerobic exercise increases adiponectin but not pancreatic β-cell function in men with type 2 diabetes: A randomized controlled trial

Biomedical Human Kinetics

Volume 18 (2026): Issue 1 (January 2026)

By: Sony Wibisono Mudjanarko , Anugrahini Irawati , Jessica Leoni and Damayanti Tinduh

Open Access

|May 2026

Amanat, S., Ghahri, S., Dianatinasab, A., Fararouei, M., & Dianatinasab, M. (2020). Exercise and type 2 diabetes. In Advances in experimental medicine and biology (Vol. 1228, pp. 91–105). Springer. doi: 10.1007/978-981-15-1792-1_6.
Open DOI Search in Google Scholar Back to article
American Diabetes Association Professional Practice Committee. (2025). 10. Cardiovascular disease and risk management: Standards of care in diabetes—2025. Diabetes Care, 48(Suppl. 1), S207–S238. https://doi.org/10.2337/dc25-S010
Search in Google Scholar Back to article
Bacha, F., Saad, R., Gungor, N., & Arslanian, S. A. (2004). Adiponectin in youth: Response to Stefan et al. Diabetes Care, 27(6), 1520–1521. doi: 10.2337/diacare.27.6.1520.
Open DOI Search in Google Scholar Back to article
Becic, T., Studenik, C., & Hoffmann, G. (2018). Exercise increases adiponectin and reduces leptin levels in prediabetic and diabetic individuals: Systematic review and meta-analysis of randomized controlled trials. Medical Sciences, 6(4), 97. doi: 10.3390/medsci6040097.
Open DOI Search in Google Scholar Back to article
Bloem, C. J., & Chang, A. M. (2008). Short-term exercise improves β-cell function and insulin resistance in older people with impaired glucose tolerance. The Journal of Clinical Endocrinology & Metabolism, 93(2), 387–392. doi: 10.1210/jc.2007-1734.
Open DOI Search in Google Scholar Back to article
Borghouts, L. B., & Keizer, H. A. (2000). Exercise and insulin sensitivity: A review. International Journal of Sports Medicine, 21(1), 1–12. doi: 10.1055/s-2000-8847.
Open DOI Search in Google Scholar Back to article
Boudou, P., Sobngwi, E., Mauvais-Jarvis, F., Vexiau, P., & Gautier, J. F. (2003). Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. European Journal of Endocrinology, 149(5), 421–424. doi: 10.1530/eje.0.1490421.
Open DOI Search in Google Scholar Back to article
Boyko, E. J., & Jensen, C. C. (2007). Do we know what homeostasis model assessment measures? If not, does it matter? Diabetes Care, 30(10), 2725–2728. doi: 10.2337/dc07-1248.
Open DOI Search in Google Scholar Back to article
Bruce, R. A., Blackmon, J. R., Jones, J. W., & Strait, G. (2004). Exercise testing in adult normal subjects and cardiac patients. Annals of Noninvasive Electrocardiology, 9(3), 291–303. doi: 10.1111/j.1542-474X.2004.93003.x.
Open DOI Search in Google Scholar Back to article
Cao, L., Jiang, Y., Li, Q., Wang, J., & Tan, S. (2019). Exercise training at maximal fat oxidation intensity for overweight or obese older women: A randomized study. Journal of Sports Science & Medicine, 18(3), 413–418. https://www.jssm.org/volume18/iss3/cap/jssm-18-413.pdf.
Cao L. Jiang Y. Li Q. Wang J. Tan S. 2019 Exercise training at maximal fat oxidation intensity for overweight or obese older women: A randomized study Journal of Sports Science & Medicine 18 3 413 418 https://www.jssm.org/volume18/iss3/cap/jssm-18-413.pdf.

Back to article
Chetboun, M., Abitbol, G., Rozenberg, K., Rozenfeld, H., Deutsch, A., Sampson, S. R., & Rosenzweig, T. (2012). Maintenance of redox state and pancreatic β-cell function: Role of leptin and adiponectin. Journal of Cellular Biochemistry, 113(6), 1966–1976. doi: 10.1002/jcb.24065.
Open DOI Search in Google Scholar Back to article
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016). Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care, 39(11), 2065–2079. doi: 10.2337/dc16-1728.
Open DOI Search in Google Scholar Back to article
Curran, M., Drayson, M. T., Andrews, R. C., Zoppi, C., Barlow, J. P., Solomon, T. P. J., & Narendran, P. (2020). The benefits of physical exercise for the health of the pancreatic β-cell: A review of the evidence. Experimental Physiology, 105(4), 579–589. doi: 10.1113/EP088220.
Open DOI Search in Google Scholar Back to article
Davis, G. R., Stephens, J. M., & Nelson, A. G. (2015). Effect of 12 weeks of periodized resistance training upon total plasma adiponectin concentration in healthy young men. Journal of Strength and Conditioning Research, 29(11), 3097–3104. doi: 10.1519/JSC.0000000000000894.
Open DOI Search in Google Scholar Back to article
Dunmore, S. J., & Brown, J. E. P. (2013). The role of adipokines in β-cell failure of type 2 diabetes. Journal of Endocrinology, 216(1), T37–T45. doi: 10.1530/JOE-12-0278.
Open DOI Search in Google Scholar Back to article
Fisman, E. Z., & Tenenbaum, A. (2014). Adiponectin: A manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease? Cardiovascular Diabetology, 13(1), 103. doi: 10.1186/1475-2840-13-103.
Open DOI Search in Google Scholar Back to article
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. International Journal of Molecular Sciences, 21(17), 6275. doi: 10.3390/ijms21176275.
Open DOI Search in Google Scholar Back to article
Ha, C. H., Swearingin, B., Jeon, Y. K., & Lee, M. (2015). Effects of combined exercise on HOMA-IR, HOMA-β, and atherogenic index in Korean obese female. Sport Sciences for Health, 11(1), 49–55. doi: 10.1007/s11332-014-0208-7.
Open DOI Search in Google Scholar Back to article
Haffner, S. M., Gonzalez, C., Miettinen, H., Kennedy, E., & Stern, M. P. (1996). A prospective analysis of the HOMA model. Diabetes Care, 19(10), 1138–1141. doi: 10.2337/diacare.19.10.1138.
Open DOI Search in Google Scholar Back to article
Heiskanen, M. A., Motiani, K. K., Mari, A., Saunavaara, V., Eskelinen, J. J., Virtanen, K. A., & Hannukainen, J. C. (2018). Exercise training decreases pancreatic fat content and improves β-cell function regardless of baseline glucose tolerance: A randomized controlled trial. Diabetologia, 62(1), 204–206. doi: 10.1007/s00125-018-4627-x.
Open DOI Search in Google Scholar Back to article
Heiston, E. M., Eichner, N. Z. M., Gilbertson, N. M., & Malin, S. K. (2020). Exercise improves adiposopathy, insulin sensitivity, and metabolic syndrome severity independent of intensity. Experimental Physiology, 105(4), 632–640. doi: 10.1113/EP088158.
Open DOI Search in Google Scholar Back to article
Jeon, J. Y., Han, J., Kim, H. J., Park, M. S., Seo, D. Y., & Kwak, Y. S. (2013). The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children. Integrative Medicine Research, 2(4), 145–150. doi: 10.1016/j.imr.2013.10.001.
Open DOI Search in Google Scholar Back to article
Jones, D. W., Hall, J. E., Carey, R. M., Whelton, P. K., Wright, J. T., Jr., Williamson, J. D., Reboussin, D. M., Rahman, M., Rocco, M. V., Snyder, J. K., Sink, K. M., & Smith, S. C., Jr. (2025). 2025 AHA/ACC guideline for the management of high blood pressure in adults. Journal of the American College of Cardiology, 86(18), 1567–1678. doi: 10.1016/j.jacc.2025.05.007.
Open DOI Search in Google Scholar Back to article
Kanaya, A. M., Harris, T., Goodpaster, B. H., Tylavsky, F., Cummings, S. R., & Health, Aging, and Body Composition Study. (2004). Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care, 27(6), 1375–1380. doi: 10.2337/diacare.27.6.1375.
Open DOI Search in Google Scholar Back to article
Karajibani, M., Montazerifar, F., Dehghani, K., Mogharnasi, M., Mousavi, G. S. R., & Dashipour, A. (2018). Effect of aerobic and anaerobic exercises on anthropometric parameters, chemerin and adiponectin levels in non-athletic men. Health Scope, 7(2), e61819. doi: 10.5812/jhealthscope.61819.
Open DOI Search in Google Scholar Back to article
Kementerian Kesehatan Republik Indonesia. (2020). Pedoman nasional pelayanan kedokteran tata laksana diabetes melitus tipe 2 dewasa [National clinical guideline for the management of type 2 diabetes mellitus in adults]. Kementerian Kesehatan Republik Indonesia. https://keslan.kemkes.go.id/unduhan/fileunduhan_1610340996_61925.pdf.
Search in Google Scholar Back to article
Khalili, D., Khayamzadeh, M., Kohansal, K., Ahanchi, N. S., Hasheminia, M., Hadaegh, F., Tohidi, M., Azizi, F., & Habibi-Moeini, A. S. (2023). Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes? BMC Endocrine Disorders, 23(1), 39. doi: 10.1186/s12902-023-01291-9.
Open DOI Search in Google Scholar Back to article
Khoramipour, K., Chamari, K., Hekmatikar, A. A., Ziyaiyan, A., Taherkhani, S., Elguindy, N. M., & Bragazzi, N. L. (2021). Adiponectin: Structure, physiological functions, role in diseases, and effects of nutrition. Nutrients, 13(4), 1180. doi: 10.3390/nu13041180.
Open DOI Search in Google Scholar Back to article
Kim, J. Y., & Jeon, J. Y. (2020). Role of exercise on insulin sensitivity and beta-cell function: Is exercise sufficient for the prevention of youth-onset type 2 diabetes? Annals of Pediatric Endocrinology and Metabolism, 25(4), 208–216. doi: 10.6065/apem.2040140.070.
Open DOI Search in Google Scholar Back to article
Kraemer, R. R., Aboudehen, K. S., Carruth, A. K., Durand, R. J., Acevedo, E. O., Hebert, E. P., Johnson, L. G., & Castracane, V. D. (2003). Adiponectin responses to continuous and progressively intense intermittent exercise. Medicine & Science in Sports & Exercise, 35(8), 1320–1325. doi: 10.1249/01.MSS.0000079072.23998.F3.
Open DOI Search in Google Scholar Back to article
Kriketos, A. D., Khee, G. S., Poynten, A. M., Furler, S. M., Chisholm, D. J., & Campbell, L. V. (2004). Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care, 27(2), 624–625. doi: 10.2337/diacare.27.2.624.
Open DOI Search in Google Scholar Back to article
Lee, S. H., Hong, H. R., Han, T. K., & Kang, H. S. (2015). Aerobic training increases the expression of adiponectin receptor genes in the peripheral blood mononuclear cells of young men. Biology of Sport, 32(3), 181–186. doi: 10.5604/20831862.1150298.
Open DOI Search in Google Scholar Back to article
Madsen, S. M., Thorup, A. C., Overgaard, K., & Jeppesen, P. B. (2015). High-intensity interval training improves glycaemic control and pancreatic β-cell function of type 2 diabetes patients. PLoS One, 10(8), e0133286. doi: 10.1371/journal.pone.0133286.
Open DOI Search in Google Scholar Back to article
Malin, S. K., Solomon, T. P. J., Blaszczak, A., Finnegan, S., Filion, J., & Kirwan, J. P. (2013). Pancreatic β-cell function increases in a linear dose–response manner following exercise training in adults with prediabetes. American Journal of Physiology – Endocrinology and Metabolism, 305(10), E1248–E1254. doi: 10.1152/ajpendo.00260.2013.
Open DOI Search in Google Scholar Back to article
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), 412–419. doi: 10.1007/BF00280883.
Open DOI Search in Google Scholar Back to article
Metin Aksu, N., Yazgan Aksoy, D., Akkaş, M., Çinar, N., Uçar, F., Yildiz, B. O., & Usman, A. (2020). Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia. Turkish Journal of Medical Sciences, 50(2), 312–315. doi: 10.3906/sag-1903-35.
Open DOI Search in Google Scholar Back to article
Muscella, A., Stefàno, E., Lunetti, P., Capobianco, L., & Marsigliante, S. (2020). The regulation of fat metabolism during aerobic exercise. Biomolecules, 10(12), 1699. doi: 10.3390/biom10121699.
Open DOI Search in Google Scholar Back to article
Nguyen, T. M. D. (2020). Adiponectin: Role in physiology and pathophysiology. International Journal of Preventive Medicine, 11, 136. doi: 10.4103/ijpvm.IJPVM_193_20.
Open DOI Search in Google Scholar Back to article
Nieuwoudt, S., Fealy, C. E., Foucher, J. A., Scelsi, A. R., Malin, S. K., Pagadala, M., Rocco, M., Burguera, B., & Kirwan, J. P. (2017). Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes. American Journal of Physiology – Endocrinology and Metabolism, 313(3), E314–E320. doi: 10.1152/ajpendo.00407.2016.
Open DOI Search in Google Scholar Back to article
Nuttall, F. Q. (2015). Body mass index. Nutrition Today, 50(3), 117–128. doi: 10.1097/NT.0000000000000092.
Open DOI Search in Google Scholar Back to article
Oberbach, A., Tönjes, A., Klöting, N., Fasshauer, M., Kratzsch, J., Busse, M. W., Paschke, R., Stumvoll, M., & Blüher, M. (2006). Effect of a 4-week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. European Journal of Endocrinology, 154(4), 577–585. doi: 10.1530/eje.1.02127.
Open DOI Search in Google Scholar Back to article
Olson, T. P., Dengel, D. R., Leon, A. S., & Schmitz, K. H. (2007). Changes in inflammatory biomarkers following one year of moderate resistance training in overweight women. International Journal of Obesity, 31(6), 996–1003. doi: 10.1038/sj.ijo.0803534.
Open DOI Search in Google Scholar Back to article
Omidi, M., & Moghadasi, M. (2017). Regular aerobic training improves insulin resistance but not pancreatic β-cell function in female patients with type 2 diabetes. Journal of Physical Activity and Hormones, 1(4), 59–70. https://journals.iau.ir/article_537495_d946aaee632bf96f1db86ec2543f78b0.pdf.
Search in Google Scholar Back to article
Pan, B., Ge, L., Xun, Y. Q., Chen, Y. J., Gao, C. Y., Han, X., Zuo, L. Q., Shan, H. Q., Yang, K. H., Ding, G. W., & Tian, J. H. (2018). Exercise training modalities in patients with type 2 diabetes mellitus: A systematic review and network meta-analysis. International Journal of Behavioral Nutrition and Physical Activity, 15(1), 72. doi: 10.1186/s12966-018-0703-3.
Open DOI Search in Google Scholar Back to article
Porszasz, J., Casaburi, R., Somfay, A., Woodhouse, L. J., & Whipp, B. J. (2003). A treadmill ramp protocol using simultaneous changes in speed and grade. Medicine & Science in Sports & Exercise, 35(9), 1596–1603. doi: 10.1249/01.MSS.0000084593.56786.DA.
Open DOI Search in Google Scholar Back to article
Rajizadeh, M. A., Moslemizadeh, A., Hosseini, M. S., Rafiei, F., Soltani, Z., & Khoramipour, K. (2023). Adiponectin receptor 1 could explain sex differences in the molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Scientific Reports, 13(1), 17664. doi: 10.1038/s41598-023-43519-7.
Open DOI Search in Google Scholar Back to article
Ruan, H., & Dong, L. Q. (2016). Adiponectin signaling and function in insulin target tissues. Journal of Molecular Cell Biology, 8(2), 101–109. doi: 10.1093/jmcb/mjw014.
Open DOI Search in Google Scholar Back to article
Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023). Obesity and type 2 diabetes mellitus: Connections in epidemiology, pathogenesis, and treatments. Frontiers in Endocrinology, 14, 1161521. doi: 10.3389/fendo.2023.1161521.
Open DOI Search in Google Scholar Back to article
Slentz, C. A., Tanner, C. J., Bateman, L. A., Durheim, M. T., Huffman, K. M., Houmard, J. A., & Kraus, W. E. (2009). Effects of exercise training intensity on pancreatic β-cell function. Diabetes Care, 32(10), 1807–1811. doi: 10.2337/dc09-0032.
Open DOI Search in Google Scholar Back to article
Sokolovska, J., Ostrovska, K., Pahirko, L., Varblane, G., Krilatiha, K., Cirulnieks, A., Folkmane, I., Pirags, V., Valeinis, J., Klavina, A., & Selavo, L. (2020). Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes. Physiological Reports, 8(13), e14506. doi: 10.14814/phy2.14506.
Open DOI Search in Google Scholar Back to article
Solomon, T. P. J., Malin, S. K., Karstoft, K., Kashyap, S. R., Haus, J. M., & Kirwan, J. P. (2013). Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. Journal of Clinical Endocrinology & Metabolism, 98(10), 4176–4186. doi: 10.1210/jc.2013-2232.
Open DOI Search in Google Scholar Back to article
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004). Use and abuse of HOMA modeling. Diabetes Care, 27(6), 1487–1495. doi: 10.2337/diacare.27.6.1487.
Open DOI Search in Google Scholar Back to article
Zheng, L., Wu, J., Wang, G., Persuitte, G., Ma, Y., Zou, L., Zhang, L., Zhao, M., Wang, J., Lan, Q., Liu, Z., Fan, H., & Li, J. (2016). Comparison of control fasting plasma glucose of exercise-only versus exercise-diet among a prediabetic population: A meta-analysis. European Journal of Clinical Nutrition, 70(4), 424–430. doi: 10.1038/ejcn.2015.128.
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.2478/bhk-2026-0012 | Journal eISSN: 2080-2234

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Language: English

Page range: 138 - 147

Submitted on: Aug 8, 2025

Accepted on: Apr 7, 2026

Published on: May 5, 2026

Published by: University of Physical Education in Warsaw

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other,

Clinical medicine,

Public health,

Sports and recreation,

Sports and recreation, other,

Physical education

© 2026 Sony Wibisono Mudjanarko, Anugrahini Irawati, Jessica Leoni, Damayanti Tinduh, published by University of Physical Education in Warsaw
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 18 (2026): Issue 1 (January 2026)