Abstract
Douglas Van Anden Frost (1910-1989) was a visionary in nutrition science, leaving an enduring legacy that reshaped the understanding of essential nutrients. From his early work on factor W and the discovery of niacin, which eradicated pellagra, to pioneering investigations into selenium’s multifaceted role, Frost’s unconventional thinking and meticulous research have significantly impacted human health. Collaborating with biochemist Raymond Shamberger (1934-2022), Frost challenged prevailing notions about selenium’s carcinogenic potential, demonstrating its anticarcinogenic properties through groundbreaking research. Beyond the laboratory, Frost’s work influences public health policies, emphasizing the interconnectedness of nutrients. This paper explores Frost’s trajectory, emphasizing the importance of questioning paradigms, interdisciplinary insights, and dedicated experimentation in advancing nutrition science. Frost’s enduring inspiration reminds us of the transformative power of curiosity in unraveling the mysteries of human health.