
A Non-Antibiotic Pectin–Morin–Quercetin Intramammary Therapy For Mild Clinical Mastitis In Dairy Cows
References
- Bagnicka E., Brzozowska P., Żukowski K., Grochowska R. (2023). The association of gene polymorphisms with milk production and mastitis resistance phenotypic traits in dairy cattle. Ann. Anim. Sci., 23: 419–430.
- Balemi A., Gumi B., Amenu K., Girma S., Gebru M., Tekle M., Ríus A.A., D'Souza D.H., Agga G.E., Kerro Dego O. (2021). Prevalence of mastitis and antibiotic resistance of bacterial isolates from CMT positive milk samples obtained from dairy cows, camels, and goats in two pastoral districts in southern Ethiopia. Animals, 11: 1530.
- Burmańczuk A., Hola P., Milczak A., Piech T., Kowalski C., Wojciechowska B., Grabowski T. (2018). Quercetin decrease somatic cells count in mastitis of dairy cows. Res. Vet. Sci., 117: 255–259.
- Debruyn E., Ghumman N.Z., Peng J., Tiwari H.K., Gogoi-Tiwari J. (2025). Alternative approaches for bovine mastitis treatment: A critical review of emerging strategies, their effectiveness and limitations. Res. Vet. Sci., 185: 105557.
- do Nascimento G.M., Rodrigues R.A., Brugnera H.C., Barbosa J.C., Favaron F.R., Rossi G.A.M., Bragança C.R.S., Schocken-Iturrino R.P., de Ávila F.A., Cardozo M.V. (2025). Antimicrobial activity of teat antiseptic formulations based on plant extracts for controlling bovine mastitis: in vitro and in vivo evaluation. Vet. Sci., 12: 293.
- Fan X., Qadeer A., Asiri M., Alzahrani F.M., Alzahrani K.J., Alsharif K.F., Khan M.Z., Jiang X. (2025). Traditional Chinese medicine and plant-derived bioactive compounds as sustainable alternatives to antibiotics in bovine mastitis: a review. Front. Vet. Sci., 12: 1642647.
- Godoy C.A., Balic I., Moreno A.A., Diaz O., Arenas Colarte C., Bruna Larenas T., Gamboa A., Caro Fuentes N. (2025). Antimicrobial and antibiofilm activity of chitosan nanoparticles against Staphylococcus aureus strains isolated from bovine mastitis milk. Pharmaceutics, 17: 186.
- Guamán S.A., Elhadi A., Salama A.A.K., Manuelian C.L., Caja G., Albanell E. (2024). Beta-glucans improve the mammary innate immune response to endotoxin challenge in dairy ewes. Animals, 14: 3023.
- Huang P., Hu P., Zhou S.Y., Li Q., Chen W.M. (2014). Morin inhibits sortase A and subsequent biofilm formation in Streptococcus mutans. Curr. Microbiol., 68: 47–52.
- Inchaisri C., Persson Waller K., Johannisson A. (2000). Studies on the modulation of leucocyte subpopulations and immunoglobulins following intramammary infusion of β1,3-glucan into the bovine udder during the dry period. J. Vet. Med. B, 47: 373–386.
- Jiang L., Li Q., Liao H., Liu H., Wang Z. (2025). Enhancing agricultural productivity in dairy cow mastitis management: Innovations in non-antibiotic treatment technologies. Vet. Sci., 12: 662.
- Jiang M., Lv Z., Huang Y., Cheng Z., Meng Z., Yang T., Yan Q., Lin M., Zhan K., Zhao G. (2022). Quercetin alleviates lipopolysaccharide-induced inflammatory response in bovine mammary epithelial cells by suppressing TLR4/NF-κB signaling pathway. Front. Vet. Sci., 9: 915726.
- Kan X., Hu G., Liu Y., Xu P., Huang Y., Cai X., Guo W., Fu S., Liu J. (2022). Mammary fibrosis tendency and mitochondrial adaptability in dairy cows with mastitis. Metabolites, 12: 1035.
- Khan M.Z., Khan A., Xiao J., Ma J., Ma Y., Chen T., Shao D., Cao Z. (2020). Overview of research development on the role of NF-κB signaling in mastitis. Animals, 10: 1625.
- Kirkeby C., Schwarz D., Denwood M., Farre M., Nielsen SS., Gussmann M., Toft N., Halasa T. (2021). Dynamics of somatic cell count (SCC) and differential SCC during and following intramammary infections. J. Dairy Sci., 104: 3427–3438.
- Kocik M., Burmańczuk A., Grabowski T., Tomaszewska E. (2025 a). Intramammary pectin therapy for clinical mastitis in dairy cows: A field pilot study. Agriculture, 15: 1760.
- Kocik M., Burmańczuk A., Bednarski M., Sołtysiuk M., Grabowski T., Tomaszewska E. (2025 b). Therapeutic potential of morin in reducing somatic cell counts and clinical scores in bovine mastitis caused by Escherichia coli and Streptococcus uberis. Agriculture, 15: 2359.
- Kovačević Z., Samardžija M., Tomanić D. (2025). A review of recent developments in essential oil-based alternatives in mastitis treatment in dairy cows. Ann. Anim. Sci., 26: 739–750.
https://doi.org/10.2478/aoas-2025-0086 - Kruk K., Winnicka K. (2022). Alginates combined with natural polymers as valuable drug delivery platforms. Marine Drugs, 21: 11.
- Pyörälä S. (2003). Indicators of inflammation in the diagnosis of mastitis. Vet. Res., 34: 565–578.
- Romanek J., Trzcińska M., Samiec M. (2024). Multi-faceted characterization of mesenchymal stem cells and their application as a powerful tool for agrobiotechnology, assisted reproductive technologies, and veterinary and regenerative biomedicine – a review. Ann. Anim. Sci., 24: 367–377.
- Sumon S., Parvin M., Ehsan M., Islam M. (2020). Dynamics of somatic cell count and intramammary infection in lactating dairy cows. J. Adv. Vet. Anim. Res., 7: 314.
- Tomanić D., Samardžija M., Kovačević Z. (2023). Alternatives to antimicrobial treatment in bovine mastitis therapy: A review. Antibiotics, 12: 683.
- Tomanić D., Kladar N., Kovačević Z. (2025). Antibiotic residues in milk as a consequence of mastitis treatment: balancing animal welfare and One Health risks. Vet. Sci., 12: 1159.
- Williamson J., Callaway T., Rollin E., Ryman V. (2022). Association of milk somatic cell count with bacteriological cure of intramammary infection – a review. Agriculture, 12: 1437.
- Xiong G., Ji W., Wang F., Zhang F., Xue P., Cheng M., Sun Y., Wang X., Zhang T. (2019). Quercetin inhibits inflammatory response induced by LPS from Porphyromonas gingivalis in human gingival fibroblasts via suppressing NF-κB signaling pathway. BioMed. Res. Int., 628263.
- Yu C., Wang D., Yang Z., Wang T. (2022). Pharmacological effects of polyphenol phytochemicals on the intestinal inflammation via targeting TLR4/NF-κB signaling pathway. Int. J. Mol. Sci., 23: 6939.
DOI: https://doi.org/10.2478/aoas-2026-0025 | Journal eISSN: 2300-8733 (formerly 1642-3402) | Journal ISSN: 1642-3402
Language: English
Submitted on: Dec 16, 2025
Accepted on: Mar 19, 2026
Published on: Oct 5, 2026
Published by: National Research Institute of Animal Production
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2026 Marcin Kocik, Artur Burmańczuk, Tomasz Grabowski, Włodzimierz Markiewicz, Oktay Yilmaz, Ewa Tomaszewska, published by National Research Institute of Animal Production
This work is licensed under the Creative Commons Attribution 3.0 License.