
Effects of Yupingfeng polysaccharide on growth performance, serum growth-related hormones, and metabolomics in chicks
By: Sifan Chen, Wendan Zheng, Yuling Guan and Bo Wu
References
- Bai Y., Wei W., Yao C., Wu S., Wang W., Guo D.A. (2023). Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San. Fitoterapia, 164: 105385.
- Chen H., Guo B., Yang M., Luo J., Hu Y., Qu M., Song X. (2021). Response of growth performance, blood biochemistry indices, and rumen bacterial diversity in lambs to diets containing supplemental probiotics and Chinese medicine polysaccharides. Front. Vet. Sci., 8: 681389.
- Deng J., Zhang J., Chang Y., Wang S., Shi M., Miao Z. (2022). Effects of Chinese yam polysaccharides on the immune function and serum biochemical indexes of broilers. Front. Vet. Sci., 9: 1013888.
- Fan W., Zheng P., Wang Y., Hao P., Liu J., Zhao X. (2017). Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo. Biomed. Pharmacother., 93: 146–155.
- Feng J., Zhao F., Sun J., Lin B., Zhao L., Liu Y., Jin Y., Li S., Li A., Wei Y. (2019). Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients. Int. J. Cancer, 144: 2728–2745.
- Fiehn O. (2001). Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genomics, 2: 155–168.
- Gaynor P.J., Lookingland K.J., Tucker H.A. (1995). 5-Hydroxytryptaminergic receptor-stimulated growth-hormone secretion occurs independently of changes in peripheral somatostatin concentration. Proc. Society for Experimental Biology and Medicine, 209: 79–85.
- Gong H., Li W., Sun J., Jia L., Guan Q., Guo Y., Wang Y. (2022). A review on plant polysaccharide based on drug delivery system for construction and application, with emphasis on traditional Chinese medicine polysaccharide. Int. J. Biol. Macromol., 211: 711–728.
- Guan Y., Zheng W., Bai Y., Wu B. (2024). Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota. Front. Vet. Sci., 11.
- He W., Li P., Wu G. (2021). Amino acid nutrition and metabolism in chickens. Adv. Exp. Med. Biol., 1285: 109–131.
- Hooper L.V. (2004). Bacterial contributions to mammalian gut development. Trend. Microbiol., 12: 129–134.
- Ibero-Baraibar I., Romo-Hualde A., Gonzalez-Navarro C.J., Zulet M.A., Martinez J.A. (2016). The urinary metabolomic profile following the intake of meals supplemented with a cocoa extract in middle-aged obese subjects. Food Funct., 7: 1924–1931.
- Kogut M.H., Lee A., Santin E. (2020). Microbiome and pathogen interaction with the immune system. Poult. Sci., 99: 1906–1913.
- Kowalik K., Sechman A. (2022). In vitro effects of polychlorinated biphenyls and their hydroxylated metabolites on the synthesis and metabolism of iodothyronines in the chicken (Gallus domesticus) thyroid gland. Gen. Comp. Endocrinol., 318: 113989.
- Li C., Zhao P., Shao Q., Chen W., Huang S., Wang X., Zhang C., He L. (2023). Effects of dietary Glycyrrhiza polysaccharide on growth performance, blood parameters and immunity in weaned piglets. J. Anim. Physiol. Anim. Nutr. (Berl.), 107: 136–146.
- Li C.X., Liu Y., Zhang Y.Z., Li J.C., Lai J. (2022). Astragalus polysaccharide: a review of its immunomodulatory effect. Arch. Pharm. Res., 45: 367–389.
- Li P., Yin Y.L., Li D., Kim S.W., Wu G. (2007). Amino acids and immune function. Br. J. Nutr., 98: 237–252.
- Li Y., Xu Q., Huang Z., Lv L., Liu X., Yin C., Yan H., Yuan J. (2016). Effect of Bacillus subtilis CGMCC 1.1086 on the growth performance and intestinal microbiota of broilers. J. Appl. Microbiol., 120: 195–204.
- Liao G., Song X., Wang X., Zhang W., Zhang L., Qiu J., Hou R. (2020). Cytotoxicity of 2,2’,3,5′,6-pentachlorobiphenyl (PCB95) and its metabolites in the chicken embryo liver cells of laying hens. Ecotoxicol. Environ. Saf., 194: 110338.
- Liu M.Y., Sun C.X., Zhou Q.L., Xu P., Wang A.M., Zheng X.C., Liu B. (2024). Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macrobrachium rosenbergii. Front. Immunol., 15.
- Liu X.M., Yu Y., Wu Y.Q., Luo A., Yang M., Li T., Li T.Q., Mao B., Chen X.T., Fu J.J., Jiang H.L., Liu W. (2023). A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment. Phytomedicine, 114.
- Long L.N., Kang B.J., Jiang Q., Chen J.S. (2020). Effects of dietary Lycium barbarum polysaccharides on growth performance, digestive enzyme activities, antioxidant status, and immunity of broiler chickens. Poult. Sci., 99: 744–751.
- Makino T., Ito Y., Sasaki S.Y., Fujimura Y., Kano Y. (2004). Preventive and curative effects of Gyokuheifu-san, a formula of traditional Chinese medicine, on allergic rhinitis induced with Japanese cedar pollens in guinea pig. Biol. Pharm. Bull., 27: 554–558.
- Matxain J.M., Ristilä M., Strid A., Eriksson L.A. (2007). Theoretical study of the reaction of vitamin B6 with 1O2. Chemistry, 13: 4636–4642.
- Mund M.D., Riaz M., Mirza M.A., Rahman Z.U., Mahmood T., Ahmad F., Ammar A. (2020). Effect of dietary tryptophan supplementation on growth performance, immune response and anti-oxidant status of broiler chickens from 7 to 21 days. Vet. Med. Sci., 6: 48–53.
- Muñoz-González I., Chamorro S., Pérez-Jiménez J., López-Andrés P., Álvarez-Acero I., Herrero A.M., Nardoia M.A., Brenes A., Viveros A., Arija I., Rey A., Ruiz-Capillas C. (2019). Phenolic metabolites in plasma and thigh meat of chickens supplemented with grape byproducts. J. Agric. Food Chem., 67: 4463–4471.
- Nai J., Zhang C., Shao H., Li B., Li H., Gao L., Dai M., Zhu L., Sheng H. (2021). Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide. Int. J. Biol. Macromol., 183: 2337–2353.
- Nie K., Ma K., Luo W., Shen Z., Yang Z., Xiao M., Tong T., Yang Y., Wang X. (2021). Roseburia intestinalis: a beneficial gut organism from the discoveries in genus and species. Front. Cell Infect. Microbiol., 11: 757718.
- Pei T., Dai Y., Tan X., Geng A., Li S., Gui Y., Hu C., An J., Yu X., Bao X., Wang D. (2023). Yupingfeng San exhibits anticancer effect in hepatocellular carcinoma cells via the MAPK pathway revealed by HTS2 technology. J. Ethnopharmacol., 306: 116134.
- Poon P.M., Wong C.K., Fung K.P., Fong C.Y., Wong E.L., Lau J.T., Leung P.C., Tsui S.K., Wan D.C., Waye M.M., Au S.W., Lau C.B., Lam C.W. (2006). Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: a self-control study. Am. J. Chin. Med., 34: 13–21.
- Rao Z.B., Li J.L., Shi B.S., Zeng Y., Liu Y.B., Sun Z.H., Wu L.T., Sun W.Z., Tang Z.R. (2021). Dietary tryptophan levels impact growth performance and intestinal microbial ecology in weaned piglets via tryptophan metabolites and intestinal antimicrobial peptides. Animals, 11.
- Rosenberg J., Ischebeck T., Commichau F.M. (2017). Vitamin B6 metabolism in microbes and approaches for fermentative production. Biotechnol. Adv., 35: 31–40.
- Rowland I., Gibson G., Heinken A., Scott K., Swann J., Thiele I., Tuohy K. (2018). Gut microbiota functions: metabolism of nutrients and other food components. Eur. J. Nutr., 57: 1–24.
- Sears C.L. (2005). A dynamic partnership: celebrating our gut flora. Anaerobe, 11: 247–251.
- Shi M., Chang Y., Cao M., Zhang J., Zhang L., Xie H., Miao Z. (2022). Effects of dietary yam polysaccharide on growth performance and intestinal microflora in growing Huoyan geese. J. Anim. Feed Sci., 31: 328–334.
- Su C., Fan D., Pan L., Lu Y., Wang Y., Zhang M. (2020). Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei. Fish Shellfish Immunol., 105: 104–116.
- Sun H., Ni X., Song X., Wen B., Zhou Y., Zou F., Yang M., Peng Z., Zhu H., Zeng Y., Wang H., Fu X., Shi Y., Yin Z., Pan K., Jing B., Zeng D., Wang P. (2016). Fermented Yupingfeng polysaccharides enhance immunity by improving the foregut microflora and intestinal barrier in weaning Rex rabbits. Appl. Microbiol. Biotechnol., 100: 8105–8120.
- Sun Z., Kong Y., Li N., Jiang X., Cao T., Jia Y., Zhang Y., Zhang Y., Cheng J., Wang J. (2018). Effect of Yupingfeng granules on the skin barrier in atopic dermatitis mice models. J. Tradit. Chin. Med., 38: 872–878.
- Valdes A.M., Walter J., Segal E., Spector T.D. (2018). Role of the gut microbiota in nutrition and health. Bmj, 361: k2179.
- Wang Y., Sun N., Luo Y., Fang Z., Fang Y., Tian J., Yu Y., Wu J., Li Y. (2021). Yu-Ping-Feng formula exerts antilung cancer effects by remodeling the tumor microenvironment through regulating myeloid-derived suppressor cells. Evid. Based Complement. Alternat. Med., 2021: 6624461.
- Wassie T., Cheng B., Zhou T., Gao L., Lu Z., Xie C., Wu X. (2022). Microbiome-metabolome analysis reveals alterations in the composition and metabolism of caecal microbiota and metabolites with dietary Enteromorpha polysaccharide and yeast glycoprotein in chickens. Front. Immunol., 13: 996897.
- Willoughby J.O., Menadue M.F., Liebelt H. (1987). Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone secretion in the unanesthetized rat. Brain Res., 404: 319–322.
- Wu G. (2013). Functional amino acids in nutrition and health. Amino Acids, 45: 407–411.
- Wu S. (2018). Effect of dietary Astragalus membranaceus polysaccharide on the growth performance and immunity of juvenile broilers. Poult. Sci., 97: 3489–3493.
- Wu X.Z., Wen Z.G., Hua J.L. (2019). Effects of dietary inclusion of Lactobacillus and inulin on growth performance, gut microbiota, nutrient utilization, and immune parameters in broilers. Poult. Sci., 98: 4656–4663.
- Xu H.A., Zhang F., Che Y., Cui Y., Yao Q.S., Guan Y.Q., Chen H., Huang Y.Y. (2025). Integrative multi-omics and bioinformatics analysis of the effects of BaiRui YuPing-Feng Powder on intestinal health in broilers. Front. Vet. Sci., 12.
- Yang H., Tan S., Chen S., Wu Y., Yang Y., Li H., Yu H. (2021). Effects of fermented Yupingfeng on intramuscular fatty acids and ruminal microbiota in Qingyuan black goats. Anim. Sci. J., 92: e13554.
- Yin F., Lan R., Wu Z., Wang Z., Wu H., Li Z., Yu H., Zhao Z., Li H. (2019). Yupingfeng polysaccharides enhances growth performance in Qingyuan partridge chicken by up-regulating the mRNA expression of SGLT1, GLUT2 and GLUT5. Vet. Med. Sci., 5: 451–461.
- Zafar H., Saier M.H Jr. (2021). Gut Bacteroides species in health and disease. Gut Microbes, 13: 1–20.
- Zarghi H., Golian A., Nikbakhtzade M. (2020). Effect of dietary digestible lysine level on growth performance, blood metabolites and meat quality of broilers 23–38 days of age. J. Anim. Physiol. Anim. Nutr. (Berl.), 104: 156–165.
- Zeng H., Xi Y., Li Y., Wang Z., Zhang L., Han Z. (2020). Analysis of Astragalus polysaccharide intervention in heat-stressed dairy cows’ serum metabolomics. Animals (Basel), 10.
- Zhang C., Li C., Zhao P., Shao Q., Ma Y., Bai D., Liao C., He L., Huang S., Wang X. (2023). Effects of dietary Glycyrrhiza polysaccharide supplementation on growth performance, intestinal antioxidants, immunity and microbiota in weaned piglets. Anim. Biotechnol., 34: 2273–2284.
- Zhang L., Zhu L., Li X., Gao W. (2011). Optimization of process conditions for extraction and alcohol precipitation of total polysaccharides from Yupingfeng. Chin. J. Experim. Tradit. Med. Formul., 17: 24–26.
- Zhang X., Akhtar M., Chen Y., Ma Z., Liang Y., Shi D., Cheng R., Cui L., Hu Y., Nafady A.A., Ansari A.R., Abdel-Kafy E.M., Liu H. (2022). Chicken jejunal microbiota improves growth performance by mitigating intestinal inflammation. Microbiome, 10: 107.
- Zheng W., Guan Y., Wu B. (2023). Effects of Yupingfeng polysaccharides as feed supplement on immune function and intestinal microbiome in chickens. Microorganisms, 11.
DOI: https://doi.org/10.2478/aoas-2026-0010 | Journal eISSN: 2300-8733 (formerly 1642-3402) | Journal ISSN: 1642-3402
Language: English
Submitted on: Aug 1, 2025
Accepted on: Jan 14, 2026
Published on: Oct 6, 2026
Published by: National Research Institute of Animal Production
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:
© 2026 Sifan Chen, Wendan Zheng, Yuling Guan, Bo Wu, published by National Research Institute of Animal Production
This work is licensed under the Creative Commons Attribution 4.0 License.