Figure 1.
Figure 2.
Figure 3.
Figure 4.
Figure 5.
Overview of identified parasporins (PS/Mpp): B_ thuringiensis strains, associated Cry genes, activation proteases, main cellular targets and observed cytotoxic outcomaes_
| PS | B. thuringiensis Strain | Cry Gene | Protease Activation | Main Cellular Target | Observed Cellular Outcome | Reference |
|---|---|---|---|---|---|---|
| PS1Aa1 | A1190 | Cry31Aa1 | Trypsin | HeLa | Apoptosis | (Mizuki Eiichi et al. 2000) |
| PS1Aa2 | M15 | Cry31Aa2 | Trypsin | HepG2 | Not determined | (Jung et al. 2007) |
| PS1Aa3 | B195 | Cry31Aa3 | Trypsin | HeLa | Not determined | (Uemori et al. 2008) |
| PS1Aa4 | Bt79-25 | Cry31Aa4 | Proteinase K | Not determined | Not determined | (Uemori et al. 2008) |
| PS1Aa5 | Bt92-10 | Cry31Aa5 | Proteinase K | Not determined | Not determined | (Uemori et al. 2008) |
| PS1Aa6 | M019, 64-1-94 | Cry31Aa6 | Trypsin | HepG2 | Not determined | (Gonzalez et al. 2011) |
| PS1Ab1 | B195 | Cry31Ab1 | Trypsin | HeLa | Not determined | (Uemori et al. 2008) |
| PS1Ab2 | Bt31-5 | Cry31Ab2 | Proteinase K | Not determined | Not determined | (Uemori et al. 2008) |
| PS1Ac1 | Bt87-29 | Cry31Ac1 | Proteinase K | Not determined | Not determined | (Uemori et al. 2008) |
| PS1Ac2 | B0462 | Cry31Ac2 | Proteinase K | HeLa | Apoptosis | (Kuroda et al. 2013) |
| PS2Aa1 | A1547 | Cry46Aa1 | Proteinase K | HepG2 | Pore-forming | (Ito et al. 2004) |
| PS2Aa2 | A1470 | Cry31Aa2 | Proteinase K | MOLT-4 | Not determined | (Okumura et al. 2013) |
| PS2Ab1 | TK-E6 | Cry31Ab1 | Proteinase K | Jurkat | Not determined | (Hayakawa et al. 2007) |
| PS3Aa1 | A1462 | Cry41Aa1 | Proteinase K | HL60 | Not determined | (Yamashita et al. 2000) |
| PS3Ab1 | A1462 | Cry41Ab1 | Proteinase K | HL60 | Not determined | (Yamashita et al. 2000) |
| PS4Aa1 | A1470 | Cry45Aa1 | Proteinase K | CaCo2 | Pore-forming | (Okumura et al. 2006) |
| PS5Aa1 | A1100 | Cry64Aa1 | Proteinase K | TCS | Not determined | (Okumura et al. 2006; Ekino et al. 2014) |
| PS6Aa1 | M019, 64-1-94 | Cry63Aa1 | Trypsin | HepG2 | Not determined | (Gonzalez et al. 2011) |