Heteronemin, a Scalarane Sesterterpenoid, Activates Apoptosis and Non-Apoptotic Ferroptosis and Inhibits Cytoprotective Autophagy in Oral Cancer Cells
Authors
Rovelyn Gallego
PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biology, College of Mathematics and Natural Sciences, Caraga State University, Butuan City, Philippines
Chun-Tzu Hung
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Sheng-Kai Hsu
PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Yi-Hua Chang
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Ciao-Ping Chen
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
En-De Shu
PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Ching-Ming Chien
Department of Applied Chemistry, National Chiayi University, Chiayi, Taiwan
Mei-Chin Lu
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung, Taiwan
Ching-Chung Ko
Department of Medical Imaging, Chi Mei Medical Center, Tainan, Taiwan
Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
DOI: https://doi.org/10.2478/aite-2026-0016 | Journal eISSN: 1661-4917
Language: English
Submitted on: Jan 27, 2026
Accepted on: Apr 20, 2026
Published on: Jul 4, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
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© 2026 Rovelyn Gallego, Chun-Tzu Hung, Sheng-Kai Hsu, Yi-Hua Chang, Ciao-Ping Chen, En-De Shu, Ching-Ming Chien, Mei-Chin Lu, Ching-Chung Ko, Chien-Chih Chiu, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.