References
- Abdel Razeq SS, Norwitz ER (2018) Septic shock. Critical Care Obstetrics: 599–629. https://doi.org/10.1002/9781119129400.ch38
- Adamik B, Frostell C, Paslawska U et al (2021) Platelet dysfunction in a large-animal model of endotoxic shock; effects of inhaled nitric oxide and low-dose steroid. Nitric Oxide 108:20–27. https://doi.org/10.1016/j.niox.2020.12.008
- Adamik B, Gozdzik W, Jakubczyk D et al (2017) Coagulation abnormalities identified by thromboelastometry in patients with severe sepsis: The relationship to endotoxemia and mortality. Blood Coagul Fibrinolysis 28:163–170. https://doi.org/10.1097/MBC.0000000000000572
- Adamzik M, Eggmann M, Frey UH et al (2010) Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults. Crit Care 4:R178. https://doi.org/10.1186/CC9284
- Albert J, Harbut P, Zieliński S et al (2007) Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets. Intensive Care Med 33:1594–1601. https://doi.org/10.1007/S00134-007-0666-3
- Albert J, Wallén NH, Li N et al (1999) Neither endogenous nor inhaled nitric oxide influences the function of circulating platelets in healthy volunteers. Clin Sci 97:345–353. https://doi.org/10.1042/CS19990064
- Bloch KD, Ichinose F, Roberts JD Jr et al (2007) Inhaled NO as a therapeutic agent. Cardiovasc Res 75:339–348. https://doi.org/10.1016/j.cardiores.2007.04.014
- Boyd CJ, Claus MA, Raisis AL et al (2018) Hypocoagulability and platelet dysfunction are exacerbated by synthetic colloids in a canine, hemorrhagic shock model. Front Vet Sci 5:279. https://doi.org/10.3389/fvets.2018.00279
- Chong DLW, Sriskandan S (2011) Pro-inflammatory mechanisms in sepsis. Contrib Microbiol 17:86–107. https://doi.org/10.1159/000324022
- Da J, Chen L, Hedenstierna G (2007) Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis. Crit Care Med 35:26–32. https://doi.org/10.1097/01.ccm.0000250319.91575.bb
- de Kruif MD, Lemaire LC, Giebelen IA et al (2007) Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia. J Immunol 178:1845–1851. https://doi.org/10.4049/jimmunol.178.3.1845
- Dragan B, Adamik B, Burzynska M et al (2021) Platelet receptor activity for predicting survival in patients with intracranial bleeding. J Clin Med 10:2205. https://doi.org/10.3390/jcm10102205
- Fei Y, Tang N, Liu H et al (2020) Coagulation dysfunction, a hallmark in COVID-19. Arch Pathol Lab Med 144:1223–1229. https://doi.org/10.5858/ARPA.2020-0324-SA
- Goldstein B, Baldassarre J, Young JN (2012) Effects of inhaled nitric oxide on hemostasis in healthy adults treated with heparin: A randomized, controlled, blinded crossover study. Thromb J 10:1. https://doi.org/10.1186/1477-9560-10-1
- Göranson SP, Goździk W, Harbut P et al (2014) Organ dysfunction among piglets treated with inhaled nitric oxide and intravenous hydrocortisone during prolonged endotoxin infusion. PLoS One 9:e96594. https://doi.org/10.1371/journal.pone.0096594
- Gozdzik W, Zielinski S, Zielinska M et al (2018) Beneficial effects of inhaled nitric oxide with intravenous steroid in an ischemia–reperfusion model involving aortic clamping. Int J Immunopathol Pharmacol 32:394632017751486. https://doi.org/101177/0394632017751486
- Gries A, Herr A, Motsch J et al (2000) Randomized, placebocontrolled, blinded and cross-matched study on the antiplatelet effect of inhaled nitric oxide in healthy volunteers. Thromb Haemost 83:309–315. https://doi.org/10.1055/S-0037-1613804
- Högman M, Frostell C, Arnberg H et al (1993) Bleeding time prolongation and NO inhalation. Lancet 341:1664–1665. https://doi.org/10.1016/0140-6736(93)90802-n
- Högman M, Frostell C, Arnberg H et al (1994) Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 151:125–129. https://doi.org/10.1111/J.1748-1716.1994.tb09728.x
- Kemper DAG, Otsuki DA, Maia DRR et al (2023) Sildenafil in endotoxin-induced pulmonary hypertension: An experimental study. Braz J Anesthesiol 73:446–454. https://doi.org/10.1016/j.bjane.2021.05.016
- Miller C, Miller M, McMullin B et al (2012) A phase I clinical study of inhaled nitric oxide in healthy adults. J Cyst Fibros 11:324–331. https://doi.org/10.1016/j.jcf.2012.01.003
- Nakamura M, Shimizu Y, Sato Y et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol 569:237–243. https://doi.org/10.1016/j.ejphar.2007.05.013
- Nates JL, Cattano D, Chelly JE et al (2015) Study of acute hemocoagulation changes in a porcine endotoxemic shock model using thrombelastography. Transl Res 165:549–557. https://doi.org/10.1016/j.trsl.2014.09.002
- National Research Council (2011) Guide for the care and use of laboratory animals, 8th edn. The National Academies Press, Washington DC.
- Nilsson KF, Goździk W, Frostell C et al (2018) Organic mononitrites of 1,2-propanediol act as an effective NO-releasing vasodilator in pulmonary hypertension and exhibit no cross-tolerance with nitroglycerin in anesthetized pigs. Drug Des Devel Ther 12:685–694. https://doi.org/10.2147/DDDT.S149727
- Schöchl H, Solomon C, Schulz A et al (2011) Thromboelastometry (TEM®) findings in disseminated intravascular coagulation in a pig model of endotoxinemia. Mol Med 7:266–272. https://doi.org/10.2119/molmed.2010.00159
- Schwarz UR, Walter U, Eigenthaler M (2001) Taming platelets with cyclic nucleotides. Biochem Pharmacol 62:1153–1161. https://doi.org/10.1016/S0006-2952(01)00760-2
- Sundy JS, Wood WA, Watt JL et al (2006) Safety of incremental inhaled lipopolysaccharide challenge in humans. J Endotoxin Res 12:113–119. https://doi.org/10.1177/09680519060120020701
- Velik-Salchner C, Streif W, Innerhofer P et al (2009) Endotoxinemia-induced changes in coagulation, as measured by rotation thrombelastometry technique and conventional laboratory tests: Results of a pilot study on pigs. Blood Coagul Fibrinolysis 20:41–46. https://doi.org/10.1097/mbc.0b013e32831be9ad
- Yang X, Cheng X, Tang Y et al (2019) Bacterial endotoxin activates the coagulation cascade through gasdermin D-dependent phosphatidylserine exposure. Immunity 51:983–996.e6. https://doi.org/10.1016/j.immuni.2019.11.005