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Effect of platelet-rich plasma combined with hyaluronic acid and collagen supplementation on tissue healing after anterior cruciate ligament reconstruction Cover

Effect of platelet-rich plasma combined with hyaluronic acid and collagen supplementation on tissue healing after anterior cruciate ligament reconstruction

By: Le Kang,  Jiefeng Li and  Fubin Li  
Open Access
|Feb 2026

Figures & Tables

Figure 1.

The flow chart shows the details of the test
The flow chart shows the details of the test

Comparison of general data

GroupPRP group (n = 70)Combination group (n = 70)χ2/tp
Male/Female36/3439/310.2590.611
Age/years46.64 ± 5.1345.31 ± 5.451.4860.140
BMI/(kg/m2)23.35 ± 3.2423.79 ± 3.150.8160.416
Left/right knee31/3933/370.1150.734
Duration/day11.84 ± 3.5512.14 ± 3.280.5190.605

Comparison of IKDC scores (x̄ ± s, score)

GroupGroupPRP group (n = 70)Combination group (n = 70)tpCohen's d
Preoperative40.44 ± 5.6139.84 ± 6.370.5910.5550.100
Postoperative1 month45.47 ± 4.4249.60 ± 4.355.572< 0.0010.942
3 months62.17 ± 6.5366.77 ± 6.214.27< 0.0010.722
6 months74.48 ± 6.2478.94 ± 6.144.273<0.0010.720
12 months82.21 ± 4.2188.44 ± 3.319.731< 0.0011.645
F754.911963.453
p<0.001< 0.001
Partial Eta Squared0.8970.918

Comparison of swelling degree (x̄ ± s, cm)

GroupnDifference in thigh circumferenceDifference in calf circumference
PRP group703.69 ± 1.273.26 ± 1.42
Combination group702.95 ± 1.582.47 ± 1.39
t 3.0123.367
p 0.0030.001
Cohen's d 0.5160.562

Comparison of postoperative tendon and bone healing (n, %)

GroupnType IType IIType III
PRP group7021 (30.00)41 (58.57)8 (11.43)
Combination group7036 (51.43)31 (44.29)3 (4.29)
χ2 7.609
p 0.022
Phi coefficient 0.233

Comparison of Lysholm scores (x̄ ± s, score)

GroupGroupPRP group (n = 70)Combination group (n = 70)tpCohen's d
Preoperative45.83 ± 6.2246.76 ± 6.240.8820.3790.149
Postoperative1 month48.14 ± 4.7352.46 ± 5.794.828< 0.0010.817
3 months59.76 ± 6.4369.23 ± 4.769.902< 0.0011.674
6 months71.54 ± 6.7182.33 ± 4.8510.905< 0.0011.843
12 months84.39 ± 4.1388.81 ± 4.536.049< 0.0011.020
F559.254838.363
p< 0.001< 0.001
Partial Eta Squared0.8660.907

Comparison of VAS scores (x̄ ± s, score)

GroupGroupPRP group (n = 70)Combination group (n = 70)tpCohen's d
Preoperative5.14 ± 2.405.20 ± 2.520.1370.8910.024
Postoperative1 month7.64 ± 1.226.87 ± 1.333.583< 0.0010.603
3 months4.41 ± 1.223.67 ± 1.643.04< 0.0010.512
6 months3.74 ± 1.452.87 ± 1.513.478< 0.0010.588
12 months2.87 ± 1.332.01 ± 1.223.973< 0.0010.674
F91.36489.49
p< 0.001< 0.001
Partial Eta Squared0.5140.509
Language: English
Page range: 195 - 206
Submitted on: Jun 25, 2025
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Accepted on: Dec 2, 2025
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Published on: Feb 8, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Le Kang, Jiefeng Li, Fubin Li, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.