Abstract
Introduction
This study aims to compare the effects of platelet-rich plasma (PRP) alone versus PRP combined with hyaluronic acid and collagen supplements in promoting healing after anterior cruciate ligament (ACL) reconstruction surgery.
Materials and Methods
Data from 140 patients undergoing arthroscopic ACL reconstruction (January 2022–January 2024) were analyzed. Participants were divided into a PRP group (n=70) and a combination group (PRP + hyaluronic acid + collagen, n=70). Both groups received their respective treatments during surgery and followed a standardized rehabilitation regimen. Outpatient follow-ups occurred at 1, 2, 3, 6, and 12 months post-surgery. Objective assessments included Visual Analog Scale (VAS), Lysholm, and International Knee Documentation Committee (IKDC) scores. Thigh and calf circumferences were measured preoperatively and on postoperative day 3. MRI scans at 12 months assessed tendon-to-bone healing.
Results
At the 12-month follow-up, the combination group showed significantly greater improvements in Lysholm and IKDC scores, and lower VAS scores compared to the PRP group at all postoperative time points (p < 0.05). The combination group also exhibited significantly smaller increases in thigh and calf circumference postoperatively (p < 0.05), indicating less swelling. MRI results revealed significantly better tendon–bone healing grades in the combination group (p < 0.05). No complications were reported in either group.
Conclusions
PRP combined with hyaluronic acid and collagen significantly enhances knee function recovery, reduces pain and swelling, and promotes tendon–bone healing after ACL reconstruction compared to PRP alone.