Potencjalne możliwości wykorzystania berberyny w przeciwdziałaniu insulinooporności i w cukrzycy typu 2

Insulin resistance is a state of decreased sensitivity of target tissues to the action of insulin, despite its normal or increased concentration in blood serum. It is a significant factor in the pathogenesis of the metabolic syndrome, including pre-diabetes and type 2 diabetes, as well as cardiovascular diseases and polycystic ovary syndrome. Nowadays, interest in the use of plant-based agents in the treatment of metabolic diseases is constantly increasing. One of these agents are plants from the barberry family containing isoquinoline alkaloids such as berberine. Current scientific evidence suggests that berberine may have a positive effect on the reduction of insulin resistance, carbohydrate metabolism and lipid metabolism. Scientists have shown that this plant alkaloid could suppress adipocyte differentiation and promote weight reduction. Other effects of berberine include a hypotensive effect and a protective on the vascular endothelium. This review largely focuses on presenting the potential use of berberine in the prevention of insulin resistance and treatment of type 2 diabetes.