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Blood metabolites as predictors of skin cancer risk: a comprehensive analysis Cover

Blood metabolites as predictors of skin cancer risk: a comprehensive analysis

Postępy Higieny i Medycyny Doświadczalnej
Volume 78 (2024): Issue 1 (January 2024)
By: Kaymin Wu,  Youwu He,  Ailian Hua and  Yi Yao  
Open Access
|Aug 2024

Figures & Tables

Figure 1.

Selection workflow
Selection workflow

Figure 2.

Scatter plot of 1-arachidonylglycerol
Scatter plot of 1-arachidonylglycerol

Figure S1.

Forrest plot of Plasma metabolites significantly associated with skin cancer (IVW)
Forrest plot of Plasma metabolites significantly associated with skin cancer (IVW)

Metabolites with significant pleiotropy

MetabolitesMethodsP
X-12117Egger Intercept0.043
X-13695Egger Intercept0.049
Oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]Egger Intercept0.024
Adenosine 5′-diphosphate (ADP) / cytidineEgger Intercept0.025
Caffeine / linoleate (18:2n6)Egger Intercept0.047
Gamma-glutamylthreonineGlobal Test<0.001
PicolinoylglycineGlobal Test<0.001
Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))Global Test0.012
CysteinylglycineGlobal Test0.017
HypotaurineGlobal Test0.011
Cortisone / 4-cholesten-3-oneGlobal Test0.029
Hypotaurine / cysteineGlobal Test0.003
Retinol (Vitamin A) / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]Global Test0.011

Plasma metabolites significantly associated with skin cancer

idMetabolitespvalue
GCST901996491-stearoyl-2-arachidonoyl-GPI (18:0/20:4)0,00051977
GCST901996521-stearoyl-2-oleoyl-GPS (18:0/18:1)0,02555615
GCST90199664Phenyllactate (PLA)0,01272859
GCST901996812-hydroxyoctanoate0,00388752
GCST901997043-hydroxysebacate0,02108698
GCST90199749Gamma-glutamylthreonine0,01482424
GCST901997701-arachidonylglycerol (20:4)0,00037937
GCST901997902-palmitoleoyl-GPC (16:1)0,00713541
GCST901997941-oleoyl-GPE (18:1)0,0064445
GCST901998163,4-dihydroxybutyrate0,0457161
GCST90199828N-acetylserine0,03545266
GCST90199861Pregnenediol sulfate (C21H34O5S)0,00620384
GCST9019987513-HODE + 9-HODE0,02436659
GCST90199879Ergothioneine0,0122909
GCST90199883Cysteinylglycine disulfide0,04409296
GCST901998991-(1-enyl-palmitoyl)-GPC (p-16:0)0,04371435
GCST901999011-methyl-5-imidazoleacetate0,02084982
GCST901999101-(1-enyl-stearoyl)-GPE (p-18:0)0,03700612
GCST901999363-methyl catechol sulfate (2)0,00225296
GCST901999522-aminoheptanoate0,0471971
GCST90199986Eugenol sulfate0,02831923
GCST902000281-stearoyl-2-oleoyl-gpc (18:0/18:1)0,03353492
GCST902000301,2-dilinoleoyl-GPC (18:2/18:2)0,04356157
GCST902000371-stearoyl-2-linoleoyl-gpc (18:0/18:2)0,02938405
GCST902000411-palmitoyl-2-stearoyl-gpc (16:0/18:0)0,04687286
GCST902000461-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)0,00835308
GCST902000511-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6)0,04290723
GCST902001021-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3)0,01098387
GCST90200104Hexadecadienoate (16:2n6)0,02519585
GCST902001612-hydroxyarachidate0,02755643
GCST90200222Dihydrocaffeate sulfate (2)0,00510208
GCST90200234Picolinoylglycine0,0205488
GCST90200243Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))0,04697794
GCST90200316N-acetylglucosaminylasparagine0,03549567
GCST90200319Cys-gly, oxidized0,00216651
GCST90200320Dihomo-linoleate (20:2n6)0,00119897
GCST90200364Cysteinylglycine0,01360229
GCST90200379Hypotaurine0,03014081
GCST90200394Inosine0,00761015
GCST90200447Maltose0,04370196
GCST90200452Plasma free asparagine0,03560774
GCST90200462X-112990,01505161
GCST90200474X-114440,04987119
GCST90200488X-121170,02906436
GCST90200524X-136950,00992943
GCST90200526X-140560,00904827
GCST90200547X-176540,03591522
GCST90200596X-236550,01764105
GCST90200601X-236540,01063422
GCST90200614X-237800,00499579
GCST90200672X-260540,03080663
GCST90200696N6,N6-dimethyllysine0,03796103
GCST90200708X-121120,00021692
GCST90200710X-134310,02265676
GCST90200711X-191410,03481623
GCST902007173-phosphoglycerate / adenosine 5′-diphosphate (ADP)0,01479885
GCST90200731Adenosine 5′-diphosphate (ADP) / mannose0,03623322
GCST90200733Adenosine 5′-diphosphate (ADP) / N-acetylglucosamine / N-acetylgalactosamine0,03158844
GCST90200739Adenosine 5′-monophosphate (AMP) / proline0,0480536
GCST90200749Arachidonate (20:4n6) / pyruvate0,03241957
GCST90200795Oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]0,0450439
GCST90200876Cortisone / 4-cholesten-3-one0,01656538
GCST90200884Mannose / N-acetylglucosamine / N-acetylgalactosamine ratio0,00172666
GCST90200886Phenylpyruvate / 4-hydroxyphenylpyruvate0,04604498
GCST90200895Hypotaurine / cysteine0,00096089
GCST90200904Phosphate / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [1]0,01887088
GCST90200908Retinol (Vitamin A) / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]0,04377634
GCST90200913Glucose / sucrose0,03063799
GCST90200919Caffeine / theophylline0,023528
GCST90200934Acetylcarnitine (C2) / propionylcarnitine (C3)0,02407541
GCST90200952Adenosine 5′-diphosphate (ADP) / cytidine0,03408387
GCST90200956Cytidine / N-acetylglucosamine / N-acetylgalactosamine ratio0,031094
GCST90200963Inosine 5′-monophosphate (IMP) / urate0,04239604
GCST90200971Leucine / phosphate0,00364409
GCST90200979Arachidonate (20:4n6) / linoleate (18:2n6)0,0003571
GCST90200981Caffeine / linoleate (18:2n6)0,04354453
GCST90200983Cholesterol / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [1]0,01367908
GCST90200992Alanine / asparagine0,02078138

Plasma metabolites increase and decrease skin cancer risk

Metabolitesmethodnsnppvaloror_lci95or_uci95
Caffeine / linoleate (18:2n6)Inverse variance weighted130,0435451,0766461,0021411,15669
Arachidonate (20:4n6) / pyruvateInverse variance weighted140,032421,0653681,0053181,129004
X-13695Inverse variance weighted160,0099291,0756291,0176371,136926
Hexadecadienoate (16:2n6)Inverse variance weighted170,0251961,0974681,0116341,190584
Cysteinylglycine disulfideInverse variance weighted180,0440931,0603591,001551,122622
X-14056Inverse variance weighted180,0090481,0637331,015511,114245
Adenosine 5′-diphosphate (ADP) / cytidineInverse variance weighted180,0340841,0610761,004461,120882
1-stearoyl-2-oleoyl-GPS (18:0/18:1) levelsInverse variance weighted190,0255561,0800051,0094511,15549
CysteinylglycineInverse variance weighted190,0136021,096441,0191191,179626
13-HODE + 9-HODEInverse variance weighted200,0243671,0826271,0103251,160103
MaltoseInverse variance weighted200,0437021,0620321,00171,125997
X-11299Inverse variance weighted200,0150521,0734461,013831,136568
Adenosine 5′-monophosphate (AMP) / prolineInverse variance weighted200,0480541,0692581,0005721,142658
2-hydroxyoctanoateInverse variance weighted210,0038881,0703161,0220621,120849
3-hydroxysebacateInverse variance weighted210,0210871,0691221,010091,131605
1-arachidonylglycerol (20:4)Inverse variance weighted220,0003791,0948371,0414751,150933
1-stearoyl-2-arachidonoyl-GPI (18:0/20:4)Inverse variance weighted230,000521,0836011,0355611,13387
Leucine / phosphateInverse variance weighted230,0036441,1023961,0322771,177277
N-acetylserineInverse variance weighted240,0354531,0794081,0052151,159077
1-(1-enyl-stearoyl)-GPE (p-18:0)Inverse variance weighted240,0370061,0537691,0031611,106929
Cys-gly, oxidizedInverse variance weighted240,0021671,0761211,0268241,127786
N6,N6-dimethyllysineInverse variance weighted240,0379611,0330571,0018081,06528
Arachidonate (20:4n6) / linoleate (18:2n6)Inverse variance weighted240,0003571,0751751,0332281,118825
2-palmitoleoyl-GPC (16:1)Inverse variance weighted250,0071351,0762911,0201611,135508
1-(1-enyl-palmitoyl)-GPC (p-16:0)Inverse variance weighted250,0437141,0571541,0015671,115827
3-methyl catechol sulfate (2)Inverse variance weighted250,0022531,0689631,0241871,115697
Phenyllactate (PLA)Inverse variance weighted260,0127291,0781431,0161751,143889
1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)Inverse variance weighted270,0083531,0641941,016111,114554
X-11444Inverse variance weighted270,0498711,0472251,0000251,096652
Phenylpyruvate / 4-hydroxyphenylpyruvateInverse variance weighted270,0460451,0614081,0010461,125409
1-oleoyl-GPE (18:1)Inverse variance weighted280,0064441,0785531,0214411,138858
HypotaurineInverse variance weighted280,0301411,0723481,0067311,142242
X-17654Inverse variance weighted280,0359151,0423191,0027281,083474
1-palmitoyl-2-stearoyl-gpc (16:0/18:0)Inverse variance weighted290,0468731,0548841,0007381,111959
Dihydrocaffeate sulfate (2)Inverse variance weighted290,0051021,0756621,0221321,131995
X-26054Inverse variance weighted300,0308071,0382381,0034741,074207
Alanine / asparagineInverse variance weighted310,0207811,0465541,0069511,087715
X-12117Inverse variance weighted320,0290641,0436751,004371,084519
1-stearoyl-2-oleoyl-gpc (18:0/18:1)Inverse variance weighted330,0335351,0685881,0051821,135993
Hypotaurine / cysteineInverse variance weighted330,0009611,12381,0485731,204424
X-12112Inverse variance weighted350,0002171,0549671,0254711,085311
X-23654Inverse variance weighted380,0106341,0589931,0134291,106605

Metabolites with significant heterogeneity (MR Egger or Inverse variance weighted)

MetabolitesMethodQQ_dfQ_pval
1-stearoyl-2-oleoyl-gpc (18:0/18:1)MR Egger45.43310.045 *
1-stearoyl-2-oleoyl-gpc (18:0/18:1)Inverse variance weighted45.62320.056
2-hydroxyarachidateMR Egger39.57200.006*
2-hydroxyarachidateInverse variance weighted47.17210.001*
Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))MR Egger48.40290.013*
Hydroxypalmitoyl sphingomyelin (d18:1/16:0(OH))Inverse variance weighted48.54300.017*
CysteinylglycineMR Egger31.72170.016*
CysteinylglycineInverse variance weighted34.74180.01*
HypotaurineMR Egger45.67260.01*
HypotaurineInverse variance weighted45.74270.013*
X-13431MR Egger39.43250.033*
X-13431Inverse variance weighted39.52260.043*
Cortisone / 4-cholesten-3-oneMR Egger39.82290.087
Cortisone / 4-cholesten-3-oneInverse variance weighted43.83300.049*
Hypotaurine / cysteineMR Egger54.17310.006*
Hypotaurine / cysteineInverse variance weighted55.86320.005*
Retinol (Vitamin A) / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]MR Egger42.15220.006*
Retinol (Vitamin A) / linoleoyl-arachidonoyl-glycerol (18:2 to 20:4) [2]Inverse variance weighted43.13230.006*
DOI: https://doi.org/10.2478/ahem-2004-0007 | Journal eISSN: 1732-2693
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Language: English
Page range: 74 - 85
Submitted on: Feb 14, 2024
|
Accepted on: Jun 19, 2024
|
Published on: Aug 19, 2024
Published by: Hirszfeld Institute of Immunology and Experimental Therapy
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
skin cancer,
plasma metabolites,
Mendelian randomization,
causal effects
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Medicine,
Basic medical science,
Immunology

© 2024 Kaymin Wu, Youwu He, Ailian Hua, Yi Yao, published by Hirszfeld Institute of Immunology and Experimental Therapy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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