References
- Ahmed MS, Yun S, Kim H-Y, Ko S, Islam M, Nam K-W. Hydrogels and Microgels: Driving Revolutionary Innovations in Targeted Drug Delivery, Strengthening Infection Management, and Advancing Tissue Repair and Regeneration. Gels 2025;11:179.
https://doi.org/10.3390/gels11030179 . - Alexandre N, Ribeiro J, Gärtner A, Pereira T, Amorim I, Fragoso J, et al. Biocompatibility and hemocompatibility of polyvinyl alcohol hydrogel used for vascular grafting- In vitro and in vivo studies. J Biomed Mater Res Part A 2014;102:4262–75.
https://doi.org/10.1002/jbm.a.35098 . - Badadare R, Mali K, Dias R. Citric Acid Crosslinked Hydrogel Dressings for Delivery of Metronidazole. Int J Sci Res 2020;9:995–1005.
https://doi.org/10.21275/SR20514125011 . - Barbary O, Al-Sohaimy S, El-Saadani M. Extraction, Composition and physicochemical properties of flaxeed mucilage. J Adv Agric Res (Faculty Saba Basha) 2009;14:605–22.
- Beikzadeh S, Khezerlou A, Jafari SM, Pilevar Z, Mortazavian AM. Seed mucilages as the functional ingredients for biodegradable films and edible coatings in the food industry. Adv Colloid Interface Sci 2020;280:102164.
https://doi.org/10.1016/j.cis.2020.102164 . - Bekhit AEDA, Shavandi A, Jodjaja T, Birch J, Teh S, Mohamed Ahmed IA, et al. Flaxseed: Composition, detoxification, utilization, and opportunities. Biocatal Agric Biotechnol 2018;13:129–52.
https://doi.org/10.1016/j.bcab.2017.11.017 . - Chen R, Yang S, Liu B, Liao Y. Eco-Friendly Semi-Interpenetrating Polymer Network Hydrogels of Sodium Carboxymethyl Cellulose/Gelatin for Methylene Blue Removal. Materials (Basel) 2023;16:3385.
https://doi.org/10.3390/ma16093385 . - Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123–133.
https://doi.org/10.1016/S0928-0987(01)00095-1 - de Paiva PHEN, Correa LG, Paulo AFS, Balan GC, Ida EI, Shirai MA. Film production with flaxseed mucilage and polyvinyl alcohol mixtures and evaluation of their properties. J Food Sci Technol 2021;58:3030–8.
https://doi.org/10.1007/s13197-020-04806-7 . - Deng Y, Chen J, Huang J, Yang X, Zhang X, Yuan S, et al. Preparation and characterization of cellulose/flaxseed gum composite hydrogel and its hemostatic and wound healing functions evaluation. Cellulose 2020;27:3971–88.
https://doi.org/10.1007/s10570-020-03055-3 . - Erikci S, van den Bergh N, Boehm H. Kinetic and Mechanistic Release Studies on Hyaluronan Hydrogels for Their Potential Use as a pH-Responsive Drug Delivery Device. Gels 2024;10:731.
https://doi.org/10.3390/gels10110731 . - Ghorpade VS, Mali KK, Dias RJ, Dhawale SC, Digole RR, Gandhi JM, et al. Citric acid crosslinked hydroxyethyl tamarind gum-based hydrogel films: A promising biomaterial for drug delivery. Int. J. Biol. Macromol 2024;282:137127.
https://doi.org/10.1016/j.ijbiomac.2024.137127 - Ghorpade VS, Yadav AV, Dias RJ. Citric acid crosslinked cyclodextrin/hydroxypropylmethylcellulose hydrogel films for hydrophobic drug delivery. Int J Biol Macromol 2016;93:75–86.
https://doi.org/10.1016/j.ijbiomac.2016.08.072 . - Haseeb MT, Hussain MA, Yuk SH, Bashir S, Nauman M. Polysaccharides based superabsorbent hydrogel from Linseed: Dynamic swelling, stimuli responsive on–off switching and drug release. Carbohydr Polym 2016;136:750–6.
https://doi.org/10.1016/j.carbpol.2015.09.092 . - Haseeb MT, Muhammad G, Hussain MA, Bukhari SNA, Sheikh FA. Flaxseed (Linum usitatissimum) mucilage: A versatile stimuli–responsive functional biomaterial for pharmaceuticals and healthcare. Int J Biol Macromol 2024;278:134817.
https://doi.org/10.1016/j.ijbiomac.2024.134817 . - Jia N, Lin S, Zhang F, Zheng D, Liu D. Improved effect of flaxseed gum on the weakened gelling properties of myofibrillar protein induced by catechin. Food Chem 2022;372:131136.
https://doi.org/10.1016/j.foodchem.2021.131136 . - Kaewmanee T, Bagnasco L, Benjakul S, Lanteri S, Morelli CF, Speranza G, et al. Characterisation of mucilages extracted from seven Italian cultivars of flax. Food Chem 2014;148:60–9.
https://doi.org/10.1016/j.foodchem.2013.10.022 . - Kanwal F, Lalji SM, Ali SI, Burney M, Tariq MO, Ahmed LH, et al. Flaxseed mucilage—a green additive for the enhancement of water-based mud system characteristics. Arab J Geosci 2024;17:256.
https://doi.org/10.1007/s12517-024-12061-9 . - Karami N, Kamkar A, Shahbazi Y, Misaghi A. Edible films based on chitosan-flaxseed mucilage: in vitro antimicrobial and antioxidant properties and their application on survival of food-borne pathogenic bacteria in raw minced trout fillets. Pharm Biomed Res 2019;5:10–6.
https://doi.org/10.18502/pbr.v5i2.1580 . - Khan MUA, Yaqoob Z, Ansari MNM, Razak SIA, Raza MA, Sajjad A, et al. Chitosan/Poly Vinyl Alcohol/Graphene Oxide Based pH-Responsive Composite Hydrogel Films: Drug Release, Anti-Microbial and Cell Viability Studies. Polymers (Basel) 2021;13:3124.
https://doi.org/10.3390/polym13183124 . - Khushbu, Warkar SG. Potential applications and various aspects of polyfunctional macromolecule-carboxymethyl tamarind kernel gum. Eur Polym J 2020;140:110042.
https://doi.org/10.1016/j.eurpolymj.2020.110042 . - Lowry O, Rosebrough N, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265–75.
- Mahmood A, Erum A, Mumtaz S, Tulain UR, Malik NS, Alqahtani MS. Preliminary Investigation of Linum usitatissimum Mucilage-Based Hydrogel as Possible Substitute to Synthetic Polymer-Based Hydrogels for Sustained Release Oral Drug Delivery. Gels 2022;8:170.
https://doi.org/10.3390/gels8030170 . - Mali KK, Dhawale SC, Dias RJ, Dhane NS, Ghorpade VS. Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery. Indian J Pharm Sci 2018;80:657–67.
https://doi.org/10.4172/pharmaceutical-sciences.1000405 . - Mali KK, Dhawale SC, Dias RJ, Ghorpade VS. Delivery of drugs using tamarind gum and modified tamarind gum: A review. Bull Fac Pharmacy, Cairo Univ 2019;57:1–24.
https://doi.org/10.21608/BFPC.2019.47260 . - Mali KK, Dhawale SC, Dias RJ, Havaldar VD, Kavitake PR. Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac. Marmara Pharm J 2017;21:771–82.
https://doi.org/10.12991/mpj.2017.20 . - Mali KK, Dhawale SC, Dias RJ. Synthesis and characterization of hydrogel films of carboxymethyl tamarind gum using citric acid. Int J Biol Macromol 2017;105:463–70.
https://doi.org/10.1016/j.ijbiomac.2017.07.058 . - Mali KK, Ghorpade VS, Dias RJ, Dhawale SC. Synthesis and characterization of citric acid crosslinked carboxymethyl tamarind gum-polyvinyl alcohol hydrogel films. Int J Biol Macromol 2023;236:123969.
https://doi.org/10.1016/j.ijbiomac.2023.123969 . - Miller K, Reichert CL, Schmid M, Loeffler M. Impact of Citric Acid on the Structure, Barrier, and Tensile Properties of Esterified/Cross-Linked Potato Peel-Based Films and Coatings. Polymers (Basel) 2024;16:3506.
https://doi.org/10.3390/polym16243506 . - Mohanta B, Sen DJ, Mahanti B, Nayak AK. Extraction, characterization, haematocompatibility and antioxidant activity of linseed polysaccharide. Carbohydr Polym Technol Appl 2023;5:100321.
https://doi.org/10.1016/j.carpta.2023.100321 . - Pargaonkar SS, Ghorpade VS, Mali KK, Dias RJ, Havaldar VD, Kadam VJ. Hydrogel Films of Citric Acid Cross-linked Hydroxypropyl Methylcellulose/Methylcellulose for Hydrophilic Drug Delivery. Indian J Pharm Educ Res 2023;57:718–27.
https://doi.org/10.5530/ijper.57.3.87 . - Puligundla P, Lim S. A Review of Extraction Techniques and Food Applications of Flaxseed Mucilage. Foods 2022;11:1677.
https://doi.org/10.3390/foods11121677 . - Sadiq T, Khalid SH, Khan IU, Mahmood H, Asghar S. Designing Deferoxamine-Loaded Flaxseed Gum and Carrageenan-Based Controlled Release Biocomposite Hydrogel Films for Wound Healing. Gels 2022;8:652.
https://doi.org/10.3390/gels8100652 . - Safdar B, Pang Z, Liu X, Jatoi MA, Mehmood A, Rashid MT, et al. Flaxseed gum: Extraction, bioactive composition, structural characterization, and its potential antioxidant activity. J Food Biochem 2019;43:1–11.
https://doi.org/10.1111/jfbc.13014 . - Salihu R, Abd Razak SI, Ahmad Zawawi N, Rafiq Abdul Kadir M, Izzah Ismail N, Jusoh N, et al. Citric acid: A green cross-linker of biomaterials for biomedical applications. Eur Polym J 2021;146:110271.
https://doi.org/10.1016/j.eurpolymj.2021.110271 . - Salunkhe NH, Mali KK, Sidwadkar PH, Pareek KM, Aundhakar AS. 2025. Synthesis and characterization of citric acid crosslinked garden cress seeds mucilage hydrogel for controlled drug release. J Drug Deliv Sci Technol 2025;112:107270.
https://doi.org/10.1016/j.jddst.2025.107270 - Sepe F, Valentino A, Marcolongo L, Petillo O, Conte R, Margarucci S, et al. Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds. Int J Mol Sci 2025;26:764.
https://doi.org/10.3390/ijms26020764 . - Sharmin N, Rosnes JT, Prabhu L, Böcker U, Sivertsvik M. Effect of Citric Acid Cross Linking on the Mechanical, Rheological and Barrier Properties of Chitosan. Molecules 2022;27:5118.
https://doi.org/10.3390/molecules27165118 . - Sheikh FA, Hussain MA, Ashraf MU, Haseeb MT, Farid-ul-Haq M. Linseed hydrogel based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection. Saudi Pharm J 2020;28:538–49.
https://doi.org/10.1016/j.jsps.2020.03.005 . - Singh B, Dhiman A. Designing bio-mimetic moxifloxacin loaded hydrogel wound dressing to improve antioxidant and pharmacology properties. RSC Adv 2015;5:44666–78.
https://doi.org/10.1039/c5ra06857f . - Słota D, Jampilek J, Sobczak-Kupiec A. Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials. Int J Mol Sci 2024;25:4386.
https://doi.org/10.3390/ijms25084386 . - Sulastri E, Zubair MS, Lesmana R, Mohammed AFA, Wathoni N. Development and characterization of ulvan polysaccharides-based hydrogel films for potential wound dressing applications. Drug Des Devel Ther 2021;15:4213–26.
https://doi.org/10.2147/DDDT.S331120 . - Surendra Babu A, Parimalavalli R, Rudra SG. Effect of citric acid concentration and hydrolysis time on physicochemical properties of sweet potato starches. Int J Biol Macromol 2015;80:557–65.
https://doi.org/10.1016/j.ijbiomac.2015.07.020 . - Tee YB, Wong J, Tan MC, Talib RA. Development of edible film from flaxseed mucilage. BioResources 2016;11:10286–95.
https://doi.org/10.15376/biores.11.4.10286-10295 . - Yadav I, Rathnam VSS, Yogalakshmi Y, Chakraborty S, Banerjee I, Anis A, et al. Synthesis and characterization of polyvinyl alcohol-carboxymethyl tamarind gum based composite films. Carbohydr Polym 2017;165:159–68.
https://doi.org/10.1016/j.carbpol.2017.02.026 .