Moderate continuous versus high-intensity interval training on gut dysbiosis and glucagon-like peptide hormone in irritable bowel syndrome

Marwa Saeed Mohamed Mansour Salama; Donia Mohamed El Masry; Alaa Mohamed El-Moatasem; Reham Assem Zeyada; Mona Ahmed Mohamed Abouelhassan; Nesreen Ghareeb Elnahas

doi:10.2478/advrehab-2026-0005

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Moderate continuous versus high-intensity interval training on gut dysbiosis and glucagon-like peptide hormone in irritable bowel syndrome

Advances in Rehabilitation

Volume 40 (2026): Issue 1 (March 2026)

By: Marwa Saeed Mohamed Mansour Salama , Donia Mohamed El Masry , Alaa Mohamed El-Moatasem , Reham Assem Zeyada , Mona Ahmed Mohamed Abouelhassan and Nesreen Ghareeb Elnahas

Open Access

|Mar 2026

Figures & Tables

CONSORT flow diagram of participant progress through the trial

Changes in mean BMI before and after the intervention in the MICT, HIIT and control groups. Values are presented as mean ± SD. p < 0.001 indicates statistically significant differences within and between groups. BMI - body mass index, HIIT - high-intensity interval training, MICT - moderate-intensity interval training, SD - standard deviation

Changes in the mean levels of (A) acetate, (B) propionate, (C) butyrate and (D) GLP-1 before and after the intervention in the MICT, HIIT and control groups. Values are expressed as mean ± SD. p < 0.05 indicates statistically significant differences between pre-and post-intervention values within each group and across groups. GLP-1 - glucagon-like peptide-1, HIIT - high-intensity interval training, MICT - moderate-intensity interval training, SD - standard deviation

Changes in (A) IBS-SSS and (B) IBS-QOL scores before and after the intervention in the MICT, HIIT and control groups. Values are presented as mean ± SD. p < 0.001 for all within-group comparisons (pre- vs post-intervention). HIIT - high-intensity interval training, MICT - moderate-intensity interval training, IBS-QOL - IBS quality of life, IBS-SSS - IBS symptom severity score, SD - standard deviation

Baseline characteristics of participants in the MICT, HIIT and control groups (n = 66)

Variables	Total (n = 66)	MICT group (n = 22)	HIIT group (n = 22)	Control group (n = 22)	Test of significance	p value
Age (Years)	34.00 ± 2.44	33.95 ± 2.92	34.50 ± 2.35	33.55 ± 1.97	F = 0.846	0.434
Age (Years)	30.00–39.00	30.00–39.00	31.00–38.00	30.00–37.00	F = 0.846	0.434

Sex, N (%)					χ² = 3.737	0.154

Male	23 (34.8)	5 (22.7)	11 (50.0)	7 (31.8)

Female	43 (65.2)	17 (77.3)	11 (50.0)	15 (68.2)

BMI (kg/m²)	32.48 ± 1.44	32.64 ± 1.65	32.73 ± 1.39	32.09 ± 1.23	F = 1.270	0.288
BMI (kg/m²)	30.00–35.00	30.00–35.00	30.00–35.00	30.00–34.00	F = 1.270	0.288

Acetate	32.68 ± 0.19	32.71 ± 0.17	32.67 ± 0.18	32.67 ± 0.21	F = 0.260	0.772
Acetate	32.22–32.93	32.38–32.93	32.38–32.92	32.22–32.93	F = 0.260	0.772

Propionate	2.40 ± 0.03	2.40 ± 0.03	2.40 ± 0.03	2.39 ± 0.03	F = 1.347	0.267
Propionate	2.32–2.45	2.37–2.45	2.34–2.43	2.32–2.44	F = 1.347	0.267

Butyrate	18.96 ± 0.02	18.96 ± 0.02	18.96 ± 0.02	18.96 ± 0.01	F = 1.500	0.231
Butyrate	18.93–19.00	18.93–19.00	18.94–19.00	18.94–18.98	F = 1.500	0.231

GLP-1	12.25 ± 2.98	12.69 ± 2.51	12.02 ± 2.68	12.04 ± 3.71	F = 0.349	0.706
GLP-1	1.21–18.43	7.80–18.43	7.43–17.34	1.21–16.61	F = 0.349	0.706

IBS-SSS	228.36 ± 34.22	228.50 ± 38.56	226.82 ± 31.38	229.77 ± 33.89	F = 0.040	0.961
IBS-SSS	175.00–290.00	175.00–290.00	180.00–280.00	175.00–290.00	F = 0.040	0.961

IBS QOL	62.44 ± 7.76	62.09 ± 8.40	62.27 ± 8.96	62.95 ± 5.91	F = 0.074	0.929
IBS QOL	50.00–80.00	50.00–75.00	50.00–80.00	50.00–75.00	F = 0.074	0.929

References

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DOI: https://doi.org/10.2478/advrehab-2026-0005 | Journal eISSN: 1734-4948

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Language: English

Page range: 69 - 86

Submitted on: Jun 25, 2025

Accepted on: Nov 7, 2025

Published on: Mar 31, 2026

Published by: University of Physical Education in Warsaw

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

irritable bowel syndrome,

gut microbiota,

glucagon-like peptide-1,

exercise therapy,

high-intensity interval training

Related subjects:

Medicine,

Clinical medicine,

Physical and rehabilitation medicine,

Rheumatology,

Cardiology,

Sports and recreation,

Sports and recreation, other

© 2026 Marwa Saeed Mohamed Mansour Salama et al., published by Józef Piłsudski University of Physical Education in Warsaw
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Volume 40 (2026): Issue 1 (March 2026)

Moderate continuous versus high-intensity interval training on gut dysbiosis and glucagon-like peptide hormone in irritable bowel syndrome

Figures & Tables

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Baseline characteristics of participants in the MICT, HIIT and control groups (n = 66)

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