Aortocoronary conduits may show a different inflammatory response - comparative study at transcript level

Nawrocki, Mariusz J.; Kałużna, Sandra; Jopek, Karol; Hutchings, Greg; Perek, Bartłomiej; Jemielity, Marek; Malińska, Agnieszka; Kempisty, Bartosz; Mozdziak, Paul; Nowicki, Michał

doi:10.2478/acb-2020-0003

Abstract

Coronary artery bypass grafting (CABG), together with percutaneous coronary intervention (PCI), are both still the most efficient procedures for myocardial revascularization to treat advanced coronary artery disease (CAD). Donor blood vessels used in CABG are usually the internal thoracic artery (ITA) and saphenous vein (SV). The importance of inflammation and inflammatory pathways in graft patency is well established. Nevertheless, not all molecular mechanisms underlying the inflammatory process appear to be clear. Employing the expressive microarray approach to analyze the transcriptome of both venous and arterial grafts, five GO BP terms has been selected: “cellular response to interferon-gamma”, “inflammatory response”, “interferon-gamma-mediated signaling pathway”, “response to interferon-gamma” and “positive regulation of inflammatory response”. This study aimed to evaluate potential molecular factors that could be characteristic markers for both SV and ITA conduits.

Running title: Aortocoronary conduits may show a different inflammatory response

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Aortocoronary conduits may show a different inflammatory response - comparative study at transcript level

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