Effects of methylphenidate on height, weight and blood biochemistry parameters in prepubertal boys with attention deficit hyperactivity disorder: an open label prospective study

Subjects	N
Prepubertal boys with ADHD	98
Parents who rejected	21
Excluded at baseline exam	8
Intellectual disability (N=2)
Pubertal signs (N=2)
Very high levels of TSH (N=1) and transaminases (N=1)
Severe anemia (N=1)
Very low growth percentile (N=1)
Recruited subjects	69
Drop-outs due to adverse effects	8
Appetite loss and insomnia (N=2)
Nausea and appetite loss (N=1)
Stomachache and irritability (N=1)
Syncope (N=1)
Headache (N=1)
Insomnia, irritability, and appetite loss (N=1)
Headache, stomachache, and insomnia (N=1)
Drop-outs due to other causes	30
Weak compliance (N=6)
Parental disagreement (N=6)
Summer holiday (N=6)
Surgical operation (N=2)
City change (N=3)
Pubertal signs (N=2)
Unknown (N=5)
Sample size	31

TABLE 2.

Comparisons of baseline and 6 months values in paired samples t-test

Variable	Baseline M (SD)	6 months M (SD)	T value	df	Significance (p)*	Effect size (r)
Height z-score	0.23 (0.87)	0.28 (0.85)	‒1.50	30	0.142
Hemoglobin	12.57 (0.87)	12.47 (0.86)	0.89	29	0.380
Hematocrit	38.22 (2.52)	37.850 (2.26)	0.91	29	0.368
Platelet	331.53 (91.91)	311.50 (59.96)	1.37	29	0.179
Glucose	82.54 (6.21)	88.09 (6.66)	‒4.33	30	0.000^*	0.6
Creatinine	0.56 (0.08)	0.60 (0.06)	‒3.27	30	0.003^*	0.5
Calcium	9.46 (0.51)	9.51 (0.45)	‒0.46	29	0.648
Phosphate	4.71 (0.45)	4.66 (0.42)	0.56	28	0.578
AST	29.26 (6.23)	29.60 (3.98)	‒0.33	29	0.738
ALP	243.06 (47.07)	215.24 (44.33)	3.63	28	0.001^*	0.5
Vitamin B12	306.72 (121.66)	288.41 (115.31)	1.10	28	0.278
TSH	2.64 (0.98)	2.38 (1.03)	1.68	28	0.104
fT3	3.96 (0.65)	3.73 (0.46)	1.93	28	0.063
fT4	0.87 (0.10)	0.86 (0.09)	0.60	28	0.553
B-ALP	84.44 (25.58)	82.98 (23.25)	0.32	28	0.750

1 Notes. *< 0.01 (two-tailed).

2 Abbreviations: M=mean, SD=standard deviation, df=degree of freedom, AS=aspartate aminotransferase, ALP=alkaline

3 phosphatase, TSH=thyreoid stimulating hormone, fT3=free triiodothyronine, fT4=free tetraiodothyronine, B-ALP=bone specific alkaline phosphatase.

4 Measurement units: cm for hight, mg/dL for glucose, creatinine, calcium, phosphatate; pg/mL for vitamin B12, free T3; U/L for

5 ALP, AST, 10^ for platelet; g/dL for hemoglobin, % for hematocrite, ulU/ml for TSH, ng/dl for free T4, ug/L for B-ALP

TABLE 3.

Comparisons of baseline and 6 months values in Wilcoxon signed-rank test

Variables	Measurements M, (SD)		Negative ranks			Positive ranks					Statistics
Variables		Baseline	6 months	N	mean rank	sum of ranks	N	mean rank	sum of ranks	Ties	Z	Significance (p)*	Effect size (r)
Weight z-	0.63 (1.12)	0.24 (1.04)	29	16.83	488	2	4	9	0	‒4.704	0.000^*	0.5
score
P1NP	471.15 (264.24)	648.30 (507.60)	14	13.14	184	17	18.35	312	0	‒1.254	0.210
NTx	248.48 (228.69)	250.29 (256.86)	21	14.33	301	10	19.50	195	0	‒1.039	0.299
WBC	8.31 (2.68)	7.65 (1.70)	21	15.29	321	9	16	144	0	‒1.822	0.069
RBC	4.84 (0.52)	4.78 (0.51)	12	16.29	195.5	13	9.96	129.50	5	‒0.896	0.370
BUN	11.20 (2.80)	12.06 (2.51)	11	11.18	123	15	15.20	228	4	‒1.339	0.181
Magnesium	2.07 (0.16)	2.01 (0.18)	11	12.36	136	8	6.75	54	11	‒1.676	0.094
ALT	16.66 (13.38)	16.46 (8.55)	12	15.83	190	15	12.53	188	3	‒0.024	0.981
Ferritin	23.34 (11.57	19.72 (8.56)	19	13.18	250.50	8	15.94	127.50	2	‒1.479	0.139
Transferrin	266.06 (51.58)	270.31 (30.90)	17	13.47	229	11	16.09	177	1	‒0.592	0.554
Iron	79.10 (31.90)	75.37 (34.01)	16	15.38	246	12	13.33	160	1	‒0.979	0.327
PTH	38.09 (14.52)	35.41 (24.25)	21	15.88	333.50	8	12.69	101.50	0	‒2.509	0.012
OSC	67.25 (18.75)	60.18 (19.07)	19	16.39	311.50	10	12.35	123.50	0	‒2.033	0.042
25OH-vit D	18.42 (7.15)	27.22 (7.18)	4	8.25	33	25	16.08	402	0	‒3.989	0.000^*	0.5

1 Notes. *< 0.01 (two-tailed).

2 Abbreviations: N=sample size, P1NP: procollagen type 1 N-propeptide, NTx: type 1 Collagen Cross-linked N-telopeptide, WBC: white blood cell, RBC: right blood cell, BUN: blood urine nitrogen, ALT: alanine aminotransferase, PTH: parathormone, OSC: osteocalcin, 25OH-vit D: 25OH-vitamin D.

3 Measurement units: kg for weight, ng/mL for P1NP, pg/mL for NTx and PTH, 10^3/mm for WBC, 10^6/mm^3 for RBC, mg/dL for BUN, magnesium and transferrin, U/L for ALT, ug/dL for iron, ng/ml for OSC, 25OH-vitamin D and ferrerin.

Association between the differences of weight z-score and ALP from baseline to 6 months

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DOI: https://doi.org/10.21307/sjcapp-2021-018 | Journal eISSN: 2245-8875

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Language: English

Page range: 163 - 173

Submitted on: Oct 9, 2020

Accepted on: Aug 17, 2021

Published online: Sep 9, 2021

Published in print: Jan 1, 2021

Published by: Center for Evidence-based Psychiatry

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

Methylphenidate,

weight,

height,

blood biochemistry,

ADHD

Related subjects:

Medicine,

Basic medical science,

Basic medical science, other

© 2021 Ahmet Çevikaslan, Mesut Parlak, Hamit Yaşar Ellidağ, Sibel Çilingiroğlu Kulaksızoğlu, Necat Yılmaz, published by Center for Evidence-based Psychiatry
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 9 (2021): Issue 1 (January 2021)

Effects of methylphenidate on height, weight and blood biochemistry parameters in prepubertal boys with attention deficit hyperactivity disorder: an open label prospective study

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TABLE 1.

TABLE 2.

TABLE 3.

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