Have a personal or library account? Click to login
Evaluation of left ventricular function using various echocardiographic techniques in hypoxic neonates during therapeutic hypothermia and after rewarming Cover

Evaluation of left ventricular function using various echocardiographic techniques in hypoxic neonates during therapeutic hypothermia and after rewarming

Open Access
|Dec 2025

References

  1. Lapointe A, Barrington KJ: Pulmonary hypertension and the asphyxiated newborn. J Pediatr 2011; 158(2 Suppl): e19–24. doi: 10.1016/j.jpeds.2010.11.008.
  2. Nestaas E, Walsh BH: Hypothermia and cardiovascular instability. Clin Perinatol 2020; 47: 575–592. doi: 10.1016/j.clp.2020.05.012.
  3. Pang R, Mintoft A, Crowley R, Sellwood M, Mitra S, Robertson NJ: Optimizing hemodynamic care in neonatal encephalopathy. Semin Fetal Neonatal Med 2020; 25: 101139. doi: 10.1016/j.siny.2020.101139.
  4. Breatnach CR, Forman E, Foran A, Monteith C, McSweeney L, Malone F et al.: Left ventricular rotational mechanics in infants with hypoxic ischemic encephalopathy and preterm infants at 36 weeks postmenstrual age: a comparison with healthy term controls. Echocardiography 2017; 34: 232–239. doi: 10.1111/echo.13421.
  5. Gebauer CM, Knuepfer M, Robel-Tillig E, Pulzer F, Vogtmann C: Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming. Pediatrics 2006; 117: 843–850. doi: 10.1542/peds.2004-1587.
  6. Bokiniec R, Własienko P, Borszewska-Kornacka MK, Madajczak D, Szymkiewicz-Dangel J: Myocardial performance index (Tei index) in term and preterm neonates during the neonatal period. Kardiol Pol 2016; 74: 1002–1009. doi: 10.5603/KP.a2016.0056
  7. Wu TW, Tamrazi B, Soleymani S, Seri I, Noori S: Hemodynamic changes during rewarming phase of whole-body hypothermia therapy in neonates with hypoxic-ischemic encephalopathy. J Pediatr 2018; 197: 68–74.e2. doi: 10.1016/j.jpeds.2018.01.067
  8. Kluckow M: Functional echocardiography in assessment of the cardiovascular system in asphyxiated neonates. J Pediatr 2011; 158 (2 Suppl): e13–8. doi: 10.1016/j.jpeds.2010.11.007
  9. Giesinger RE, Bailey LJ, Deshpande P, McNamara PJ: Hypoxic-ischemic encephalopathy and therapeutic hypothermia: the hemodynamic perspective. J Pediatr 2017; 180: 22–30.e2. doi: 10.1016/j.jpeds.2016.09.009
  10. Standardy opieki medycznej nad noworodkiem w Polsce 2021. Zalecenia Polskiego Towarzystwa Neonatologicznego. Media-Press 2021.
  11. Thoresen M, Whitelaw A: Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics 2000; 106: 92–99. doi: 10.1542/peds.106.1.92
  12. Thomsen JH, Hassager C, Bro-Jeppesen J, Søholm H, Nielsen N, Wanscher M et al.: Sinus bradycardia during hypothermia in comatose survivors of out- of-hospital cardiac arrest – a new early marker of favorable outcome? Resuscitation 2015; 89: 36–42. doi: 10.1016/j.resuscitation.2014.12.031
  13. Drury PP, Gunn ER, Bennet L, Gunn AJ: Mechanisms of hypothermic neuroprotection. Clin Perinatol 2014; 41: 161–175. doi: 10.1016/j.clp.2013.10.005
  14. Sobeih AA, El-Baz MS, El-Shemy DM, Abu El-Hamed WA: Tissue Doppler imaging versus conventional echocardiography in assessment of cardiac diastolic function in full term neonates with 566 perinatal asphyxia. J Matern Fetal Neonatal Med 2021; 34: 3896–3901. doi: 10.1080/14767058.2019.1702640
  15. Matter M, Abdel-Hady H, Attia G, Hafez M, Seliem W, Al-Arman M: Myocardial performance in asphyxiated full-term infants assessed by Doppler tissue imaging. Pediatr Cardiol 2010; 31: 634–642. doi: 10.1007/s00246-010-9661-5
  16. Hochwald O, Jabr M, Osiovich H, Miller SP, McNamara PJ, Lavoie PM: Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy. J Pediatr 2014; 164: 999–1004.e1. doi: 10.1016/j.jpeds.2014.01.028
  17. Jiang K, Li Y, Xu X, Sun C: Application of the Tei index in neonates with perinatal asphyxia. Int J Clin Exp Med 2016; 9: 13111–13116.
  18. Karpuz D, Celik Y, Giray D, Tasdelen B, Hallioglu O: Therapeutic hypothermia and myocardium in perinatal asphyxia: a microvolt T-wave alternans and Doppler echocardiography study. Bratisl Lek Listy 2017; 118: 765–771. doi: 10.4149/BLL_2017_144
  19. Kanik E, Ozer EA, Bakiler AR, Aydinlioglu H, Dorak C, Dogrusoz B et al.: Assessment of myocardial dysfunction in neonates with hypoxic-ischemic encephalopathy: is it a significant predictor of mortality? J Matern Fetal Neonatal Med 2009; 22: 239–242. doi: 10.1080/14767050802430834
  20. Montaldo P, Cuccaro P, Caredda E, Pugliese U, De Vivo M, Orbinato F et al.: Electrocardiographic and echocardiographic changes during therapeutic hypothermia in encephalopathic infants with long-term adverse outcome. Resuscitation 2018; 130: 99–104. doi: 10.1016/j.resuscitation.2018.07.014
  21. Eriksen VR, Trautner S, Hahn GH, Greisen G: Lactate acidosis and cardiac output during initial therapeutic cooling in asphyxiated newborn infants. PLoS One 2019; 14: e0213537. doi: 10.1371/journal.pone.0213537
DOI: https://doi.org/10.15557/jou.2025.0033 | Journal eISSN: 2451-070X | Journal ISSN: 2084-8404
Language: English
Submitted on: Sep 13, 2025
|
Accepted on: Dec 23, 2025
|
Published on: Dec 30, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Natalia Brunets, Veronika Brunets, Agata Wójcik-Sęp, Renata Bokiniec, published by MEDICAL COMMUNICATIONS Sp. z o.o.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.