Genetic Dilated Cardiomyopathy: A Review

Madelyn Boslough; Matthew R.G. Taylor; Luisa Mestroni; Raffaela Lombardi

doi:10.14797/mdcvj.1849

Genetic Dilated Cardiomyopathy: A Review

Methodist DeBakey Cardiovascular Journal

Volume 22 (2026): Issue 4

By: Madelyn Boslough , Matthew R.G. Taylor , Luisa Mestroni and Raffaela Lombardi

Open Access

|Sep 2026

Abstract

Dilated cardiomyopathy (DCM) is a leading cause of nonischemic heart failure. Genetic causes are identifiable in 25% to 30% of patients. This review describes the pathophysiology underlying genetic DCM, the genes most strongly associated with DCM, and both standard and novel therapies for treating genetic DCM.

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Articles in this issue

DOI: https://doi.org/10.14797/mdcvj.1849 | Journal eISSN: 1947-6108

Journal RSS Feed

Language: English

Page range: 68 - 77

Submitted on: Apr 16, 2026

Accepted on: Jul 24, 2026

Published on: Sep 15, 2026

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

dilated cardiomyopathy,

genetics,

TTN,

LMNA,

DSP,

FLNC

© 2026 Madelyn Boslough, Matthew R.G. Taylor, Luisa Mestroni, Raffaela Lombardi, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 22 (2026): Issue 4