Cardiac Allograft Vasculopathy: A Focus on Advances in Diagnosis and Management

Colin T. Stomberski; Monica M. Colvin

doi:10.14797/mdcvj.1580

Cardiac Allograft Vasculopathy: A Focus on Advances in Diagnosis and Management

Methodist DeBakey Cardiovascular Journal

Volume 21 (2025): Issue 3

By: Colin T. Stomberski and Monica M. Colvin

Open Access

|May 2025

Khush KK, Cherikh WS, Chambers DC, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match. J Heart Lung Transplant. 2019 Oct;38(10):1056-66. doi: 10.1016/j.healun.2019.08.004
Open DOI Search in Google Scholar Back to article
Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovasc Res. 2021 Nov 22;117(13):2624-38. doi: 10.1093/cvr/cvab259
Open DOI Search in Google Scholar Back to article
Chang A, Martin KA, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. lin Transplant. 2023 Dec;37(12):e15153. doi: 10.1111/ctr.15153
Open DOI Search in Google Scholar Back to article
Day JD, Rayburn BK, Gaudin PB, et al. Cardiac allograft vasculopathy: the central pathogenetic role of ischemia-induced endothelial cell injury. J Heart Lung Transplant. 1995 Nov-Dec;14(6 Pt 2):S142-9. PMID: 8719476
Search in Google Scholar Back to article
Valantine H, Rickenbacker P, Kemna M, et al. Metabolic abnormalities characteristic of dysmetabolic syndrome predict the development of transplant coronary artery disease: a prospective study. Circulation. 2001 May 1;103(17):2144-52. doi: 10.1161/01.cir.103.17.2144
Open DOI Search in Google Scholar Back to article
Lu WH, Palatnik K, Fishbein GA, et al. Diverse morphologic manifestations of cardiac allograft vasculopathy: a pathologic study of 64 allograft hearts. J Heart Lung Transplant. 2011 Sep;30(9):1044-50. doi: 10.1016/j.healun.2011.04.008
Open DOI Search in Google Scholar Back to article
Huibers MM, Vink A, Kaldeway J, et al. Distinct phenotypes of cardiac allograft vasculopathy after heart transplantation: a histopathological study. Atherosclerosis. 2014 Oct;236(2):353-9. doi: 10.1016/j.atherosclerosis.2014.07.016
Open DOI Search in Google Scholar Back to article
van Loosdregt J, van Oosterhout MF, Bruggink AH, et al. The chemokine and chemokine receptor profile of infiltrating cells in the wall of arteries with cardiac allograft vasculopathy is indicative of a memory T-helper 1 response. Circulation. 2006 Oct;114(15):1599-607. doi: 10.1161/CIRCULATIONAHA.105.597526
Open DOI Search in Google Scholar Back to article
Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon15 gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest. 1997 Aug 1;100(3):550-7. doi: 10.1172/JCI119564
Open DOI Search in Google Scholar Back to article
Tellides G, Tereb DA, Kirkiles-Smith NC, et al. Interferon-gamma elicits arteriosclerosis in the absence of leukocytes. Nature. 2000 Jan 13;403(6766):207-11. doi: 10.1038/35003221
Open DOI Search in Google Scholar Back to article
Wang Y, Bai Y, Qin L, et al. Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex activation. Circ Res. 2007 Sep 14;101(6):560-9. doi: 10.1161/CIRCRESAHA.107.151068
Open DOI Search in Google Scholar Back to article
Tellides G, Pober JS. Interferon-gamma axis in graft arteriosclerosis. Circ Res. 2007 Mar 16;100(5):622-32. doi: 10.1161/01.RES.0000258861.72279.29
Open DOI Search in Google Scholar Back to article
Zhang Q, Cecka JM, Gjertson DW, et al. HLA and MICA: targets of antibody-mediated rejection in heart transplantation. Transplantation. 2011 May 27;91(10):1153-8. doi: 10.1097/TP.0b013e3182157d60
Open DOI Search in Google Scholar Back to article
Galvani S, Auge N, Calise D, et al. HLA class I antibodies provoke graft arteriosclerosis in human arteries transplanted into SCID/beige 12 mice. Am J Transplant. 2009 Nov;9(11):2607-14. doi: 10.1111/j.1600-6143.2009.02804.x
Open DOI Search in Google Scholar Back to article
Hirohashi T, Chase CM, Della Pelle P, et al. A novel pathway of chronic allograft rejection mediated by NK cells and 16 alloantibody. Am J Transplant. 2012 Feb;12(2):313-21. doi: 10.1111/j.1600-6143.2011.03836.x
Open DOI Search in Google Scholar Back to article
Hiemann NE, Meyer R, Wellnhofer E, et al. Non-HLA antibodies targeting vascular receptors enhance alloimmune response and microvasculopathy after heart transplantation. Transplantation. 2012 Nov 15;94(9):919-24. doi: 10.1097/TP.0b013e3182692ad2
Open DOI Search in Google Scholar Back to article
Shaw SM, Williams SG. Is brain natriuretic peptide clinically 1 useful after cardiac transplantation? J Heart Lung Transplant. 2006 Dec;25(12):1396-401. doi: 10.1016/j.healun.2006.10.001
Open DOI Search in Google Scholar Back to article
Labarrere CA, Lee JB, Nelson DR, Al-Hassani M, Miller SJ, Pitts DE. C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: a prospective study. Lancet. 2002 Nov 9;360(9344):1462-7. doi: 10.1016/S0140-6736(02)11473-5.
Open DOI Search in Google Scholar Back to article
Singh N, Heggermont W, Fieuws S, Vanhaecke J, Van Cleemput J, De Geest B. Endothelium-enriched microRNAs as diagnostic biomarkers for cardiac allograft vasculopathy. J Heart Lung Transplant. 2015 Nov;34(11):1376-84. Epub 20150617. doi: 10.1016/j.healun.2015.06.008
Open DOI Search in Google Scholar Back to article
Neumann A, Napp LC, Kleeberger JA, et al. MicroRNA 628-5p as a Novel Biomarker for Cardiac Allograft Vasculopathy. Transplantation. 2017 Jan;101(1):e26-e33. doi: 10.1097/TP.0000000000001477
Open DOI Search in Google Scholar Back to article
Przybylek B, Boethig D, Neumann A, et al. Novel Cytokine Score and Cardiac Allograft Vasculopathy. Am J Cardiol. 2019 Apr 1;123(7):1114-9. doi: 10.1016/j.amjcard.2018.12.034
Open DOI Search in Google Scholar Back to article
Almufleh A, Zhang L, Mielniczuk LM, et al. Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics. Clin Transplant. 2020 Jan;34(1):e13765. doi: 10.1111/ctr.13765
Open DOI Search in Google Scholar Back to article
Kennel PJ, Saha A, Maldonado DA, et al. Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection. J Heart Lung Transplant. 2018 Mar;37(3):409-17. doi: 10.1016/j.healun.2017.07.012
Open DOI Search in Google Scholar Back to article
Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010 Aug;29(8):914-56. doi: 10.1016/j.healun.2010.05.034
Open DOI Search in Google Scholar Back to article
Prada-Delgado O, Estevez-Loureiro R, Paniagua-Martin MJ, Lopez-Sainz A, Crespo-Leiro MG. Prevalence and prognostic value of cardiac allograft vasculopathy 1 year after heart transplantation according to the ISHLT recommended nomenclature. J Heart Lung Transplant. 2012 Mar;31(3):332-3. doi: 10.1016/j.healun.2011.12.006
Open DOI Search in Google Scholar Back to article
Costanzo MR, Naftel DC, Pritzker MR, et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac Transplant Research Database. J Heart Lung Transplant. 1998 Aug;17(8):744-53. PMID: 9730422
Search in Google Scholar Back to article
Tuzcu EM, Hobbs RE, Rincon G, et al. Occult and frequent transmission of atherosclerotic coronary disease with cardiac transplantation. Insights from intravascular ultrasound. Circulation. 1995 Mar 15;91(6):1706-13. doi: 10.1161/01.cir.91.6.1706
Open DOI Search in Google Scholar Back to article
Shahandeh N, Kashiyama K, Honda Y, et al. Invasive Coronary Imaging Assessment for Cardiac Allograft Vasculopathy: State-of-the-Art Review. J Soc Cardiovasc Angiogr Interv. 2022 May 13;1(4):100344. doi: 10.1016/j.jscai.2022.100344
Open DOI Search in Google Scholar Back to article
St Goar FG, Pinto FJ, Alderman EL, et al. Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of “angiographically silent” intimal thickening. Circulation. 1992 Mar;85(3):979-87. doi: 10.1161/01.cir.85.3.979
Open DOI Search in Google Scholar Back to article
Mehra MR, Ventura HO, Stapleton DD, Smart FW, Collins TC, Ramee SR. Presence of severe intimal thickening by intravascular ultrasonography predicts cardiac events in cardiac allograft vasculopathy. J Heart Lung Transplant. 1995;14(4):632-9. PMID: 7578168
Search in Google Scholar Back to article
Rickenbacher PR, Pinto FJ, Lewis NP, et al. Prognostic importance of intimal thickness as measured by intracoronary ultrasound after cardiac transplantation. Circulation. 1995 Dec 15;92(12):3445-52. doi: 10.1161/01.cir.92.12.3445
Open DOI Search in Google Scholar Back to article
Kobashigawa JA, Tobis JM, Starling RC, et al. Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years. J Am Coll Cardiol. 2005 May 3;45(9):1532-7. doi: 10.1016/j.jacc.2005.02.035
Open DOI Search in Google Scholar Back to article
Tuzcu EM, Kapadia SR, Sachar R, et al. Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac 1 transplantation. J Am Coll Cardiol. 2005 May 3;45(9):1538-42. doi: 10.1016/j.jacc.2004.12.076
Open DOI Search in Google Scholar Back to article
Hou J, Lv H, Jia H, et al. OCT assessment of allograft vasculopathy in heart transplant recipients. JACC Cardiovasc Imaging. 2012 Jun;5(6):662-3. doi: 10.1016/j.jcmg.2012.01.018
Open DOI Search in Google Scholar Back to article
Khandhar SJ, Yamamoto H, Teuteberg JJ, et al. Optical coherence tomography for characterization of cardiac allograft vasculopathy after heart transplantation (OCTCAV study). J Heart Lung Transplant. 2013 Jun;32(6):596- 602. doi: 10.1016/j.healun.2013.02.005
Open DOI Search in Google Scholar Back to article
Chih S, Chong AY, Dzavik V, et al. Fibrotic Plaque and Microvascular Dysfunction Predict Early Cardiac Allograft Vasculopathy Progression After Heart Transplantation: The Early Post Transplant Cardiac Allograft Vasculopathy Study. Circ Heart Fail. 2023 Jun;16(6):e010173. doi: 10.1161/CIRCHEARTFAILURE.122.010173
Open DOI Search in Google Scholar Back to article
Ahn JM, Zimmermann FM, Arora S, et al. Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation. Eur Heart J. 2021 Dec 21;42(48):4918-29. doi: 10.1093/eurheartj/ehab568
Open DOI Search in Google Scholar Back to article
Lee JH, Okada K, Khush K, et al. Coronary Endothelial Dysfunction and the Index of Microcirculatory Resistance as a Marker of Subsequent Development of Cardiac Allograft Vasculopathy. Circulation. 2017 Mar 14;135(11):1093-5. doi: 10.1161/Circulationaha.116.025268
Open DOI Search in Google Scholar Back to article
Yang HM, Khush K, Luikart H, et al. Invasive Assessment of Coronary Physiology Predicts Late Mortality After Heart Transplantation. Circulation. 2016 May 17;133(20):1945-50. doi: 10.1161/CIRCULATIONAHA.115.018741
Open DOI Search in Google Scholar Back to article
Feher A, Miller EJ. PET Myocardial Blood Flow for Post-transplant Surveillance and Cardiac Allograft Vasculopathy in Heart Transplant Recipients. Curr Cardiol Rep. 2022 Oct 24;24(12):1865-71. doi: 10.1007/s11886-022-01804-3
Open DOI Search in Google Scholar Back to article
Ajluni SC Jr., Mously H, Chami T, et al. Non-invasive Imaging in the Evaluation of Cardiac Allograft Vasculopathy in Heart Transplantation: A Systematic Review. Curr Probl Cardiol. 2022 Aug;47(8):101103. doi: 10.1016/j.cpcardiol.2022.101103
Open DOI Search in Google Scholar Back to article
Chih S, Chong AY, Erthal F, et al. PET Assessment of Epicardial Intimal Disease and Microvascular Dysfunction in Cardiac Allograft Vasculopathy. J Am Coll Cardiol. 2018 Apr 3;71(13):1444-56. doi: 10.1016/j.jacc.2018.01.062
Open DOI Search in Google Scholar Back to article
Bravo PE, Bergmark BA, Vita T, et al. Diagnostic and prognostic value of myocardial blood flow quantification as non-invasive indicator of cardiac allograft vasculopathy. Eur Heart J. 2018;39(4):316-23. doi: 10.1093/eurheartj/ehx683
Open DOI Search in Google Scholar Back to article
Konerman MC, Lazarus JJ, Weinberg RL, Shah RV, Ghannam M, Hummel SL, et al. Reduced Myocardial Flow Reserve by Positron Emission Tomography Predicts Cardiovascular Events After Cardiac Transplantation. Circ Heart Fail. 2018 Jan 21;11(6):e004473. doi: 10.1161/CIRCHEARTFAILURE.117.004473
Open DOI Search in Google Scholar Back to article
Prasad N, Harris E, Yuzefpolskaya M, et al. Can the grading of mild cardiac allograft vasculopathy be further refined? An angiographic and physiologic assessment of heart transplant recipients with ISHLT CAV 1. J Heart Lung Transplant. 2024 Dec 30:S1053-2498(24)02028-X. doi: 10.1016/j.healun.2024.12.013
Open DOI Search in Google Scholar Back to article
Gondi KT, Hammer Y, Yosef M, et al. Longitudinal Change and Predictors of Myocardial Flow Reserve by Positron Emission Tomography for the Evaluation of Cardiac Allograft Vasculopathy Following Heart Transplantation. J Card Fail. 2024 Jul;30(7):915-25. doi: 10.1016/j.cardfail.2023.09.013
Open DOI Search in Google Scholar Back to article
Gondi KT, Kaul DR, Gregg KS, et al. Cytomegalovirus infection is associated with impaired myocardial flow reserve after heart transplantation. J Heart Lung Transplant. 2024 Mar;43(3):432-41. doi: 10.1016/j.healun.2023.10.005
Open DOI Search in Google Scholar Back to article
Madamanchi C, Konerman MC, Murthy VL. Imaging Coronary Allograft Vasculopathy with Cardiac PET and Cardiac MRI. Curr Cardiol Rep. 2021 Oct 16;23(12):175. doi: 10.1007/s11886-021-01606-z
Open DOI Search in Google Scholar Back to article
Muehling OM, Wilke NM, Panse P, et al. Reduced myocardial perfusion reserve and transmural perfusion gradient in heart transplant arteriopathy assessed by magnetic resonance imaging. J Am Coll Cardiol. 2003 Sep 17;42(6):1054-60. doi: 10.1016/s0735-1097(03)00924-0
Open DOI Search in Google Scholar Back to article
Miller CA, Sarma J, Naish JH, et al. Multiparametric cardiovascular magnetic resonance assessment of cardiac allograft vasculopathy. J Am Coll Cardiol. 2014 Mar 4;63(8):799-808. doi: 10.1016/j.jacc.2013.07.119
Open DOI Search in Google Scholar Back to article
Hughes A, Okasha O, Farzaneh-Far A, et al. Myocardial Fibrosis and Prognosis in Heart Transplant Recipients. Circ Cardiovasc Imaging. 2019;12(10):e009060. doi: 10.1161/CIRCIMAGING.119.009060
Open DOI Search in Google Scholar Back to article
Kazmirczak F, Nijjar PS, Zhang L, Hughes A, Chen KA, Okasha O, et al. Safety and prognostic value of regadenoson stress cardiovascular magnetic resonance imaging in heart transplant recipients. J Cardiovasc Magn Reson. 2019 Oct;21(1):9. doi: 10.1186/s12968-018-0515-2
Open DOI Search in Google Scholar Back to article
Erbel C, Mukhammadaminova N, Gleissner CA, et al. Myocardial Perfusion Reserve and Strain-Encoded CMR for Evaluation of Cardiac Allograft Microvasculopathy. JACC Cardiovasc Imaging. 2016 Mar;9(3):255-66. doi: 10.1016/j.jcmg.2015.10.012
Open DOI Search in Google Scholar Back to article
Velleca A, Shullo MA, Dhital K, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023 May;42(5):e1-e141. doi: 10.1016/j.healun.2022.10.015
Open DOI Search in Google Scholar Back to article
Chirakarnjanakorn S, Starling RC, Popovic ZB, Griffin BP, Desai MY. Dobutamine stress echocardiography during follow-up surveillance in heart transplant patients: Diagnostic accuracy and predictors of outcomes. J Heart Lung Transplant. 2015 May;34(5):710-7. doi: 10.1016/j.healun.2014.11.019
Open DOI Search in Google Scholar Back to article
Clerkin KJ, Farr MA, Restaino SW, Ali ZA, Mancini DM. Dobutamine stress echocardiography is inadequate to detect early cardiac allograft vasculopathy. J Heart Lung Transplant. 2016 Aug;35(8):1040-1. doi: 10.1016/j.healun.2016.05.012
Open DOI Search in Google Scholar Back to article
Wever-Pinzon O, Romero J, Kelesidis I, et al. Coronary computed tomography angiography for the detection of cardiac allograft vasculopathy: a meta-analysis of prospective trials. J Am Coll Cardiol. 2014 May 20;63(19):1992-2004. doi: 10.1016/j.jacc.2014.01.071
Open DOI Search in Google Scholar Back to article
Asleh R, Briasoulis A, Smith B, et al. Association of Aspirin Treatment With Cardiac Allograft Vasculopathy Progression and Adverse Outcomes After Heart Transplantation. J Card Fail. 2021 May;27(5):542-51. doi: 10.1016/j.cardfail.2021.01.019
Open DOI Search in Google Scholar Back to article
Kim M, Bergmark BA, Zelniker TA, et al. Early aspirin use and the development of cardiac allograft vasculopathy. J Heart Lung Transplant. 2017 Dec;36(12):1344-9. doi: 10.1016/j.healun.2017.06.015
Open DOI Search in Google Scholar Back to article
Peled Y, Lavee J, Raichlin E, et al. Early aspirin initiation following heart transplantation is associated with reduced risk of allograft vasculopathy during long-term follow-up. Clin Transplant. 2017 Dec;31(12). doi: 10.1111/ctr.13133
Open DOI Search in Google Scholar Back to article
Fang JC, Kinlay S, Beltrame J, et al. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomized trial. Lancet. 2002 Mar 30;359(9312):1108-13. doi: 10.1016/S0140-6736(02)08154-0
Open DOI Search in Google Scholar Back to article
Kobashigawa JA, Katznelson S, Laks H, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med. 1995 Sep 7;333(10):621-7. doi: 10.1056/NEJM199509073331003
Open DOI Search in Google Scholar Back to article
Kobashigawa JA, Moriguchi JD, Laks H, et al. Ten-year follow-up of a randomized trial of pravastatin in heart transplant patients. J Heart Lung Transplant. 2005 Nov;24(11):1736-40. doi: 10.1016/j.healun.2005.02.009
Open DOI Search in Google Scholar Back to article
Wenke K, Meiser B, Thiery J, et al. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial. Circulation. 1997 Sep 2;96(5):1398-402. doi: 10.1161/01.cir.96.5.1398
Open DOI Search in Google Scholar Back to article
Wenke K, Meiser B, Thiery J, et al. Simvastatin initiated early after heart transplantation: 8-year prospective experience. Circulation. 2003 Jan 7;107(1):93-7. doi: 10.1161/01.cir.0000043241.32523.ee
Open DOI Search in Google Scholar Back to article
Golbus JR, Adie S, Yosef M, Murthy VL, Aaronson KD, Konerman MC. Statin 6 intensity and risk for cardiovascular events after heart transplantation. ESC Heart Fail. 2020 Oct;7(5):2074-81. doi: 10.1002/ehf2.12784
Open DOI Search in Google Scholar Back to article
Ellimuttil TM, Harrison K, Rollins AT, et al. Effect of Statin Intensity on the Progression of Cardiac Allograft Vasculopathy. Card Fail Rev. 2021 Nov 12;7:e15. doi: 10.15420/cfr.2021.07
Open DOI Search in Google Scholar Back to article
Harris J, Teuteberg J, Shullo M. Optimal low-density lipoprotein concentration for cardiac allograft vasculopathy prevention. Clin Transplant. 2018 May;32(5):e13248. doi: 10.1111/ctr.13248
Open DOI Search in Google Scholar Back to article
Broch K, Lemstrom KB, Gustafsson F, et al. Randomized Trial of Cholesterol Lowering With Evolocumab for Cardiac Allograft Vasculopathy in Heart Transplant Recipients. JACC Heart Fail. 2024 Oct;12(10):1677-88. doi: 10.1016/j.jchf.2024.04.026
Open DOI Search in Google Scholar Back to article
Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med. 2003 Aug 28;349(9):847-58. doi: 10.1056/NEJMoa022171
Open DOI Search in Google Scholar Back to article
Eisen HJ, Kobashigawa J, Starling RC, et al. Everolimus versus mycophenolate mofetil in heart transplantation: a randomized, multicenter trial. Am J Transplant. 2013 May;13(5):1203-16. doi: 10.1111/ajt.12181
Open DOI Search in Google Scholar Back to article
Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation. 2004 Oct 26;110(17):2694-700. doi: 10.1161/01.CIR.0000136812.90177.94
Open DOI Search in Google Scholar Back to article
Mancini D, Pinney S, Burkhoff D, et al. Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation. 2003 Jul 8;108(1):48-53. doi: 10.1161/01.CIR.0000070421.38604.2B
Open DOI Search in Google Scholar Back to article
Raichlin E, Bae JH, Khalpey Z, et al. Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation. Circulation. 2007 Dec 4;116(23):2726-33. doi: 10.1161/CIRCULATIONAHA.107.692996
Open DOI Search in Google Scholar Back to article
Asleh R, Briasoulis A, Kremers WK, et al. Long-Term Sirolimus for Primary Immunosuppression in Heart Transplant Recipients. J Am Coll Cardiol. 2018 Feb 13;71(6):636-50. doi: 10.1016/j.jacc.2017.12.005
Open DOI Search in Google Scholar Back to article
Halle AA 3rd, DiSciascio G, Massin EK, et al. Coronary angioplasty, atherectomy and bypass surgery in cardiac transplant recipients. J Am Coll Cardiol. 1995 Jul;26(1):120-8. doi: 10.1016/0735-1097(95)00124-i
Open DOI Search in Google Scholar Back to article
Heublein B, Pethig K, Maass C, Wahlers T, Haverich A. Coronary artery stenting in cardiac allograft vascular disease. Am Heart J. 1997 Nov;134(5 Pt 1):930-8. doi: 10.1016/s0002-8703(97)80017-8
Open DOI Search in Google Scholar Back to article
Wong PM, Piamsomboon C, Mathur A, et al. Efficacy of coronary stenting in the management of cardiac allograft vasculopathy. Am J Cardiol. 1998 Jul 15;82(2):239-41. doi: 10.1016/s0002-9149(98)00295-1
Open DOI Search in Google Scholar Back to article
Jain SP, Ramee SR, White CJ, et al. Coronary stenting in cardiac allograft vasculopathy. J Am Coll Cardiol. 1998 Nov 15;32(6):1636-40. doi: 10.1016/s0735-1097(98)00432-x
Open DOI Search in Google Scholar Back to article
Lee MS, Kobashigawa J, Tobis J. Comparison of percutaneous coronary intervention with bare-metal and drug-eluting stents for cardiac allograft vasculopathy. JACC Cardiovasc Interv. 2008 Dec;1(6):710-5. doi: 10.1016/j.jcin.2008.10.001
Open DOI Search in Google Scholar Back to article
Lee MS, Lluri G, Finch W, Park KW. Role of Percutaneous Coronary Intervention in the Treatment of Cardiac Allograft Vasculopathy. Am J Cardiol. 2018 May 1;121(9):1051-5. doi: 10.1016/j.amjcard.2018.01.025
Open DOI Search in Google Scholar Back to article
Rizvi SSA, Luc JGY, Choi JH, et al. Outcomes and survival following heart retransplantation for cardiac allograft failure: a systematic review and meta-analysis. Ann Cardiothorac Surg. 2018 Jan;7(1):12-8. doi: 10.21037/acs.2018.01.09
Open DOI Search in Google Scholar Back to article
Lund LH, Edwards LB, Kucheryavaya AY, et al. The registry of the International Society for Heart and Lung Transplantation: thirty first official adult heart transplant report--2014; focus theme: retransplantation. J Heart Lung Transplant. 2014 Oct;33(10):996-1008. doi: 10.1016/j.healun.2014.08.003
Open DOI Search in Google Scholar Back to article
Goldraich LA, Stehlik J, Kucheryavaya AY, Edwards LB, Ross HJ. Retransplant and Medical Therapy for Cardiac Allograft Vasculopathy: International Society for Heart and Lung Transplantation Registry Analysis. Am J Transplant. 2016 Jan;16(1):301-9. doi: 10.1111/ajt.13418
Open DOI Search in Google Scholar Back to article
Alba AC, Fan CS, Manlhiot C, Dipchand AI, Stehlik J, Ross HJ. The evolving risk of sudden cardiac death after heart transplant. An analysis of the ISHLT Thoracic Transplant Registry. Clin Transplant. 2019 Mar;33(3):e13490. doi: 10.1111/ctr.13490
Open DOI Search in Google Scholar Back to article
Tsai VW, Cooper J, Garan H, et al. The efficacy of implantable cardioverter-defibrillators in heart transplant recipients: results from a multicenter registry. Circ Heart Fail. 2009 May;2(3):197-201. doi: 10.1161/CIRCHEARTFAILURE.108.814525
Open DOI Search in Google Scholar Back to article
Mehra MR, Crespo-Leiro MG, Dipchand A, et al. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy 2010. J Heart Lung Transplant. 2010 Jul;29(7):717-27. doi: 10.1016/j.healun.2010.05.017
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.14797/mdcvj.1580 | Journal eISSN: 1947-6108

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Language: English

Page range: 58 - 71

Submitted on: Feb 7, 2025

Accepted on: Apr 12, 2025

Published on: May 15, 2025

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

heart transplant,

rejection,

vasculopathy,

mTORi,

coronary angiography,

IVUS,

PET

© 2025 Colin T. Stomberski, Monica M. Colvin, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 21 (2025): Issue 3