From Chronic Use of Minocycline to Pigmented Unicuspid Aortic Valve: A Unique Single Case

We discuss the case of a 47-year-old female who presented to our institution with progressive exertional shortness of breath. Her history was notable for severe acne medicated with 100 mg oral daily minocycline for 2 years and a presumptive diagnosis of a bicuspid aortic valve. Investigations revealed severe aortic stenosis, prompting a decision for elective aortic valve repair. Intraoperatively, significant calcification of a unicuspid aortic valve, atypically blackened valve, and endocardium of the left ventricle and aorta were visualized.