Learnings from the 2024 Utah Cardiac Recovery Symposium: A Roadmap for the Field of Myocardial Recovery
References
- Huggins GS, Kinnamon DD, Haas GJ, et al. Prevalence and Cumulative Risk of Familial Idiopathic Dilated Cardiomyopathy. JAMA. 2022 Feb 1;327(5):454-463. doi: 10.1001/jama.2021.24674
- Felkin LE, Walsh R, Ware JS, et al. Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation. JAMA Cardiol. 2016 May 1;1(2):234-5. doi: 10.1001/jamacardio.2016.0208
- Coste Pradas J, Auguste G, Matkovich SJ, et al. Identification of Genes and Pathways Regulated by Lamin A in Heart. J Am Heart Assoc. 2020 Aug 18;9(16):
e015690 . doi: 10.1161/JAHA.119.015690 - Sadek H, Olson EN. Toward the Goal of Human Heart Regeneration. Cell Stem Cell. 2020 Jan 2;26(1):7-16. doi: 10.1016/j.stem.2019.12.004
- Deacon DC, Happe CL, Chen C, et al. Combinatorial interactions of genetic variants in human cardiomyopathy. Nat Biomed Eng. 2019 Feb 3;3(2):147-157. doi: 10.1038/s41551-019-0348-9
- Destici E, Zhu F, Tran S, et al. Human-gained heart enhancers are associated with species-specific cardiac attributes. Nat Cardiovasc Res. 2022 Sep;1(9):830-843. doi: 10.1038/s44161-022-00124-7
- Zhang Y, Bassel-Duby R, Olson EN. CRISPR-Cas9 Correction of Duchenne Muscular Dystrophy in Mice by a Self-Complementary AAV Delivery System. Methods Mol Biol. 2023;2587:411-425. doi: 10.1007/978-1-0716-2772-3_21
- Long C, Li H, Tiburcy M, et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018 Jan 31;4(1):
eaap9004 . doi: 10.1126/sciadv.aap9004 - Zhang Y, Nishiyama T, Li H, et al. A consolidated AAV system for single-cut CRISPR correction of a common Duchenne muscular dystrophy mutation. Mol Ther Methods Clin Dev. 2021 Jun 4;22:122-132. doi: 10.1016/j.omtm.2021.05.014
- Helgadottir A, Thorleifsson G, Snaebjarnarson A, et al. Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles: a Mendelian randomization analysis. Eur J Prev Cardiol. 2022 Dec 21:29(18):2374-2385. doi: 10.1093/eurjpc/zwac219
- Ghouse J, Tragante V, Ahlberg G, et al. Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism. Nat Genet. 2023 Mar;55(3):399-409. doi: 10.1038/s41588-022-01286-7
- Snaebjarnarson AS, Helgadottir A, Arnadottir GA, et al. Complex effects of sequence variants on lipid levels and coronary artery disease. Cell. 2023 Sep 14;186(19):4085-4099.e15. doi: 10.1016/j.cell.2023.08.01
- National Library of Medicine [Internet]. Washington, DC: National Library of Medicine; c2024. Lee DSM, Cardone KM, Zhang DY, et al.
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum ; 2023 Oct 2 [cited 2024 Jul 10]. Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371173/ - Kolwicz SC
Jr. , Purohit S, Tian R. Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res. 2013 Aug 16;113(5):603-16. doi: 10.1161/CIRCRESAHA.113.302095 - Cluntun AA, Badolia R, Lettlova S, et al. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure. Cell Metab. 2021 Mar 2;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003
- Ng SM, Neubauer S, Rider OJ. Myocardial Metabolism in Heart Failure. Curr Heart Fail Rep. 2023 Feb;20(1):63-75. doi: 10.1007/s11897-023-00589-y
- Karwi QG, Lopaschuk GD. Branched-Chain Amino Acid Metabolism in the Failing Heart. Cardiovasc Drugs Ther. 2023 Apr;37(2):413-420. doi: 10.1007/s10557-022-07320-4
- Park TS, Hu Y, Noh HL, et al. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res. 2008 Oct;49(10):2101-12. doi: 10.1194/jlr.M800147-JLR200
- Sasset L, Manzo OL, Zhang Y, et al. Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure. Cardiovasc Res. 2023 Mar 31;119(2):506-519. doi: 10.1093/cvr/cvac108
- Ji R, Akashi H, Drosatos K, et al. Increased de novo ceramide synthesis and accumulation in failing myocardium. JCI Insight. 2017 May 4;2(9):
e82922 . doi: 10.1172/jci.insight.82922 - Wilkerson JL, Tatum SM, Holland WL, Summers SA. Ceramides are fuel gauges on the drive to cardiometabolic disease. Physiol Rev. 2024 Jul 1;104(3):1061-1119. doi: 10.1152/physrev.00008.2023
- Cantalupo A, Sasset L, Gargiulo A, et al. Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide. Hypertension, 2020 May;75(5):1279-1288. doi: 10.1161/HYPERTENSIONAHA.119.14507
- McDonagh TA, Metra M, Adamo M, et al. Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021 Dec 21;42(48):4901. doi: 10.1093/eurheartj/ehab670
- Kaplon-Cieslicka A, Benson L, Chioncel O, et al.; on behalf of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) and the ESC Heart Failure Long-Term Registry Investigators. A comprehensive characterization of acute heart failure with preserved versus mildly reduced versus reduced ejection fraction - insights from the ESC-HFA EORP Heart Failure Long-Term Registry. Eur J Heart Fail. 2022 Feb;24(2):335-350. doi: 10.1002/ejhf.2408
- Tsao CW, Lyass A, Enserro D, et al. Temporal Trends in the Incidence of and Mortality Associated With Heart Failure With Preserved and Reduced Ejection Fraction. JACC Heart Fail. 2018 Aug;6(8):678-685. doi: 10.1016/j.jchf.2018.03.006
- Florea VG, Rector TS, Anand IS, Cohn JN. Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival: Results From the Valsartan Heart Failure Trial. Circ Heart Fail. 2016 Jul;9(7):
e003123 . doi: 10.1161/CIRCHEARTFAILURE.116.003123 - Wilcox JE, Fang JC, Margulies KB, Mann DL. Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel. J Am Coll Cardiol. 2020 Aug 11;76(6):719-734. doi: 10.1016/j.jacc.2020.05.075
- Heidenreich, PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022 May 3;145(18):e895-e1032. doi: 10.1161/CIR.0000000000001063
- Wang G, Cruz AS, Youker K, et al. Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter. Front Genet. 2021 Jan 15;11:609262. doi: 10.3389/fgene.2020.609262
- Weinheimer CJ, Kovacs A, Evans S, Matkovich SJ, Barger PM, Mann DL. Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure. Circ Heart Fail. 2018 May;11(5):
e004351 . doi: 10.1161/CIRCHEARTFAILURE.117.004351 - Visker JR, Brintz BJ, Kyriakopoulos CP, et al. Integrating molecular and clinical variables to predict myocardial recovery. bioRxiv. 2024 Apr 20. doi: 10.1101/2024.04.16.589326
- Halliday BP, Wassall R, Lota AS, et al. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial. Lancet. 2019 Jan 5;393(10166):61-73. doi: 10.1016/S0140-6736(18)32484-X
- Moon J, Ko YG, Chung N, et al. Recovery and recurrence of left ventricular systolic dysfunction in patients with idiopathic dilated cardiomyopathy. Can J Cardiol. 2009 May;25(5):e147-50. doi: 10.1016/s0828-282x(09)70497-0
- Wilcox J, Yancy CW. Stopping medication for heart failure with improved ejection fraction. Lancet. 2019 Jan 5;393(10166):8-10. doi: 10.1016/S0140-6736(18)32825-3
- Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563
- Baggio LL, Yusta B, Mulvihill EE, et al. GLP-1 Receptor Expression Within the Human Heart. Endocrinology. 2018 Apr 1;159(4):1570-1584. doi: 10.1210/en.2018-00004
- Khan MS, Fonarow GC, McGuire DK, et al. Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization. Circulation. 2020 Sep 22;142(12):1205-1218. doi: 10.1161/CIRCULATIONAHA.120.045888
- Triposkiadis F, Xanthopoulos A, Drakos SG, et al. Back to the basics: The need for an etiological classification of chronic heart failure. Curr Probl Cardiol. 2024 Apr;49(4):102460. doi: 10.1016/j.cpcardiol.2024.102460
- Frea S, Centofanti P, Pidello S, et al. Noninvasive Assessment of Hemodynamic Status in HeartWare Left Ventricular Assist Device Patients: Validation of an Echocardiographic Approach. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1121-1131. doi: 10.1016/j.jcmg.2018.01.026
- Vidula H, Takeda K, Estep JD, et al. Hospitalization Patterns and Impact of a Magnetically-Levitated Left Ventricular Assist Device in the MOMENTUM 3 Trial. JACC Heart Fail. 2022 Jul;10(7):470-481. doi: 10.1016/j.jchf.2022.03.007
- Tedford RJ, Leacche M, Lorts A, Drakos SG, Pagani FD, Cowger J. Durable Mechanical Circulatory Support: JACC Scientific Statement. J Am Coll Cardiol. 2023 Oct 3;82(14):1464-1481. doi: 10.1016/j.jacc.2023.07.019
- Grinstein J, Kruse E, Sayer G, et al. Novel echocardiographic parameters of aortic insufficiency in continuous-flow left ventricular assist devices and clinical outcome. J Heart Lung Transplant. 2016 Aug;35(8):976-85. doi: 10.1016/j.healun.2016.05.009
- Uriel N, Milano C, Agarwal R, et al. Incidence and clinical correlates of de-novo aortic regurgitation with a fully magnetically levitated left ventricular assist device: a MOMENTUM 3 trial portfolio analysis. Eur J Heart Fail. 2023 Feb;25(2):286-294. doi: 10.1002/ejhf.2746
- Topkara VK, Garan AR, Fine B, et al. Myocardial Recovery in Patients Receiving Contemporary Left Ventricular Assist Devices: Results From the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail. 2016 Jul;9(7):
e003157 . doi: 10.1161/CIRCHEARTFAILURE.116.003157 - Wever-Pinzon O, Drakos SG, McKellar SH, et al. Cardiac Recovery During Long-Term Left Ventricular Assist Device Support. J Am Coll Cardiol. 2016 Oct 4;68(14):1540-53. doi: 10.1016/j.jacc.2016.07.743
- Drakos SG, Pagani FD, Lundberg MS, Baldwin JT. Advancing the Science of Myocardial Recovery With Mechanical Circulatory Support: A Working Group of the National, Heart, Lung and Blood Institute. J Card Fail. 2017 May;23(5):416-421. doi: 10.1016/j.cardfail.2017.04.005
- Kanwar MK, Selzman CH, Ton VK, et al. Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support. J Heart Lung Transplant. 2022 Oct;41(10):1324-1334. doi: 10.1016/j.healun.2022.05.015
- Saeed D, Feldman D, Banayosy AE, et al. The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10-year Update. J Heart Lung Transplant. 2023 Jul;42(7):e1-e222. doi: 10.1016/j.healun.2022.12.004
- Nickel I, Potapov E, Sun B, et al. Deactivation of LVAD support for myocardial recovery-surgical perspectives. J Heart Lung Transplant. 2024 May 12:S1053-2498(24)01662-0. doi: 10.1016/j.healun.2024.05.005. Online ahead of print.
- Virani SS, Alonso A, Aparicio HJ, et al. American Heart Association Council on, E.; Prevention Statistics, C.; Stroke Statistics, S., Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation. 2021 Feb 23;143(8):e254-e743. doi: 10.1161/CIR.0000000000000950
- Schluep M, Gravesteijn BY. Stolker RJ. Endeman H, Hoeks SE. One-year survival after in-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2018 Nov;132:90-100. doi: 10.1016/j.resuscitation.2018.09.001
- Thompson LE, Chan PS, Tang F, et al. American Heart Association›s Get With the Guidelines-Resuscitation, I., Long-Term Survival Trends of Medicare Patients After In-Hospital Cardiac Arrest: Insights from Get With The Guidelines-Resuscitation®. Resuscitation. 2018 Feb;123:58-64. doi: 10.1016/j.resuscitation.2017.10.023
- Chan PS, McNally B, Tang F, Kellermann A, Group CS. Recent trends in survival from out-of-hospital cardiac arrest in the United States. Circulation. 2014 Nov 18;130(21):1876-82. doi: 10.1161/CIRCULATIONAHA.114.009711
- Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS. American Heart Association Get with the Guidelines-Resuscitation, I., Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2012 Nov 15;367(20):1912-20. doi: 10.1056/NEJMoa1109148
- McNally B, Robb R, Mehta M, et al. Centers for Disease, C.; Prevention, Out-of-hospital cardiac arrest surveillance --- Cardiac Arrest Registry to Enhance Survival (CARES), United States, October 1, 2005--December 31, 2010. MMWR Surveill Summ. 2011 Jul 29;60(8):1-19. PMID: 21796098
- Mozaffarian D, Benjamin EJ, Go AS, et al. American Heart Association Statistics, C.; Stroke Statistics, S., Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152
- Shin TG, Jo IJ, Sim MS, et al. Two-year survival and neurological outcome of in-hospital cardiac arrest patients rescued by extracorporeal cardiopulmonary resuscitation. Int J Cardiol. 2013 Oct 9;168(4):3424-30. doi: 10.1016/j.ijcard.2013.04.183
- Chen YS, Yu HY, Huang SC, et al. Extracorporeal membrane oxygenation support can extend the duration of cardiopulmonary resuscitation. Crit Care Med. 2008 Sep;36(9):2529-35. doi: 10.1097/CCM.0b013e318183f491
- Tonna JE, McKellar SH, Selzman CH, et al. Exploratory analysis of myocardial function after extracorporeal cardiopulmonary resuscitation vs conventional cardiopulmonary resuscitation. BMC Res Notes. 2020 Mar 6;13(1):137. doi: 10.1186/s13104-020-04982-x
- Yannopoulos D, Bartos JA, Raveendran G, et al. Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest. J Am Coll Cardiol. 2017 Aug 29;70(9):1109-1117. doi: 10.1016/j.jacc.2017.06.059
- Yannopoulos D, Bartos JA. Aufderheide TP, et al. The Evolving Role of the Cardiac Catheterization Laboratory in the Management of Patients With Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation. 2019 Mar 19;139(12):e530-e552. doi: 10.1161/CIR.0000000000000630
- Lamhaut L, Tea V, Raphalen JH, et al. Coronary lesions in refractory out of hospital cardiac arrest (OHCA) treated by extra corporeal pulmonary resuscitation (ECPR). Resuscitation. 2018 May;126:154-159. doi: 10.1016/j.resuscitation.2017.12.017
- Diakos NA, Taleb I, Kyriakopoulos CP, et al. Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support. J Am Heart Assoc. 2021 Oct 19;10(20):
e020238 . doi: 10.1161/JAHA.120.020238 - Drakos SG, Badolia R, Makaju A, et al. Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support. Circulation. 2023 Jan 31;147(5):409-424. doi: 10.1161/CIRCULATIONAHA.121.056600
- Seidel T, Navankasattusas S, Ahmad A, et al. Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading. Circulation. 2017 Apr 25;135(17):1632-1645. doi: 10.1161/CIRCULATIONAHA.116.024470
- Mann DL, Barger PM. Burkhoff D. Myocardial recovery and the failing heart: myth, magic, or molecular target? J Am Coll Cardiol. 2012 Dec 18;60(24):2465-72. doi: 10.1016/j.jacc.2012.06.062
DOI: https://doi.org/10.14797/mdcvj.1443 | Journal eISSN: 1947-6108
Language: English
Page range: 88 - 97
Submitted on: Jul 3, 2024
Accepted on: Jul 4, 2024
Published on: Aug 20, 2024
Published by: Houston Methodist DeBakey Heart & Vascular Center
In partnership with: Paradigm Publishing Services
Keywords:
© 2024 Muthu Kumar Krishnamoorthi, Konstantinos Sideris, Arvind Bhimaraj, Stavros G. Drakos, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.