Management of Myocardial Infarction: Emerging Paradigms for the Future

Vandan D. Upadhyaya; Christopher Wong; Ramzan M. Zakir; Nima Aghili; Haroon Faraz; Navin K. Kapur

doi:10.14797/mdcvj.1393

Management of Myocardial Infarction: Emerging Paradigms for the Future

Methodist DeBakey Cardiovascular Journal

Volume 20 (2024): Issue 4

By: Vandan D. Upadhyaya , Christopher Wong , Ramzan M. Zakir , Nima Aghili, Haroon Faraz and Navin K. Kapur

Open Access

|Aug 2024

Abstract

Despite significant advancements in managing acute ST-segment elevation myocardial infarctions, the prevalence of heart failure has not decreased. Emerging paradigms with a focus on reducing infarct size show promising evidence in the improvement of the incidence of heart failure after experiencing acute coronary syndromes. Limiting infarct size has been the focus of multiple clinical trials over the past decades and has led to left ventricular (LV) unloading as a potential mechanism. Contemporary use of microaxial flow devices for LV unloading has suggested improvement in mortality in acute myocardial infarction complicated by cardiogenic shock. This review focuses on clinical data demonstrating evidence of infarct size reduction and highlights ongoing clinical trials that provide a new therapeutic approach to the management of acute myocardial infarction.

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Articles in this issue

DOI: https://doi.org/10.14797/mdcvj.1393 | Journal eISSN: 1947-6108

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Language: English

Page range: 54 - 63

Submitted on: Apr 10, 2024

Accepted on: Jul 25, 2024

Published on: Aug 20, 2024

Published by: Houston Methodist DeBakey Heart & Vascular Center

In partnership with: Paradigm Publishing Services

Keywords:

mechanical circulatory support,

cardiogenic shock,

myocardial infarction,

reperfusion injury,

hemodynamics,

Impella

© 2024 Vandan D. Upadhyaya, Christopher Wong, Ramzan M. Zakir, Nima Aghili, Haroon Faraz, Navin K. Kapur, published by Houston Methodist DeBakey Heart & Vascular Center
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 License.

Volume 20 (2024): Issue 4