Intravenous insulin protocol reduces time to target glucose in critically ill trauma and burn patients
References
- Mukherjee JJ, Chatterjee PS, Saikia M, Muruganathan A, Das AK. Diabetes Consensus recommendations for the management of hyperglycaemia in critically ill patients in the Indian setting. J Assoc Physicians India. 2014 Jul;62(7):16–25.
- Viana MV, Moraes RB, Fabbrin AR, Santos MF, Gerchman F. Assessment and treatment of hyperglycemia in critically ill patients. Rev Bras Ter Intensiva. 2014 Jan–Mar;26(1):71–6.
- Wijdicks EFM, Cartin-Ceba R, Freeman, WD. et.al. Glycemic Control in Neurocritically Ill Patients’, Mayo Clinic Critical and Neurocritical Care Board Review, 2 edn, Mayo Clinic Scientific Press (2025; online edn, Oxford Academic 1 June 2025)
https://doi.org/10.1093/med/9780197628638.003.0037 , accessed 23 July 2025. - Godoy DA, Di Napoli M, Rabinstein AA. Treating hyperglycemia in neurocritical patients: benefits and perils. Neurocrit Care. 2010 Dec;13(3):425–38. doi: 10.1007/s12028-010-9404-8. PMID: 20652767.
- Han J, Lee YI, Ryu J. Prognostic Value of Early Hyperglycemia in Neurocritically Ill Patients. Neurointensive Care 2020 Vol. 3 Issue 1 Pages 6–11 DOI: 10.32587/jnic.2020.00255
- Jeschke MG. (2013). Clinical review: Glucose control in severely burned patients - current best practice. Critical care (London, England), 17(4), 232.
https://doi.org/10.1186/cc12678 - Bohé J, Abidi H, Brunot V. et al. CONTROLe INdividualisé de la Glycémie (CONTROLING) Study Group. Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study-a randomized clinical trial. Intensive Care Med. 2021 Nov;47(11):1271–1283. doi: 10.1007/s00134-021-06526-8. Epub 2021 Sep 29. PMID: 34590159; PMCID: PMC8550173.
- “Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2021.” Diabetes Care, 2020; 44(1).
- “Clinical Evidence for Glucose Control in the Inpatient Setting.” American Association of Clinical Endocrinologists. April 2021; 20.
- Lal A, Haque N, Lee J. et al. (2021). Optimal Blood Glucose Monitoring Interval for Insulin Infusion in Critically Ill Non-Cardiothoracic Patients: A Pilot Study. Acta biomedica: Atenei Parmensis, 92(1), e2021036.
https://doi.org/10.23750/abm.v92i1.9083 - Tran KK, Kibert JL, Telford ED, Franck AJ. Intravenous Insulin Infusion Protocol Compared With Subcutaneous Insulin for the Management of Hyperglycemia in Critically Ill Adults. Ann Pharmacother. 2019;53(9):894–898.
- Desgrouas M, Demiselle J, Stiel L. et al. Insulin therapy and blood glucose management in critically ill patients: a 1-day cross-sectional observational study in 69 French intensive care units. Ann Intensive Care. 2023 Jun 17;13(1):53.
- Avanzini F, Marelli G, Saltafossi D. et al. Effectiveness, safety, and feasibility of an evidence-based insulin infusion protocol targeting moderate glycaemic control in intensive cardiac care units. Eur Heart J Acute Cardiovasc Care. 2016 Apr;5(2):117–24.
- Khalaila R, Libersky E, Catz D. et. al. Nurse-led implementation of a safe and effective intravenous insulin protocol in a medical intensive care unit. Crit Care Nurse. 2011 Dec;31(6):27–35.
- Moghissi ES. Reexamining the evidence for inpatient glucose control: new recommendations for glycemic targets. Am J Health Syst Pharm. 2010 Aug;67; 16(8): S3–8.
- Jacobi J, Bircher N, Krinsley J. et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients Crit Care Med. 2012 Dec;40(12):3251–76.
- Faust AC, Attridge RL, Ryan L. (2011). How low should you go? The limbo of glycemic control in intensive care units. Critical care nurse, 31(4), e9–e18.
https://doi.org/10.4037/ccn2011188 - Kramer AH, Roberts DJ, Zygun DA. (2012). Optimal glycemic control in neurocritical care patients: a systematic review and meta-analysis. Critical care (London, England), 16(5), R203.
https://doi.org/10.1186/cc11812 - Rabinovich M, Grahl J, Durr E. et al. (2018). Risk of Hypoglycemia During Insulin Infusion Directed by Paper Protocol Versus Electronic Glycemic Management System in Critically Ill Patients at a Large Academic Medical Center. Journal of diabetes science and technology, 12(1), 47–52.
https://doi.org/10.1177/1932296817747617 - Almagthali A, Alsohimi S, Alkhalaf A. Sulaiman KA, Aljuhani O. Assessing glycemic variability in critically ill patients: A prospective cohort study comparing insulin infusion therapy with insulin sliding scale. Sci Rep 14, 10128 (2024).
https://doi.org/10.1038/s41598-024-57403-5 - Pérez A, Ramos A, Carreras G. Insulin Therapy in Hospitalized Patients. Am J Ther. 2020 Jan/Feb;27(1): e71–e78.
- Gunst J, Debaveye Y, Güiza F. et al. Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU. N Engl J Med. 2023 Sep 28;389(13):1180–1190. doi: 10.1056/NEJMoa2304855. PMID: 37754283.
- Alhatemi G, Aldiwani H, Alhatemi R, Hussein M, Mahdai S, Seyoum B. Glycemic control in the critically ill: Less is more Cleveland Clinic Journal of Medicine 2022 Vol. 89 Issue 4 Pages 191–199 DOI: 10.3949/ccjm.89a.20171
- Honarmand K, Sirimaturos M, Hirshberg EL. et. al. Society of Critical Care Medicine guidelines on glycemic control for critically ill children and adults 2024. Crit Care Med. 2024 Apr1;52(4) e161–e181
- Takahashi Y, Matsuura H, Domi H, Yamamura H. A continuous intravenous insulin infusion protocol to manage high-dose methylprednisolone-induced hyperglycemia in patients with severe COVID-19. Clin Diabetes Endocrinol. 2022 Apr 27; 8(1): 4.
- Pasquel FJ, Lansang MC, Dhatariya K, Umpierrez GE. (2021). Management of diabetes and hyperglycaemia in the hospital. The lancet. Diabetes & endocrinology, 9(3), 174–188.
https://doi.org/10.1016/S2213-8587(20)30381-8 - Marvin MR, Inzucchi SE, Besterman BJ (2016). Minimization of Hypoglycemia as an Adverse Event During Insulin Infusion: Further Refinement of the Yale Protocol. Diabetes technology & therapeutics, 18(8), 480–486.
https://doi.org/10.1089/dia.2016.0101 - Park SW, Lee S, Cha WC. et.al. (2020). An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment. Diabetes & metabolism journal, 44(1), 56–66.
https://doi.org/10.4093/dmj.2018.0227 - Clergeau A, Parienti JJ, Reznik Y. et.al. Impact of a Paper-Based Dynamic Insulin Infusion Protocol on Glycemic Variability, Time in Target, and Hypoglycemic Risk: A Stepped Wedge Trial in Medical Intensive Care Unit Patients. Diabetes Technol Ther. 2017 Feb;19(2):115–123. doi: 10.1089/dia.2016.0314. PMID: 28118045.
Language: English
Page range: 359 - 367
Submitted on: Mar 5, 2026
Accepted on: Apr 12, 2026
Published on: Jul 27, 2026
Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2026 Oluwafolaranmi E. Sodade, Connor J. English, Cindy L. Austin, Charles A. Lunday, Yang Wang, Brian B. Draper, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.