The effect of oral protein and carbohydrate solution administration on NLR, IL-6 and CRP levels in patients undergoing surgery
References
- Brown EN, Pavone KJ, Naranjo M. Multimodal general anesthesia: Theory and practice. Anesth Analg. 2018;127(5):1246–58.
- Markovic-Bozic J, Karpe B, Potocnik I, et al. Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy. BMC Anesthesiol. 2016;16(1):4–11.
- Duff S, Connolly C, Buggy DJ. Immune Function in the Setting of Oncological Surgery Their Effects on Cancer Progression and the Role of the Anesthetic Technique in their Modulation. Int Anesth Clin. 2016;54(4):48–57.
- Fawcett WJ, Thomas M. Pre-operative fasting in adults and children: clinical practice and guidelines. Anaesthesia. 2019;74(1):83–8.
- Gillis C, Wischmeyer PE. Pre-operative nutrition and the elective surgical patient: why, how and what? Anaesthesia. 2019;74:27–35.
- Ravanini G de AG, Filho PEP, Luna RA, et al. Organic inflammatory response to reduced preoperative fasting time, with a carbohydrate and protein enriched solution; a randomized trial. Nutr Hosp. 2015;32(2):952–7.
- Haider KZ, Ahmed Z. Does a Preoperative Carbohydrate Drink Reduce Postoperative Inflammation? A Systematic Review and Meta-Analysis. Trauma Care. 2023;3(4):294–307.
- Rizvanović N, Nesek Adam V, KalajdŽija M, Čaušević S, Dervišević S, Smajić J. Effects of Preoperative Oral Carbohydrate Loading on Neutrophil/Lymphocyte Ratio and Postoperative Complications following Colorectal Cancer Surgery: A Randomized Controlled Study. Eur Surg Res. 2023;64(2):278–85.
- Ekawati D, Wijayanti DR, Ritonga AFR. Hubungan NLR Dengan Kadar Hs-Crp Pada Kasus Demam Dengueperiode Tahun 2019–2021 Di Prodia Depok. Binawan Student J. 2022;4(3):37–43.
- Buonacera A, Stancanelli B, Colaci M, et al. Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases. Int J Mol Sci. 2022;23(7);1208–1215
- Hu Z, Liu J, Wang F. Effects of Preoperative Carbohydrate Intake on Inflammatory Markers and Clinical Outcomes in Elderly Patients Undergoing Radical Prostatectomy: A Single-Centre, Double-Blind Randomised Controlled Trial. Front Surg. 2021;8(9):1–9.
- Wang K, Xiao J, Wang Y, et al. Effects of preoperative and postoperative carbohydrate loading on gastrointestinal function and stress-induced inflammation after radical prostatectomy. Int J Surg Glob Heal. 2024;7(2):1–9.
- Kumar SM, Anandhi A, Sureshkumar S, et al. Effect of preoperative oral carbohydrate loading on postoperative insulin resistance, patient-perceived well-being, and surgical outcomes in elective colorectal surgery: a randomized controlled trial. J Gastrointest Surg. 2024;28(10):1654–60.
- Quevedo AS De. Surgical complexity score as a predictor of surgical site infection in dentoalveolar surgeries. Res Soc Dev. 2023;2023:1–10.
- Yi HC, Ibrahim Z, Zaid ZA, et al. Impact of enhanced recovery after surgery with preoperative whey protein-infused carbohydrate loading and postoperative early oral feeding among surgical gynecologic cancer patients: An open-labelled randomized controlled trial. Nutrients. 2020;12(1):1–14.
- Andreanto ES, Primatika AD, Pujo JL. Pengaruh Pemberian Minuman Karbohidrat Dan Protein Whey Pra Operasi Terhadap Kadar C - Reactive Protein Pasca Operasi Pada Pasien Mastektomi Effect Of Oral Preoperative Carbohydrate And Whey Protein On Level Of C - Reactive Protein On Post operative Maste. J Anestesiol Indon. 2019;7(1):21–9.
- Gumus K, Aydın G. The Effect of Preoperative Nutrition on Postoperative CRP and Albumin Levels in Patients Undergoing Laparoscopic Surgery: A Surgical Nursing Perspective. J Perianesthesia Nurs. 2020;35(6):592–6.
- Zhang Y, Min J. Preoperative Carbohydrate Loading in Gynecological Patients Undergoing Combined Spinal and Epidural Anesthesia. J Investig Surg. 2020;33(7):587–95.
- Giannakopoulou SP, Antonopoulou S, Chrysohoou C, et al. The Impact of Dietary Carbohydrates on Inflammation-Related Cardiovascular Disease Risk: The ATTICA Study (2002–2022). Nutrients. 2024;16(13);1–15
- Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology. 2015;123(6):1455–72.
- Xu D, Zhu X, Xu Y, et al. Shortened preoperative fasting for prevention of complications associated with laparoscopic cholecystectomy: a meta-analysis. J Int Med Res. 2017;45(1):22–37.
- Carvalho CAL de B, de Carvalho AA, Preza AD oliveir. G, et al. Metabolic and inflammatory benefits of reducing preoperative fasting time in pediatric surgery. Rev Col Bras Cir. 2020;47(1):1–10.
- Gao M, Guo H, Dong X, et al. Regulation of inflammation during wound healing: the function of mesenchymal stem cells and strategies for therapeutic enhancement. Front Pharmacol. 2024;15(2):1–15.
- Liu F, Li L, Xu M Da, et al. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J Clin Virol. 2020;127(4):104370.
- Agita A, Thaha M. Inflammation, Immunity, and Hypertension. Acta Med Indones. 2017;49(2):158–65.
- Savulescu-Fiedler I, Mihalcea R, Dragosloveanu S, et al. The Interplay between Obesity and Inflammation. Life. 2024;14(7):1–28.
- Fernandez-Guarino M, Naharro-Rodriguez J, Bacci S. Aberrances of the Wound Healing Process: A Review. MDPI. 2024;11(6):1–22.
Language: English
Page range: 243 - 251
Submitted on: Aug 22, 2025
Accepted on: Feb 2, 2026
Published on: Apr 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
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© 2026 Mahendratama P. Adhi, Oscar Febriano, Alfi Yasmina, Iwan Nuryawan, Agung Ary Wibowo, Kenanga Marwan Sikumbang, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.