Prognosis prediction by urinary liver-type fatty acid-binding protein in patients in the intensive care unit admitted from the emergency department: A single-center, historical cohort study
References
- Desai N, Gross J. Scoring systems in the critically ill: uses, cautions, and future directions. BJA Educ. 2019;19:212–8.
- Rahmatinejad Z, Hoseini B, Rahmatinejad F, et al. Internal validation of the predictive performance of models based on three ED and ICU scoring systems to predict inhospital mortality for intensive care patients referred from the emergency department. BioMed Res Int. 2022;2022:3964063.
- Moreno-Torres V, Royuela A, Múñez E, et al. Better prognostic ability of NEWS2, SOFA and SAPS-II in septic patients. Mejor capacidad pronóstica de NEWS2. Med Clin (Barc). 2022;159:224–9.
- Naqvi IH, Mahmood K, Ziaullaha S, Kashif SM, Sharif A. Better prognostic marker in ICU—Apache II, SOFA or SAP II! Pak J Med Sci. 2016;32:1146–51.
- Vincent JL, Moreno R. Clinical review: scoring systems in the critically ill. Crit Care. 2010;14:207.
- Sarfati S, Ehrmann S, Vodovar D, et al. Inadequate intensive care physician supply in France: a point-prevalence prospective study. Ann Intensive Care. 2024;14:92.
- Watanabe T, Ohsugi K, Suminaga Y, et al. An evaluation of the impact of the implementation of the Tele-ICU: a retrospective observational study. J Intensive Care. 2023;11:9.
- Suzuki G, Ichibayashi R, Yamamoto S, et al. Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients. Ren Fail. 2021;43:1041–8.
- van de Poll MCG, Derikx JPM, Buurman WA, et al. Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection. World J Surg. 2007;31:2033–8.
- Doi K, Negishi K, Ishizu T, et al. Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit. Crit Care Med. 2011;39:2464–9.
- Suzuki G, Ichibayashi R, Yamamoto S, Nakamichi Y, Watanabe M, Honda M. Clinical significance of urinary L-FABP in the emergency department. Int J Emerg Med. 2019;12:24.
- Parr SK, Clark AJ, Bian A, et al. Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. Kidney Int. 2015;87:640–8.
- Thuijls G, van Wijck K, Grootjans J, et al. Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins. Ann Surg. 2011;253:303–8. DOI: 10.1097/SLA.0b013e318207a767.
- Kim H, Gil G, Lee S, et al. Cytokine-like activity of liver type fatty acid binding protein (L-FABP) inducing inflammatory cytokine interleukin-6. Immune Netw. 2016;16:296–304.
- Naruse H, Ishii J, Takahashi H, et al. Urinary liver-type fatty-acid-binding protein predicts long-term adverse outcomes in medical cardiac intensive care units. J Clin Med. 2020;9:482.
- Cho E, Yang HN, Jo SK, Cho WY, Kim HK. The role of urinary liver-type fatty acid-binding protein in critically ill patients. J Korean Med Sci. 2013;28:100–5.
- Masud F, Lam TYC, Fatima S. Is 24/7 in-house intensivist staffing necessary in the intensive care unit? Methodist Debakey CardioVasc J. 2018;14:134–40.
Language: English
Page range: 207 - 214
Submitted on: Nov 17, 2025
Accepted on: Feb 1, 2026
Published on: Apr 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2026 Hirozumi Okuda, Hideki Asai, Koji Yamamoto, Keita Miyazaki, Hidetada Fukushima, Keigo Saeki, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.