Fig. 1.
Fig. 2.
Fig. 3.
Baseline clinical characteristics of the study population
| Parameters | Survival group (n = 101) median [IQR] | Death group (n = 17) median [IQR] | p |
|---|---|---|---|
| Physical data | |||
| Age (years) | 65[48–80] | 79[75–83] | <0.01 |
| Male, n (%) | 61(60.4) | 11(64.7) | 0.94 |
| Height (cm) | 161[154.3–168] | 156.5[151–161] | 0.09 |
| Body weight(kg) | 60.1[50–68.5] | 52.6[40–57.8] | 0.02 |
| Laboratory data | |||
| WBC (/μL) | 11200[8200–16300] | 8900[7500–12000] | 0.35 |
| Hb (g/dL) | 12.2[10.6–13.8] | 12[9.9–12.8] | 0.30 |
| CRP (mg/dL) | 0.14[0.03–1.55] | 1.09[0.18–5.33] | 0.07 |
| ALB (g/dL) | 3.8[3.3–4.2] | 3.2[2.8–3.6] | <0.01 |
| Cre (mg/dL) | 0.95[0.73–1.45] | 1.3[0.89–1.45] | 0.17 |
| Lac (mg/dL) | 2.1[1.2–3.5] | 5.4[2.2–12.9] | <0.01 |
| L-FABP (at admission) (ng/mL) | 24.23[5.95–191.04] | 1006.9[134.41–7381] | <0.01 |
| L-FABP (3 hours later) (ng/mL) | 20.69[7.38–153.96] | 2921.5[519.02–6104.5] | <0.01 |
| Scoring data | |||
| APACHE II score | 19[14–27] | 34[28–40] | <0.01 |
| SOFA score | 7[3–10] | 11[9–13] | <0.01 |
| Others | |||
| External causes, n (%) | 65(64.4) | 5(29.4) | 0.01 |
| Time to ICU admission (min) | 113[86–203] | 93[82–107] | 0.03 |
Hazard ratio for 28-day survival by urinary L-FABP at 3 hours after ICU admission
| Hazard Ratio for 28-Day Survival | Low L-FABP* (n=74) | High L-FABP† (n=44) | p-value |
|---|---|---|---|
| Crude model, HR [95% CI] | 1 (reference) | 32.35 [4.29–244] | <0.01 |
| IPTW adjusted, HR [95% CI] | 1 (reference) | 8.60 [1.02–72.64] | 0.047 |