Impact of creatinine measurement methods on eGFR and GFR category assignment
References
- Brosnan JT, Brosnan ME. Creatine metabolism and the urea cycle. Mol Genet Metab. 2010;100 Suppl 1:S49–52.
- Kidney Disease: Improving Global Outcomes CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2024; 105(4S):S117–S314.
- Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney int Suppl. 2012; 2:1–138
- Miners JO, Yang X, Knights KM, Zhang L. The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug Clearance. Clin Pharmacol Ther. 2017;102(3):436–449.
- Glassock RJ, Winearls C. Ageing and the glomerular filtration rate: truths and consequences. Trans Am Clin Climatol Assoc. 2009;120:419–428.
- Otto F, Hsien W, A system of blood analysys, Journal of Biological Chemistry. 1919; 38(1):81–110.
- Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics. 6th ed. St. Louis, MO: Elsevier; 2018. p. 463–467
- Greenberg N, Roberts WL, Bachmann LM, Wright EC, Dalton RN, Zakowski JJ, et al. Specificity characteristics of 7 commercial creatinine measurement procedures by enzymatic and jaffe method principles. Clinical Chemistry. 2012;58(2):391–401.
- Lehman CM, Pearson L, Salmond J, Raphael K, Schmidt RL. A Reflex Protocol for Creatinine Testing Reduces Costs and Maintains Patient Safety. Lab Med. 2019;50(2):202–207.
- Cavalier, Etienne, Makris, Konstantinos, Portakal, Oytun, Nikler, Ana, Datta, Pradip, Zima, Tomas, Delanaye, Pierre and for the EFLM Task Group on CKD,. “Assessing the status of European laboratories in evaluating biomarkers for chronic kidney diseases (CKD) and recommendations for improvement: insights from the 2022 EFLM Task Group on CKD survey” Clinical Chemistry and Laboratory Medicine (CCLM).2024; 62(2): 253–261
- Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et all. CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9):604–12.
- Pottel H, Björk J, Courbebaisse M, Couzi L, Ebert N, Eriksen BO, et all. Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate : A Cross-sectional Analysis of Pooled Data. Ann Intern Med. 2021; 174(2):183–191.
- Clinical and Laboratory Standards Institute. Measurement procedure comparison and bias estimation using patient samples. Approved guideline. 3rd ed. Wayne (PA): Clinical and Laboratory Standards Institute; 2013.
- Duru OK, Vargas RB, Kermah D, Pan D, Norris KC. High prevalence of stage 3 chronic kidney disease in older adults despite normal serum creatinine. J Am Soc Nephrol. 2008;19(8):1569–1577.
- Mitchell AM, Jones AE, Tumlin JA, Kline JA. Incidence of contrast-induced nephropathy after contrast-enhanced CT in the outpatient setting. AJR Am J Roentgenol. 2005;185(2):469–474.
- Kidney Disease: Improving Global Outcomes CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2012; 3:S1–S150.
- Schober P, Boer C, Schwarte, Lothar A. Correlation Coefficients: Appropriate Use and Interpretation. Anesthesia & Analgesia. 2018. 126(5):1763–1768.
- Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977 Mar;33(1):159–74. PMID: 843571.
- Guppy M, Thomas ET, Glasziou P, Clark J, Jones M, O’Hara DV, Doust J. Rate of decline in kidney function with age: a systematic review. BMJ Open 2024;14(11):e089783.
- Delanaye P, Cavalier E, Stehlé T, Pottel H. Glomerular Filtration Rate Estimation in Adults: Myths and Promises. Nephron. 2024;148(6):408–414.
- Syme NR, Stevens K, Stirling C, McMillan DC, Talwar D. Clinical and Analytical Impact of Moving from Jaffe to Enzymatic Serum Creatinine Methodology. J Appl Lab Med. 2020;5(4):631–642.
- Osmic-Husni A, Hukic F, Saric MP. Comparison of Jaffe Method and Enzymatic Method at Measuring Serum Creatinine Level, Creatinine Clearance and Estimated Glomerular Filtration Rate. Mater Sociomed. 2023;35(2):113–117.
- Schmidt RL, Straseski JA, Raphael KL, Adams AH, Lehman CM. A Risk Assessment of the Jaffe vs Enzymatic Method for Creatinine Measurement in an Outpatient Population. PLoS One. 2015;10(11):e0143205.
- Carobene A, Aarsand AK, Bartlett WA, Coskun A, Diaz-Garzon J, Fernandez-Calle P, Guerra E, Jonker N, Locatelli M, Plebani M, Sandberg S, Ceriotti F. The European Biological Variation Study (EuBIVAS): a summary report. Clin Chem Lab Med. 2021 May 31;60(4):505–517.
- Lovrenčić MV, Biljak VR, Blaslov K, Božičević S, Duvnjak LS. Impact of creatinine methodology on glomerular filtration rate estimation in diabetes. World J Diabetes. 2017;8(5):222–229.
- Boss K, Stolpe S, Müller A, et al. Effect of Difference in Serum Creatinine between Jaffe and Enzymatic Methods in Outpatient Kidney Transplant Recipients. J Clin Med. 2024;13(20):6066. Published 2024 Oct 11.
- Davenport MS, Perazella MA, Yee J, Dillman JR, Fine D, McDonald RJ, Rodby RA, Wang CL, Weinreb JC. Use of Intravenous Iodinated Contrast Media in Patients With Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation. Kidney Med. 2020 Jan 22;2(1):85–93.
Language: English
Page range: 199 - 206
Submitted on: Jun 24, 2025
Accepted on: Jan 30, 2026
Published on: Apr 30, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:
© 2026 Elena-Cristina Preda, Oana Oprea, Zsolt Albert Barabas, Ioana Paula Simion, Ana-Maria Fotache, Minodora Dobreanu, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.