Impact of creatinine measurement methods on eGFR and GFR category assignment

Elena-Cristina Preda; Oana Oprea; Zsolt Albert Barabas; Ioana Paula Simion; Ana-Maria Fotache; Minodora Dobreanu

doi:10.62838/jccm-2026-0007

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Impact of creatinine measurement methods on eGFR and GFR category assignment

The Journal of Critical Care Medicine

Volume 12 (2026): Issue 2 (April 2026)

By: Elena-Cristina Preda, Oana Oprea, Zsolt Albert Barabas, Ioana Paula Simion, Ana-Maria Fotache and Minodora Dobreanu

Open Access

|Apr 2026

Figures & Tables

Comparison between enzymatic and Jaffe methods for serum creatinine (SCr) measurement. The upper part of the figure shows the analysis for all samples, while the lower part shows the analysis for samples with SCrENZ < 1.5 mg/dL. Bland-Altman plots are shown on the left, and Passing-Bablok regression plots on the right.

Reclassification matrix of GFR categories in male (left side) and female (right side) patients using CKD-EPI (upper side) and EKFC (down) equations using enzymatic and Jaffe serum creatinine measurement.

Agreement in eGFR-based CKD staging between enzymatic and Jaffe methods using CKD-EPI and EKFC equations, assessed by weighted kappa and Kendall’s tau, stratified by sex_

Equation	Male patients		Female patients
Equation	Weighted Kappa	Kendall’s Tau	Weighted Kappa	Kendall’s Tau
CKD-EPI	0.928 (CI: 0.900–0.956)	0.949	0.923 (CI: 0.894–0.951)	0.943
EKFC	0.916 (CI: 0.885–0.947)	0.95	0.943 (CI: 0.918–0.969)	0.959

Multiple linear regression models for ΔeGFR by sex and eGFR equation (CKD-EPI, EKFC), with SCr (enzymatic, Jaffe) and age as predictors_

Sex	Equation	Predictor	B	p
Male	ΔeGFR_CKD-EPI	SCr_Enz	−11.579	<0.001
		SCr_Jaffe	11.17	<0.001
		Age	0.005	0.756
	ΔeGFR_EKFC	SCr_Enz	−11.042	<0.001
		SCr_Jaffe	10.667	<0.001
		Age	0.004	0.783

Female	ΔeGFR_CKD-EPI	SCr_Enz	−8.497	<0.001
		SCr_Jaffe	8.235	<0.001
		Age	−0.018	0.153
	ΔeGFR_EKFC	SCr_Enz	−7.684	<0.001
		SCr_Jaffe	7.443	<0.001
		Age	−0.019	0.097

Descriptive statistics for patient age and serum creatinine values measured by enzymatic and Jaffe methods_

Variable:	Age	Female age	Men age	SCr_Enzymatic (mg/dL)	SCr_Jaffe (mg/dL)
Number	427	213	214	427	427
Min	42	42	42	0.66	0.66
Max	98	98	90	18.59	19.2
Mean/Median	67	66	66	1.78	1.79
SD / IQR	15	6.25	11.6	1.7	2.2

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Articles in this issue

DOI: https://doi.org/10.62838/jccm-2026-0007 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809

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Language: English

Page range: 199 - 206

Submitted on: Jun 24, 2025

Accepted on: Jan 30, 2026

Published on: Apr 30, 2026

Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

creatinine,

glomerular filtration rate,

clinical decision-making,

Related subjects:

Internal medicine, other,

Surgery,

Surgery, other,

Anaesthesiology,

Emergency medicine and intensive-care medicine

© 2026 Elena-Cristina Preda, Oana Oprea, Zsolt Albert Barabas, Ioana Paula Simion, Ana-Maria Fotache, Minodora Dobreanu, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 12 (2026): Issue 2 (April 2026)

Impact of creatinine measurement methods on eGFR and GFR category assignment

Figures & Tables

Fig. 1.

Fig. 2.

Agreement in eGFR-based CKD staging between enzymatic and Jaffe methods using CKD-EPI and EKFC equations, assessed by weighted kappa and Kendall’s tau, stratified by sex_

Multiple linear regression models for ΔeGFR by sex and eGFR equation (CKD-EPI, EKFC), with SCr (enzymatic, Jaffe) and age as predictors_

Descriptive statistics for patient age and serum creatinine values measured by enzymatic and Jaffe methods_

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