Figure 1
Figure 2
Frequency of genotype distribution and mean dosage requirements of tacrolimus defined by 9 matching groups of genotypes_
| Group | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | CYP3A5*1/*1- | CYP3A5*1/*1- | CYP3A5*1/*1- | CYP3A5*1/*3- | CYP3A5*1/*3- | CYP3A5*1/*3- | CYP3A5*3/*3- | CYP3A5*3/*3- | CYP3A5*3/*3- | |
| POR*1/*1 | POR*1/*28 | POR*28/*28 | POR*1/*1 | POR*1/*28 | POR*28/*28 | POR*1/*1 | POR*1/*28 | POR*28/*28 | ||
| N | 6 | 11 | 1 | 21 | 36 | 6 | 21 | 30 | 12 | 150 |
| % | 4 | 7.3 | 0.7 | 18 | 24 | 4 | 14 | 20 | 8 | 100 |
| Mean dose (mg/kg/day) | 0.163 | 0.167 | 0.141 | 0.128 | 0.131 | 0.174 | 0.081 | 0.073 | 0.069 | 0.113 |
| SD | 0.050 | 0.065 | – | 0.057 | 0.049 | 0.065 | 0.051 | 0.031 | 0.023 | 0.059 |
Baseline characteristics of 150 Thai recipients of kidney transplants, defined by CYP3A5 and POR genotype
| Parameters | CYP3A5 (n = 150) | POR (n = 150) | Total | ||||
|---|---|---|---|---|---|---|---|
P=0.013 | P=0.013 | P=0.013 | P=0.013 | ||||
| Genotype | P=0.013 P=0.013 | P=0.013 P=0.013 | P=0.013 P=0.013 | P=0.013 P=0.013 | P=0.013 P=0.013 | P=0.013 P=0.013 | N/A |
| n(%) | 18(12) | 69(46) | 63 (42) | 54(36) | 77(51.3) | 19(12.7) | 150(100) |
| Male/female (n) | 11/7 | 31/38 | 35/28 | 24/30 | 46/31 | 7/12 | 77/73 |
| Age (years) | 43.3 | 42.9 | 45.2 | 43.9 | 44.5 | 41.3 | 43.9 |
| Weight (kg) | 59.7 | 56.0 | 59.0 | 58.4 | 57.8 | 55.4 | 57.7 |
| Living donors (n) | 11 | 30 | 34 | 28 | 37 | 10 | 7575 |
| Cadaveric donors (n) | 7 | 39 | 29 | 26 | 40 | 9 | |
| Blood urea nitrogen (mg/dL) | 16.4(7.87) | 20.2(12.9) | 19.9(9.21) | 20.3(14.1) | 19.1(8.16) | 19.6(11.2) | 19.6(11.0) |
| Serum creatinine (mg/dL) | 1.38(0.47) | 1.37(0.40) | 1.48(0.72) | 1.33(0.41) | 1.48(0.65) | 1.41 (0.57) | 1.42(0.56) |
| Tacrolimus C0 (ng/mL) | P=0.013 | P = 0.008 compared with CYP3A5*3/*3. Values are presented as mean (SD). C0: trough concentration. | 8.53 (2.79) | 7.68(2.77) | 7.71 (2.67) | 7.34(2.62) | 7.65 (2.69) |