Table 1
Demographics of participants and DBS lead parameters. There were not statistically significant differences between age, disease duration, or months to follow-up between unilateral and bilateral participants.
| UNILATERAL | BILATERAL | |
|---|---|---|
| Number of Participants | 3 | 2 |
| Average Age (yrs) | 73.3 | 72 |
| Disease Duration (yrs) | 33.3 | 22.5 |
| Gender (M;F) | 1;2 | 0;2 |
| Lead Type | Medtronic 3389(1) | BS DB 2201 (1) |
| Boston Scientific Directional 2202 (2) | BS 2202(1) | |
| Follow-up (months, mean) | 8.3 | 7.6 |
Table 2
Summary of Patient lead parameters during post-operative assessment. R = Right, L = Left.
| FREQUENCY (HZ) | PULSE WIDTH | AMPLITUDE (MA) | ||||
|---|---|---|---|---|---|---|
| SUBJECT | L | R | L | R | L | R |
| Bilateral 1 | 130 | 130 | 30 | 60 | 4 | 4.3 |
| Bilateral 2 | 149 | 149 | 60 | 30 | 4.2 | 2.3 |
| Unilateral 1 | 130 | 60 | 2.8 | |||
| Unilateral 2 | 179 | 60 | 4 | |||
| Unilateral 3 | 185 | 90 | 3 | |||
Table 3
Summary of the results for all measures. Significant p value of less than 0.05 is indicated by *, p value of less than 0.01 is indicated by **.
| MEASURE | AVERAGE CHANGE ALL PARTICIPANTS | AVERAGE CHANGE BILATERAL | AVERAGE CHANGE UNILATERAL | STANDARD DEVIATION ALL PARTICIPANTS | P VALUE ALL PARTICIPANTS |
|---|---|---|---|---|---|
| ATRI | –45.3% | –64.1% | –32.8% | 21.9% | 0.02* |
| FTRI | –46.3% | –61.1% | –36.4% | 14.8% | 0.05* |
| Rate F0 | –30.0% | –36.8% | –25.6% | 22.5% | 0.03* |
| Extent Intensity | –50.1% | –66.8% | –38.9% | 23.0% | 0.03* |
| Rate Intensity | –34.8% | –45.8% | 27.5% | 18.9% | 0.02* |
| Extent F0 | –51.5% | –79.9% | –32.5% | 33.2% | 0.07 |
| VHI-10 | –20 | –33.0 | –11.3 | 14.7 | 0.04* |
| CSID Vowel | –71.4% | –115.5% | –41.9% | 54.5% | 0.10 |
| CSID Speech | –67.4% | –75.32% | –62.2% | 95.5% | 0.20 |
| CPP Vowel | +66.8% | +148.4% | +12.4% | 66.8% | 0.14 |
| CPP Speech | +86.1% | +211.4% | +2.5% | 125.0% | 0.20 |
| mTRS | –78.0% | –55.4% | –93.2% | 22.7% | 0.004** |
Figure 1
Summary of pre and post procedure scores for outcome measures with significant changes. All participants had a decrease in post operative score compared to baseline. Subjects with bilateral procedure had a greater average decrease than participants with unilateral procedure for all 3 measures. For statistical evaluation, please see Table 3.
Figure 2
Extent of F0 Modulation, rate of F0 modulation, extent intensity, and rate intensity preoperatively and postoperatively. All participants had improvement in values postoperatively for all four measures, with the exception of unilateral subject 3. This subject had worsening post operative values in the extent of F0 modulation parameter. For statistical evaluation, please see Table 3.
Figure 3
MTRS scores pre-operatively and post-operatively. All participants had a decrease in score postoperatively, indicating improvement. For statistical evaluation, please see Table 2.