Table 1
Comparison of participant’s characteristics.
| NOVO-PD N = 19 | PD N = 35 | ET N = 19 | CONTROLS N = 35 | P-VALUE | ||
|---|---|---|---|---|---|---|
| ON-STATE | OFF-STATE | |||||
| Males (%) | 13 (68) | 24 (69) | 22 (67) | 12 (63) | 11 (31) | 0.01 |
| Age (years)a | 66.9 (8.8) | 64.5 (9.1) | 64.1 (9.0) | 70.8 (6.7) | 61.4 (7.3) | 0.002 |
| Disease duration (years) | 1 (0.6; 3) | 10 (2; 25) | – | 7 (1; 29) | – | – |
| UPDRS-III score | 20 (8; 41) | 24 (5; 49) | 35 (12; 70) | – | – | 0.01 |
| NMSS total score | 42 (24; 86) | 69 (12; 119) | – | – | – | 0.08 |
| PDCRS total score | 74 (58; 112) | 80 (43; 109) | – | – | – | 0.91 |
[i] Values are expressed in medians (interquartile range) otherwise specified a = mean (Standard deviation). Parkinson’s disease (PD) (total sample = 35) measured in the ON state (ON-PD) (n = 35) and OFF state (OFF-PF), (n = 33); ET = Essential Tremor; UPDRS = Unified Parkinson’s disease Rating Scale; NMSS = Non motor symptoms severity score: PDCRS = Parkinson’s disease cognitive rating scale. Data were compared using the ANOVA test.
Table 2
Plasma α-synuclein quantitation (ng/ml) stratified by age and gender.
| GROUPS | α-SYNUCLEIN (ng/ml) MEAN ± SD | p-VALUE | α-SYNUCLEIN (ng/ml) MEAN ± SD | P-VALUE | ||
|---|---|---|---|---|---|---|
| MEN (n) | WOMEN (n) | <66 YEARS OLD (n) | ≥66 YEARS OLD (n) | |||
| CONTROL (1) | 158.40 ± 102.95 (11) | 177.12 ± 86.53 (24) | 0.57 | 174.81 ± 94.85 (25) | 162.32 ± 84.18 (10) | 0.71 |
| ON-PD (2) | 112.30 ± 56.63 (23) | 111.08 ± 40.45 (10) | 0.95 | 125.76 ± 56.77 (17) | 97.24 ± 42.45 (16) | 0.11 |
| OFF-PD (3) | 128.64 ± 46.37 (21) | 127.26 ± 29.16 (10) | 0.92 | 137.40 ± 43.43 (16) | 118.37 ± 37.40 (15) | 0.20 |
| NOVO-PD (4) | 91.92 ± 35.28 (13) | 131.25 ± 50.01 (6) | 0.06 | 90.21 ± 26.38 (7) | 112.58 ± 49.91 (12) | 0.21 |
| ET (5) | 79.74 ± 32.11 (12) | 143.73 ± 71.89 (6) | 0.08 | 54.33 ± 1.95 (2) | 106.92 ± 56.94 (16) | |
| Pairwise comparisons | (1) vs. (5)(2) vs. (4)(3) vs. (5) | (1) vs. (2)(1) vs. (3) | <0.05* | (1) vs. (2)(1) vs. (4)(3) vs. (4) | n.s | <0.05* |
[i] SD = Standard deviation. Age was stratified based on the median distribution of the total sample. * Pairwise intra-group comparisons as indicated in each column; n.s = not significant.