Table 1
International Restless Legs Syndrome Study Group Consensus Diagnostic Criteria for RLS
| 1) An urge to move the legs usually but not always accompanied by, or felt to be caused by, uncomfortable and unpleasant sensations in the legs. |
| 2) The urge to move the legs and any accompanying unpleasant sensations begin or worsen during periods of rest or inactivity such as lying down or sitting. |
| 3) The urge to move the legs and any accompanying unpleasant sensations are partially or totally relieved by movement, such as walking or stretching, at least as long as the activity continues. |
| 4) The urge to move the legs and any accompanying unpleasant sensations during rest or inactivity only occur or are worse in the evening or night rather than during the day. |
| 5) The occurrence of the above features is not solely accounted for as symptoms primary to another medical or behavioral condition (e.g., myalgia, venous stasis, leg edema, arthritis, leg cramps, positional discomfort, habitual foot tapping). |
| A. Chronic-persistent RLS/WED: symptoms when not treated would occur on average at least twice weekly for the past year. |
| B. Intermittent RLS/WED: symptoms when not treated would occur on average |
[i] Abbreviations: RLS, Restless Legs Syndrome; WED, Willis Ekbom Disease.
Table 2
Similarities between Restless Legs Syndrome and Periodic Limb Movements during Sleep
| Restless Legs Syndrome | Periodic Limb Movements During Sleep | |
|---|---|---|
| Pathophysiology | ||
| Pharmacology | ||
| Genetics | ||
| Epidemiology |
|
|
[i] Abbreviations: MAP2KD, Mitogen-Activated Protein Kinase Kinase 5; PLMS, Periodic Limb Movements during Sleep; PTPRD, Protein Tyrosine Phosphatase Receptor Type D; RLS, Restless Legs Syndrome.
