Brittle Dyskinesia Following STN but not GPi Deep Brain Stimulation

Ashok Sriram; Kelly D. Foote; Genko Oyama; Joshua Kwak; Pam R. Zeilman; Michael S. Okun

doi:10.5334/tohm.183

Figures & Tables

Table 1

DBS Lead Locations for Active Contacts

Patient	DBS Lead	y	x	z
Case 1	Left STN	−1.30	−12.6	−4.35
	Right STN	−0.40	11.16	−0.30
	Left GPi	4.28	−20.7	−1.40
	Right GPi	7.45	23.07	−1.23
Case 2	Left STN	0.81	−12.3	−1.48
Case 2	Right STN	−0.23	13.8	−0.92
Case 3	Left STN	−1.69	−11.9	2.83
Case 3	Right STN	−0.20	11.58	1.91
Case 4	Left STN	−2.98	−12.3	−1.27
Case 4	Right STN	0.13	9.69	−3.45

[i] DBS, Deep Brain stimulation; GPi, globus pallidus internus; STN, subthalamic nucleus.

[ii] A summary of the location of the active STN DBS contact(s) with respect to mid-commissural point in antero-posterior (y), lateral (x), and axial (z) plane measured in millimeters from a postoperative computed tomography–magnetic resonance imaging fusion.

Table 2

Preoperative and Postoperative UPDRS Motor Scores. GPi represents the UPDRS scores with the added bilateral GPi DBS leads (all four activated)

	Preoperative off-medication	Preoperative on-medication	Postoperative off-medication and on DBS	Postoperative on-medication and on DBS
Patient 1	45 (43 GPi)	31 (35 GPi)	39 (34 GPi)	25 (29 GPi)
Patient 2	52	40	44	34
Patient 3	46	15	25	14
Patient 4	40	20	N/A	N/A

[i] DBS, Deep Brain stimulation; GPi, globus pallidus internus; STN, subthalamic nucleus; UPDRS, Universal Parkinson's Disease Rating Scale.