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Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor Cover

Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor

Open Access
|Jan 2026

References

  1. Lin PT, Ross EK, Chidester P, et al. Noninvasive neuromodulation in essential tremor demonstrates relief in a sham-controlled pilot trial: Neuromodulation for Essential Tremor. Mov Disord. 2018;33(7):11821183. DOI: 10.1002/mds.27350
  2. Pahwa R, Dhall R, Ostrem J, et al. An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor. Neuromodulation. 2019;22(5):537545. DOI: 10.1111/ner.12930
  3. Dai D, Fernandes J, Kim H, Coetzer H. Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial. Tremor Other Hyperkinet Mov (N Y). 2023;13(1):38. DOI: 10.5334/tohm.798
  4. Ondo WG, Lv W, Zhu X, et al. Transcutaneous Peripheral Nerve Stimulation for Essential Tremor. JAMA Neurol. Published online October 20, 2025. DOI: 10.1001/jamaneurol.2025.3905
  5. Isaacson SH, Peckham E, Tse W, et al. Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2020;10(0):29. DOI: 10.5334/tohm.59
  6. Dewey R, Isaacson S, Dewey R, et al. A Pilot Study of AI-Controlled Transcutaneous Peripheral Nerve Stimulation for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2025;15(1):10. DOI: 10.5334/tohm.991
  7. Brillman S, Colletta K, Borucki S, et al. Real-World Evidence of Transcutaneous Afferent Patterned Stimulation for Essential Tremor. Tremor Other Hyperkinet Mov (N Y). 2022;12(1):27. DOI: 10.5334/tohm.715
  8. Lu C, Khosla D, Kent A, Bronte-Stewart H, Rosenbluth K. Transcutaneous Afferent Patterned Stimulation for Essential Tremor: Real-World Evidence with Long Term Follow-Up. Tremor Other Hyperkinet Mov (N Y). 2023;13(1):113. DOI: 10.5334/tohm.775
  9. Dai D, Fernandes J, Samuel L, Lu C, Reitmaier S, Berk A. Transcutaneous Afferent Patterned Stimulation Therapy Provides Tremor Relief and Reduces Healthcare Costs in Patients with Essential Tremor (P1-5.001). Neurology. 2025;104(7_Supplement_1):1549. DOI: 10.1212/WNL.0000000000208604
  10. Barath AS, Rusheen AE, Min HK, et al. Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects. Tremor Other Hyperkinet Mov (N Y). 2020;10(0):52. DOI: 10.5334/tohm.565
  11. Luu CP, Ranum J, Youn Y, et al. Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation. Brain Stimulation. 2025;18(4):11621173. DOI: 10.1016/j.brs.2025.06.004
  12. Pascual-Valdunciel A, Rajagopal A, Pons JL, Delp S. Non-invasive electrical stimulation of peripheral nerves for the management of tremor. Journal of the Neurological Sciences. 2022;435:120195. DOI: 10.1016/j.jns.2022.120195
  13. Yu JY, Rajagopal A, Syrkin-Nikolau J, et al. Transcutaneous Afferent Patterned Stimulation Therapy Reduces Hand Tremor for One Hour in Essential Tremor Patients. Front Neurosci. 2020;14:530300. DOI: 10.3389/fnins.2020.530300
  14. Isaacson SH, Pahwa R, Brillman S, Lu C, Kent AR. Clinical benefit of transcutaneous afferent patterned stimulation (TAPS) in essential tremor patients with high unmet need: a secondary analysis of TAPS studies. Expert Review of Medical Devices. Published online October 25, 2023:18. DOI: 10.1080/17434440.2023.2274604
  15. Adabi K, Ondo WG. Shaking Up Essential Tremor: Peripheral Devices and Mechanical Strategies to Reduce Tremor. Tremor Other Hyperkinet Mov (N Y). 2024;14(1):55. DOI: 10.5334/tohm.930
  16. Ondo W, Lv W, Zhu X, et al. TRANQUIL: Pivotal study of the Felix NeuroAI Wristband in patients with essential tremor. Parkinsonism Relat Disord. 2025;134:107452. DOI: 10.1016/j.parkreldis.2025.107452
  17. Nahab FB, Kim HB, Nekkanti S, et al. Safety and Efficacy of a Wrist-Worn Vibratory Wearable for Upper Limb Tremor Reduction in ET (ULTRE): A Randomized, Controlled Trial. Parkinsonism Relat Disord. 2025;134:107456. DOI: 10.1016/j.parkreldis.2025.107456
  18. Elble RJ. The Essential Tremor Rating Assessment Scale. Journal of Neurology & Neuromedicine. Published online 2016. DOI: 10.29245/2572.942X/2016/4.1038
  19. Bain PG, Findley LJ, Atchison P, et al. Assessing tremor severity. J Neurol Neurosurg Psychiatry. 1993;56(8):868873. DOI: 10.1136/jnnp.56.8.868
  20. LCDExternal Upper Limb Tremor Stimulator Therapy (L39591). https://www.cms.gov/medicare-coverage-database/view/lcd.aspx?lcdId=39591
  21. Louis ED. The Essential Tremors: Evolving Concepts of a Family of Diseases. Front Neurol. 2021;12:650601. DOI: 10.3389/fneur.2021.650601
DOI: https://doi.org/10.5334/tohm.1091 | Journal eISSN: 2160-8288
Language: English
Submitted on: Sep 13, 2025
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Accepted on: Dec 23, 2025
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Published on: Jan 9, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Stuart H. Isaacson, Elizabeth Peckham, Winona Tse, Melita T. Petrossian, Michael J. Soileau, Mark Lew, Cameron Dietiker, Nijee Luthra, Pinky Agarwal, Rohit Dhall, John Morgan, Ejaz A. Shamim, Holly A. Shill, Fernando L. Pagan, Pravin Khemani, Jessica Tate, Lan Luo, William Ondo, Mark Hallett, Chiahao Lu, Kathryn H. Rosenbluth, Scott L. Delp, Rajesh Pahwa, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.