Figure 1
(A) Average BF-ADL dominant hand score (left, scale range 8 to 32) and TETRAS dominant hand score (right, scale range 0–24) are shown pre- and post-stimulation conducted at each in-clinic visit. Analysis of underlying tremor response (changes in BF-ADL and TETRAS scores) demonstrated that TAPS significantly improved underlying tremor severity, as measured by the pre-stimulation assessment, as well as providing tremor improvement post-stimulation as previously reported [5]. The origin of 16 (BF-ADL) and 12 (TETRAS) reflects an average score of 2 (i.e., ‘mild’) per task. Error bars represent ±1 SE and * indicates p < 0.001. (B) The percentage of patients who improved from pre-stimulation at enrollment are shown for both 1-month and 3-month visits. Analysis of the responder rate demonstrated that over 80% of patients demonstrated underlying tremor improvement as measured pre-stimulation and at least 90% improved post-stimulation.
Table 1
Pre-Stimulation Tremor Improvement by TAPS Usage at 1-Month and 3-Month Visits.
| FOLLOW-UP TIME | USAGEa | N | AVERAGE DAILY USAGE | TOTAL SCORE IMPROVEMENT (PRE-STIM) | RESPONDER RATE | ||
|---|---|---|---|---|---|---|---|
| BF-ADL | TETRAS | BF-ADL | TETRAS | ||||
| 1-Month | High | 154 | 1.8 ± 0.0 | 2.2 ± 0.3 | 0.8 ± 0.2 | 85.1% | 80.5% |
| Low | 38 | 1.0 ± 0.1 | 1.4 ± 0.6 | 0.8 ± 0.4 | 81.6% | 84.2% | |
| 3-Month | High | 140 | 1.8 ± 0.0 | 2.7 ± 0.3 | 1.0 ± 0.2 | 86.4% | 83.6% |
| Low | 52 | 1.1 ± 0.0 | 2.7 ± 0.6 | 0.3 ± 0.4 | 82.7% | 78.9% | |
[i] Note: Descriptive statistics are reported in mean ± SE or percentages.
aHigh usage defined as use above the average number of daily sessions (i.e., 1.4 sessions per day) before the visit; low usage defined as below-average daily session use before the visit.