1LouisED, McCrearyM. How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor. Tremor and Other Hyperkinetic Movements. 2021Jul9;11(1):28. DOI: 10.5334/tohm.632
2BhatiaKP, BainP, BajajN, ElbleRJ, HallettM, LouisED, et al. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Movement Disorders. 2018Jan;33(1):75–87. DOI: 10.1002/mds.27121
4LouisED, RiosE, HenchcliffeC. How are we doing with the treatment of essential tremor (ET)?: Persistence of patients with ET on medication: data from 528 patients in three settings. Euro J of Neurology. 2010Jun;17(6):882–4. DOI: 10.1111/j.1468-1331.2009.02926.x
5Santos de AlencarS, CrippaJAS, BritoMCM, PimentelÂV, Cecilio HallakJE, TumasV. A single oral dose of cannabidiol did not reduce upper limb tremor in patients with essential tremor. Parkinsonism & Related Disorders. 2021Feb;83:37–40. DOI: 10.1016/j.parkreldis.2021.01.001
6NasreddineZS, PhillipsNA, BédirianV, CharbonneauS, WhiteheadV, CollinI, et al. Montreal Cognitive Assessment [Internet]. American Psychological Association; 2014 [cited 2023 Mar 29]. Available from: http://doi.apa.org/getdoi.cfm?doi=10.1037/t27279-000.
9JohnsonJR, Burnell-NugentM, LossignolD, Ganae-MotanED, PottsR, FallonMT. Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain. Journal of Pain and Symptom Management. 2010Feb;39(2):167–79. DOI: 10.1016/j.jpainsymman.2009.06.008
10PortenoyRK, Ganae-MotanED, AllendeS, YanagiharaR, ShaiovaL, WeinsteinS, et al. Nabiximols for Opioid-Treated Cancer Patients With Poorly-Controlled Chronic Pain: A Randomized, Placebo-Controlled, Graded-Dose Trial. The Journal of Pain. 2012May;13(5):438–49. DOI: 10.1016/j.jpain.2012.01.003
11LangfordRM, MaresJ, NovotnaA, VachovaM, NovakovaI, NotcuttW, et al. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. J Neurol. 2013Apr;260(4):984–97. DOI: 10.1007/s00415-012-6739-4
13TaylorL, GidalB, BlakeyG, TayoB, MorrisonG. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects. CNS Drugs. 2018Nov;32(11):1053–67. DOI: 10.1007/s40263-018-0578-5
14SilmoreLH, WillmerAR, CapparelliEV, RosaniaGR. Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies. Pharmacotherapy. 2021Apr;41(4):405–20. DOI: 10.1002/phar.2512
15MillarSA, StoneNL, YatesAS, O’SullivanSE. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Front Pharmacol. 2018Nov26;9:1365. DOI: 10.3389/fphar.2018.01365
16HaubenbergerD, KalowitzD, NahabFB, ToroC, IppolitoD, LuckenbaughDA, et al. Validation of digital spiral analysis as outcome parameter for clinical trials in essential tremor. Mov Disord. 2011Sep;26(11):2073–80. DOI: 10.1002/mds.23808
17LongardnerK, ShenQ, TangB, WrightBA, KunduP, NahabFB. An Algorithm for Automated Measurement of Kinetic Tremor Magnitude Using Digital Spiral Drawings. Digit Biomark. 2024;8(1):140–8. DOI: 10.1159/000539529
18GuyW. ECDEU assessment manual for psychopharmacology. US Department of Health, Education, and Welfare, Public Health Service …; 1976. DOI: 10.1037/e591322011-001
19BaschE, ReeveBB, MitchellSA, ClauserSB, MinasianLM, DueckAC, et al. Development of the National Cancer Institute’s Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). JNCI Journal of the National Cancer Institute. 2014 Sep 29;106(9):dju244–dju244. DOI: 10.1093/jnci/dju244
20PosnerK, BrownGK, StanleyB, BrentDA, YershovaKV, OquendoMA, et al. The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults. AJP. 2011Dec;168(12):1266–77. DOI: 10.1176/appi.ajp.2011.10111704
21HubbardJA, SmithBE, SoboleskyPM, KimS, HoffmanMA, StoneJ, et al. Validation of a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to detect cannabinoids in whole blood and breath. Clinical Chemistry and Laboratory Medicine (CCLM). 2020Apr28;58(5):673–81. DOI: 10.1515/cclm-2019-0600
22PacherP, SteffensS, HaskóG, SchindlerTH, KunosG. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly. Nat Rev Cardiol. 2018Mar;15(3):151–66. DOI: 10.1038/nrcardio.2017.130
23EllisRJ, ToperoffW, VaidaF, van den BrandeG, GonzalesJ, GouauxB, et al. Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology. 2009Feb;34(3):672–80. DOI: 10.1038/npp.2008.120
24BenjaminiY, HochbergY. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal statistical society: series B (Methodological). 1995;57(1):289–300. DOI: 10.1111/j.2517-6161.1995.tb02031.x
28GuyGW, RobsonPJ. A Phase I, Open Label, Four-Way Crossover Study to Compare the Pharmacokinetic Profiles of a Single Dose of 20 mg of a Cannabis Based Medicine Extract (CBME) Administered on 3 Different Areas of the Buccal Mucosa and to Investigate the Pharmacokinetics of CBME per Oral in Healthy Male and Female Volunteers (GWPK0112). Journal of Cannabis Therapeutics. 2004Jan29;3(4):79–120. DOI: 10.1300/J175v03n04_01
29PressmanP, HayesAW, HoengJ, LatinoDA, MazurovA, SchlageWK, et al. Δ9-Tetrahydrocannabinol (THC): a critical overview of recent clinical trials and suggested guidelines for future research. Journal of Clinical Medicine. 2024;13(6):1540. DOI: 10.3390/jcm13061540
30PatricianA, Versic-BratincevicM, MijacikaT, BanicI, MarendicM, SutlovićD, et al. Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study. Adv Ther. 2019Nov;36(11):3196–210. DOI: 10.1007/s12325-019-01074-6