Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease May Benefit from GPi Deep Brain Stimulation: A Case Report
Abstract
Background: Dyskinesia-hyperpyrexia syndrome (DHS) is a rare but life-threatening complication in Parkinson’s disease (PD). Its prevention and treatment are clinical challenges.
Case report: We herein present a case of a female PD patient who experienced recurrent episodes of DHS and levodopa-induced dyskinesia. The complications were alleviated after bilateral globus pallidus internus (GPi) deep brain stimulation (DBS).
Discussion: Our report provides evidence that GPi DBS may reduce the susceptibility to DHS. More evidences are warranted to validate this hypothesis.
© 2025 Shi-Shi Huang, Lu-Lu Ma, Han-Song Sheng, Rong-Pei Liu, Shi-Guo Zhu, Shan-Shan Xu, Mei-Ling Sheng, Zhu-Ling Chen, Nu Zhang, Xiong Zhang, Jian-Yong Wang, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.