Skip to main content
Have a personal or library account? Click to login
Teaching Personalized Doctor-Patient Communication with AI: PerTRAIN – a Prototype for Interpersonally Responsive Virtual Patients in Medical Education Cover

Teaching Personalized Doctor-Patient Communication with AI: PerTRAIN – a Prototype for Interpersonally Responsive Virtual Patients in Medical Education

Open Access
|May 2026

Figures & Tables

Figure 1

A Circumplex adapted from Wiggins 1982, visualization of four prototypical patient profiles aligned with the extremes of the underlying scale. Pictures of Patients were AI-generated using GPT-5 B Illustration of continuing state changes depending on conversation.

Table 1

Exemplary overview of General Communication and Challenges, Identifying the Problem, and Compliance for the four different basic state combinations.

GENERAL COMMUNICATION AND CHALLENGES
SP PERSONALITY COMBINATIONCOMMUNICATIONPROFESSIONAL CHALLENGE
Agency high, Communion high (dominant & friendly)Open, cooperative, but with clear expectations and straight communicationMaintain a balance between participation and medical guidance – do not allow yourself to be overruled by the “friendly expert” in the patient
Agency high, Communion low (dominant & cold/confrontative)Directive, critical, suspicious, possibly aggressiveConversations can quickly become confrontational; high risk of resistance or escalation
Agency low, Communion high (submissive & friendly)Calm, polite, avoids confrontation, rarely addresses problems on his own initiativeConversation seems harmonious, but there is a risk of false compliance; important issues remain unsaid
Agency low, Communion low (passive & cold)Short-tempered, defensive, reserved, deflectingDifficult to access, high risk of conversation breakdown or avoidance of important topics
IDENTIFYING THE PROBLEM
COMBINATION (AGENCY/COMMUNION)COMMUNICATION PATHPROFESSIONAL NEEDS
high/highPatient actively names symptoms, even embarrassing ones, but selectively and with a focus on solutionsAsk specific questions, verify priorities and psychological stress to identify blind spots
high/lowPatient selectively brings up topics, is skeptical about medical questions, avoids weaknessesFocusing on facts and emphasizing benefits is required
low/highReveals little, but responds openly when asked; requires active explorationGentle, structured questioning of potential problems is necessary to uncover hidden issues (such as ED)
low/lowRarely gives information voluntarily, avoids contact and opennessLaborious, requires a high degree of structure, patience, and dominant conversation steering
COMPLIANCE
COMBINATION (AGENCY/COMMUNION)ASSUMED COMPLIANCESPECIFICS
high/highHigh, if convinced, wants to have a say, feels responsibleShared decision-making is crucial; clear professional communication is necessary
high/lowLow, questions authority, makes their own decisionsCompliance often only occurs with self-motivation – highlight personal goals
low/highModerate, happy to cooperate, but without real convictionOften does not understand the reason, does things “because the doctor says so” – education and participation are important
low/lowLow – avoids, forgets, or ignores therapyRequires structured follow-up care, continuous motivation, relationship building
Figure 2

Screenshot of the browser-based application, showing a chat with a sample patient. Shown is the exemplary start of the conversation with Mr. P. Engel.

AIArtificial Intelligence
CIITContemporary Integrative Interpersonal Theory
DEGAMGerman Society for General Medicine and Family Medicine (German: Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin)
IPCInterpersonal Circumplex
LLMLarge Language Models
PerTRAINPersonalization Training in Medicine
SBLSimulation-based learning
SPsSimulated Patients
DOI: https://doi.org/10.5334/pme.2379 | Journal eISSN: 2212-277X
Language: English
Page range: 465 - 474
Submitted on: Jan 5, 2026
Accepted on: Feb 3, 2026
Published on: May 29, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2026 Anna Junga, Ole Hätscher, Jennifer Dabel, Gabriyel Mado, Alberta Ajani, Leon Pielage, Pascal Kockwelp, Simon M. Breil, Helena Baur, Jan Siebenbrock, Benjamin Risse, Tanja Grammer, Bernhard Marschall, Mitja D. Back, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.