Figure 1
Circadian variations of blood pressure (A), heart period (B) and baroreflex sensitivity (C) in 1K-1C arterial hypertension and sham-operated (SO) rats.
Table 1
Circadian profile of endothelin-1, epoxyeicosatrienoic acids (EETs) and calcitonin generelated peptide (CGRP) in plasma of rats with 1K-1C model of arterial hypertension (1K-1C AH).
| Hours | Endothelin-1, fmol/ml | EETs, ng/ml | CGRP, pg/ml | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SO | 1K-1C AH, week | SO | 1K-1C AH, week | SO | 1K-1C AH, week | ||||
| 4 | 8 | 4 | 8 | 4 | 8 | ||||
| 8:00 | 1.0 ± 0.2 | 2.0 ± 0.2*** | 3.5 ± 0.2***### | 15.2 ± 0.6 | 12.1 ± 1.6** | 10.0 ± 0.8***## | 68.6 ± 3.5 | 61.4 ± 3.4* | 52.4 ± 2.9***### |
| 12:00 | 1.4 ± 0.2 | 2.2 ± 0.2** | 3.0 ± 0.4***## | 15.6 ± 1.0 | 13.5 ± 1.2* | 10.6 ± 0.7***# | 69.0 ± 4.6 | 58.0 ± 3.6** | 48.8 ± 2.5**### |
| 16:00 | 1.9 ± 0.2 | 1.6 ± 0.2 | 2.8 ± 0.4**### | 17.4 ± 1.5 | 14.9 ± 0.9* | 11.6 ± 0.5**### | 72.8 ± 5.4 | 54.2 ± 3.2*** | 45.2 ± 3.4***# |
| 20:00 | l.8 ± 0.2 | 3.2 ± 0.3*** | 4.2 ± 0.25***## | 18.0 ± 1.2 | 12.5 ± 0.8*** | 9.5 ± 0.4***## | 76.0 ± 6.5 | 52.5 ± 3.8*** | 44.0 ± 3.2***# |
| 24:00 | 1.6 ± 0.3 | 3.4 ± 0.3*** | 4.8 ± 0.4***## | 18.6 ± 1.8 | 11.8 ± 1.0*** | 8.2 ± 0.6***### | 80.4 ± 8.2 | 50.2 ± 2.8*** | 41.8 ± 2.0***## |
| Mean | 1.54 ± 0.22 | 2.5 ± 0.2*** | 3.7 ± 0.3***### | 17.0 ± 1.2 | 13.0 ± 1.0*** | 10.6 ± 0.6***# | 73.4 ± 5.6 | 55.3 ± 3.0 | 46.4 ± 2.6## |
[i] Note: Significance of difference of comparison: * – with SO group, # – with 1K-1C AH 4-weeks group; one symbol – p < 0.05, two – p < 0.01, three – p < 0.001.