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Quality of Life Assessment in Heart Failure Patients: Insights from a Low- to Middle-Income Country Cover

Quality of Life Assessment in Heart Failure Patients: Insights from a Low- to Middle-Income Country

Global Heart
Volume 21 (2026): Issue 1
By: Muhammad Nauman Khan,  Najia Aslam Soomro,  Muhammad Navaid Iqbal,  Rubina Rauf,  Hina Sohail and  Khalid Naseeb  
Open Access
|Mar 2026

References

  1. Johansson I, Joseph P, Balasubramanian K, McMurray JJ, Lund LH, Ezekowitz JA, Kamath D, Alhabib K, Bayes-Genis A, Budaj A, Dans AL. Health-related quality of life and mortality in heart failure: the global congestive heart failure study of 23 000 patients from 40 countries. Circulation. 2021;143(22):2129–2142. DOI: 10.1161/CIRCULATIONAHA.120.050850
    Open DOISearch in Google ScholarBack to article
  2. Garin O, Herdman M, Vilagut G, Ferrer M, Ribera A, Rajmil L, Valderas JM, Guillemin F, Revicki D, Alonso J. Assessing health-related quality of life in patients with heart failure: a systematic, standardized comparison of available measures. Heart Failure Reviews. 2014;19(3):359–367. DOI: 10.1007/s10741-013-9394-7
    Open DOISearch in Google ScholarBack to article
  3. Jaarsma T, Beattie JM, Ryder M, Rutten FH, McDonagh T, Mohacsi P, Murray SA, Grodzicki T, Bergh I, Metra M, Ekman I. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure. 2009;11(5):433–443. DOI: 10.1093/eurjhf/hfp041
    Open DOISearch in Google ScholarBack to article
  4. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2016;18(8):891–975. DOI: 10.1093/eurheartj/ehw128
    Open DOISearch in Google ScholarBack to article
  5. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16):1810–52. DOI: 10.1161/CIR.0b013e31829e8807
    Open DOISearch in Google ScholarBack to article
  6. Spertus JA. Evolving applications for patient-centered health status measures. Circulation. 2008;118(20):2103–2110. DOI: 10.1161/CIRCULATIONAHA.107.747568
    Open DOISearch in Google ScholarBack to article
  7. Spertus JA, Jones PG. Development and validation of a short version of the Kansas City Cardiomyopathy Questionnaire. Circulation: Cardiovascular Quality and Outcomes. 2015;(5):469–476. DOI: 10.1161/CIRCOUTCOMES.115.001958
    Open DOISearch in Google ScholarBack to article
  8. Zamora E, González B, Lupón J, Borrellas A, Domingo M, Santiago-Vacas E, Cediel G, Codina P, Rivas C, Pulido A, Crespo E. Quality of life in patients with heart failure and improved ejection fraction: One-year changes and prognosis. ESC Heart Failure. 2022;9(6):3804–3813. DOI: 10.1002/ehf2.14098
    Open DOISearch in Google ScholarBack to article
  9. Jaarsma T, Johansson P, Ågren S, Strömberg A. Quality of life and symptoms of depression in advanced heart failure patients and their partners. Current Opinion in Supportive and Palliative Care. 2010;4(4):233–237. DOI: 10.1097/SPC.0b013e328340744d
    Open DOISearch in Google ScholarBack to article
  10. Voils CI, Maciejewski ML, Hoyle RH, Reeve BB, Gallagher P, Bryson CL, Yancy WS Jr. Initial validation of a self-report measure of the extent of and reasons for medication nonadherence. Med Care. 2012;50(12):1013–9. DOI: 10.1097/MLR.0b013e318269e121
    Open DOISearch in Google ScholarBack to article
  11. Ekman I, Chassany O, Komajda M, Böhm M, Borer JS, Ford I, Tavazzi L, Swedberg K. Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: Results from the SHIFT study. Eur Heart J. 2011;32:2395–2404. DOI: 10.1093/eurheartj/ehr343
    Open DOISearch in Google ScholarBack to article
  12. McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O’Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM, DAPA-HF Trial Committees and Investigators. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381:1995–2008. DOI: 10.1056/NEJMoa1911303
    Open DOISearch in Google ScholarBack to article
  13. Gastelurrutia P, Lupón J, Moliner P, Yang X, Cediel G, de Antonio M, Domingo M, Altimir S, González B, Rodríguez M, Rivas C, Díaz V, Fung E, Zamora E, Santesmases J, Núñez J, Woo J, Bayes-Genis A. Comorbidities, fragility, and quality of life in heart failure patients with midrange ejection fraction. Mayo Clin Proc Innov Qual Outcomes. 2018;2:176–185. DOI: 10.1016/j.mayocpiqo.2018.02.004
    Open DOISearch in Google ScholarBack to article
  14. Roy B, Wolf JR, Carlson MD, Akkermans R, Bart B, Batalden P, Johnson JK, Wollersheim H, Hesselink G. An international comparison of factors affecting quality of life among patients with congestive heart failure: A cross-sectional study. PloS One. 2020:15(4):e0231346. DOI: 10.1371/journal.pone.0231346
    Open DOISearch in Google ScholarBack to article
  15. Gallagher AM, Lucas R, Cowie MR. Assessing health-related quality of life in heart failure patients attending an outpatient clinic: a pragmatic approach. ESC Heart Failure. 2019;6(1):3–9. DOI: 10.1002/ehf2.12363
    Open DOISearch in Google ScholarBack to article
  16. Ewnetu Tarekegn G, Derseh Gezie L, Yemanu Birhan T, Ewnetu F. Health-related quality of life among heart failure patients attending an outpatient clinic in the University of Gondar Comprehensive Specialized Hospital Northwest, Ethiopia, 2020: using structural equation modeling approach. Patient Related Outcome Measures. 2021;12:279–90. DOI: 10.2147/PROM.S322421
    Open DOISearch in Google ScholarBack to article
  17. Zhang J, Gilmour S, Liu Y, Ota E. Effect of health literacy on quality of life among patients with chronic heart failure in China. Quality of Life Research. 2020;29:453–61. DOI: 10.1007/s11136-019-02332-4
    Open DOISearch in Google ScholarBack to article
  18. Abdi A, Doulatyari PK, Mahmodi M, Torabi Y. Relationship of spiritual wellbeing with life expectancy and quality of life for patients living with heart failure. International Journal of Palliative Nursing. 2022;28(6):262–9. DOI: 10.12968/ijpn.2022.28.6.262
    Open DOISearch in Google ScholarBack to article
  19. Kyriakou M, Middleton N, Ktisti S, Philippou K, Lambrinou E. Supportive care interventions to promote health-related quality of life in patients living with heart failure: a systematic review and meta-analysis. Heart, Lung and Circulation. 2020;29(11):1633–47. DOI: 10.1016/j.hlc.2020.04.019
    Open DOISearch in Google ScholarBack to article
  20. Peng X, Su Y, Hu Z, Sun X, Li X, Dolansky MA, Qu M, Hu X. Home-based telehealth exercise training program in Chinese patients with heart failure: a randomized controlled trial. Medicine. 2018;97(35):e12069. DOI: 10.1097/MD.0000000000012069
    Open DOISearch in Google ScholarBack to article
  21. Paz LF, Medeiros CD, Martins SM, Bezerra SM, Oliveira WD, Silva MB. Qualidade de vida relacionada à saúde em pacientes com insuficiência cardíaca. Revista Brasileira de Enfermagem. 2018;72:140–6. DOI: 10.1590/0034-7167-2018-0368
    Open DOISearch in Google ScholarBack to article
  22. Bernocchi P, Vitacca M, La Rovere MT, Volterrani M, Galli T, Baratti D, Paneroni M, Campolongo G, Sposato B, Scalvini S. Home-based telerehabilitation in older patients with chronic obstructive pulmonary disease and heart failure: a randomised controlled trial. Age and Ageing. 2018;47(1):82–8. DOI: 10.1093/ageing/afx146
    Open DOISearch in Google ScholarBack to article
  23. McMahon SR, Ades PA, Thompson PD. The role of cardiac rehabilitation in patients with heart disease. Trends in Cardiovascular Medicine. 2017;27(6):420–5. DOI: 10.1016/j.tcm.2017.02.005
    Open DOISearch in Google ScholarBack to article
  24. Reddy YN, Rikhi A, Obokata M, Shah SJ, Lewis GD, AbouEzzedine OF, Dunlay S, McNulty S, Chakraborty H, Stevenson LW, Redfield MM. Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity. European Journal of Heart Failure. 2020;22(6):1009–18. DOI: 10.1002/ejhf.1788
    Open DOISearch in Google ScholarBack to article
  25. Ly R, Karsenty C, Amedro P, Cohen S, Domanski O, Godart F, Radojevic J, Vaksmann G, Naccache N, Boubrit A, Bataille V. Health-Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH-ACHD Registry. Journal of the American Heart Association. 2023;12(8):e027819. DOI: 10.1161/JAHA.122.027819
    Open DOISearch in Google ScholarBack to article
  26. Wohlfahrt P, Nativi-Nicolau J, Zhang M, Selzman CH, Greene T, Conte J, Biber JE, Hess R, Mondesir FL, Wever-Pinzon O, Drakos SG. Quality of life in patients with heart failure with recovered ejection fraction. JAMA Cardiology. 2021;6(8):957–62. DOI: 10.1001/jamacardio.2021.0939
    Open DOISearch in Google ScholarBack to article
  27. Pokharel Y, Khariton Y, Tang Y, Nassif ME, Chan PS, Arnold SV, Jones PG, Spertus JA. Association of serial Kansas City Cardiomyopathy Questionnaire assessments with death and hospitalization in patients with heart failure with preserved and reduced ejection fraction: a secondary analysis of 2 randomized clinical trials. JAMA Cardiology. 2017;2(12):1315–21. DOI: 10.1001/jamacardio.2017.3983
    Open DOISearch in Google ScholarBack to article
  28. Opotowsky AR, Rhodes J, Landzberg MJ, Bhatt AB, Shafer KM, Yeh DD, Crouter SE, Tikkanen AU. A randomized trial comparing cardiac rehabilitation to standard of care for adults with congenital heart disease. World J Pediatr Congenit Heart Surg. 2018;9:185–193. DOI: 10.1177/2150135117752123
    Open DOISearch in Google ScholarBack to article
  29. Jani BD, Mair FS, Roger VL, Weston SA, Jiang R, Chamberlain AM. Comorbid depression and heart failure: a community cohort study. PLoS One. 2016;11:e0158570. DOI: 10.1371/journal.pone.0158570
    Open DOISearch in Google ScholarBack to article
  30. Kovacs AH, Saidi AS, Kuhl EA, Sears SF, Silversides C, Harrison JL, Ong L, Colman J, Oechslin E, Nolan RP. Depression and anxiety in adult congenital heart disease: predictors and prevalence. Int J Cardiol. 2009;137:158–164. DOI: 10.1016/j.ijcard.2008.06.042
    Open DOISearch in Google ScholarBack to article
  31. Taylor RS, Dalal HM, McDonagh ST. The role of cardiac rehabilitation in improving cardiovascular outcomes. Nat Rev Cardiol. 2022;19:180–94. DOI: 10.1038/s41569-021-00611-7
    Open DOISearch in Google ScholarBack to article
DOI: https://doi.org/10.5334/gh.1538 | Journal eISSN: 2211-8179
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Language: English
Submitted on: Oct 30, 2025
|
Accepted on: Feb 25, 2026
|
Published on: Mar 17, 2026
Published by: Ubiquity Press
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
heart failure,
quality of life,
KCCQ-12,
medication non-adherence

© 2026 Muhammad Nauman Khan, Najia Aslam Soomro, Muhammad Navaid Iqbal, Rubina Rauf, Hina Sohail, Khalid Naseeb, published by Ubiquity Press
This work is licensed under the Creative Commons Attribution 4.0 License.

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