References
- 1Jager KJ, Fraser S. The ascending rank of chronic kidney disease in the global burden of disease study. Nephrology Dialysis Transplantation. 2017; 32(suppl_2):ii121–ii128. DOI: 10.1093/ndt/gfw330
- 2Tonelli M, Muntner P, Lloyd A, Manns BJ, Klarenbach S, Pannu N, et al. Risk of coronary events in people with chronic kidney disease compared with those with diabetes: A population-level cohort study. Lancet. 2012; 380(9844):807–814. DOI: 10.1016/S0140-6736(12)60572-8
- 3Pedrinelli R, Giampietro O, Carmassi F, Melillo E, Dell’Omo G, Catapano G, et al. Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet. 1994; 344(8914):14–18. DOI: 10.1016/S0140-6736(94)91047-2
- 4Paoletti E, De Nicola L, Gabbai FB, Chiodini P, Ravera M, Pieracci L, et al. Associations of left ventricular hypertrophy and geometry with adverse outcomes in patients with CKD and hypertension. Clinical Journal of the American Society of Nephrology. 2016; 11(2):271–279. DOI: 10.2215/CJN.06980615
- 5Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA. 2017; 318(19):1925–1926. DOI: 10.1001/jama.2017.17219
- 6Levin MG, Burgess S. Mendelian randomization as a tool for cardiovascular research: A review. JAMA Cardiology. 2024; 9(1):79–89. DOI: 10.1001/jamacardio.2023.4115
- 7Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. International Journal of Epidemiology. 2011; 40(3):755–764. DOI: 10.1093/ije/dyr036
- 8Bowden J, Del GMF, Minelli C, Davey SG, Sheehan N, Thompson J. A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Statistics in Medicine. 2017; 36(11):1783–1802. DOI: 10.1002/sim.7221
- 9Bowden J, Davey SG, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. International Journal of Epidemiology. 2015; 44(2):512–525. DOI: 10.1093/ije/dyv080
- 10Bowden J, Holmes MV. Meta-analysis and Mendelian randomization: A review. Research Synthesis Methods. 2019; 10(4):486–496. DOI: 10.1002/jrsm.1346
- 11Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nature Genetics. 2018; 50:693–698. DOI: 10.1038/s41588-018-0099-7
- 12Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, et al. Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: The Hisayama study. American Journal of Kidney Diseases. 2010; 55(1):21–30. DOI: 10.1053/j.ajkd.2009.06.034
- 13Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension. 2003; 42(5):1050–1065. DOI: 10.1161/01.HYP.0000102971.85504.7c
- 14Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010; 375(9731):2073–2081. DOI: 10.1016/S0140-6736(10)60674-5
- 15Cai Q, Mukku VK, Ahmad M. Coronary artery disease in patients with chronic kidney disease: A clinical update. Current Cardiology Reviews. 2013; 9(4):331–339. DOI: 10.2174/1573403X10666140214122234
- 16Lin CC, Chen TY, Li CI, Liu CS, Lin CH, Wang MC, et al. Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study. Scientific Reports. 2021; 11:14143. DOI: 10.1038/s41598-021-93627-5
- 17Masson P, Webster AC, Hong M, Turner R, Lindley RI, Craig JC. Chronic kidney disease and the risk of stroke: A systematic review and meta-analysis. Nephrology Dialysis Transplantation. 2015; 30(7):1162–1169. DOI: 10.1093/ndt/gfv009
- 18Ghoshal S, Freedman BI. Mechanisms of stroke in patients with chronic kidney disease. American Journal of Nephrology. 2019; 50(4):229–239. DOI: 10.1159/000502446
- 19Xiao L, Lan W, Sun W, Dai Q, Xiong Y, Li L, et al. Chronic kidney disease in patients with lacunar stroke: Association with enlarged perivascular spaces and total magnetic resonance imaging burden of cerebral small vessel disease. Stroke. 2015; 46(8):2081–2086. DOI: 10.1161/STROKEAHA.114.008155
- 20Zhao Q, Yan T, Chopp M, Venkat P, Chen J. Brain-kidney interaction: Renal dysfunction following ischemic stroke. Journal of Cerebral Blood Flow & Metabolism. 2020; 40(2):246–262. DOI: 10.1177/0271678X19890931
- 21Tisdall M, Crocker M, Watkiss J, Smith M. Disturbances of sodium in critically ill adult neurologic patients: A clinical review. Journal of Neurosurgical Anesthesiology. 2006; 18(1):57–63. DOI: 10.1097/01.ana.0000191280.05170.0f
- 22Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, et al. A global view of pulmonary hypertension. Lancet Respiratory Medicine. 2016; 4(4):306–322. DOI: 10.1016/S2213-2600(15)00543-3
- 23Sise ME, Courtwright AM, Channick RN. Pulmonary hypertension in patients with chronic and end-stage kidney disease. Kidney International. 2013; 84(4):682–692. DOI: 10.1038/ki.2013.186
- 24Bolignano D, Rastelli S, Agarwal R, Fliser D, Massy Z, Ortiz A, et al. Pulmonary hypertension in CKD. American Journal of Kidney Diseases. 2013; 61(4):612–622. DOI: 10.1053/j.ajkd.2012.07.029
- 25Matsushita K, Kwak L, Sang Y, Ballew SH, Skali H, Shah AM, et al. Kidney disease measures and left ventricular structure and function: The Atherosclerosis Risk in Communities study. Journal of American Heart Association. 2017; 6(9):
e006259 . DOI: 10.1161/JAHA.117.006259 - 26van der Velde M, Matsushita K, Coresh J, Astor BC, Woodward M, Levey A, et al. Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts. Kidney International. 2011; 79(12):1341–1352. DOI: 10.1038/ki.2010.536
- 27Matsushita K, Selvin E, Bash LD, Astor BC, Coresh J. Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD study equation for estimated GFR: The Atherosclerosis Risk in Communities (ARIC) study. American Journal of Kidney Diseases. 2010; 55(4):648–659. DOI: 10.1053/j.ajkd.2009.12.016
- 28Felipo V, Butterworth RF. Neurobiology of ammonia. Progress in Neurobiology. 2002; 67(4):259–279. DOI: 10.1016/S0301-0082(02)00019-9
- 29Kohlhaas M, Nickel AG, Maack C. Mitochondrial energetics and calcium coupling in the heart. The Journal of Physiology. 2017; 595(12):3753–3763. DOI: 10.1113/JP273609