Abstract
There are ethical, legal, and governance challenges surrounding data, particularly in the context of digital sequence information (DSI) on genetic resources. I focus on the shift in the international framework, as exemplified by the CBD-COP15 decision on benefit-sharing from DSI and discuss the growing significance of data sovereignty in the age of AI and synthetic biology. Using the example of the COVID-19 pandemic, the tension between open science principles and data control rights is explained. This opinion also highlights the importance of inclusive and equitable data sharing frameworks that respect both privacy and sovereign data rights, stressing the need for international cooperation and equitable access to data to reduce global inequalities in scientific and technological advancement.