Downregulation of Signal Regulatory Protein Alfa 1 in K562 Cells Results in the Aberrant Cell Growth in Low Serum Culture
References
- Barclay, AN and Brown, MH. The SIRP family of receptors and immune regulation. Nat Rev Immunol. 2006; 6: 457–64. DOI: 10.1038/nri1859
- Birkenkamp, KU, Dokter, WH, Esselink, MT, Jonk, LJ, Kruijer, W and Vellenga, E. A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation. Leukemia. 1999; 13: 1037–45. DOI: 10.1038/sj.leu.2401447
- Chen, J, Zhong, MC, Guo, H, Davidson, D, Mishel, S, Lu, Y, Rhee, I, Perez-Quintero, LA, Zhang, S, Cruz-Munoz, ME, Wu, N, Vinh, DC, Sinha, M, Calderon, V, Lowell, CA, Danska, JS and Veillette, A. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017; 544: 493–497. DOI: 10.1038/nature22076
- Cortez, D, Reuther, G and Pendergast, AM. The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene. 1997; 15: 2333–42. DOI: 10.1038/sj.onc.1201400
- Ding, Q, Xia, W, Liu, JC, Yang, JY, Lee, DF, Xia, J, Bartholomeusz, G, Li, Y, Pan, Y, Li, Z, Bargou, RC, Qin, J, Lai, CC, Tsai, FJ, Tsai, CH and Hung, MC. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell. 2005; 19: 159–70. DOI: 10.1016/j.molcel.2005.06.009
- Franklin, RA and Mccubrey, JA. Kinases: positive and negative regulators of apoptosis. Leukemia. 2000; 14: 2019–34. DOI: 10.1038/sj.leu.2401967
- Hirako,
N,
Nakano,
H and
Takahashi,
S.
A PU.1 suppressive target gene, metallothionein 1G, inhibits
retinoic acid-induced NB4 cell differentiation. PLoS
One. 2014; 9:
e103282 . DOI: 10.1371/journal.pone.0103282 - Hirosawa, M, Nakahara, M, Otosaka, R, Imoto, A, Okazaki, T and Takahashi, S. The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells. Leuk Res. 2009; 33: 693–9. DOI: 10.1016/j.leukres.2008.09.028
- Jaiswal, S, Jamieson, CH, Pang, WW, Park, CY, Chao, MP, Majeti, R, Traver, D, Van Rooijen, N. and Weissman, IL. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. 2009; 138: 271–85. DOI: 10.1016/j.cell.2009.05.046
- Kapoor, GS and O’rourke, DM. SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration. Oncogene. 2010; 29: 4130–44. DOI: 10.1038/onc.2010.164
- Kharitonenkov, A, Chen, Z, Sures, I, Wang, H, Schilling, J and Ullrich, A. A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature. 1997; 386: 181–6. DOI: 10.1038/386181a0
- Liu,
J,
Wang,
L,
Zhao,
F,
Tseng,
S,
Narayanan,
C,
Shura,
L,
Willingham,
S,
Howard,
M,
Prohaska,
S,
Volkmer,
J,
Chao,
M,
Weissman,
IL and
Majeti,
R.
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with
Anti-Cancer Therapeutic Potential. PLoS
One. 2015; 10:
e0137345 . DOI: 10.1371/journal.pone.0137345 - Liu, Y, Buhring, HJ, Zen, K, Burst, SL, Schnell, FJ, Williams, IR and Parkos, CA. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem. 2002; 277: 10028–36. DOI: 10.1074/jbc.M109720200
- Lunghi, P, Tabilio, A, Dall’aglio, PP, Ridolo, E, Carlo-Stella, C, Pelicci, PG and Bonati, A. Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia. 2003; 17: 1783–93. DOI: 10.1038/sj.leu.2403032
- Maekawa, T, Imoto, A, Satoh, T, Okazaki, T and Takahashi, S. Induction of beta-catenin by the suppression of signal regulatory protein alpha1 in K562 cells. Int J Mol Med. 2011; 27: 865–72. DOI: 10.3892/ijmm.2011.630
- Mccracken, MN, Cha, AC and Weissman, IL. Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 “Don’t Eat Me” Signals. Clin Cancer Res. 2015; 21: 3597–601. DOI: 10.1158/1078-0432.CCR-14-2520
- Milella, M, Kornblau, SM, Estrov, Z, Carter, BZ, Lapillonne, H, Harris, D, Konopleva, M, Zhao, S, Estey, E and Andreeff, M. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest. 2001; 108: 851–9. DOI: 10.1172/JCI12807
- Mitsui, H, Takuwa, N, Maruyama, T, Maekawa, H, Hirayama, M, Sawatari, T, Hashimoto, N, Takuwa, Y and Kimura, S. The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells. Int J Cancer. 2001; 92: 55–62. DOI: 10.1002/1097-0215(200102)9999:9999<;::AID-IJC1143>3.0.CO;2-O
- Oshima, K, Machida, K, Ichigotani, Y, Nimura, Y, Shirafuji, N, Hamaguchi, M and Matsuda, S. SHPS-1: a budding molecule against cancer dissemination. Cancer Res. 2002; 62: 3929–33.
- Platanias, LC. Map kinase signaling pathways and hematologic malignancies. Blood. 2003; 101: 4667–79. DOI: 10.1182/blood-2002-12-3647
- Qin, JM, Yan, HX, Liu, SQ, Wan, XW, Zeng, JZ, Cao, HF, Qiu, XH, Wu, MC and Wang, HY. Negatively regulating mechanism of Sirpalpha1 in hepatocellular carcinoma: an experimental study. Hepatobiliary Pancreat Dis Int. 2006; 5: 246–51.
- Rosenbauer, F, Wagner, K, Kutok, JL, Iwasaki, H, Le Beau, MM, Okuno, Y, Akashi, K, Fiering, S and Tenen, DG. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004; 36: 624–30. Epub 2004 May 16. DOI: 10.1038/ng1361
- Seiffert, M, Cant, C, Chen, Z, Rappold, I, Brugger, W, Kanz, L, Brown, EJ, Ullrich, A and Buhring, HJ. Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood. 1999; 94: 3633–43. DOI: 10.1182/blood.V94.11.3633.423k01_3633_3643
- Takahashi, S. Inhibition of the MEK/MAPK signal transduction pathway strongly impairs the growth of Flt3-ITD cells. Am J Hematol. 2006; 81: 154–5. DOI: 10.1002/ajh.20520
- Takahashi, S. Molecular functions of SIRPalpha and its role in cancer. Biomed Rep. 2018; 9: 3–7. DOI: 10.3892/br.2018.1102
- Valent, P, Ghannadan, M, Hauswirth, AW, Schernthaner, GH, Sperr, WR and Arock, M. Signal transduction-associated and cell activation-linked antigens expressed in human mast cells. Int J Hematol. 2002; 75: 357–62. DOI: 10.1007/BF02982124
- Van Der Valk, J, Brunner, D, De Smet, K, Fex Svenningsen, A, Honegger, P, Knudsen, LE, Lindl, T, Noraberg, J, Price, A, Scarino, ML and Gstraunthaler, G. Optimization of chemically defined cell culture media--replacing fetal bovine serum in mammalian in vitro methods. Toxicol In Vitro. 24: 1053–63. DOI: 10.1016/j.tiv.2010.03.016
- Wu, CJ, Chen, Z, Ullrich, A, Greene, MI and O’rourke, DM. Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs). Oncogene. 2000; 19: 3999–4010. DOI: 10.1038/sj.onc.1203748
- Yan, M, Burel, SA, Peterson, LF, Kanbe, E, Iwasaki, H, Boyapati, A, Hines, R, Akashi, K and Zhang, DE. Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Proc Natl Acad Sci U S A. 2004; 101: 17186–91. Epub 2004 Nov 29. DOI: 10.1073/pnas.0406702101
- Yao, C, Li, G, Cai, M, Qian, Y, Wang, L, Xiao, L, Thaiss, F and Shi, B. Prostate cancer downregulated SIRP-alpha modulates apoptosis and proliferation through p38-MAPK/NF-kappaB/COX-2 signaling. Oncol Lett. 2017; 13: 4995–5001. DOI: 10.3892/ol.2017.6070
DOI: https://doi.org/10.5334/1750-2187-15-1 | Journal eISSN: 1750-2187
Language: English
Page range: 1 - 1
Submitted on: Jul 14, 2020
Accepted on: Dec 3, 2021
Published on: Dec 27, 2021
Published by: Danny N. Dhanasekaran
In partnership with: Paradigm Publishing Services
Keywords:
© 2021 Shinichiro Takahashi, published by Danny N. Dhanasekaran
This work is licensed under the Creative Commons Attribution 4.0 License.