Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation

Shauna A. Rasmussen; Michelle Kwon; Jeffrey D. Pressly; Joe B. Blumer; Kevin R. Regner; Frank Park

doi:10.5334/1750-2187-10-5

Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation

Journal of Molecular Signaling

Volume 10 (2015): Issue 0

By: Shauna A. Rasmussen, Michelle Kwon, Jeffrey D. Pressly, Joe B. Blumer, Kevin R. Regner and Frank Park

Open Access

|Nov 2015

Park F Accessory proteins for heterotrimeric G-proteins in the kidney Frontiers in physiology 2015 6 219 10.3389/fphys.2015.00219 PMid: 26300785; PMCid: PMC4528294
Open DOI Search in Google Scholar Back to article
Cismowski MJ Takesono A Ma C Lizano JS Xie X Fuernkranz H Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling Nature biotechnology 1999 Sep 17 9 878 83 10.1038/12867 PMid: 10471929
Open DOI Search in Google Scholar Back to article
Takesono A Cismowski MJ Ribas C Bernard M Chung P Hazard S 3rd Receptor-independent activators of heterotrimeric G-protein signaling pathways The Journal of biological chemistry 1999 Nov 19 274 47 33202 5 10.1074/jbc.274.47.33202 PMid: 10559191
Open DOI Search in Google Scholar Back to article
Blumer JB Cismowski MJ Sato M Lanier SM AGS proteins: receptor-independent activators of G-protein signaling Trends in pharmacological sciences 2005 Sep 26 9 470 6 10.1016/j.tips.2005.07.003 PMid: 16084602
Open DOI Search in Google Scholar Back to article
Conley JM Watts VJ Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling Cellular and molecular neurobiology 2013 May 33 4 551 8 10.1007/s10571-013-9925-8 PMid: 23504261; PMCid: PMC3628818
Open DOI Search in Google Scholar Back to article
Oner SS An N Vural A Breton B Bouvier M Blumer JB Regulation of the AGS3.G{alpha}i signaling complex by a seven-transmembrane span receptor The Journal of biological chemistry 2010 Oct 29 285 44 33949 58 10.1074/jbc.M110.138073 PMid: 20716524; PMCid: PMC2962495
Open DOI Search in Google Scholar Back to article
Sato M Gettys TW Lanier SM AGS3 and signal integration by Galpha(s)- and Galpha(i)-coupled receptors: AGS3 blocks the sensitization of adenylyl cyclase following prolonged stimulation of a Galpha(i)-coupled receptor by influencing processing of Galpha(i) The Journal of biological chemistry 2004 Apr 2 279 14 13375 82 10.1074/jbc.M312660200 PMid: 14726514
Open DOI Search in Google Scholar Back to article
Blumer JB Chandler LJ Lanier SM Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis The Journal of biological chemistry 2002 May 3 277 18 15897 903 10.1074/jbc.M112185200 PMid: 11832491
Open DOI Search in Google Scholar Back to article
De Vries L Fischer T Tronchere H Brothers GM Strockbine B Siderovski DP Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits Proceedings of the National Academy of Sciences of the United States of America 2000 Dec 19 97 26 14364 9 10.1073/pnas.97.26.14364 PMid: 11121039; PMCid: 18924
Open DOI Search in Google Scholar Back to article
Pizzinat N Takesono A Lanier SM Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains The Journal of biological chemistry 2001 May 18 276 20 16601 10 10.1074/jbc.M007573200 PMid: 11278352
Open DOI Search in Google Scholar Back to article
Branham-O’Connor M Robichaux WG 3rd Zhang XK Cho H Kehrl JH Lanier SM Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3) The Journal of biological chemistry 2014 Apr 11 289 15 10738 47 10.1074/jbc.M113.515031 PMid: 24573680; PMCid: PMC4036190
Open DOI Search in Google Scholar Back to article
Kwon M Pavlov TS Nozu K Rasmussen SA Ilatovskaya DV Lerch-Gaggl A G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 26 109 52 21462 7 10.1073/pnas.1216830110 PMid: 23236168; PMCid: PMC3535663
Open DOI Search in Google Scholar Back to article
Lenarczyk M Pressly JD Arnett J Regner KR Park F Localization and expression profile of Group I and II Activators of G-protein Signaling in the kidney Journal of molecular histology 2015 Apr 46 2 123 36 10.1007/s10735-014-9605-0 PMid: 25533045; PMCid: 4369180
Open DOI Search in Google Scholar Back to article
Nadella R Blumer JB Jia G Kwon M Akbulut T Qian F Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD Journal of the American Society of Nephrology: JASN 2010 Aug 21 8 1275 80 10.1681/ASN.2009121224 PMid: 20488951; PMCid: PMC2938587
Open DOI Search in Google Scholar Back to article
Regner KR Nozu K Lanier SM Blumer JB Avner ED Sweeney WE Jr. Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2011 Jun 25 6 1844 55 PMid: 21343176; PMCid: 3101034
Search in Google Scholar Back to article
Vural A McQuiston TJ Blumer JB Park C Hwang IY Williams-Bey Y Normal autophagic activity in macrophages from mice lacking Galphai3, AGS3, or RGS19 PloS one 2013 8 11 e81886 10.1371/journal.pone.0081886 PMid: 24312373; PMCid: PMC3842979
Open DOI Search in Google Scholar Back to article
Natochin M Lester B Peterson YK Bernard ML Lanier SM Artemyev NO AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin The Journal of biological chemistry 2000 Dec 29 275 52 40981 5 10.1074/jbc.M006478200 PMid: 11024022
Open DOI Search in Google Scholar Back to article
Fan P Jiang Z Diamond I Yao L Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons Molecular pharmacology 2009 Sep 76 3 526 33 10.1124/mol.109.057802 PMid: 19549762; PMCid: PMC2730385
Open DOI Search in Google Scholar Back to article
Yao L McFarland K Fan P Jiang Z Inoue Y Diamond I Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior Proceedings of the National Academy of Sciences of the United States of America 2005 Jun 14 102 24 8746 51 10.1073/pnas.0503419102 PMid: 15937104; PMCid: PMC1142483. Epub 2005/06/07.eng
Open DOI Search in Google Scholar Back to article
Sanada K Tsai LH G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors Cell 2005 Jul 15 122 1 119 31 10.1016/j.cell.2005.05.009 PMid: 16009138
Open DOI Search in Google Scholar Back to article
Yeh C Li A Chuang JZ Saito M Caceres A Sung CH IGF-1 activates a cilium-localized noncanonical Gbetagamma signaling pathway that regulates cell-cycle progression Developmental cell 2013 Aug 26 26 4 358 68 10.1016/j.devcel.2013.07.014 PMid: 23954591; PMCid: PMC3790638
Open DOI Search in Google Scholar Back to article
White SM North LM Haines E Goldberg M Sullivan LM Pressly JD G-protein betagamma subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats Molecular pharmacology 2014 Oct 86 4 369 77 10.1124/mol.114.092346 PMid: 25028481; PMCid: PMC4164983
Open DOI Search in Google Scholar Back to article
Robles-Molina E Dionisio-Vicuna M Guzman-Hernandez ML Reyes-Cruz G Vazquez-Prado J Gbetagamma interacts with mTOR and promotes its activation Biochemical and biophysical research communications 2014 Feb 7 444 2 218 23 10.1016/j.bbrc.2014.01.044 PMid: 24462769
Open DOI Search in Google Scholar Back to article
Schwindinger WF Robishaw JD Heterotrimeric G-protein betagamma-dimers in growth and differentiation Oncogene 2001 Mar 26 20 13 1653 60 10.1038/sj.onc.1204181 PMid: 11313913
Open DOI Search in Google Scholar Back to article
Tian W Zhang Z Cohen DM MAPK signaling and the kidney American journal of physiology Renal physiology 2000 Oct 279 4 F593 604 PMid: 10997909
Search in Google Scholar Back to article
Nithianandarajah-Jones GN Wilm B Goldring CE Muller J Cross MJ ERK5: structure, regulation and function Cellular signalling 2012 Nov 24 11 2187 96 10.1016/j.cellsig.2012.07.007 PMid: 22800864
Open DOI Search in Google Scholar Back to article
Blumer JB Bernard ML Peterson YK Nezu J Chung P Dunican DJ Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha The Journal of biological chemistry 2003 Jun 27 278 26 23217 20 10.1074/jbc.C200686200 PMid: 12719437
Open DOI Search in Google Scholar Back to article
Akbulut T Regner KR Roman RJ Avner ED Falck JR Park F 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism American journal of physiology Renal physiology 2009 Sep 297 3 F662 70 10.1152/ajprenal.00146.2009 PMid: 19570883; PMCid: PMC2739708
Open DOI Search in Google Scholar Back to article
Park F Sweeney WE Jia G Roman RJ Avner ED 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease Journal of the American Society of Nephrology : JASN 2008 Oct 19 10 1929 39 10.1681/ASN.2007070771 PMid: 18596124; PMCid: PMC2551562
Open DOI Search in Google Scholar Back to article
Cude K Wang Y Choi HJ Hsuan SL Zhang H Wang CY Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway The Journal of cell biology 2007 Apr 23 177 2 253 64 10.1083/jcb.200609166 PMid: 17452529; PMCid: PMC2064134
Open DOI Search in Google Scholar Back to article
Simoes AE Pereira DM Gomes SE Brito H Carvalho T French A Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kappaB activation Cell death & disease 2015 6 e1718 PMid: 25855966
Search in Google Scholar Back to article
Kato Y Tapping RI Huang S Watson MH Ulevitch RJ Lee JD Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor Nature 1998 Oct 15 395 6703 713 6 10.1038/27234 PMid: 9790194
Open DOI Search in Google Scholar Back to article
Mulloy R Salinas S Philips A Hipskind RA Activation of cyclin D1 expression by the ERK5 cascade Oncogene 2003 Aug 21 22 35 5387 98 10.1038/sj.onc.1206839 PMid: 12934098
Open DOI Search in Google Scholar Back to article
Perez-Madrigal D Finegan KG Paramo B Tournier C The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs) Cellular signalling 2012 Dec 24 12 2360 8 10.1016/j.cellsig.2012.08.001 PMid: 22917534
Open DOI Search in Google Scholar Back to article
Wang X Gocek E Novik V Harrison JS Danilenko M Studzinski GP Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3) Cell cycle 2010 Nov 15 9 22 4542 51 10.4161/cc.9.22.13790 PMid: 21084834; PMCid: PMC3048050
Open DOI Search in Google Scholar Back to article
Wang X Merritt AJ Seyfried J Guo C Papadakis ES Finegan KG Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway Molecular and cellular biology 2005 Jan 25 1 336 45 10.1128/MCB.25.1.336-345.2005 PMid: 15601854; PMCid: PMC538774
Open DOI Search in Google Scholar Back to article
Li CJ Elsasser TH Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: involvement of caspase and proteasome pathways Journal of animal science 2005 Jan 83 1 89 97 PMid: 15583047
Search in Google Scholar Back to article
Webb CK McCudden CR Willard FS Kimple RJ Siderovski DP Oxford GS D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides Journal of neurochemistry 2005 Mar 92 6 1408 18 10.1111/j.1471-4159.2004.02997.x PMid: 15748159
Open DOI Search in Google Scholar Back to article
Bowers MS Hopf FW Chou JK Guillory AM Chang SJ Janak PH Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma Proceedings of the National Academy of Sciences of the United States of America 2008 Aug 26 105 34 12533 8 10.1073/pnas.0706999105 PMid: 18719114; PMCid: PMC2527946
Open DOI Search in Google Scholar Back to article
Robichaux WG Oner SS Lanier SM Blumer JB Direct Coupling of a Seven Transmembrane Span Receptor to a GalphaiGPR Complex Molecular pharmacology 2015 May 13 PMid: 25972449
Search in Google Scholar Back to article
Ouyang G Yao L Ruan K Song G Mao Y Bao S Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways Cell biology international 2009 Dec 33 12 1237 44 10.1016/j.cellbi.2009.08.011 PMid: 19732843
Open DOI Search in Google Scholar Back to article
Rieder CL Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2011 Apr 19 3 291 306 PMid: 21194009
Search in Google Scholar Back to article
Zhang Z Miao L Lv C Sun H Wei S Wang B Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells Cell death & disease 2013 4 e657 10.1038/cddis.2013.182 PMid: 23744357; PMCid: PMC3698549
Open DOI Search in Google Scholar Back to article
Groves B Abrahamsen H Clingan H Frantz M Mavor L Bailey J An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy PloS one 2010 5 1 e8877 10.1371/journal.pone.0008877 PMid: 20126274; PMCid: PMC2811177
Open DOI Search in Google Scholar Back to article
Sancho-Martinez SM Lopez-Novoa JM Lopez-Hernandez FJ Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury Clinical kidney journal 2015 Oct 8 5 548 59 PMid: 26413280; PMCid: PMC4581387
Search in Google Scholar Back to article
Goilav B Apoptosis in polycystic kidney disease Biochimica et biophysica acta 2011 Oct 1812 10 1272 80 10.1016/j.bbadis.2011.01.006 PMid: 21241798
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.5334/1750-2187-10-5 | Journal eISSN: 1750-2187

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Language: English

Page range: 6 - 6

Published on: Nov 27, 2015

Published by: Danny N. Dhanasekaran

In partnership with: Paradigm Publishing Services

Keywords:

Activator of G-protein Signaling 3,

cell signaling,

renal epithelial cell,

lentiviral vectors

© 2015 Shauna A. Rasmussen, Michelle Kwon, Jeffrey D. Pressly, Joe B. Blumer, Kevin R. Regner, Frank Park, published by Danny N. Dhanasekaran
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 10 (2015): Issue 0