Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A

Mingda Yan; Ji Hee Ha; Danny N Dhanasekaran

doi:10.5334/1750-2187-10-3

Gα13 Stimulates the Tyrosine Phosphorylation of Ric-8A

Journal of Molecular Signaling

Volume 10 (2015): Issue 0

By: Mingda Yan, Ji Hee Ha and Danny N Dhanasekaran

Open Access

|Jul 2015

Worzfeld T Wettschureck N Offermanns S G(12)/G(13)-mediated signalling in mammalian physiology and disease Trends in pharmacological sciences 2008 29 11 582 589 10.1016/j.tips.2008.08.002 PMid: 18814923
Open DOI Search in Google Scholar Back to article
Kelly P Casey PJ Meigs TE Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis Biochemistry 2007 46 23 6677 6687 10.1021/bi700235f PMid: 17503779
Open DOI Search in Google Scholar Back to article
Hart MJ Jiang X Kozasa T Roscoe W Singer WD Gilman AG Sternweis PC Bollag G Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 Science 1998 280 5372 2112 2114 10.1126/science.280.5372.2112 PMid: 9641916
Open DOI Search in Google Scholar Back to article
Jiang Y Ma W Wan Y Kozasa T Hattori S Huang XY The G protein G alpha12 stimulates Bruton’s tyrosine kinase and a rasGAP through a conserved PH/BM domain Nature 1998 395 6704 808 813 10.1038/27454 PMid: 9796816
Open DOI Search in Google Scholar Back to article
Yamaguchi Y Katoh H Mori K Negishi M Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity Curr Biol 2002 12 15 1353 1358 10.1016/S0960-9822(02)01034-5
Open DOI Search in Google Scholar Back to article
Meigs TE Fields TA McKee DD Casey PJ Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta-catenin release Proc Natl Acad Sci U S A 2001 98 2 519 524 10.1073/pnas.98.2.519 PMid: 11136230 PMCid: PMC14619
Open DOI Search in Google Scholar Back to article
Vaiskunaite R Adarichev V Furthmayr H Kozasa T Gudkov A Voyno-Yasenetskaya TA Conformational activation of radixin by G13 protein alpha subunit J Biol Chem 2000 275 34 26206 26212 10.1074/jbc.M001863200 PMid: 10816569
Open DOI Search in Google Scholar Back to article
Radhika V Onesime D Ha JH Dhanasekaran N Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1 J Biol Chem 2004 279 47 49406 49413 10.1074/jbc.M408836200 PMid: 15339924
Open DOI Search in Google Scholar Back to article
Kashef K Lee CM Ha JH Reddy EP Dhanasekaran DN JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway Biochemistry 2005 44 43 14090 14096 10.1021/bi050604l PMid: 16245925
Open DOI Search in Google Scholar Back to article
Miller KG Emerson MD McManus JR Rand JB RIC-8 (Synembryn). a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system Neuron 2000 27 2 289 299 10.1016/S0896-6273(00)00037-4
Open DOI Search in Google Scholar Back to article
Miller KG Rand JB A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans Genetics 2000 156 4 1649 1660 PMid: 11102364; PMCid: PMC1461398
Search in Google Scholar Back to article
Afshar K Willard FS Colombo K Johnston CA McCudden CR Siderovski DP Gonczy P RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos Cell 2004 119 2 219 230 10.1016/j.cell.2004.09.026 PMid: 15479639
Open DOI Search in Google Scholar Back to article
Tall GG Krumins AM Gilman AG Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor J Biol Chem 2003 278 10 8356 8362 10.1074/jbc.M211862200 PMid: 12509430
Open DOI Search in Google Scholar Back to article
Gloeckner CJ Boldt K Schumacher A Roepman R Ueffing M A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes Proteomics 2007 7 23 4228 4234 10.1002/pmic.200700038 PMid: 17979178
Open DOI Search in Google Scholar Back to article
Ha JH Ward JD Varadarajalu L Kim SG Dhanasekaran DN The gep proto-oncogene Galpha12 mediates LPA-stimulated activation of CREB in ovarian cancer cells Cellular signalling 2014 26 1 122 132 10.1016/j.cellsig.2013.08.012 PMid: 24055910; PMCid: PMC3992271
Open DOI Search in Google Scholar Back to article
Gomathinayagam R Muralidharan J Ha JH Varadarajalu L Dhanasekaran DN Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration Genes & cancer 2014 5 3–4 84 99 PMid: 25053987; PMCid: PMC4091533
Search in Google Scholar Back to article
Tall GG, Gilman AG Purification and functional analysis of Ric-8A: a guanine nucleotide exchange factor for G-protein alpha subunits Methods Enzymol 2004 390 377 388 10.1016/S0076-6879(04)90023-7
Open DOI Search in Google Scholar Back to article
Thomas CJ Tall GG Adhikari A Sprang SR Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3 J Biol Chem 2008 283 34 23150 23160 10.1074/jbc.M802422200 PMid: 18541531; PMCid: PMC2516996
Open DOI Search in Google Scholar Back to article
Wang L Guo D Xing B Zhang JJ Shu HB Guo L Huang XY Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem 2011 286 35 31055 31061 10.1074/jbc.M111.253427 PMid: 21771786; PMCid: PMC3162464
Open DOI Search in Google Scholar Back to article
Goldsmith ZG Ha JH Jayaraman M Dhanasekaran DN Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Galpha(12) Genes & cancer 2011 2 5 563 575 10.1177/1947601911419362 PMid: 21901169; PMCid: PMC3161422
Open DOI Search in Google Scholar Back to article
Klattenhoff C Montecino M Soto X Guzman L Romo X Garcia MA Mellstrom B Naranjo JR Hinrichs MV Olate J Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol Journal of cellular physiology 2003 195 2 151 157 10.1002/jcp.10300 PMid: 12652642
Open DOI Search in Google Scholar Back to article
Nishimura A Okamoto M Sugawara Y Mizuno N Yamauchi J Itoh H Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells Genes Cells 2006 11 5 487 498 10.1111/j.1365-2443.2006.00959.x PMid: 16629901
Open DOI Search in Google Scholar Back to article
Vellano CP Shu FJ Ramineni S Yates CK Tall GG Hepler JR Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A Biochemistry 2011 50 5 752 762 10.1021/bi101910n PMid: 21158412; PMCid: PMC3087496
Open DOI Search in Google Scholar Back to article
Woodard GE Huang NN Cho H Miki T Tall GG Kehrl JH Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle Mol Cell Biol 2010 30 14 3519 3530 10.1128/MCB.00394-10 PMid: 20479129; PMCid: PMC2897540
Open DOI Search in Google Scholar Back to article
Thomas CJ Briknarova K Hilmer JK Movahed N Bothner B Sumida JP Tall GG Sprang SR The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Galphai1 PloS one 2011 6 8 e23197 10.1371/journal.pone.0023197 PMid: 21853086; PMCid: PMC3154933
Open DOI Search in Google Scholar Back to article
Lambright DG Sondek J Bohm A Skiba NP Hamm HE Sigler PB The 2.0 A crystal structure of a heterotrimeric G protein Nature 1996 379 6563 311 319 10.1038/379311a0 PMid: 8552184
Open DOI Search in Google Scholar Back to article
Chan P Thomas CJ Sprang SR Tall GG Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein alpha subunits Proc Natl Acad Sci U S A 2013 110 10 3794 3799 10.1073/pnas.1220943110 PMid: 23431197; PMCid: PMC3593926
Open DOI Search in Google Scholar Back to article
Gabay M Pinter ME Wright FA Chan P Murphy AJ Valenzuela DM Yancopoulos GD Tall GG Ric-8 proteins are molecular chaperones that direct nascent G protein alpha subunit membrane association Sci Signal 2011 4 200 ra79 10.1126/scisignal.2002223 PMid: 22114146; PMCid: PMC3870195
Open DOI Search in Google Scholar Back to article
Chishiki K Kamakura S Yuzawa S Hayase J Sumimoto H Ubiquitination of the heterotrimeric G protein alpha subunits Galphai2 and Galphaq is prevented by the guanine nucleotide exchange factor Ric-8A Biochemical and biophysical research communications 2013 435 3 414 419 10.1016/j.bbrc.2013.04.103 PMid: 23665327
Open DOI Search in Google Scholar Back to article
Hasegawa Y Murph M Yu S Tigyi G Mills GB Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells Molecular oncology 2008 2 1 54 69 10.1016/j.molonc.2008.03.009 PMid: 19081821; PMCid: PMC2597858
Open DOI Search in Google Scholar Back to article
Ward JD Ha JH Jayaraman M Dhanasekaran DN LPA-mediated migration of ovarian cancer cells involves translocalization of Galphai2 to invadopodia and association with Src and beta-pix Cancer letters 2015 356 2 Pt B 382 391 10.1016/j.canlet.2014.09.030 PMid: 25451317
Open DOI Search in Google Scholar Back to article
Kwon T Kwon DY Chun J Kim JH Kang SS Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1 J Biol Chem 2000 275 1 423 428 10.1074/jbc.275.1.423 PMid: 10617634
Open DOI Search in Google Scholar Back to article
Schoentaube J Olling A Tatge H Just I Gerhard R Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A Cellular microbiology 2009 11 12 1816 1826 10.1111/j.1462-5822.2009.01373.x PMid: 19709124
Open DOI Search in Google Scholar Back to article
Schwarz J Proff J Havemeier A Ladwein M Rottner K Barlag B Pich A Tatge H Just I Gerhard R Serine-71 phosphorylation of Rac1 modulates downstream signaling PloS one 2012 7 9 e44358 10.1371/journal.pone.0044358 PMid: 22970203; PMCid: PMC3438190
Open DOI Search in Google Scholar Back to article
Hooley R Yu CY Symons M Barber DL G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways J Biol Chem 1996 271 11 6152 6158 10.1074/jbc.271.11.6152 PMid: 8626403
Open DOI Search in Google Scholar Back to article
Voyno-Yasenetskaya TA Faure MP Ahn NG Bourne HR Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells J Biol Chem 1996 271 35 21081 21087 10.1074/jbc.271.35.21081 PMid: 8702875
Open DOI Search in Google Scholar Back to article
Vanni C Mancini P Gao Y Ottaviano C Guo F Salani B Torrisi MR Zheng Y Eva A Regulation of proto-Dbl by intracellular membrane targeting and protein stability J Biol Chem 2002 277 22 19745 19753 10.1074/jbc.M111025200 PMid: 11907027
Open DOI Search in Google Scholar Back to article
Vanni C Mancini P Ottaviano C Ognibene M Parodi A Merello E Russo C Varesio L Zheng Y Torrisi MR Galpha13 regulation of proto-Dbl signaling Cell cycle 2007 6 16 2058 2070 10.4161/cc.6.16.4574 PMid: 17721084
Open DOI Search in Google Scholar Back to article
Chan PM Lim L Manser E PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway J Biol Chem 2008 283 36 24949 24961 10.1074/jbc.M801728200 PMid: 18586681; PMCid: PMC3259815
Open DOI Search in Google Scholar Back to article
Kang JS Bae GU Yi MJ Yang YJ Oh JE Takaesu G Zhou YT Low BC Krauss RS A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation J Cell Biol 2008 182 3 497 507 10.1083/jcb.200801119 PMid: 18678706 PMCid: PMC2500135
Open DOI Search in Google Scholar Back to article
Meyer TN Hunt J Schwesinger C Denker BM Galpha12 regulates epithelial cell junctions through Src tyrosine kinases American journal of physiology Cell physiology 2003 285 5 C1281 1293 10.1152/ajpcell.00548.2002 PMid: 12890651
Open DOI Search in Google Scholar Back to article
Gong H Shen B Flevaris P Chow C Lam SC Voyno-Yasenetskaya TA Kozasa T Du X G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin “outside-in” signaling Science 2010 327 5963 340 343 10.1126/science.1174779 PMid: 20075254. PMCid: PMC2842917
Open DOI Search in Google Scholar Back to article
Siderovski DP Willard FS The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits International journal of biological sciences 2005 1 2 51 66 10.7150/ijbs.1.51 PMid: 15951850; PMCid: PMC1142213
Open DOI Search in Google Scholar Back to article
Sethakorn N Yau DM Dulin NO Non-canonical functions of RGS proteins Cellular signalling 2010 22 9 1274 1281 10.1016/j.cellsig.2010.03.016 PMid: 20363320; PMCid: PMC2893250
Open DOI Search in Google Scholar Back to article
Blumer JB Lanier SM Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad Mol Pharmacol 2014 85 3 388 396 10.1124/mol.113.090068 PMid: 24302560; PMCid: PMC3935153
Open DOI Search in Google Scholar Back to article
Ghosh P Garcia-Marcos M Farquhar MG GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression Cell adhesion & migration 2011 5 3 237 248 10.4161/cam.5.3.15909 PMCid: PMC3210208
Open DOI Search in Google Scholar Back to article
Tall GG Ric-8 regulation of heterotrimeric G proteins Journal of receptor and signal transduction research 2013 33 3 139 143 10.3109/10799893.2013.763828 PMid: 23384070; PMCid: PMC3870196
Open DOI Search in Google Scholar Back to article
Bian D Mahanivong C Yu J Frisch SM Pan ZK Ye RD Huang S The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration Oncogene 2006 25 15 2234 2244 10.1038/sj.onc.1209261 PMid: 16301993
Open DOI Search in Google Scholar Back to article
Malik S Ghosh M Bonacci TM Tall GG Smrcka AV Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells Mol Pharmacol 2005 68 1 129 136 PMid: 15802611
Search in Google Scholar Back to article
Hampoelz B Hoeller O Bowman SK Dunican D Knoblich JA Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins Nat Cell Biol 2005 7 11 1099 1105 10.1038/ncb1318 PMid: 16228011
Open DOI Search in Google Scholar Back to article
Wang H Ng KH Qian H Siderovski DP Chia W Yu F Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins Nat Cell Biol 2005 7 11 1091 1098 10.1038/ncb1317 PMid: 16228012
Open DOI Search in Google Scholar Back to article
David NB Martin CA Segalen M Rosenfeld F Schweisguth F Bellaiche Y Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division Nat Cell Biol 2005 7 11 1083 1090 10.1038/ncb1319 PMid: 16228010
Open DOI Search in Google Scholar Back to article
Peters KA Rogers SL Drosophila Ric-8 interacts with the Galpha12/13 subunit, Concertina, during activation of the Folded gastrulation pathway Mol Biol Cell 2013 24 21 3460 3471 http://dx.doi.org/10.1091/mbc.E12-11-0813. PMid: 24006487; PMCid: PMC3818808
Search in Google Scholar Back to article
Yang F Camp DG 2nd Gritsenko MA Luo Q Kelly RT Clauss TR Brinkley WR Smith RD Stenoien DL Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus J Cell Sci 2007 120 Pt 22 4060 4070 10.1242/jcs.014795 PMid: 17971412
Open DOI Search in Google Scholar Back to article
Mayya V Lundgren DH Hwang SI Rezaul K Wu L Eng JK Rodionov V Han DK Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions Sci Signal 2009 2 84 ra46 10.1126/scisignal.2000007 PMid: 19690332
Open DOI Search in Google Scholar Back to article
Mao J Xie W Yuan H Simon MI Mano H Wu D Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13 The EMBO journal 1998 17 19 5638 5646 10.1093/emboj/17.19.5638 PMid: 9755164; PMCid: PMC1170892
Open DOI Search in Google Scholar Back to article
Bunda S Wang Y Mitts TF Liu P Arab S Arabkhari M Hinek A Aldosterone stimulates elastogenesis in cardiac fibroblasts via mineralocorticoid receptor-independent action involving the consecutive activation of Galpha13, c-Src, the insulin-like growth factor-I receptor, and phosphatidylinositol 3-kinase/Akt J Biol Chem 2009 284 24 16633 16647 10.1074/jbc.M109.008748 PMid: 19372600; PMCid: PMC2713569
Open DOI Search in Google Scholar Back to article
Wang L Guo D Xing B Zhang JJ Shu HB Guo L Huang XY Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem 2011 286 35 31055 31061 10.1074/jbc.M111.253427 PMid: 21771786; PMCid: PMC3162464
Open DOI Search in Google Scholar Back to article

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DOI: https://doi.org/10.5334/1750-2187-10-3 | Journal eISSN: 1750-2187

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Language: English

Page range: 3 - 3

Published on: Jul 27, 2015

Published by: Danny N. Dhanasekaran

In partnership with: Paradigm Publishing Services

Keywords:

Gα13,

Ric-8A,

membrane-translocation,

Src,

Cdc42,

p38MAPK

© 2015 Mingda Yan, Ji Hee Ha, Danny N Dhanasekaran, published by Danny N. Dhanasekaran
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 10 (2015): Issue 0