Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

Adam Byrski; Magdalena Kopernik; Łukasz Major; Katarzyna Kasperkiewicz; Marcin Dyner; Juergen M. Lackner; David B. Lumenta; Roman Major

doi:10.37190/abb-02156-2022-02

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Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants

Acta of Bioengineering and Biomechanics

Volume 25 (2023): Issue 1 (March 2023)

By: Adam Byrski, Magdalena Kopernik, Łukasz Major, Katarzyna Kasperkiewicz, Marcin Dyner, Juergen M. Lackner, David B. Lumenta and Roman Major

Open Access

|May 2024

Abstract

Purpose: The research was focused on determining basic mechanical properties, surface, and phase structure taking into consideration basic cytotoxicity analysis towards human cells.

Methods: Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing.

Results: Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance increasing cell survivability by more than 10%.

Conclusions: Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.

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Articles in this issue

DOI: https://doi.org/10.37190/abb-02156-2022-02 | Journal eISSN: 2450-6303 | Journal ISSN: 1509-409X

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Language: English

Page range: 3 - 17

Submitted on: Nov 21, 2022

Accepted on: Feb 22, 2023

Published on: May 18, 2024

Published by: Wroclaw University of Science and Technology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

laser based-powder bed fusion,

lithography-based ceramic manufacturing,

bone implant,

cytotoxicity,

micromechanical properties

Related subjects:

Engineering,

Bioengineering and biomedical engineering,

Cellular and tissue engineering,

Biomechanics,

Medicine,

Biomedical engineering,

Materials sciences,

Biomaterials and natural materials

© 2024 Adam Byrski, Magdalena Kopernik, Łukasz Major, Katarzyna Kasperkiewicz, Marcin Dyner, Juergen M. Lackner, David B. Lumenta, Roman Major, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 25 (2023): Issue 1 (March 2023)