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Ferric Carboxymaltose as an Effective and Safe Alternative to Iron Sucrose for Treatment of Iron Deficiency Anemia during Pregnancy Cover

Ferric Carboxymaltose as an Effective and Safe Alternative to Iron Sucrose for Treatment of Iron Deficiency Anemia during Pregnancy

Open Access
|Nov 2025

References

  1. CDC criteria for anaemia in children and child-bearing-aged women. MMWR Morb Mortal Wkly Rep. 1989;138(22):400–404.
  2. Kharde PS, Bangal VB, Panicker KK. Comparative study of intravenous iron sucrose versus oral iron therapy in iron deficiency anaemia during postpartum period. Int J Biomed Adv Res. 2012;3(4):238–43. doi:10.7439/IJBAR.V3I4.426.
  3. National Family Health Survey (NFHS-4) (2015–16). Anaemia in children and adults. Available from: rchiips.org/NFHS/factsheet_NFHS-4.shtml.
  4. Tandon R, Jain A, Malhotra P. Management of iron deficiency anaemia in pregnancy in India. Indian J Hematol Blood Transfus. 2018;34(2):204–15. doi:10.1007/s12288-018-0949-6.
  5. McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I. Routine iron supplementation and screening for iron deficiency anaemia in pregnant women: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2015;162:566–576. doi:10.7326/M14-2932.
  6. Cunningham F, Leveno K, Bloom S, Spong CY, Dashe JS, Hoffman BL, Casey B, Sheffield J. Maternal physiology. Williams obstetrics. 25th ed. New York: McGraw Hills; 2018, p. 58.
  7. Chandra S, Tripathi AK, Mishra S, Amzarul M, Vaish AK. Physiological changes in hematological parameters during pregnancy. Indian J Hematol Blood Transfus. 2012;28(3):144–6. doi:10.1007/s12288-012-0175-6.
  8. World Health Organization. Guideline: daily iron and folic acid supplementation in pregnant women. Geneva: World Health Organization; Nutrition and Food Safety (NFS), 2012. ISBN: 978 92 4 150199 6.
  9. Beris P, Maniatis A. on behalf of the NATA working group on intravenous iron therapy. Guidelines on intravenous iron supplementation in surgery and obstetrics/gynecology. Transfus Altern Transfus Med. 2007;9(Suppl 1):29.
  10. Kumar A, Jain S, Singh NP, Singh T. Oral versus high dose parenteral iron supplementation in pregnancy. Int J Gynecol & Obstet. 2005;89(1):7–13. doi:10.1016/j.ijgo.2005.01.016.
  11. Johnson-Wimbley TD, Graham DY. Diagnosis and management of iron deficiency anaemia in the 21st century. Therap Adv Gastroenterol. 2011;4(3):177–84. doi:10.1177/1756283X11398736.
  12. Sharma N. Iron absorption: IPC therapy is superior to conventional iron salts. Obstet Gynecol. 2001;18:515–9.
  13. Kriplani A, Mahey R, Dash BB, Kulshreshta V, Agarwal N, Bhatla N. Intravenous iron sucrose therapy for moderate to severe anaemia in pregnancy. Indian J Med Res. 2013;138:78–82.
  14. Breymann C, Milman N, Mezzacasa A, Bernard R, Dudenhausen J. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med. 2017;45(4):443–53. doi:10.1515/jpm-2016-0050.
  15. Rathod S, Samal SK, Mahapatra PC, Samal S. Ferric carboxymaltose: a revolution in the treatment of postpartum anaemia in Indian women. Int J Appl Basic Med Res. 2015;5(1):25–30. doi:10.4103/2229-516X.149230.
  16. Mishra VV, Chaudhary S, Gandhi K, Sharma U, Patel U. Study of intravenous ferric carboxy maltose in iron deficiency anaemia during pregnancy and post-partum period: safety and efficacy. Ind J Obstet Gynecol Res. 2015;2(2):69–72. https://ijogr.org/archive/volume/2/issue/2/article/12642#article.
  17. Patel J, Patel K, Patel J, Sharma A, Date S. Comparison of intravenous iron sucrose and ferric carboxymaltose therapy in iron deficiency anaemia during pregnancy and postpartum period. J Pharm Sci Bioscientific Res (JPSBR). 2015;5(3):239–43. https://www.jpsbr.org/volume_5/JPSBR_Vol_5_Issue_1_htm_files/JPSBR15RS3011.pdf.
  18. Hol KV, Damle H, Shekhawat GS, Hol A. Comparative study of intravenous iron sucrose versus ferric carboxymaltose for the treatment of iron deficiency anaemia in postpartum patients. Int J Reprod Contracept Obstet Gynecol. 2015;4(3):669–73. doi:10.18203/2320-1770.ijrcog20150071.
  19. Singh A, Yerragudi R. Comparative study of safety and efficacy of intravenous iron sucrose and ferric carboxymaltose in the treatment of postpartum iron deficiency anaemia. Int J Reprod Contracept Obstet Gynecol. 2016;5(4):1130–3. doi:10.18203/2320-1770.ijrcog20160871.
  20. Lunagariya M, Nakum KD, Vithal A, Patel J, Patel M. Iron sucrose vs ferric carboxymaltose: in search of better treatment option in cases of post partum iron deficiency anaemia. Int J Contemp Med Res (IJCMR). 2018; 5(1):12–16. https://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_1852_v1.pdf.
  21. Christoph P, Schuller C, Studer H, Irion O, De Tejada BM, Surbek D. Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose. J Perinat Med. 2012;40(5):469–74. doi:10.1515/jpm-2011-0231.
  22. Boughton S, Chen L, Kidson-Gerber G, Curtain C, Zaidi ST, Henry A. Intravenous iron sucrose and ferric carboxymaltose in pregnant patients: an observational study of maternal efficacy and tolerance. J Pharm Pract Res. 2017;47(6):419–25. doi:10.1002/jppr.1265.
  23. Dhanani JV, Ganguly BP, Chauhan LN. Comparison of efficacy and safety of two parenteral iron preparations in pregnant women. J Pharmacol Pharmacother. 2012;3(4):314–9. doi:10.4103/0976-500X.103688.
  24. Jose A, Mahey R, Sharma JB, Bhatla N, Saxena R, Kalaivani M et al. Comparison of ferric carboxymaltose and iron sucrose complex for treatment of iron deficiency anaemia in pregnancy: randomised controlled trial. BMC Pregnancy Childbirth. 2019;19(1):54:1–8. doi:10.1186/s12884-019-2200-3.
  25. Qassim A, Mol BW, Grivell RM, Grzeskowiak LE. Safety and efficacy of intravenous iron polymaltose, iron sucrose and ferric carboxymaltose in pregnancy: a systematic review. Aust NZ J Obstet Gynecol. 2018;58(1):22–39. doi:10.1111/ajo.12695.
  26. Patel GR, Thanvi I, Seervi RC, Jakhar R. Evaluation of therapeutic response and tolerability to intravenous iron sucrose and ferric carboxymaltose among pregnant women with iron deficiency anemia: a 6 year experience in a tertiary care center. Med Int (Lond). 2025;5(4):34. doi:10.3892/mi.2025.233.
DOI: https://doi.org/10.34763/jmotherandchild.20252901.d-25-00018 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488
Language: English
Page range: 187 - 192
Submitted on: Mar 16, 2025
Accepted on: Aug 16, 2025
Published on: Nov 5, 2025
Published by: Institute of Mother and Child
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Aparajita Singh, Manu Goyal, Shashank Shekhar, Pratibha Singh, Praveen Sharma, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.