Impact of Maternal Diet During Pregnancy on Allergic Predisposition in Offspring: Immune Programming Mechanisms

Lisiecka, Maria Zofia

Impact of Maternal Diet During Pregnancy on Allergic Predisposition in Offspring: Immune Programming Mechanisms

Journal of Mother and Child

Volume 29 (2025): Issue 1 (February 2025)

By: Maria Zofia Lisiecka

Open Access

|Nov 2025

References

Ogrodowczyk AM, Zakrzewska M, Romaszko E, Wróblewska B. Gestational dysfunction-driven diets and probiotic supplementation correlate with the profile of allergen-specific antibodies in the serum of allergy sufferers. Nutrients. 2020;12(8):2381. doi:10.3390/nu12082381.
Open DOI Search in Google Scholar Back to article
Jerzyńska A, Polańska A, Trafalska E, Jankowska A, Podlecka D, Brzozowska A. Prenatal polyunsaturated fatty acids and atopic dermatitis and food allergy in children from Polish Mother and Child Cohort study. Int J Occup Med Environ Health. 2023;36(3):428–436. doi:10.13075/ijomeh.1896.02222.
Open DOI Search in Google Scholar Back to article
Bogoyavlenskiy A, Alexyuk M, Alexyuk P, Amanbayeva M, Anarkulova E, Imangazy A, et al. Metagenomic exploration of Koumiss from Kazakhstan. Microbiol Resour Announc. 2022;11(1):e01082–21. doi:10.1128/mra.01082-21.
Open DOI Search in Google Scholar Back to article
Michońska I, Łuszczki E, Zielińska M, Oleksy Ł, Stolarczyk A, Dereń K. Nutritional programming: history, hypotheses, and the role of prenatal factors in the prevention of metabolic diseases–a narrative review. Nutrients. 2022;14(20):4422. doi:10.3390/nu14204422.
Open DOI Search in Google Scholar Back to article
Gao Y, Nanan R, Macia L, Tan J, Sominsky L, Quinn TP, et al. The maternal gut microbiome during pregnancy and offspring allergy and asthma. J Allergy Clin Immunol. 2021;148(3):669–678. doi:10.1016/j.jaci.2021.07.011.
Open DOI Search in Google Scholar Back to article
Smiyan O, Lyndin M, Romaniuk O, Sikora V, Piddubnyi A, Yurchenko A, et al. The case of undiagnosed immunodeficiency in child from mother with leukemia anamnesis. Intervent Med Appl Sci. 2018;10(4):216–221. doi:10.1556/1646.10.2018.46.
Open DOI Search in Google Scholar Back to article
Aktaeva LM, Mirzakhmetova DD, Padaiga Z. Extragenital pathologies of pregnant women in the southern regions of the Republic of Kazakhstan. Syst Rev Pharm. 2020;11(4):405–412.
Search in Google Scholar Back to article
Di Costanzo M, De Paulis N, Capra ME, Biasucci G. Nutrition during pregnancy and lactation: epigenetic effects on infants’ immune system in food allergy. Nutrients. 2022;14(9):1766. doi:10.3390/nu14091766.
Open DOI Search in Google Scholar Back to article
Bai T, Wang Z, Shao H, Zhang X, Lorenz A, Meng X, et al. Novel perspective on the regulation of offspring food allergy by maternal diet and nutrients. J Agric Food Chem. 2024;72(19):10679–10691. doi:10.1021/acs.jafc.3c09108.
Open DOI Search in Google Scholar Back to article
Venter C, Tan W, Pickett-Nairne K, Amara S, Venter M, Glueck DH, et al. Systematic review on maternal dietary patterns during pregnancy and offspring allergy. Pediatr Allergy Immunol. 2024;35(12):e70016. doi:10.1111/pai.70016.
Open DOI Search in Google Scholar Back to article
Coppola S, Paparo L, Chiariotti L, Ercolini D, Nocerino R, de Giovanni di Santa Severina AF, et al. Effects of the Mediterranean eiet during pregnancy on the onset of allergy in at risk children: a study protocol of a multi-center, randomized-controlled, parallel groups, prospective trial (the PREMEDI study). Front Nutr. 2022;9:951223. doi:10.3389/fnut.2022.951223.
Open DOI Search in Google Scholar Back to article
World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi:10.1001/jama.2013.281053.
Open DOI Search in Google Scholar Back to article
World Health Organization. Good clinical laboratory practice (GCLP). Geneva: World Health Organization, 2009. https://iris.who.int/handle/10665/44092.
Search in Google Scholar Back to article
Food Frequency Questionnaire. 2025. https://biolincc.nhlbi.nih.gov/media/studies/framoffspring/Forms/Exam%203%20Food%20Frequency%20Questionnaire.pdf?link_time=2018-08-11_23:58:42.966309. August 11, 2025.
Search in Google Scholar Back to article
Araujo LML, Souza C, Zanchin NIT, Rosário Filho NA. Identification of the major allergenic proteins from silkworm moth (Bombyx mori) involved in respiratory allergic diseases. Allergol Immunopathol (Madr). 2020;48(6):597–602.
Search in Google Scholar Back to article
Hartmane I, Ivdra I, Mikazans I, Bondare-Ansberga V. Immunopathogenic treatment options for psoriasis patients under a restrictive reimbursement environment. Proceed Latv Acad Sci, Sec B: Nat, Exact, Appl Sci. 2021;75(3):158–166. doi:10.2478/prolas-2021-0025.
Open DOI Search in Google Scholar Back to article
Hartmane I. Study of genetic mutations and their association with the development of atopic dermatitis and other skin diseases. Plast Aesthet Nurs. 2024;44(3):200–209. doi:10.1097/PSN.0000000000000564.
Open DOI Search in Google Scholar Back to article
Kasian S, Loboda A, Smiyan O, Popov S, Petrashenko V, Zahorodnii M, et al. The lead content in biological media term infants with hypoxic-ischemic cns. Banglad J Med Sci. 2021;20(2):330–333. doi:10.3329/bjms.v20i2.51543.
Open DOI Search in Google Scholar Back to article
Gulamov I, Abylov K, Uulu Nurlan R, Satyvaldiev M, Kalmatov R, Batyraliev T. Urogenital disease morbidity among the adult and child population of the Osh Region for the period from 2010 to 2019. Gac Med Caracas. 2023;131(3):656–661. doi:10.47307/GMC.2023.131.3.17.
Open DOI Search in Google Scholar Back to article
Diaferio L, Parisi GF, Brindisi G, Indolfi C, Marchese G, Ghiglioni DG, et al. Cross-sectional survey on impact of paediatric COVID-19 among Italian paediatricians: report from the SIAIP rhino-sinusitis and conjunctivitis committee. Ital J Pediatr. 2020;46(1):146. doi:10.1186/s13052-020-00906-4.
Open DOI Search in Google Scholar Back to article
Skak K, Tabriz NS, Nurtazina ZB, Mutaikhan Z. Drug-resistant tuberculosis and modern approaches towards its diagnosis. Int J Clin Skills. 2017;11(3):73–78.
Search in Google Scholar Back to article
Tabriz N, Nurtazina ZB, Kozhamuratov MT, Skak K, Mutaikhan Z. Effects of secondary infections on the multidrug-resistant tuberculosis: a cohort study. Med J Islam Repub Iran. 2021; 35(1):1–7.
Search in Google Scholar Back to article
Kim JK. Effects of maternal diet during pregnancy or lactation on the development or prevention of allergic diseases in offspring. J Korean Maternal Child Health. 2022;26(3):121–131. doi:10.21896/jksmch.2022.26.3.121.
Open DOI Search in Google Scholar Back to article
Gupta A, Singh A, Fernando RL, Dharmage SC, Lodge CJ, Waidyatillake NT. The association between sugar intake during pregnancy and allergies in offspring: a systematic review and a meta-analysis of cohort studies. Nutr Rev. 2022;80(4):904–918. doi:10.1093/nutrit/nuab052.
Open DOI Search in Google Scholar Back to article
Bai T, Shao H, Yang F, Zhang X, Tong P, Meng X, et al. Maternal high-fat diet exacerbates epicutaneous sensitization and oral challenge-induced food allergy to ovalbumin in offspring mice. J Agric Food Chem. 2024;72(38):21240–21253. doi:10.1021/acs.jafc.4c05373.
Open DOI Search in Google Scholar Back to article
Popov S, Profatylo A, Turner M, Smiian O, Vasylieva O. Features of the progression of the inflammatory response in newborns with neonatal encephalopathy. East Ukrain Med J. 2024;12(1):50–60. doi:10.21272/eumj.2024;12(1):50-60.
Open DOI Search in Google Scholar Back to article
Salaks J, Žalnora A, Toomsalu M. Comments on the article. Combatting venereal diseases as an instrument of politicised medicine: an analysis of the example of the Soviet occupation zone in Germany, the German Democratic Republic, and the Polish Peoples’ Republic by Marcin Orzechowski, Maximilian Schochow and Florian Steger. Acta Med-Histor Rigens. 2020;13:83–92. doi:10.25143/amhr.2020.XIII.05.
Open DOI Search in Google Scholar Back to article
Salaks J, Garnizone M. Review of the Centennial Congress of the International Ssociety for the History of Medicine in Riga. Acta Baltica Histor Philos Scient. 2021;9(2):116–133. doi:10.11590/ABHPS.2021.2.06.
Open DOI Search in Google Scholar Back to article
Ogawa K, Pak K, Yamamoto-Hanada K, Ishitsuka K, Sasaki H, Mezawa H, et al. Association between maternal vegetable intake during pregnancy and allergy in offspring: Japan Environment and Children’s Study. PLoS One. 2021;16(1):e0245782. doi:10.1371/journal.pone.0245782.
Open DOI Search in Google Scholar Back to article
Lee HY, Nazmul T, Lan J, Oyoshi MK. Maternal influences on offspring food allergy. Immunol Rev. 2024;326(1):130–150. doi:10.1111/imr.13392.
Open DOI Search in Google Scholar Back to article
Venter C, Pickett-Nairne K, Leung D, Fleischer D, O'Mahony L, Glueck DH, et al. Maternal allergy-preventive diet index, offspring infant diet diversity, and childhood allergic diseases. Allergy. 2024;79(12):3475–3488. doi:10.1111/all.16292.
Open DOI Search in Google Scholar Back to article
Grijincu M, Buzan M-R, Zbîrcea L-E, Păunescu V, Panaitescu C. Prenatal factors in the development of allergic diseases. Int J Mol Sci. 2024;25(12):6359. doi:10.3390/ijms25126359.
Open DOI Search in Google Scholar Back to article
Jiao L, Su CW, Cao T, Zheng S, Walker WA, Shi HN. Maternal influences and intervention strategies on the development of food allergy in offspring. Front Immunol. 2022;13:817062. doi:10.3389/fimmu.2022.817062.
Open DOI Search in Google Scholar Back to article
Sid Idris F, Anis Shaikh H, Vahora I, Moparthi KP, Al Rushaidi MT, Muddam M, et al. Maternal diet and infant risk of eczema and food allergy: systematic review. Cureus. 2023;15(9):e45114. doi:10.7759/cureus.45114.
Open DOI Search in Google Scholar Back to article
Nelson B, Friedman JE. Developmental programming of the fetal immune system by maternal Western-style diet: mechanisms and implications for disease pathways in the offspring. Int J Mol Sci. 2024;25(11):5951. doi:10.3390/ijms25115951.
Open DOI Search in Google Scholar Back to article
Coronado J. Maternal infection and altered fetal immune programming. J Immunol. 2024;212(1_Supplement):0662_6255. doi:10.4049/jimmunol.212.supp.0662.6255.
Open DOI Search in Google Scholar Back to article
Zainal NHM, Nor NHM, Saat A, Clifton VL. Childhood allergy susceptibility: the role of the immune system development in the in-utero period. Hum Immunol. 2022;83(5):437–446. doi:10.1016/j.humimm.2022.02.002.
Open DOI Search in Google Scholar Back to article
Xie Q, Cui D, Zhu Q, Qin X, Ren D, Xu X. Supplementing maternal diet with milk oligosaccharides and probiotics helps develop the immune system and intestinal flora of offsprings. Food Sci Nutr. 2023;11(11):6868–6877. doi:10.1002/fsn3.3579.
Open DOI Search in Google Scholar Back to article
Zhao S, Chen Z, Liu H, Wang X, Zhang X, Shi H. Maternal nutrition and offspring lung health: sex-specific pathway modulation in fibrosis, metabolism, and immunity. Food Nutr Res. 2025;69:11035. doi:10.29219/fnr.v69.11035.
Open DOI Search in Google Scholar Back to article
Reiter AS, Kawaida MY, Tillquist NM, Smith B, Govoni KE, Zinn SA, et al. PSVI-10 effects of poor maternal nutrition during gestation on offspring basal immune status. J Anim Sci. 2023;101(Supplement_3):410–411. doi:10.1093/jas/skad281.487.
Open DOI Search in Google Scholar Back to article
Dyba MB, Berezenko VS. Possibilities of shear wave elastography in the diagnosis of liver fibrosis and monitoring of autoimmune liver diseases in children. Modern Pediatr Ukr. 2023;8:34–41. doi:10.15574/SP.2023.136.34.
Open DOI Search in Google Scholar Back to article
Berezenko VS, Mykhailiuk KhZ, Krechko YaV, Tkalyk OM, Dyba MB, Bezpala AV. Ornithine transcarbamylase deficiency is a little-known rare disease in pediatric hepatology (clinical case). Modern Pediatr Ukr. 2022;7(127):111–116. doi:10.15574/SP.2022.127.111.
Open DOI Search in Google Scholar Back to article
Balla J, Rathore APS, St. John AL. Mechanisms and risk factors for perinatal allergic disease. Curr Opin Immunol. 2024;91:102505. doi:10.1016/j.coi.2024.102505.
Open DOI Search in Google Scholar Back to article
Lim AI, McFadden T, Link VM, Han SJ, Karlsson RM, Stacy A, et al. Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring. Science. 2021;373(6558):eabf3002. doi:10.1126/science.abf3002.
Open DOI Search in Google Scholar Back to article
Damron CL, Bloodworth JC, Hoji A, Casasnovas J, Kua KL, Cook-Mills JM. Increased allergic inflammation and decreased lung insulin sensitivity in offspring of obese allergic mothers. J Leukoc Biol. 2024;116(5):985–994. doi:10.1093/jleuko/qiae135.
Open DOI Search in Google Scholar Back to article
Wu Y, Chen B, Wu H, Gao J, Meng X, Chen H. How maternal factors shape the immune system of breastfed infants to alleviate food allergy: a systematic and updated review. Immunology. 2025;174(1):1–16. doi:10.1111/imm.13864.
Open DOI Search in Google Scholar Back to article
Hanson C, Rifas-Shiman SL, Shivappa N, Wirth MD, Hebert JR, Gold D, et al. Associations of prenatal dietary inflammatory potential with childhood respiratory outcomes in Project Viva. J Allergy Clin Immunol Pract. 2020;8(3):945–952.e4. doi:10.1016/j.jaip.2019.10.010.
Open DOI Search in Google Scholar Back to article
Han VX, Patel S, Jones HF, Dale RC. Maternal immune activation and neuroinflammation in human neurodevelopmental disorders. Nat Rev Neurol. 2021;17:564–579. doi:10.1038/s41582-021-00530-8.
Open DOI Search in Google Scholar Back to article
Pretorius RA, McKinnon E, Palmer DJ. Higher maternal bread and thiamine intakes are associated with increased infant allergic disease. Pediatr Allergy Immunol. 2024;35(9):e14237. doi:10.1111/pai.14237.
Open DOI Search in Google Scholar Back to article