Leptin, Leptin Receptor Concentrations and Free Leptin Index (FLI) in Polish Healthy Children and Adolescents

Gajewska, Joanna; Rowicka, Grażyna; Klemarczyk, Witold; Głąb-Jabłońska, Ewa; Ambroszkiewicz, Jadwiga

Leptin, Leptin Receptor Concentrations and Free Leptin Index (FLI) in Polish Healthy Children and Adolescents

Journal of Mother and Child

Volume 29 (2025): Issue 1 (February 2025)

By: Joanna Gajewska

, Grażyna Rowicka

, Witold Klemarczyk

, Ewa Głąb-Jabłońska

and Jadwiga Ambroszkiewicz

Open Access

|Mar 2025

References

Park HK, Ahima RS. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 2015;64(1):24–34. doi: 10.1016/j.metabol.2014.08.004.
Open DOI Search in Google Scholar Back to article
Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci. 2013;9(2):191–200. doi: 10.5114/aoms.2013.33181.
Open DOI Search in Google Scholar Back to article
Rosenbaum M, Leibel RL. 20 years of leptin: role of leptin in energy homeostasis in humans. J Endocrinol. 2014;223(1):T83–96. doi: 10.1530/JOE-14-0358.
Open DOI Search in Google Scholar Back to article
Stefanakis K, Upadhyay J, Ramirez-Cisneros A, Patel N, Sahai A, Mantzoros CS. Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health. Metabolism. 2024;161:156056. doi: 10.1016/j.metabol.2024.156056. Epub 2024 Oct 30.
Open DOI Search in Google Scholar Back to article
Górczyńska-Kosiorz S, Kosiorz M, Dzięgielewska-Gęsiak S. Górczyńska-Kosiorz S, Kosiorz M, Dzięgielewska-Gęsiak S. Exploring the interplay of genetics and nutrition in the rising epidemic of obesity and metabolic diseases. Nutrients. 2024; 16(20):3562. doi: 10.3390/nu16203562.
Open DOI Search in Google Scholar Back to article
Alipoor E, Mohammad Hosseinzadeh F, Hosseinzadeh-Attar MJ. Adipokines in critical illness: A review of the evidence and knowledge gaps. Biomed Pharmacother. 2018;108:1739–1750. doi: 10.1016/j.biopha.2018.09.165.
Open DOI Search in Google Scholar Back to article
Zhang Q, Ye H, Miao Q, Zhang Z, Wang Y, Zhu X, et al. Differences in the metabolic status of healthy adults with and without active brown adipose tissue. Wien Klin Wochenschr. 2013;125(21–22):687–95. doi: 10.1007/s00508-013-0431-2.
Open DOI Search in Google Scholar Back to article
Zhou X, Chai Y, Chen K, Yang Y, Liu Z. A meta-analysis of reference values of leptin concentration in healthy postmenopausal women. PLoS One. 2013;8(8):e72734. doi: 10.1371/journal.pone.0072734.
Open DOI Search in Google Scholar Back to article
Martos-Moreno GA, Barrios V, Argente J. Normative data for adiponectin, resistin, interleukin 6, and leptin/receptor ratio in a healthy Spanish pediatric population: relationship with sex steroids. Eur J Endocrinol. 2006;155(3):429–34. doi: 10.1530/eje.1.02227.
Open DOI Search in Google Scholar Back to article
Schaab M, Kratzsch J. The soluble leptin receptor. Best Pract Res Clin Endocrinol Metab. 2015;29(5):661–70. doi: 10.1016/j.beem.2015.08.002.
Open DOI Search in Google Scholar Back to article
Owecki M, Nikisch E, Miczke A, Pupek-Musialik D, Sowiński J. Leptin, soluble leptin receptors, free leptin index, and their relationship with insulin resistance and BMI: high normal BMI is the threshold for serum leptin increase in humans. Horm Metab Res. 2010;42(8):585–9. doi: 10.1055/s-0030-1253422.
Open DOI Search in Google Scholar Back to article
Holm JC, Gamborg M, Ward LC, Gammeltoft S, Kaas-Ibsen K, Heitmann BL, et al. Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children. Sørensen TI. Obes Facts. 2011;4(6):461–8. doi: 10.1159/000335121.
Open DOI Search in Google Scholar Back to article
Herrick JE, Panza GS, Gollie JM. Leptin, leptin soluble receptor, and the free leptin index following a diet and physical activity lifestyle intervention in obese males and females. J Obes. 2016;2016:8375828. doi: 10.1155/2016/8375828.
Open DOI Search in Google Scholar Back to article
Baranowska-Bik A, Baranowska B, Martyńska L, Litwiniuk A, Kalisz M, Kochanowski J, et al. Adipokine profile in patients with anorexia nervosa. Endokrynol Pol. 2017;68(4):422–429. doi: 10.5603/EP.a2017.0035.
Open DOI Search in Google Scholar Back to article
Boutari C, Pappas PD, Mintziori G, Nigdelis MP, Athanasiadis L, Goulis DG, et al. The effect of underweight on female and male reproduction. Metabolism. 2020;107:154229. doi: 10.1016/j.metabol.2020.154229.
Open DOI Search in Google Scholar Back to article
Vigouroux C, Mosbah H, Vatier C. Leptin replacement therapy in the management of lipodystrophy syndromes. Ann Endocrinol (Paris). 2024;85(3):201–204. doi: 10.1016/j.ando.2024.05.022.
Open DOI Search in Google Scholar Back to article
Mondal S, Rathor R, Singh SN, Suryakumar G. miRNA and leptin signaling in metabolic diseases and at extreme environments. Pharmacol Res Perspect. 2024;12(4):e1248. doi: 10.1002/prp2.1248.
Open DOI Search in Google Scholar Back to article
Wang C, Chang L, Wang J, Xia L, Cao L, Wang W, et al. Leptin and risk factors for atherosclerosis: A review. Medicine (Baltimore). 2023;102(46):e36076. doi: 10.1097/MD.0000000000036076.
Open DOI Search in Google Scholar Back to article
Blüher S, Shah S, Mantzoros CS. Leptin deficiency: clinical implications and opportunities for therapeutic interventions. J Investig Med. 2009;57(7):784–788. doi: 10.2310/JIM.0b013e3181b9163d.
Open DOI Search in Google Scholar Back to article
Kempf E, Vogel M, Vogel T, Kratzsch J, Landgraf K, Kühnapfel A, et al. Dynamic alterations in linear growth and endocrine parameters in children with obesity and height reference values. Clinical Medicine. 2021;37:100977. doi: 10.1016/j.eclinm.2021.100977.
Open DOI Search in Google Scholar Back to article
Catli G, Anik A, Tuhan HÜ, Kume T, Bober E, Abaci A. The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children. Peptides. 2014;56:72–76. doi: 10.1016/j.peptides.2014.03.015.
Open DOI Search in Google Scholar Back to article
Hebebrand J, Hildebrandt T, Schlögl H, Seitz J, Denecke S, Vieira D, et al. The role of hypoleptinemia in the psychological and behavioral adaptation to starvation: Implications for anorexia nervosa. Neurosci Biobehav Rev. 2022;141:104807. doi: 10.1016/j.neubiorev.2022.104807.
Open DOI Search in Google Scholar Back to article
Villasis-Keever MA, Zurita-Cruz JN, Zepeda-Martinez C, Alegria-Torres G, Serret-Montoya J, Estrada-Loza MJ, et al. Adipokines as predictive factor of cardiac function in pediatric patients with chronic kidney disease. Front Endocrinol (Lausanne). 2023;14:1120445. doi: 10.3389/fendo.2023.1120445.
Open DOI Search in Google Scholar Back to article
Kułaga Z, Różdżyńska - Świątkowska A, Grajda A, Gurzkowska B, Wojtyło M, Góźdź M, et al. Percentile charts for growth and nutritional status assessment in Polish children and adolescents from birth to 18 year of age. Stand. Med. 2015;12:119–135.
Search in Google Scholar Back to article
Hamann TV, Mørk FCB, Jensen AK, Jørgensen NR, Heidemann MS, Schou AJ, et al. Reference serum percentile values of adiponectin, leptin, and adiponectin/leptin ratio in healthy Danish children and adolescents. Scand J Clin Lab Invest. 2022;82(4):267–276. doi: 10.1080/00365513.2022.2073911.
Open DOI Search in Google Scholar Back to article
Lausten-Thomsen U, Christiansen M, Louise Hedley P, Esmann Fonvig C, Stjernholm T, Pedersen O, et al. Reference values for serum leptin in healthy non-obese children and adolescents. Scand J Clin Lab Invest. 2016;76(7):561–567. doi: 10.1080/00365513.2016.1210226.
Open DOI Search in Google Scholar Back to article
Erhardt E, Foraita R, Pigeot I, Barba G, Veidebaum T, Tornaritis M, et al. Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort. Int J Obes (Lond). 2014;38 Suppl 2:S32–8. doi: 10.1038/ijo.2014.133.
Open DOI Search in Google Scholar Back to article
Papaioannou HI, Stakos DA, Tziakas DN, Chalikias G, Tsigalou C, Kartali S, et al. Plasma leptin and adiponectin concentrations in healthy, non-obese children. J Pediatr Endocrinol Metab. 2011;24(5–6):313–8. doi: 10.1515/jpem.2011.037.
Open DOI Search in Google Scholar Back to article
Brandão CM, Lombardi MT, Nishida SK, Hauache OM, Vieira JG. Serum leptin concentration during puberty in healthy non-obese adolescents. Braz J Med Biol Res. 2003;36(10):1293–6. doi: 10.1590/s0100-879x2003001000003.
Open DOI Search in Google Scholar Back to article
Madsen A, Almås B, Bruserud IS, Oehme NHB, Nielsen CS, Roelants M, et al. Reference curves for pediatric endocrinology: leveraging biomarker Z-scores for clinical classifications. J Clin Endocrinol Metab. 2022;107(7):2004–2015. doi: 10.1210/clinem/dgac155.
Open DOI Search in Google Scholar Back to article
Wilasco MI, Goldani HA, Dornelles CT, Maurer RL, Kieling CO, Porowski M, et al. Ghrelin, leptin and insulin in healthy children: Relationship with anthropometry, gender, and age distribution. Regul Pept. 2012;173(1–3):21–6. doi: 10.1016/j.regpep.2011.08.013.
Open DOI Search in Google Scholar Back to article
Zastrow O, Seidel B, Kiess W, Thiery J, Keller E, Bottuer A, et al. The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int. J. Obes. Relat. Metab. Disord. 2003; 27:1472–1478.
Search in Google Scholar Back to article
Aller R, Primo Martín D, Izaola O, Martínez JA, de Luis Román D. Association of the leptin receptor rs 1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects. Nutr Hosp. 2023;40(1):35–40. doi: 10.20960/nh.04139.
Open DOI Search in Google Scholar Back to article
Gajewska J, Kuryłowicz A, Mierzejewska E, Ambroszkiewicz J, Chełchowska M, Weker H, et al. Complementary effects of genetic variations in LEPR on body composition and soluble leptin receptor concentration after 3-month lifestyle intervention in prepubertal obese children. Nutrients. 2016;8(6):328. doi: 10.3390/nu8060328.
Open DOI Search in Google Scholar Back to article
de Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Conde R, de la Fuente B, et al. Effect of Lys656Asn polymorphism of leptin receptor gene on cardiovascular risk factors and serum adipokine levels after a high polyunsaturated fat diet in obese patients. J Clin Lab Anal. 2015;29(6):432–6. doi: 10.1002/jcla.21790.
Open DOI Search in Google Scholar Back to article
Lu J, Zou D, Zheng L, Chen G, Lu J, Feng Z. Synergistic effect of LEP and LEPR gene polymorphism on body mass index in a Chinese population. Obes Res Clin Pract. 2013;7(6):e445–9. doi: 10.1016/j.orcp.2012.06.007.
Open DOI Search in Google Scholar Back to article
Hojeij B, Rousian M, Sinclair KD, Dinnyes A, Steegers-Theunissen RPM, Schoenmakers S. Periconceptional biomarkers for maternal obesity: a systematic review. Rev Endocr Metab Disord. 2023;24(2):139–175. doi: 10.1007/s11154-022-09762-5.
Open DOI Search in Google Scholar Back to article
Kulik-Rechberger B, Bury AM, Rakuś-Kwiatosz A, Beń-Skowronek I. Cortisol, leptin and free leptin index (FLI) in newborns in the first days of life and their importance for body weight programming. Ital J Pediatr. 2019;45(1):141. doi: 10.1186/s13052-019-0743-6.
Open DOI Search in Google Scholar Back to article
Moody L, Chen H, Pan YX. Early-life nutritional programming of cognition-the fundamental role of epigenetic mechanisms in mediating the relation between early-life environment and learning and memory process. Adv Nutr. 2017;8(2):337–350. doi: 10.3945/an.116.014209.
Open DOI Search in Google Scholar Back to article
Nier A, Brandt A, Baumann A, Conzelmann IB, Özel Y, Bergheim I. Metabolic abnormalities in normal weight children are associated with increased visceral fat accumulation, elevated plasma endotoxin levels and a higher monosaccharide intake. Nutrients. 2019;11(3):652. doi: 10.3390/nu11030652.
Open DOI Search in Google Scholar Back to article
Stakos DA, Papaioannou HI, Angelidou I, Mantadakis E, Paraskakis E, Tsigalou C, Chatzimichael A. Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children. J Pediatr Endocrinol Metab. 2014 Mar;27(3–4):221–8. doi: 10.1515/jpem-2013-0195.
Open DOI Search in Google Scholar Back to article
Lubis SM, Fattah M, Batubara JRL, Quinka M. High free leptin index as the risk factor for childhood obesity in Indonesia: A case-control study. Clin Obes. 2023 Jun;13(3):e12586. doi: 10.1111/cob.12586.
Open DOI Search in Google Scholar Back to article
Pratapwar MP, Sheth HJ, Ravi AK, Block ML, Korber KA, Kepsel A, et al. Use of biomarkers in nutrition intervention studies of children: a scoping review. Nutrients. 2024;16(21):3584. doi: 10.3390/nu16213584.
Open DOI Search in Google Scholar Back to article
Alzamil H, Aldokhi L, Habib SS. Physical fitness and its relationship to plasma leptin, leptin soluble receptor, and free leptin index in a Saudi population: a comparison between diabetic and non-diabetic individuals. Med Sci Monit Basic Res. 2018 Aug 9;24:113–119. doi: 10.12659/MSMBR.910573.
Open DOI Search in Google Scholar Back to article
Gajewska J, Weker H, Ambroszkiewicz J, Szamotulska K, Chełchowska M, Franek E, et al. Alterations in markers of bone metabolism and adipokines following a 3-month lifestyle intervention induced weight loss in obese prepubertal children. Exp Clin Endocrinol Diabetes. 2013;121(8):498–504. doi: 10.1055/s-0033-1347198.
Open DOI Search in Google Scholar Back to article
Serin Y, Acar Tek N. Effect of circadian rhythm on metabolic processes and the regulation of energy balance. Ann Nutr Metab. 2019;74(4):322–330. doi: 10.1159/000500071.
Open DOI Search in Google Scholar Back to article

DOI: https://doi.org/10.34763/jmotherandchild.20252901.d-24-00049 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488

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Language: English

Page range: 1 - 9

Submitted on: Nov 27, 2024

Accepted on: Jan 24, 2025

Published on: Mar 28, 2025

Published by: Institute of Mother and Child

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

adipokines,

leptin,

soluble leptin receptor,

healthy children

Related subjects:

Medicine,

Clinical medicine,

Pediatrics and juvenile medicine,

Paediatric haematology and oncology,

Public health

© 2025 Joanna Gajewska, Grażyna Rowicka, Witold Klemarczyk, Ewa Głąb-Jabłońska, Jadwiga Ambroszkiewicz, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.

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